YBL048W_d / RRT1

Identified in a screen for mutants with increased levels of rDNA transcription; dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YBL048W / RRT1

Click on Significant Values for Screen Details ID:SGTC_99|Compound:0109-0120|FD-Score:-4.19|P-value:5.65E-5 ID:SGTC_160|Compound:3453-0671|FD-Score:5.54|P-value:1.76E-7 ID:SGTC_220|Compound:paclitaxel|FD-Score:3.69|P-value:3.53E-4 ID:SGTC_296|Compound:1222-0039|FD-Score:3.73|P-value:3.06E-4 ID:SGTC_364|Compound:0083-0097|FD-Score:-5.35|P-value:3.99E-7 ID:SGTC_426|Compound:0988-0037|FD-Score:4.16|P-value:6.66E-5 ID:SGTC_515|Compound:4092-1064|FD-Score:-3.71|P-value:3.11E-4 ID:SGTC_516|Compound:3992-2719|FD-Score:3.66|P-value:3.92E-4 ID:SGTC_517|Compound:1365-0151|FD-Score:7.09|P-value:3.49E-11 ID:SGTC_521|Compound:r062-0005|FD-Score:4.75|P-value:6.26E-6 ID:SGTC_522|Compound:1273-0010|FD-Score:-3.97|P-value:1.27E-4 ID:SGTC_651|Compound:3253-0966|FD-Score:6.52|P-value:1.00E-9 ID:SGTC_652|Compound:0437-0092|FD-Score:-3.81|P-value:2.18E-4 ID:SGTC_667|Compound:1498-1044|FD-Score:6.31|P-value:3.29E-9 ID:SGTC_824|Compound:1304-0008|FD-Score:3.54|P-value:5.67E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:-3.81|P-value:2.21E-4 ID:SGTC_1168|Compound:k815-0004|FD-Score:4.44|P-value:2.27E-5 ID:SGTC_1320|Compound:1313-0481|FD-Score:4.87|P-value:3.78E-6 ID:SGTC_1329|Compound:1447-1697|FD-Score:3.93|P-value:1.51E-4 ID:SGTC_1354|Compound:1498-1681|FD-Score:3.56|P-value:5.41E-4 ID:SGTC_1432|Compound:4049-0298|FD-Score:4.37|P-value:2.95E-5 ID:SGTC_1454|Compound:4239-0054|FD-Score:4.40|P-value:2.64E-5 ID:SGTC_1573|Compound:oleylamine|FD-Score:3.56|P-value:5.33E-4 ID:SGTC_1684|Compound:st024538|FD-Score:4.75|P-value:6.32E-6 ID:SGTC_1771|Compound:st048882|FD-Score:5.18|P-value:9.49E-7 ID:SGTC_1925|Compound:st057770|FD-Score:4.99|P-value:2.27E-6 ID:SGTC_1936|Compound:st074407|FD-Score:4.26|P-value:4.61E-5 ID:SGTC_2014|Compound:4013930|FD-Score:4.48|P-value:1.91E-5 ID:SGTC_2068|Compound:5226020|FD-Score:4.15|P-value:6.83E-5 ID:SGTC_2125|Compound:5246583|FD-Score:7.05|P-value:4.60E-11 ID:SGTC_2132|Compound:5317594|FD-Score:8.06|P-value:6.29E-14 ID:SGTC_2325|Compound:6158266|FD-Score:3.93|P-value:1.54E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:-3.38|P-value:9.16E-4 ID:SGTC_2545|Compound:solidagenone|FD-Score:-3.61|P-value:4.29E-4 ID:SGTC_2549|Compound:cedrol|FD-Score:-4.84|P-value:4.01E-6 ID:SGTC_2550|Compound:chrysin dimethyl ether|FD-Score:-4.50|P-value:1.64E-5 ID:SGTC_2551|Compound:apiole|FD-Score:-3.78|P-value:2.43E-4 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:4.30|P-value:3.88E-5 ID:SGTC_2755|Compound:lomerizine|FD-Score:5.22|P-value:7.86E-7 ID:SGTC_2875|Compound:9039966|FD-Score:3.96|P-value:1.37E-4 ID:SGTC_2904|Compound:7225135|FD-Score:3.91|P-value:1.65E-4 ID:SGTC_2915|Compound:7971052|FD-Score:-3.74|P-value:2.80E-4 ID:SGTC_2952|Compound:9073731|FD-Score:3.86|P-value:1.97E-4 ID:SGTC_2958|Compound:9077254|FD-Score:3.89|P-value:1.76E-4 ID:SGTC_3121|Compound:9125696|FD-Score:4.16|P-value:6.61E-5 ID:SGTC_3203|Compound:9113543|FD-Score:-5.60|P-value:1.21E-7 ID:SGTC_3218|Compound:9131285|FD-Score:-3.66|P-value:3.66E-4 ID:SGTC_3284|Compound:9108171|FD-Score:-3.42|P-value:7.97E-4 ID:SGTC_3295|Compound:9122362|FD-Score:3.46|P-value:7.48E-4 ID:SGTC_3296|Compound:9122258|FD-Score:3.65|P-value:3.93E-4 ID:SGTC_99|Compound:0109-0120|FD-Score:-4.19|P-value:5.65E-5 ID:SGTC_160|Compound:3453-0671|FD-Score:5.54|P-value:1.76E-7 ID:SGTC_220|Compound:paclitaxel|FD-Score:3.69|P-value:3.53E-4 ID:SGTC_296|Compound:1222-0039|FD-Score:3.73|P-value:3.06E-4 ID:SGTC_364|Compound:0083-0097|FD-Score:-5.35|P-value:3.99E-7 ID:SGTC_426|Compound:0988-0037|FD-Score:4.16|P-value:6.66E-5 ID:SGTC_515|Compound:4092-1064|FD-Score:-3.71|P-value:3.11E-4 ID:SGTC_516|Compound:3992-2719|FD-Score:3.66|P-value:3.92E-4 ID:SGTC_517|Compound:1365-0151|FD-Score:7.09|P-value:3.49E-11 ID:SGTC_521|Compound:r062-0005|FD-Score:4.75|P-value:6.26E-6 ID:SGTC_522|Compound:1273-0010|FD-Score:-3.97|P-value:1.27E-4 ID:SGTC_651|Compound:3253-0966|FD-Score:6.52|P-value:1.00E-9 ID:SGTC_652|Compound:0437-0092|FD-Score:-3.81|P-value:2.18E-4 ID:SGTC_667|Compound:1498-1044|FD-Score:6.31|P-value:3.29E-9 ID:SGTC_824|Compound:1304-0008|FD-Score:3.54|P-value:5.67E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:-3.81|P-value:2.21E-4 ID:SGTC_1168|Compound:k815-0004|FD-Score:4.44|P-value:2.27E-5 ID:SGTC_1320|Compound:1313-0481|FD-Score:4.87|P-value:3.78E-6 ID:SGTC_1329|Compound:1447-1697|FD-Score:3.93|P-value:1.51E-4 ID:SGTC_1354|Compound:1498-1681|FD-Score:3.56|P-value:5.41E-4 ID:SGTC_1432|Compound:4049-0298|FD-Score:4.37|P-value:2.95E-5 ID:SGTC_1454|Compound:4239-0054|FD-Score:4.40|P-value:2.64E-5 ID:SGTC_1573|Compound:oleylamine|FD-Score:3.56|P-value:5.33E-4 ID:SGTC_1684|Compound:st024538|FD-Score:4.75|P-value:6.32E-6 ID:SGTC_1771|Compound:st048882|FD-Score:5.18|P-value:9.49E-7 ID:SGTC_1925|Compound:st057770|FD-Score:4.99|P-value:2.27E-6 ID:SGTC_1936|Compound:st074407|FD-Score:4.26|P-value:4.61E-5 ID:SGTC_2014|Compound:4013930|FD-Score:4.48|P-value:1.91E-5 ID:SGTC_2068|Compound:5226020|FD-Score:4.15|P-value:6.83E-5 ID:SGTC_2125|Compound:5246583|FD-Score:7.05|P-value:4.60E-11 ID:SGTC_2132|Compound:5317594|FD-Score:8.06|P-value:6.29E-14 ID:SGTC_2325|Compound:6158266|FD-Score:3.93|P-value:1.54E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:-3.38|P-value:9.16E-4 ID:SGTC_2545|Compound:solidagenone|FD-Score:-3.61|P-value:4.29E-4 ID:SGTC_2549|Compound:cedrol|FD-Score:-4.84|P-value:4.01E-6 ID:SGTC_2550|Compound:chrysin dimethyl ether|FD-Score:-4.50|P-value:1.64E-5 ID:SGTC_2551|Compound:apiole|FD-Score:-3.78|P-value:2.43E-4 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:4.30|P-value:3.88E-5 ID:SGTC_2755|Compound:lomerizine|FD-Score:5.22|P-value:7.86E-7 ID:SGTC_2875|Compound:9039966|FD-Score:3.96|P-value:1.37E-4 ID:SGTC_2904|Compound:7225135|FD-Score:3.91|P-value:1.65E-4 ID:SGTC_2915|Compound:7971052|FD-Score:-3.74|P-value:2.80E-4 ID:SGTC_2952|Compound:9073731|FD-Score:3.86|P-value:1.97E-4 ID:SGTC_2958|Compound:9077254|FD-Score:3.89|P-value:1.76E-4 ID:SGTC_3121|Compound:9125696|FD-Score:4.16|P-value:6.61E-5 ID:SGTC_3203|Compound:9113543|FD-Score:-5.60|P-value:1.21E-7 ID:SGTC_3218|Compound:9131285|FD-Score:-3.66|P-value:3.66E-4 ID:SGTC_3284|Compound:9108171|FD-Score:-3.42|P-value:7.97E-4 ID:SGTC_3295|Compound:9122362|FD-Score:3.46|P-value:7.48E-4 ID:SGTC_3296|Compound:9122258|FD-Score:3.65|P-value:3.93E-4

Top fitness defect scores for YBL048W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2132 5317594 8.06 122.7 µM 6.29E-14 SWF1 & branched chain AA biosynthesis 5 3.89E-16
2 SGTC_517 1365-0151 7.09 113.0 µM 3.49E-11 7 6.65E-13
3 SGTC_2125 5246583 7.05 200.0 µM 4.60E-11 tubulin folding & SWR complex 11 9.20E-13
4 SGTC_651 3253-0966 6.52 34.4 µM 1.00E-9 calcium & mitochondrial duress 5 3.45E-11
5 SGTC_667 1498-1044 6.31 59.0 µM 3.29E-9 RPP1 & pyrimidine depletion 2 1.40E-10
6 SGTC_160 3453-0671 5.54 289.7 µM 1.76E-7 13 1.52E-8
7 SGTC_2755 lomerizine 5.22 42.7 µM 7.86E-7 8 8.77E-8
8 SGTC_1771 st048882 5.18 4.2 µM 9.49E-7 RPP1 & pyrimidine depletion 6 1.10E-7
9 SGTC_1925 st057770 4.99 10.1 µM 2.27E-6 TSC3-RPN4 7 3.05E-7
10 SGTC_1320 1313-0481 4.87 95.3 µM 3.78E-6 12 5.55E-7
11 SGTC_521 r062-0005 4.75 13.8 µM 6.26E-6 6 1.00E-6
12 SGTC_1684 st024538 4.75 14.6 µM 6.32E-6 2 1.02E-6
13 SGTC_2014 4013930 4.48 200.0 µM 1.91E-5 16 3.72E-6
14 SGTC_1168 k815-0004 4.44 80.5 µM 2.27E-5 DNA damage response 12 4.56E-6
15 SGTC_1454 4239-0054 4.40 42.6 µM 2.64E-5 20 5.45E-6
16 SGTC_1432 4049-0298 4.37 68.4 µM 2.95E-5 2 6.20E-6
17 SGTC_2621 lithochol-11-enic acid 4.30 100.0 µM 3.88E-5 16 8.53E-6
18 SGTC_1936 st074407 4.26 74.3 µM 4.61E-5 DNA damage response 28 1.04E-5
19 SGTC_3121 9125696 4.16 49.5 µM 6.61E-5 3 1.59E-5
20 SGTC_426 0988-0037 4.16 14.6 µM 6.66E-5 ERAD & cell cycle 28 1.61E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.087 4.42E-7 YKL066W_d YKL066W_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified gene YNK1
0.080 3.80E-6 YGL180W ATG1 hom Protein ser/thr kinase required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; structurally required for phagophore assembly site formation; during autophagy forms a complex with Atg13p and Atg17p
0.079 5.06E-6 YNL162W-A_p YNL162W-A_p hom Putative protein of unknown function; identified by homology
0.078 6.60E-6 YDR430C CYM1 hom Lysine-specific metalloprotease of the mitochondrial intermembrane space, member of the pitrilysin family; degrades proteins and presequence peptides cleaved from imported proteins; required for normal mitochondrial morphology
0.077 8.04E-6 YOR355W GDS1 hom Protein of unknown function, required for growth on glycerol as a carbon source; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.076 9.99E-6 YMR020W FMS1 hom Polyamine oxidase, converts spermine to spermidine, which is required for the essential hypusination modification of translation factor eIF-5A; also involved in pantothenic acid biosynthesis
0.076 1.01E-5 YIL104C SHQ1 het Chaperone protein required for the assembly of box H/ACA snoRNPs and thus for pre-rRNA processing, forms a complex with Naf1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; homology with known Hsp90p cochaperones
0.074 1.76E-5 YOR111W_p YOR111W_p hom Putative protein of unknown function
0.073 2.29E-5 YCL075W YCL075W hom Pseudogene: encodes fragment of Ty Pol protein
0.072 3.01E-5 YLR406C RPL31B hom Ribosomal 60S subunit protein L31B; associates with karyopherin Sxm1p; loss of both Rpl31p and Rpl39p confers lethality; homologous to mammalian ribosomal protein L31, no bacterial homolog; RPL31B has a paralog, RPL31A, that arose from the whole genome duplication
0.072 3.10E-5 YOL078W AVO1 het Component of a membrane-bound complex containing the Tor2p kinase and other proteins, which may have a role in regulation of cell growth
0.071 4.03E-5 YMR109W MYO5 hom One of two type I myosins; contains proline-rich tail homology 2 (TH2) and SH3 domains; MYO5 deletion has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization
0.069 6.13E-5 YMR090W_p YMR090W_p hom Putative protein of unknown function with similarity to DTDP-glucose 4,6-dehydratases; GFP-fusion protein localizes to the cytoplasm; up-regulated in response to the fungicide mancozeb; not essential for viability
0.069 6.31E-5 YDL222C FMP45 hom Integral membrane protein localized to mitochondria (untagged protein); required for sporulation and maintaining sphingolipid content; has sequence similarity to SUR7 and YNL194C
0.069 6.25E-5 YHR121W LSM12 hom Protein of unknown function that may function in RNA processing; interacts with Pbp1p and Pbp4p and associates with ribosomes; contains an RNA-binding LSM domain and an AD domain; GFP-fusion protein is induced by the DNA-damaging agent MMS; relative distribution to the nucleus increases upon DNA replication stress