YBL047C / EDE1

Endocytic protein; involved in a network of interactions with other endocytic proteins, binds membranes in a ubiquitin-dependent manner, may also bind ubiquitinated membrane-associated proteins; interacts with Cmk2 and functions upstream of CMK2 in regulating non-apoptotic cell death

Zygosity: Homozygous strain
fixedexpanded
Profile for YBL047C / EDE1

Click on Significant Values for Screen Details ID:SGTC_65|Compound:0798-0905|FD-Score:5.22|P-value:2.91E-9 ID:SGTC_138|Compound:0850-0259|FD-Score:3.43|P-value:5.27E-5 ID:SGTC_307|Compound:1501-1223|FD-Score:2.80|P-value:7.06E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:-3.14|P-value:5.48E-4 ID:SGTC_424|Compound:splitomicin|FD-Score:3.32|P-value:8.69E-5 ID:SGTC_451|Compound:chloral hydrate|FD-Score:4.28|P-value:8.06E-7 ID:SGTC_663|Compound:1486-0733|FD-Score:5.11|P-value:5.75E-9 ID:SGTC_700|Compound:3453-2283|FD-Score:3.61|P-value:2.33E-5 ID:SGTC_728|Compound:3030-5151|FD-Score:3.42|P-value:5.56E-5 ID:SGTC_800|Compound:3448-7362|FD-Score:2.97|P-value:3.74E-4 ID:SGTC_802|Compound:4112-3352|FD-Score:3.01|P-value:3.18E-4 ID:SGTC_823|Compound:0417-1665|FD-Score:3.27|P-value:1.08E-4 ID:SGTC_840|Compound:0245-0196|FD-Score:3.11|P-value:2.05E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:-3.53|P-value:1.14E-4 ID:SGTC_948|Compound:3448-0295|FD-Score:3.23|P-value:1.26E-4 ID:SGTC_961|Compound:1252-1571|FD-Score:3.64|P-value:2.05E-5 ID:SGTC_975|Compound:1335-0046|FD-Score:6.45|P-value:4.17E-13 ID:SGTC_1002|Compound:4049-0206|FD-Score:2.79|P-value:7.43E-4 ID:SGTC_1005|Compound:4092-0690|FD-Score:3.07|P-value:2.47E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:3.65|P-value:1.93E-5 ID:SGTC_1097|Compound:itavastatin|FD-Score:3.77|P-value:1.11E-5 ID:SGTC_1103|Compound:duloxetine|FD-Score:2.82|P-value:6.64E-4 ID:SGTC_1123|Compound:mangostin|FD-Score:2.89|P-value:4.94E-4 ID:SGTC_1179|Compound:1021-1431|FD-Score:8.18|P-value:8.00E-20 ID:SGTC_1297|Compound:1068-0111|FD-Score:2.93|P-value:4.34E-4 ID:SGTC_1301|Compound:naphtanilide LB|FD-Score:3.95|P-value:4.40E-6 ID:SGTC_1367|Compound:1812-0510|FD-Score:3.64|P-value:1.98E-5 ID:SGTC_1480|Compound:1070-0044|FD-Score:2.75|P-value:8.67E-4 ID:SGTC_1502|Compound:4534-4282|FD-Score:3.22|P-value:1.34E-4 ID:SGTC_1521|Compound:st012942|FD-Score:2.77|P-value:8.00E-4 ID:SGTC_1817|Compound:st052116|FD-Score:7.66|P-value:1.22E-17 ID:SGTC_1844|Compound:rapamycin|FD-Score:5.65|P-value:1.60E-10 ID:SGTC_1923|Compound:st058458|FD-Score:2.77|P-value:7.97E-4 ID:SGTC_1933|Compound:st074711|FD-Score:3.54|P-value:3.25E-5 ID:SGTC_1986|Compound:st071812|FD-Score:3.25|P-value:1.14E-4 ID:SGTC_2026|Compound:5148700|FD-Score:3.25|P-value:1.16E-4 ID:SGTC_2071|Compound:5230951|FD-Score:3.48|P-value:4.30E-5 ID:SGTC_2114|Compound:5491910|FD-Score:2.96|P-value:3.84E-4 ID:SGTC_2130|Compound:NSC 7|FD-Score:4.31|P-value:6.68E-7 ID:SGTC_2166|Compound:5933061|FD-Score:2.91|P-value:4.57E-4 ID:SGTC_2216|Compound:7189485|FD-Score:3.10|P-value:2.15E-4 ID:SGTC_2238|Compound:6671620|FD-Score:5.06|P-value:8.18E-9 ID:SGTC_2241|Compound:6772625|FD-Score:3.38|P-value:6.67E-5 ID:SGTC_2261|Compound:9010538|FD-Score:5.08|P-value:7.21E-9 ID:SGTC_2306|Compound:7482397|FD-Score:4.11|P-value:1.93E-6 ID:SGTC_2345|Compound:9052315|FD-Score:2.84|P-value:6.08E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:5.22|P-value:2.87E-9 ID:SGTC_2423|Compound:st077119|FD-Score:2.95|P-value:3.90E-4 ID:SGTC_2428|Compound:5615643|FD-Score:2.76|P-value:8.23E-4 ID:SGTC_2431|Compound:5490079|FD-Score:2.88|P-value:5.27E-4 ID:SGTC_2456|Compound:5770359|FD-Score:3.47|P-value:4.49E-5 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:4.09|P-value:2.23E-6 ID:SGTC_2582|Compound:agaric acid|FD-Score:2.90|P-value:4.79E-4 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:2.93|P-value:4.25E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:5.66|P-value:1.50E-10 ID:SGTC_2726|Compound:cimetidine|FD-Score:3.07|P-value:2.47E-4 ID:SGTC_2867|Compound:9039098|FD-Score:2.77|P-value:7.95E-4 ID:SGTC_2871|Compound:9038510|FD-Score:-3.51|P-value:1.24E-4 ID:SGTC_2873|Compound:9040596|FD-Score:2.79|P-value:7.25E-4 ID:SGTC_2912|Compound:7964298|FD-Score:2.90|P-value:4.76E-4 ID:SGTC_2971|Compound:9092186|FD-Score:3.02|P-value:3.02E-4 ID:SGTC_3016|Compound:9080866|FD-Score:3.12|P-value:1.99E-4 ID:SGTC_3073|Compound:9114972|FD-Score:4.20|P-value:1.19E-6 ID:SGTC_3112|Compound:9123419|FD-Score:2.89|P-value:5.10E-4 ID:SGTC_3200|Compound:9114385|FD-Score:4.52|P-value:2.13E-7 ID:SGTC_3203|Compound:9113543|FD-Score:5.40|P-value:8.55E-10 ID:SGTC_3205|Compound:9113483|FD-Score:3.20|P-value:1.43E-4 ID:SGTC_3222|Compound:9128301|FD-Score:4.56|P-value:1.70E-7 ID:SGTC_65|Compound:0798-0905|FD-Score:5.22|P-value:2.91E-9 ID:SGTC_138|Compound:0850-0259|FD-Score:3.43|P-value:5.27E-5 ID:SGTC_307|Compound:1501-1223|FD-Score:2.80|P-value:7.06E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:-3.14|P-value:5.48E-4 ID:SGTC_424|Compound:splitomicin|FD-Score:3.32|P-value:8.69E-5 ID:SGTC_451|Compound:chloral hydrate|FD-Score:4.28|P-value:8.06E-7 ID:SGTC_663|Compound:1486-0733|FD-Score:5.11|P-value:5.75E-9 ID:SGTC_700|Compound:3453-2283|FD-Score:3.61|P-value:2.33E-5 ID:SGTC_728|Compound:3030-5151|FD-Score:3.42|P-value:5.56E-5 ID:SGTC_800|Compound:3448-7362|FD-Score:2.97|P-value:3.74E-4 ID:SGTC_802|Compound:4112-3352|FD-Score:3.01|P-value:3.18E-4 ID:SGTC_823|Compound:0417-1665|FD-Score:3.27|P-value:1.08E-4 ID:SGTC_840|Compound:0245-0196|FD-Score:3.11|P-value:2.05E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:-3.53|P-value:1.14E-4 ID:SGTC_948|Compound:3448-0295|FD-Score:3.23|P-value:1.26E-4 ID:SGTC_961|Compound:1252-1571|FD-Score:3.64|P-value:2.05E-5 ID:SGTC_975|Compound:1335-0046|FD-Score:6.45|P-value:4.17E-13 ID:SGTC_1002|Compound:4049-0206|FD-Score:2.79|P-value:7.43E-4 ID:SGTC_1005|Compound:4092-0690|FD-Score:3.07|P-value:2.47E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:3.65|P-value:1.93E-5 ID:SGTC_1097|Compound:itavastatin|FD-Score:3.77|P-value:1.11E-5 ID:SGTC_1103|Compound:duloxetine|FD-Score:2.82|P-value:6.64E-4 ID:SGTC_1123|Compound:mangostin|FD-Score:2.89|P-value:4.94E-4 ID:SGTC_1179|Compound:1021-1431|FD-Score:8.18|P-value:8.00E-20 ID:SGTC_1297|Compound:1068-0111|FD-Score:2.93|P-value:4.34E-4 ID:SGTC_1301|Compound:naphtanilide LB|FD-Score:3.95|P-value:4.40E-6 ID:SGTC_1367|Compound:1812-0510|FD-Score:3.64|P-value:1.98E-5 ID:SGTC_1480|Compound:1070-0044|FD-Score:2.75|P-value:8.67E-4 ID:SGTC_1502|Compound:4534-4282|FD-Score:3.22|P-value:1.34E-4 ID:SGTC_1521|Compound:st012942|FD-Score:2.77|P-value:8.00E-4 ID:SGTC_1817|Compound:st052116|FD-Score:7.66|P-value:1.22E-17 ID:SGTC_1844|Compound:rapamycin|FD-Score:5.65|P-value:1.60E-10 ID:SGTC_1923|Compound:st058458|FD-Score:2.77|P-value:7.97E-4 ID:SGTC_1933|Compound:st074711|FD-Score:3.54|P-value:3.25E-5 ID:SGTC_1986|Compound:st071812|FD-Score:3.25|P-value:1.14E-4 ID:SGTC_2026|Compound:5148700|FD-Score:3.25|P-value:1.16E-4 ID:SGTC_2071|Compound:5230951|FD-Score:3.48|P-value:4.30E-5 ID:SGTC_2114|Compound:5491910|FD-Score:2.96|P-value:3.84E-4 ID:SGTC_2130|Compound:NSC 7|FD-Score:4.31|P-value:6.68E-7 ID:SGTC_2166|Compound:5933061|FD-Score:2.91|P-value:4.57E-4 ID:SGTC_2216|Compound:7189485|FD-Score:3.10|P-value:2.15E-4 ID:SGTC_2238|Compound:6671620|FD-Score:5.06|P-value:8.18E-9 ID:SGTC_2241|Compound:6772625|FD-Score:3.38|P-value:6.67E-5 ID:SGTC_2261|Compound:9010538|FD-Score:5.08|P-value:7.21E-9 ID:SGTC_2306|Compound:7482397|FD-Score:4.11|P-value:1.93E-6 ID:SGTC_2345|Compound:9052315|FD-Score:2.84|P-value:6.08E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:5.22|P-value:2.87E-9 ID:SGTC_2423|Compound:st077119|FD-Score:2.95|P-value:3.90E-4 ID:SGTC_2428|Compound:5615643|FD-Score:2.76|P-value:8.23E-4 ID:SGTC_2431|Compound:5490079|FD-Score:2.88|P-value:5.27E-4 ID:SGTC_2456|Compound:5770359|FD-Score:3.47|P-value:4.49E-5 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:4.09|P-value:2.23E-6 ID:SGTC_2582|Compound:agaric acid|FD-Score:2.90|P-value:4.79E-4 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:2.93|P-value:4.25E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:5.66|P-value:1.50E-10 ID:SGTC_2726|Compound:cimetidine|FD-Score:3.07|P-value:2.47E-4 ID:SGTC_2867|Compound:9039098|FD-Score:2.77|P-value:7.95E-4 ID:SGTC_2871|Compound:9038510|FD-Score:-3.51|P-value:1.24E-4 ID:SGTC_2873|Compound:9040596|FD-Score:2.79|P-value:7.25E-4 ID:SGTC_2912|Compound:7964298|FD-Score:2.90|P-value:4.76E-4 ID:SGTC_2971|Compound:9092186|FD-Score:3.02|P-value:3.02E-4 ID:SGTC_3016|Compound:9080866|FD-Score:3.12|P-value:1.99E-4 ID:SGTC_3073|Compound:9114972|FD-Score:4.20|P-value:1.19E-6 ID:SGTC_3112|Compound:9123419|FD-Score:2.89|P-value:5.10E-4 ID:SGTC_3200|Compound:9114385|FD-Score:4.52|P-value:2.13E-7 ID:SGTC_3203|Compound:9113543|FD-Score:5.40|P-value:8.55E-10 ID:SGTC_3205|Compound:9113483|FD-Score:3.20|P-value:1.43E-4 ID:SGTC_3222|Compound:9128301|FD-Score:4.56|P-value:1.70E-7

Top fitness defect scores for YBL047C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1179 1021-1431 8.18 9.3 µM 8.00E-20 4 1.44E-16
2 SGTC_1817 st052116 7.66 64.4 µM 1.22E-17 RNA processing & uracil transport 2 9.59E-15
3 SGTC_975 1335-0046 6.45 28.5 µM 4.17E-13 RPP1 & pyrimidine depletion 4 5.72E-11
4 SGTC_2679 rapamycin 5.66 1.0 nM 1.50E-10 86 7.63E-9
5 SGTC_1844 rapamycin 5.65 4.0 nM 1.60E-10 95 8.05E-9
6 SGTC_3203 9113543 5.40 49.5 µM 8.55E-10 8 3.24E-8
7 SGTC_2418 pentamidine 5.22 31.7 µM 2.87E-9 mitochondrial processes 22 8.85E-8
8 SGTC_65 0798-0905 5.22 35.0 µM 2.91E-9 calcium & mitochondrial duress 47 8.96E-8
9 SGTC_663 1486-0733 5.11 13.9 µM 5.75E-9 cell wall signaling 28 1.58E-7
10 SGTC_2261 9010538 5.08 184.7 µM 7.21E-9 5 1.90E-7
11 SGTC_2238 6671620 5.06 73.2 µM 8.18E-9 11 2.11E-7
12 SGTC_3222 9128301 4.56 49.5 µM 1.70E-7 60S ribosome export 12 2.61E-6
13 SGTC_3200 9114385 4.52 49.5 µM 2.13E-7 22 3.15E-6
14 SGTC_2130 NSC 7 4.31 2.5 µM 6.68E-7 copper-dependent oxidative stress 15 8.11E-6
15 SGTC_451 chloral hydrate 4.28 100.0 µM 8.06E-7 40 9.48E-6
16 SGTC_3073 9114972 4.20 49.5 µM 1.19E-6 60S ribosome export 8 1.31E-5
17 SGTC_2306 7482397 4.11 179.5 µM 1.93E-6 RPP1 & pyrimidine depletion 19 1.95E-5
18 SGTC_2531 methyl deoxycholate 4.09 70.1 µM 2.23E-6 21 2.20E-5
19 SGTC_1301 naphtanilide LB 3.95 4.8 µM 4.40E-6 heme requiring 9 3.86E-5
20 SGTC_1097 itavastatin 3.77 7.2 µM 1.11E-5 azole & statin 26 8.28E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.208 5.14E-34 YKL203C TOR2 het PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis; TOR2 has a paralog, TOR1, that arose from the whole genome duplication
0.198 6.11E-31 YLR114C AVL9 hom Conserved protein involved in exocytic transport from the Golgi; mutation is synthetically lethal with apl2 vps1 double mutation; member of a protein superfamily with orthologs in diverse organisms; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.183 1.19E-26 YJR066W TOR1 hom PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis; TOR1 has a paralog, TOR2, that arose from the whole genome duplication
0.172 9.45E-24 YML121W GTR1 hom Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB
0.168 1.26E-22 YHR186C KOG1 het Subunit of TORC1, a rapamycin-sensitive complex involved in growth control that contains Tor1p or Tor2p, Lst8p and Tco89p; contains four HEAT repeats and seven WD-40 repeats; may act as a scaffold protein to couple TOR and its effectors
0.162 3.76E-21 YBR077C SLM4 hom Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; gene exhibits synthetic genetic interaction with MSS4
0.161 8.15E-21 YHR111W UBA4 hom Protein that activates Urm1p before its conjugation to proteins (urmylation); also acts in thiolation of the wobble base of cytoplasmic tRNAs by adenylating and then thiolating Urm1p; receives sulfur from Tum1p
0.149 5.28E-18 YKR007W MEH1 hom Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; loss results in a defect in vacuolar acidification
0.146 1.84E-17 YNL119W NCS2 hom Protein required for thiolation of the uridine at the wobble position of Lys(UUU) and Glu(UUC) tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae
0.146 2.05E-17 YKL110C KTI12 hom Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p
0.145 2.57E-17 YHR187W IKI1 hom Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; iki1 mutations confer resistance to the K. lactis toxin zymocin
0.145 3.27E-17 YGR163W GTR2 hom Putative GTP binding protein that negatively regulates Ran/Tc4 GTPase cycle; activates transcription; subunit of EGO and GSE complexes; required for sorting of Gap1p; localizes to cytoplasm and to chromatin; homolog of human RagC and RagD
0.143 6.96E-17 YLL043W FPS1 hom Plasma membrane channel, member of major intrinsic protein (MIP) family; involved in efflux of glycerol and in uptake of acetic acid and the trivalent metalloids arsenite and antimonite; phosphorylated by Hog1p MAPK under acetate stress
0.143 8.66E-17 YGL211W NCS6 hom Protein required for thiolation of the uridine at the wobble position of Gln, Lys, and Glu tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae
0.129 5.72E-14 YOR184W SER1 hom 3-phosphoserine aminotransferase; catalyzes the formation of phosphoserine from 3-phosphohydroxypyruvate, required for serine and glycine biosynthesis; regulated by the general control of amino acid biosynthesis mediated by Gcn4p; protein abundance increases in response to DNA replication stress