YBL050W / SEC17

Peripheral membrane protein required for vesicular transport between ER and Golgi, the 'priming' step in homotypic vacuole fusion, and autophagy; stimulates the ATPase activity of Sec18p; has similarity to mammalian alpha-SNAP

Zygosity: Heterozygous strain
fixedexpanded
Profile for YBL050W / SEC17

Click on Significant Values for Screen Details ID:SGTC_38|Compound:0929-0051|FD-Score:5.24|P-value:3.98E-9 ID:SGTC_49|Compound:0717-0965|FD-Score:3.90|P-value:8.72E-6 ID:SGTC_60|Compound:0986-0278|FD-Score:2.89|P-value:7.20E-4 ID:SGTC_81|Compound:0411-0046|FD-Score:2.91|P-value:6.72E-4 ID:SGTC_144|Compound:4161-2749|FD-Score:-3.05|P-value:4.12E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:3.62|P-value:3.37E-5 ID:SGTC_157|Compound:1348-1695|FD-Score:-3.77|P-value:1.70E-5 ID:SGTC_325|Compound:2810-4341|FD-Score:-3.03|P-value:4.44E-4 ID:SGTC_371|Compound:0195-0006|FD-Score:-3.32|P-value:1.35E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:-3.12|P-value:3.00E-4 ID:SGTC_801|Compound:0866-0028|FD-Score:2.84|P-value:8.81E-4 ID:SGTC_854|Compound:0422-0053|FD-Score:3.30|P-value:1.37E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:-3.26|P-value:1.69E-4 ID:SGTC_936|Compound:3005-4620|FD-Score:2.86|P-value:8.28E-4 ID:SGTC_961|Compound:1252-1571|FD-Score:2.81|P-value:9.79E-4 ID:SGTC_964|Compound:1287-0107|FD-Score:3.40|P-value:8.94E-5 ID:SGTC_1105|Compound:epirubicin|FD-Score:2.83|P-value:9.26E-4 ID:SGTC_1305|Compound:1181-0477|FD-Score:2.87|P-value:7.74E-4 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:3.67|P-value:2.70E-5 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:2.96|P-value:5.45E-4 ID:SGTC_1651|Compound:st011928|FD-Score:3.05|P-value:3.90E-4 ID:SGTC_1687|Compound:st020778|FD-Score:3.10|P-value:3.13E-4 ID:SGTC_1709|Compound:st033179|FD-Score:-3.55|P-value:4.87E-5 ID:SGTC_1714|Compound:st033236|FD-Score:3.84|P-value:1.17E-5 ID:SGTC_1754|Compound:st042065|FD-Score:2.88|P-value:7.45E-4 ID:SGTC_1779|Compound:st039427|FD-Score:4.24|P-value:1.54E-6 ID:SGTC_1850|Compound:st056238|FD-Score:-3.28|P-value:1.60E-4 ID:SGTC_1936|Compound:st074407|FD-Score:-3.24|P-value:1.88E-4 ID:SGTC_1991|Compound:st073000|FD-Score:4.23|P-value:1.61E-6 ID:SGTC_2005|Compound:4024620|FD-Score:-3.97|P-value:6.41E-6 ID:SGTC_2026|Compound:5148700|FD-Score:-4.20|P-value:1.99E-6 ID:SGTC_2075|Compound:5212009|FD-Score:3.32|P-value:1.26E-4 ID:SGTC_2139|Compound:5578692|FD-Score:4.32|P-value:1.01E-6 ID:SGTC_2141|Compound:5621638|FD-Score:3.74|P-value:1.86E-5 ID:SGTC_2149|Compound:5554786|FD-Score:3.97|P-value:6.18E-6 ID:SGTC_2163|Compound:5671233|FD-Score:-2.88|P-value:7.92E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:4.31|P-value:1.02E-6 ID:SGTC_2257|Compound:7960413|FD-Score:2.88|P-value:7.41E-4 ID:SGTC_2283|Compound:7944793|FD-Score:-3.16|P-value:2.57E-4 ID:SGTC_2308|Compound:7584454|FD-Score:3.05|P-value:3.97E-4 ID:SGTC_2320|Compound:7373003|FD-Score:4.38|P-value:7.02E-7 ID:SGTC_2412|Compound:st077135|FD-Score:2.87|P-value:7.84E-4 ID:SGTC_2576|Compound:guaiol|FD-Score:3.49|P-value:5.92E-5 ID:SGTC_2725|Compound:haloperidol|FD-Score:-3.01|P-value:4.68E-4 ID:SGTC_2732|Compound:terfenadine|FD-Score:-2.86|P-value:8.48E-4 ID:SGTC_2808|Compound:7946468|FD-Score:3.28|P-value:1.49E-4 ID:SGTC_2928|Compound:9011484|FD-Score:2.83|P-value:9.15E-4 ID:SGTC_2964|Compound:9083345|FD-Score:-2.99|P-value:5.15E-4 ID:SGTC_2972|Compound:9093619|FD-Score:-3.96|P-value:6.73E-6 ID:SGTC_3071|Compound:9117417|FD-Score:2.96|P-value:5.62E-4 ID:SGTC_3074|Compound:9116018|FD-Score:-3.51|P-value:5.81E-5 ID:SGTC_3148|Compound:9097893|FD-Score:3.26|P-value:1.67E-4 ID:SGTC_38|Compound:0929-0051|FD-Score:5.24|P-value:3.98E-9 ID:SGTC_49|Compound:0717-0965|FD-Score:3.90|P-value:8.72E-6 ID:SGTC_60|Compound:0986-0278|FD-Score:2.89|P-value:7.20E-4 ID:SGTC_81|Compound:0411-0046|FD-Score:2.91|P-value:6.72E-4 ID:SGTC_144|Compound:4161-2749|FD-Score:-3.05|P-value:4.12E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:3.62|P-value:3.37E-5 ID:SGTC_157|Compound:1348-1695|FD-Score:-3.77|P-value:1.70E-5 ID:SGTC_325|Compound:2810-4341|FD-Score:-3.03|P-value:4.44E-4 ID:SGTC_371|Compound:0195-0006|FD-Score:-3.32|P-value:1.35E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:-3.12|P-value:3.00E-4 ID:SGTC_801|Compound:0866-0028|FD-Score:2.84|P-value:8.81E-4 ID:SGTC_854|Compound:0422-0053|FD-Score:3.30|P-value:1.37E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:-3.26|P-value:1.69E-4 ID:SGTC_936|Compound:3005-4620|FD-Score:2.86|P-value:8.28E-4 ID:SGTC_961|Compound:1252-1571|FD-Score:2.81|P-value:9.79E-4 ID:SGTC_964|Compound:1287-0107|FD-Score:3.40|P-value:8.94E-5 ID:SGTC_1105|Compound:epirubicin|FD-Score:2.83|P-value:9.26E-4 ID:SGTC_1305|Compound:1181-0477|FD-Score:2.87|P-value:7.74E-4 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:3.67|P-value:2.70E-5 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:2.96|P-value:5.45E-4 ID:SGTC_1651|Compound:st011928|FD-Score:3.05|P-value:3.90E-4 ID:SGTC_1687|Compound:st020778|FD-Score:3.10|P-value:3.13E-4 ID:SGTC_1709|Compound:st033179|FD-Score:-3.55|P-value:4.87E-5 ID:SGTC_1714|Compound:st033236|FD-Score:3.84|P-value:1.17E-5 ID:SGTC_1754|Compound:st042065|FD-Score:2.88|P-value:7.45E-4 ID:SGTC_1779|Compound:st039427|FD-Score:4.24|P-value:1.54E-6 ID:SGTC_1850|Compound:st056238|FD-Score:-3.28|P-value:1.60E-4 ID:SGTC_1936|Compound:st074407|FD-Score:-3.24|P-value:1.88E-4 ID:SGTC_1991|Compound:st073000|FD-Score:4.23|P-value:1.61E-6 ID:SGTC_2005|Compound:4024620|FD-Score:-3.97|P-value:6.41E-6 ID:SGTC_2026|Compound:5148700|FD-Score:-4.20|P-value:1.99E-6 ID:SGTC_2075|Compound:5212009|FD-Score:3.32|P-value:1.26E-4 ID:SGTC_2139|Compound:5578692|FD-Score:4.32|P-value:1.01E-6 ID:SGTC_2141|Compound:5621638|FD-Score:3.74|P-value:1.86E-5 ID:SGTC_2149|Compound:5554786|FD-Score:3.97|P-value:6.18E-6 ID:SGTC_2163|Compound:5671233|FD-Score:-2.88|P-value:7.92E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:4.31|P-value:1.02E-6 ID:SGTC_2257|Compound:7960413|FD-Score:2.88|P-value:7.41E-4 ID:SGTC_2283|Compound:7944793|FD-Score:-3.16|P-value:2.57E-4 ID:SGTC_2308|Compound:7584454|FD-Score:3.05|P-value:3.97E-4 ID:SGTC_2320|Compound:7373003|FD-Score:4.38|P-value:7.02E-7 ID:SGTC_2412|Compound:st077135|FD-Score:2.87|P-value:7.84E-4 ID:SGTC_2576|Compound:guaiol|FD-Score:3.49|P-value:5.92E-5 ID:SGTC_2725|Compound:haloperidol|FD-Score:-3.01|P-value:4.68E-4 ID:SGTC_2732|Compound:terfenadine|FD-Score:-2.86|P-value:8.48E-4 ID:SGTC_2808|Compound:7946468|FD-Score:3.28|P-value:1.49E-4 ID:SGTC_2928|Compound:9011484|FD-Score:2.83|P-value:9.15E-4 ID:SGTC_2964|Compound:9083345|FD-Score:-2.99|P-value:5.15E-4 ID:SGTC_2972|Compound:9093619|FD-Score:-3.96|P-value:6.73E-6 ID:SGTC_3071|Compound:9117417|FD-Score:2.96|P-value:5.62E-4 ID:SGTC_3074|Compound:9116018|FD-Score:-3.51|P-value:5.81E-5 ID:SGTC_3148|Compound:9097893|FD-Score:3.26|P-value:1.67E-4

Top fitness defect scores for YBL050W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_38 0929-0051 5.24 58.3 µM 3.98E-9 2 8.01E-8 1.00
2 SGTC_2320 7373003 4.38 200.0 µM 7.02E-7 7 5.90E-6 0.32
3 SGTC_2139 5578692 4.32 56.5 µM 1.01E-6 superoxide 11 7.97E-6 0.12
4 SGTC_2249 haloperidol 4.31 116.4 µM 1.02E-6 ergosterol depletion effects on membrane 33 8.07E-6 0.01
5 SGTC_1779 st039427 4.24 55.0 µM 1.54E-6 2 1.14E-5 0.27
6 SGTC_1991 st073000 4.23 8.9 µM 1.61E-6 NEO1 15 1.17E-5 0.27
7 SGTC_2149 5554786 3.97 194.8 µM 6.18E-6 cell wall signaling 7 3.61E-5 0.23
8 SGTC_49 0717-0965 3.90 32.1 µM 8.72E-6 60S ribosome export 8 4.80E-5 0.11
9 SGTC_1714 st033236 3.84 13.6 µM 1.17E-5 8 6.12E-5 0.09
10 SGTC_2141 5621638 3.74 7.7 µM 1.86E-5 tubulin folding & SWR complex 2 9.05E-5 0.46
11 SGTC_1528 arabinosylhypoxanthine 3.67 74.6 µM 2.70E-5 5 1.23E-4 0.08
12 SGTC_146 3448-8650 3.62 53.1 µM 3.37E-5 NEO1-PIK1 14 1.48E-4 0.17
13 SGTC_2576 guaiol 3.49 23.1 µM 5.92E-5 12 2.37E-4 0.04
14 SGTC_964 1287-0107 3.40 19.4 µM 8.94E-5 cell wall 29 3.35E-4 0.10
15 SGTC_2075 5212009 3.32 200.0 µM 1.26E-4 10 4.45E-4 0.15
16 SGTC_854 0422-0053 3.30 192.0 µM 1.37E-4 PDR1 14 4.79E-4 0.04
17 SGTC_2808 7946468 3.28 45.5 µM 1.49E-4 16 5.13E-4 0.06
18 SGTC_3148 9097893 3.26 49.5 µM 1.67E-4 17 5.62E-4 0.01
19 SGTC_1687 st020778 3.10 55.4 µM 3.13E-4 19 9.52E-4 0.03
20 SGTC_1651 st011928 3.05 86.1 µM 3.90E-4 RSC complex & mRNA processing 17 0.00114 0.01

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.121 2.02E-12 YIL170W HXT12 hom Possible pseudogene in strain S288C; YIL170W/HXT12 and the adjacent ORF, YIL171W, together encode a non-functional member of the hexose transporter family
0.117 9.19E-12 YML062C MFT1 hom Subunit of the THO complex, which is a nuclear complex comprised of Hpr1p, Mft1p, Rlr1p, and Thp2p, that is involved in transcription elongation and mitotic recombination; involved in telomere maintenance
0.114 3.22E-11 YMR008C PLB1 hom Phospholipase B (lysophospholipase) involved in lipid metabolism, required for deacylation of phosphatidylcholine and phosphatidylethanolamine but not phosphatidylinositol
0.110 1.77E-10 YDR185C UPS3 hom Mitochondrial protein of unknown function; similar to Ups1p and Ups2p which are involved in regulation of mitochondrial cardiolipin and phosphatidylethanolamine levels; null is viable but interacts synthetically with ups1 and ups2 mutations
0.103 1.99E-9 YDL184C RPL41A hom Ribosomal 60S subunit protein L41A; comprises only 25 amino acids; rpl41a rpl41b double null mutant is viable; homologous to mammalian ribosomal protein L41, no bacterial homolog; RPL41A has a paralog, RPL41B, that arose from the whole genome duplication
0.103 2.58E-9 YKL017C HCS1 hom Hexameric DNA polymerase alpha-associated DNA helicase A involved in lagging strand DNA synthesis; contains single-stranded DNA stimulated ATPase and dATPase activities; replication protein A stimulates helicase and ATPase activities
0.102 3.57E-9 YGL098W USE1 het Essential SNARE protein localized to the ER, involved in retrograde traffic from the Golgi to the ER; forms a complex with the SNAREs Sec22p, Sec20p and Ufe1p
0.101 4.59E-9 YGR072W UPF3 hom Component of the nonsense-mediated mRNA decay (NMD) pathway, along with Nam7p and Nmd2p; involved in decay of mRNA containing nonsense codons; involved in telomere maintenance
0.098 1.43E-8 YBR181C RPS6B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S6, no bacterial homolog; RPS6B has a paralog, RPS6A, that arose from the whole genome duplication
0.095 3.38E-8 YKL069W YKL069W hom Methionine-R-sulfoxide reductase; reduces the R enantiomer of free Met-SO, in contrast to Ycl033Cp which reduces Met-R-SO in a peptide linkage; has a role in protection against oxidative stress; relative distribution to the nucleus increases upon DNA replication stress
0.094 5.65E-8 YLL061W MMP1 hom High-affinity S-methylmethionine permease, required for utilization of S-methylmethionine as a sulfur source; has similarity to S-adenosylmethionine permease Sam3p
0.093 6.37E-8 YKL100C_p YKL100C_p hom Putative protein of unknown function with similarity to a human minor histocompatibility antigen and signal peptide peptidases; YKL100C is not an essential gene
0.091 1.12E-7 YGL019W CKB1 hom Beta regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases
0.091 1.35E-7 YNL044W YIP3 hom Protein localized to COPII vesicles, proposed to be involved in ER to Golgi transport; interacts with members of the Rab GTPase family and Yip1p; also interacts with Rtn1p
0.090 1.59E-7 YLR049C_p YLR049C_p hom Putative protein of unknown function