YBL051C / PIN4

Protein involved in G2/M phase progression and response to DNA damage, interacts with Rad53p; contains an RNA recognition motif, a nuclear localization signal, and several SQ/TQ cluster domains; hyperphosphorylated in response to DNA damage

Zygosity: Homozygous strain
fixedexpanded
Profile for YBL051C / PIN4

Click on Significant Values for Screen Details ID:SGTC_97|Compound:0535-0701|FD-Score:3.81|P-value:2.55E-4 ID:SGTC_108|Compound:0509-0257|FD-Score:5.00|P-value:2.55E-6 ID:SGTC_114|Compound:0364-0001|FD-Score:3.46|P-value:8.03E-4 ID:SGTC_121|Compound:0557-0495|FD-Score:8.87|P-value:3.13E-16 ID:SGTC_122|Compound:0236-0016|FD-Score:-4.24|P-value:5.81E-5 ID:SGTC_253|Compound:dyclonine|FD-Score:3.90|P-value:1.92E-4 ID:SGTC_279|Compound:1273-0055|FD-Score:4.48|P-value:2.19E-5 ID:SGTC_305|Compound:1682-2595|FD-Score:-3.76|P-value:3.17E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:3.51|P-value:6.77E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:5.12|P-value:1.50E-6 ID:SGTC_315|Compound:k915-0449|FD-Score:3.87|P-value:2.09E-4 ID:SGTC_327|Compound:1273-0057|FD-Score:4.57|P-value:1.56E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.08|P-value:1.03E-4 ID:SGTC_467|Compound:ro 31-8220|FD-Score:9.59|P-value:1.23E-18 ID:SGTC_505|Compound:gw-5074|FD-Score:4.65|P-value:1.12E-5 ID:SGTC_528|Compound:3492-0019|FD-Score:14.60|P-value:9.25E-41 ID:SGTC_533|Compound:1222-0222|FD-Score:5.10|P-value:1.67E-6 ID:SGTC_540|Compound:1187-0821|FD-Score:5.70|P-value:1.03E-7 ID:SGTC_582|Compound:0987-0078|FD-Score:5.50|P-value:2.66E-7 ID:SGTC_690|Compound:glyoxal|FD-Score:16.10|P-value:4.78E-49 ID:SGTC_710|Compound:3448-4187|FD-Score:4.05|P-value:1.10E-4 ID:SGTC_866|Compound:0495-0101|FD-Score:4.36|P-value:3.48E-5 ID:SGTC_922|Compound:1866-0035|FD-Score:4.36|P-value:3.49E-5 ID:SGTC_924|Compound:2046-0044|FD-Score:3.59|P-value:5.27E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:3.44|P-value:8.55E-4 ID:SGTC_1057|Compound:3448-5381|FD-Score:5.22|P-value:9.60E-7 ID:SGTC_1081|Compound:sertraline|FD-Score:6.07|P-value:1.63E-8 ID:SGTC_1120|Compound:ficusin|FD-Score:3.53|P-value:6.48E-4 ID:SGTC_1167|Compound:k781-0610|FD-Score:-3.63|P-value:4.79E-4 ID:SGTC_1179|Compound:1021-1431|FD-Score:4.10|P-value:9.22E-5 ID:SGTC_1269|Compound:0831-0796|FD-Score:5.87|P-value:4.41E-8 ID:SGTC_1290|Compound:0986-0249|FD-Score:3.78|P-value:2.86E-4 ID:SGTC_1310|Compound:1188-0297|FD-Score:6.71|P-value:4.87E-10 ID:SGTC_1311|Compound:1190-0148|FD-Score:5.39|P-value:4.47E-7 ID:SGTC_1318|Compound:1280-3875|FD-Score:-3.45|P-value:8.47E-4 ID:SGTC_1319|Compound:1306-0155|FD-Score:-3.54|P-value:6.51E-4 ID:SGTC_1335|Compound:1486-0900|FD-Score:-3.54|P-value:6.51E-4 ID:SGTC_1336|Compound:1486-0901|FD-Score:-4.67|P-value:1.10E-5 ID:SGTC_1377|Compound:2944-0135|FD-Score:3.46|P-value:7.94E-4 ID:SGTC_1522|Compound:st012842|FD-Score:4.05|P-value:1.10E-4 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:4.22|P-value:5.89E-5 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:4.24|P-value:5.62E-5 ID:SGTC_1600|Compound:coumarin 106|FD-Score:-3.66|P-value:4.39E-4 ID:SGTC_1664|Compound:st014217|FD-Score:3.53|P-value:6.51E-4 ID:SGTC_1687|Compound:st020778|FD-Score:6.52|P-value:1.40E-9 ID:SGTC_1700|Compound:st030840|FD-Score:3.60|P-value:5.21E-4 ID:SGTC_1712|Compound:st032288|FD-Score:11.80|P-value:3.74E-27 ID:SGTC_1754|Compound:st042065|FD-Score:9.29|P-value:1.27E-17 ID:SGTC_1786|Compound:berberine|FD-Score:5.14|P-value:1.39E-6 ID:SGTC_1787|Compound:fluconazole|FD-Score:-4.59|P-value:1.54E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:7.95|P-value:2.22E-13 ID:SGTC_1877|Compound:wortmannin|FD-Score:10.60|P-value:3.65E-22 ID:SGTC_1892|Compound:st058411|FD-Score:3.49|P-value:7.39E-4 ID:SGTC_1941|Compound:st076221|FD-Score:4.78|P-value:6.71E-6 ID:SGTC_2127|Compound:5253358|FD-Score:3.84|P-value:2.29E-4 ID:SGTC_2242|Compound:6630449|FD-Score:3.86|P-value:2.14E-4 ID:SGTC_2243|Compound:6634756|FD-Score:5.33|P-value:6.00E-7 ID:SGTC_2245|Compound:6637752|FD-Score:3.50|P-value:7.07E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.07|P-value:1.02E-4 ID:SGTC_2272|Compound:7805186|FD-Score:3.83|P-value:2.43E-4 ID:SGTC_2289|Compound:7946404|FD-Score:7.27|P-value:1.70E-11 ID:SGTC_2460|Compound:5552655|FD-Score:-3.82|P-value:2.59E-4 ID:SGTC_2511|Compound:berberine|FD-Score:3.86|P-value:2.15E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-5.88|P-value:4.46E-8 ID:SGTC_2662|Compound:daunorubicin|FD-Score:3.72|P-value:3.51E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:7.33|P-value:1.22E-11 ID:SGTC_2688|Compound:kanamycin b|FD-Score:11.40|P-value:2.10E-25 ID:SGTC_2752|Compound:diclazuril|FD-Score:7.94|P-value:2.32E-13 ID:SGTC_2831|Compound:7999036|FD-Score:4.16|P-value:7.54E-5 ID:SGTC_2832|Compound:7992762|FD-Score:4.20|P-value:6.51E-5 ID:SGTC_2929|Compound:9013348|FD-Score:-4.89|P-value:4.35E-6 ID:SGTC_2937|Compound:9044753|FD-Score:6.10|P-value:1.38E-8 ID:SGTC_2984|Compound:9022109|FD-Score:-3.52|P-value:6.87E-4 ID:SGTC_3037|Compound:9091026|FD-Score:3.41|P-value:9.43E-4 ID:SGTC_3126|Compound:9127922|FD-Score:4.97|P-value:3.01E-6 ID:SGTC_3152|Compound:9099253|FD-Score:3.39|P-value:9.95E-4 ID:SGTC_3249|Compound:9135183|FD-Score:4.91|P-value:3.79E-6 ID:SGTC_97|Compound:0535-0701|FD-Score:3.81|P-value:2.55E-4 ID:SGTC_108|Compound:0509-0257|FD-Score:5.00|P-value:2.55E-6 ID:SGTC_114|Compound:0364-0001|FD-Score:3.46|P-value:8.03E-4 ID:SGTC_121|Compound:0557-0495|FD-Score:8.87|P-value:3.13E-16 ID:SGTC_122|Compound:0236-0016|FD-Score:-4.24|P-value:5.81E-5 ID:SGTC_253|Compound:dyclonine|FD-Score:3.90|P-value:1.92E-4 ID:SGTC_279|Compound:1273-0055|FD-Score:4.48|P-value:2.19E-5 ID:SGTC_305|Compound:1682-2595|FD-Score:-3.76|P-value:3.17E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:3.51|P-value:6.77E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:5.12|P-value:1.50E-6 ID:SGTC_315|Compound:k915-0449|FD-Score:3.87|P-value:2.09E-4 ID:SGTC_327|Compound:1273-0057|FD-Score:4.57|P-value:1.56E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.08|P-value:1.03E-4 ID:SGTC_467|Compound:ro 31-8220|FD-Score:9.59|P-value:1.23E-18 ID:SGTC_505|Compound:gw-5074|FD-Score:4.65|P-value:1.12E-5 ID:SGTC_528|Compound:3492-0019|FD-Score:14.60|P-value:9.25E-41 ID:SGTC_533|Compound:1222-0222|FD-Score:5.10|P-value:1.67E-6 ID:SGTC_540|Compound:1187-0821|FD-Score:5.70|P-value:1.03E-7 ID:SGTC_582|Compound:0987-0078|FD-Score:5.50|P-value:2.66E-7 ID:SGTC_690|Compound:glyoxal|FD-Score:16.10|P-value:4.78E-49 ID:SGTC_710|Compound:3448-4187|FD-Score:4.05|P-value:1.10E-4 ID:SGTC_866|Compound:0495-0101|FD-Score:4.36|P-value:3.48E-5 ID:SGTC_922|Compound:1866-0035|FD-Score:4.36|P-value:3.49E-5 ID:SGTC_924|Compound:2046-0044|FD-Score:3.59|P-value:5.27E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:3.44|P-value:8.55E-4 ID:SGTC_1057|Compound:3448-5381|FD-Score:5.22|P-value:9.60E-7 ID:SGTC_1081|Compound:sertraline|FD-Score:6.07|P-value:1.63E-8 ID:SGTC_1120|Compound:ficusin|FD-Score:3.53|P-value:6.48E-4 ID:SGTC_1167|Compound:k781-0610|FD-Score:-3.63|P-value:4.79E-4 ID:SGTC_1179|Compound:1021-1431|FD-Score:4.10|P-value:9.22E-5 ID:SGTC_1269|Compound:0831-0796|FD-Score:5.87|P-value:4.41E-8 ID:SGTC_1290|Compound:0986-0249|FD-Score:3.78|P-value:2.86E-4 ID:SGTC_1310|Compound:1188-0297|FD-Score:6.71|P-value:4.87E-10 ID:SGTC_1311|Compound:1190-0148|FD-Score:5.39|P-value:4.47E-7 ID:SGTC_1318|Compound:1280-3875|FD-Score:-3.45|P-value:8.47E-4 ID:SGTC_1319|Compound:1306-0155|FD-Score:-3.54|P-value:6.51E-4 ID:SGTC_1335|Compound:1486-0900|FD-Score:-3.54|P-value:6.51E-4 ID:SGTC_1336|Compound:1486-0901|FD-Score:-4.67|P-value:1.10E-5 ID:SGTC_1377|Compound:2944-0135|FD-Score:3.46|P-value:7.94E-4 ID:SGTC_1522|Compound:st012842|FD-Score:4.05|P-value:1.10E-4 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:4.22|P-value:5.89E-5 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:4.24|P-value:5.62E-5 ID:SGTC_1600|Compound:coumarin 106|FD-Score:-3.66|P-value:4.39E-4 ID:SGTC_1664|Compound:st014217|FD-Score:3.53|P-value:6.51E-4 ID:SGTC_1687|Compound:st020778|FD-Score:6.52|P-value:1.40E-9 ID:SGTC_1700|Compound:st030840|FD-Score:3.60|P-value:5.21E-4 ID:SGTC_1712|Compound:st032288|FD-Score:11.80|P-value:3.74E-27 ID:SGTC_1754|Compound:st042065|FD-Score:9.29|P-value:1.27E-17 ID:SGTC_1786|Compound:berberine|FD-Score:5.14|P-value:1.39E-6 ID:SGTC_1787|Compound:fluconazole|FD-Score:-4.59|P-value:1.54E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:7.95|P-value:2.22E-13 ID:SGTC_1877|Compound:wortmannin|FD-Score:10.60|P-value:3.65E-22 ID:SGTC_1892|Compound:st058411|FD-Score:3.49|P-value:7.39E-4 ID:SGTC_1941|Compound:st076221|FD-Score:4.78|P-value:6.71E-6 ID:SGTC_2127|Compound:5253358|FD-Score:3.84|P-value:2.29E-4 ID:SGTC_2242|Compound:6630449|FD-Score:3.86|P-value:2.14E-4 ID:SGTC_2243|Compound:6634756|FD-Score:5.33|P-value:6.00E-7 ID:SGTC_2245|Compound:6637752|FD-Score:3.50|P-value:7.07E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.07|P-value:1.02E-4 ID:SGTC_2272|Compound:7805186|FD-Score:3.83|P-value:2.43E-4 ID:SGTC_2289|Compound:7946404|FD-Score:7.27|P-value:1.70E-11 ID:SGTC_2460|Compound:5552655|FD-Score:-3.82|P-value:2.59E-4 ID:SGTC_2511|Compound:berberine|FD-Score:3.86|P-value:2.15E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-5.88|P-value:4.46E-8 ID:SGTC_2662|Compound:daunorubicin|FD-Score:3.72|P-value:3.51E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:7.33|P-value:1.22E-11 ID:SGTC_2688|Compound:kanamycin b|FD-Score:11.40|P-value:2.10E-25 ID:SGTC_2752|Compound:diclazuril|FD-Score:7.94|P-value:2.32E-13 ID:SGTC_2831|Compound:7999036|FD-Score:4.16|P-value:7.54E-5 ID:SGTC_2832|Compound:7992762|FD-Score:4.20|P-value:6.51E-5 ID:SGTC_2929|Compound:9013348|FD-Score:-4.89|P-value:4.35E-6 ID:SGTC_2937|Compound:9044753|FD-Score:6.10|P-value:1.38E-8 ID:SGTC_2984|Compound:9022109|FD-Score:-3.52|P-value:6.87E-4 ID:SGTC_3037|Compound:9091026|FD-Score:3.41|P-value:9.43E-4 ID:SGTC_3126|Compound:9127922|FD-Score:4.97|P-value:3.01E-6 ID:SGTC_3152|Compound:9099253|FD-Score:3.39|P-value:9.95E-4 ID:SGTC_3249|Compound:9135183|FD-Score:4.91|P-value:3.79E-6

Top fitness defect scores for YBL051C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_690 glyoxal 16.10 20.3 µM 4.78E-49 5 1.03E-58
2 SGTC_528 3492-0019 14.60 172.0 µM 9.25E-41 calcium & mitochondrial duress 17 1.00E-48
3 SGTC_1712 st032288 11.80 53.4 µM 3.74E-27 calcium & mitochondrial duress 12 2.49E-32
4 SGTC_2688 kanamycin b 11.40 96.7 µM 2.10E-25 calcium & mitochondrial duress 17 3.17E-30
5 SGTC_1877 wortmannin 10.60 25.0 µM 3.65E-22 10 2.54E-26
6 SGTC_467 ro 31-8220 9.59 72.8 µM 1.23E-18 calcium & mitochondrial duress 9 4.48E-22
7 SGTC_1754 st042065 9.29 16.1 µM 1.27E-17 NEO1-PIK1 37 7.44E-21
8 SGTC_121 0557-0495 8.87 61.3 µM 3.13E-16 calcium & mitochondrial duress 8 3.50E-19
9 SGTC_1844 rapamycin 7.95 4.0 nM 2.22E-13 58 9.39E-16
10 SGTC_2752 diclazuril 7.94 33.1 µM 2.32E-13 36 9.93E-16
11 SGTC_2679 rapamycin 7.33 1.0 nM 1.22E-11 51 1.16E-13
12 SGTC_2289 7946404 7.27 165.1 µM 1.70E-11 24 1.73E-13
13 SGTC_1310 1188-0297 6.71 994.0 nM 4.87E-10 azole & statin 5 9.73E-12
14 SGTC_1687 st020778 6.52 55.4 µM 1.40E-9 100 3.45E-11
15 SGTC_2937 9044753 6.10 11.3 µM 1.38E-8 60S ribosome export 7 5.38E-10
16 SGTC_1081 sertraline 6.07 6.0 µM 1.63E-8 60S ribosome export 10 6.57E-10
17 SGTC_1269 0831-0796 5.87 3.0 µM 4.41E-8 60S ribosome export 2 2.17E-9
18 SGTC_540 1187-0821 5.70 17.3 µM 1.03E-7 3 5.98E-9
19 SGTC_582 0987-0078 5.50 156.0 µM 2.66E-7 calcium & mitochondrial duress 30 1.88E-8
20 SGTC_1311 1190-0148 5.39 100.0 µM 4.47E-7 azole & statin 12 3.49E-8

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.400 4.10E-129 YDR475C JIP4 hom Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence
0.332 2.42E-87 YJL164C TPK1 hom cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; regulates Whi3p; partially redundant with Tpk2p and Tpk3p; TPK1 has a paralog, TPK3, that arose from the whole genome duplication
0.310 1.37E-75 YJL165C HAL5 hom Putative protein kinase; overexpression increases sodium and lithium tolerance, whereas gene disruption increases cation and low pH sensitivity and impairs potassium uptake, suggesting a role in regulation of Trk1p and/or Trk2p transporters; HAL5 has a paralog, KKQ8, that arose from the whole genome duplication
0.290 4.35E-66 YBL022C PIM1 hom ATP-dependent Lon protease, involved in degradation of misfolded proteins in mitochondria; required for biogenesis and maintenance of mitochondria
0.286 4.33E-64 YOL016C CMK2 hom Calmodulin-dependent protein kinase; may play a role in stress response, many CA++/calmodulan dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to mammalian Cam Kinase II; CMK2 has a paralog, CMK1, that arose from the whole genome duplication
0.264 9.76E-55 YIL170W HXT12 hom Possible pseudogene in strain S288C; YIL170W/HXT12 and the adjacent ORF, YIL171W, together encode a non-functional member of the hexose transporter family
0.264 1.75E-54 YNL288W CAF40 hom Evolutionarily conserved subunit of the CCR4-NOT complex involved in controlling mRNA initiation, elongation and degradation; binds Cdc39p
0.256 1.64E-51 YKL051W SFK1 hom Plasma membrane protein that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, at least partially mediates proper localization of Stt4p to the plasma membrane
0.255 7.71E-51 YKL176C LST4 hom Protein possibly involved in a post-Golgi secretory pathway; required for the transport of nitrogen-regulated amino acid permease Gap1p from the Golgi to the cell surface
0.254 2.08E-50 YIL105C SLM1 hom Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm2p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; phosphorylated by the TORC2 complex; protein abundance increases in response to DNA replication stress; SLM1 has a paralog, SLM2, that arose from the whole genome duplication
0.251 1.88E-49 YFL033C RIM15 hom Glucose-repressible protein kinase involved in signal transduction during cell proliferation in response to nutrients, specifically the establishment of stationary phase; identified as a regulator of IME2; substrate of Pho80p-Pho85p kinase
0.246 1.32E-47 YML121W GTR1 hom Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB
0.243 2.85E-46 YJL129C TRK1 hom Component of the Trk1p-Trk2p potassium transport system; 180 kDa high affinity potassium transporter; phosphorylated in vivo and interacts physically with the phosphatase Ppz1p, suggesting Trk1p acitivy is regulated by phosphorylation; TRK1 has a paralog, TRK2, that arose from the whole genome duplication
0.243 3.44E-46 YDL019C OSH2 hom Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability
0.237 5.65E-44 YGL035C MIG1 hom Transcription factor involved in glucose repression; sequence specific DNA binding protein containing two Cys2His2 zinc finger motifs; regulated by the SNF1 kinase and the GLC7 phosphatase; regulates filamentous growth along with Mig2p in response to glucose depletion