YBL052C / SAS3

Histone acetyltransferase catalytic subunit of NuA3 complex that acetylates histone H3, involved in transcriptional silencing; homolog of the mammalian MOZ proto-oncogene; mutant has aneuploidy tolerance; sas3gcn5 double mutation is lethal

Zygosity: Homozygous strain
fixedexpanded
Profile for YBL052C / SAS3

Click on Significant Values for Screen Details ID:SGTC_95|Compound:0471-0001|FD-Score:3.40|P-value:7.63E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:4.09|P-value:7.19E-5 ID:SGTC_153|Compound:4077-0274|FD-Score:4.03|P-value:9.17E-5 ID:SGTC_159|Compound:3970-0959|FD-Score:3.37|P-value:8.42E-4 ID:SGTC_324|Compound:1315-0088|FD-Score:3.72|P-value:2.68E-4 ID:SGTC_608|Compound:k048-0125|FD-Score:3.78|P-value:2.20E-4 ID:SGTC_781|Compound:4335-2806|FD-Score:3.89|P-value:1.48E-4 ID:SGTC_813|Compound:k007-0158|FD-Score:-3.67|P-value:5.01E-4 ID:SGTC_917|Compound:harmaline|FD-Score:6.74|P-value:2.54E-10 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:3.90|P-value:1.43E-4 ID:SGTC_929|Compound:2805-0021|FD-Score:3.43|P-value:6.88E-4 ID:SGTC_931|Compound:2812-0076|FD-Score:3.40|P-value:7.63E-4 ID:SGTC_932|Compound:2857-0803|FD-Score:3.61|P-value:3.88E-4 ID:SGTC_934|Compound:2950-0684|FD-Score:3.48|P-value:5.95E-4 ID:SGTC_1032|Compound:k061-1018|FD-Score:3.91|P-value:1.41E-4 ID:SGTC_1062|Compound:mesoridazine|FD-Score:5.46|P-value:2.25E-7 ID:SGTC_1066|Compound:ketoconazole|FD-Score:3.74|P-value:2.54E-4 ID:SGTC_1087|Compound:pterostilbene|FD-Score:4.15|P-value:5.77E-5 ID:SGTC_1142|Compound:3253-1408|FD-Score:-3.61|P-value:6.17E-4 ID:SGTC_1149|Compound:3909-7961|FD-Score:4.03|P-value:8.92E-5 ID:SGTC_1224|Compound:0823-0416|FD-Score:3.43|P-value:7.01E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:3.74|P-value:2.49E-4 ID:SGTC_1527|Compound:coumarin|FD-Score:3.39|P-value:7.89E-4 ID:SGTC_1591|Compound:genipin|FD-Score:-4.98|P-value:3.55E-6 ID:SGTC_1602|Compound:st001878|FD-Score:4.00|P-value:1.01E-4 ID:SGTC_1616|Compound:st002734|FD-Score:5.30|P-value:4.59E-7 ID:SGTC_1678|Compound:st019265|FD-Score:3.85|P-value:1.72E-4 ID:SGTC_1746|Compound:st038117|FD-Score:-4.36|P-value:4.39E-5 ID:SGTC_1914|Compound:st062367|FD-Score:3.86|P-value:1.64E-4 ID:SGTC_2016|Compound:5121758|FD-Score:-3.62|P-value:5.88E-4 ID:SGTC_2127|Compound:5253358|FD-Score:-4.01|P-value:1.61E-4 ID:SGTC_2172|Compound:5754775|FD-Score:-3.86|P-value:2.63E-4 ID:SGTC_2237|Compound:6667747|FD-Score:-6.19|P-value:1.11E-8 ID:SGTC_2241|Compound:6772625|FD-Score:3.49|P-value:5.84E-4 ID:SGTC_2286|Compound:7945697|FD-Score:3.79|P-value:2.14E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:-3.53|P-value:7.90E-4 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:-5.15|P-value:1.71E-6 ID:SGTC_2416|Compound:tofa|FD-Score:-5.74|P-value:1.08E-7 ID:SGTC_2437|Compound:5741531|FD-Score:3.91|P-value:1.41E-4 ID:SGTC_2492|Compound:derrusnin|FD-Score:3.86|P-value:1.64E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:6.62|P-value:4.88E-10 ID:SGTC_2507|Compound:purpurin|FD-Score:-3.75|P-value:3.82E-4 ID:SGTC_2639|Compound:lactacystin|FD-Score:-3.89|P-value:2.43E-4 ID:SGTC_2763|Compound:lisinopril|FD-Score:3.33|P-value:9.47E-4 ID:SGTC_2803|Compound:7707263|FD-Score:3.55|P-value:4.77E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-3.66|P-value:5.18E-4 ID:SGTC_2844|Compound:9010103|FD-Score:4.87|P-value:3.27E-6 ID:SGTC_2884|Compound:9058502|FD-Score:4.01|P-value:9.58E-5 ID:SGTC_3020|Compound:9089140|FD-Score:-3.80|P-value:3.23E-4 ID:SGTC_3037|Compound:9091026|FD-Score:4.62|P-value:9.33E-6 ID:SGTC_3075|Compound:9116269|FD-Score:3.59|P-value:4.19E-4 ID:SGTC_3154|Compound:9100113|FD-Score:3.85|P-value:1.71E-4 ID:SGTC_3279|Compound:9140807|FD-Score:3.60|P-value:3.99E-4 ID:SGTC_3314|Compound:9135860|FD-Score:3.80|P-value:2.08E-4 ID:SGTC_95|Compound:0471-0001|FD-Score:3.40|P-value:7.63E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:4.09|P-value:7.19E-5 ID:SGTC_153|Compound:4077-0274|FD-Score:4.03|P-value:9.17E-5 ID:SGTC_159|Compound:3970-0959|FD-Score:3.37|P-value:8.42E-4 ID:SGTC_324|Compound:1315-0088|FD-Score:3.72|P-value:2.68E-4 ID:SGTC_608|Compound:k048-0125|FD-Score:3.78|P-value:2.20E-4 ID:SGTC_781|Compound:4335-2806|FD-Score:3.89|P-value:1.48E-4 ID:SGTC_813|Compound:k007-0158|FD-Score:-3.67|P-value:5.01E-4 ID:SGTC_917|Compound:harmaline|FD-Score:6.74|P-value:2.54E-10 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:3.90|P-value:1.43E-4 ID:SGTC_929|Compound:2805-0021|FD-Score:3.43|P-value:6.88E-4 ID:SGTC_931|Compound:2812-0076|FD-Score:3.40|P-value:7.63E-4 ID:SGTC_932|Compound:2857-0803|FD-Score:3.61|P-value:3.88E-4 ID:SGTC_934|Compound:2950-0684|FD-Score:3.48|P-value:5.95E-4 ID:SGTC_1032|Compound:k061-1018|FD-Score:3.91|P-value:1.41E-4 ID:SGTC_1062|Compound:mesoridazine|FD-Score:5.46|P-value:2.25E-7 ID:SGTC_1066|Compound:ketoconazole|FD-Score:3.74|P-value:2.54E-4 ID:SGTC_1087|Compound:pterostilbene|FD-Score:4.15|P-value:5.77E-5 ID:SGTC_1142|Compound:3253-1408|FD-Score:-3.61|P-value:6.17E-4 ID:SGTC_1149|Compound:3909-7961|FD-Score:4.03|P-value:8.92E-5 ID:SGTC_1224|Compound:0823-0416|FD-Score:3.43|P-value:7.01E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:3.74|P-value:2.49E-4 ID:SGTC_1527|Compound:coumarin|FD-Score:3.39|P-value:7.89E-4 ID:SGTC_1591|Compound:genipin|FD-Score:-4.98|P-value:3.55E-6 ID:SGTC_1602|Compound:st001878|FD-Score:4.00|P-value:1.01E-4 ID:SGTC_1616|Compound:st002734|FD-Score:5.30|P-value:4.59E-7 ID:SGTC_1678|Compound:st019265|FD-Score:3.85|P-value:1.72E-4 ID:SGTC_1746|Compound:st038117|FD-Score:-4.36|P-value:4.39E-5 ID:SGTC_1914|Compound:st062367|FD-Score:3.86|P-value:1.64E-4 ID:SGTC_2016|Compound:5121758|FD-Score:-3.62|P-value:5.88E-4 ID:SGTC_2127|Compound:5253358|FD-Score:-4.01|P-value:1.61E-4 ID:SGTC_2172|Compound:5754775|FD-Score:-3.86|P-value:2.63E-4 ID:SGTC_2237|Compound:6667747|FD-Score:-6.19|P-value:1.11E-8 ID:SGTC_2241|Compound:6772625|FD-Score:3.49|P-value:5.84E-4 ID:SGTC_2286|Compound:7945697|FD-Score:3.79|P-value:2.14E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:-3.53|P-value:7.90E-4 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:-5.15|P-value:1.71E-6 ID:SGTC_2416|Compound:tofa|FD-Score:-5.74|P-value:1.08E-7 ID:SGTC_2437|Compound:5741531|FD-Score:3.91|P-value:1.41E-4 ID:SGTC_2492|Compound:derrusnin|FD-Score:3.86|P-value:1.64E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:6.62|P-value:4.88E-10 ID:SGTC_2507|Compound:purpurin|FD-Score:-3.75|P-value:3.82E-4 ID:SGTC_2639|Compound:lactacystin|FD-Score:-3.89|P-value:2.43E-4 ID:SGTC_2763|Compound:lisinopril|FD-Score:3.33|P-value:9.47E-4 ID:SGTC_2803|Compound:7707263|FD-Score:3.55|P-value:4.77E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-3.66|P-value:5.18E-4 ID:SGTC_2844|Compound:9010103|FD-Score:4.87|P-value:3.27E-6 ID:SGTC_2884|Compound:9058502|FD-Score:4.01|P-value:9.58E-5 ID:SGTC_3020|Compound:9089140|FD-Score:-3.80|P-value:3.23E-4 ID:SGTC_3037|Compound:9091026|FD-Score:4.62|P-value:9.33E-6 ID:SGTC_3075|Compound:9116269|FD-Score:3.59|P-value:4.19E-4 ID:SGTC_3154|Compound:9100113|FD-Score:3.85|P-value:1.71E-4 ID:SGTC_3279|Compound:9140807|FD-Score:3.60|P-value:3.99E-4 ID:SGTC_3314|Compound:9135860|FD-Score:3.80|P-value:2.08E-4

Top fitness defect scores for YBL052C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_917 harmaline 6.74 728.1 nM 2.54E-10 ergosterol biosynthesis 3 8.11E-12
2 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 6.62 3.7 µM 4.88E-10 9 1.75E-11
3 SGTC_1062 mesoridazine 5.46 14.2 µM 2.25E-7 2 2.43E-8
4 SGTC_1616 st002734 5.30 56.1 µM 4.59E-7 9 5.64E-8
5 SGTC_2844 9010103 4.87 26.0 µM 3.27E-6 11 5.69E-7
6 SGTC_3037 9091026 4.62 49.5 µM 9.33E-6 NEO1-PIK1 87 1.95E-6
7 SGTC_1087 pterostilbene 4.15 9.1 µM 5.77E-5 20 1.64E-5
8 SGTC_142 0335-0849 4.09 62.7 µM 7.19E-5 ubiquinone biosynthesis & proteasome 118 2.13E-5
9 SGTC_1149 3909-7961 4.03 23.3 µM 8.92E-5 17 2.74E-5
10 SGTC_153 4077-0274 4.03 519.7 µM 9.17E-5 14 2.83E-5
11 SGTC_2884 9058502 4.01 52.0 µM 9.58E-5 28 2.98E-5
12 SGTC_1602 st001878 4.00 87.6 µM 1.01E-4 19 3.16E-5
13 SGTC_2437 5741531 3.91 144.2 µM 1.41E-4 38 4.68E-5
14 SGTC_1032 k061-1018 3.91 98.7 µM 1.41E-4 24 4.68E-5
15 SGTC_920 mycophenolic acid 3.90 780.4 nM 1.43E-4 32 4.75E-5
16 SGTC_781 4335-2806 3.89 94.4 µM 1.48E-4 22 4.95E-5
17 SGTC_1914 st062367 3.86 72.6 µM 1.64E-4 22 5.57E-5
18 SGTC_2492 derrusnin 3.86 100.0 µM 1.64E-4 4 5.57E-5
19 SGTC_3154 9100113 3.85 49.5 µM 1.71E-4 32 5.87E-5
20 SGTC_1678 st019265 3.85 80.2 µM 1.72E-4 60S ribosome export 23 5.89E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.104 1.85E-9 YHR072W ERG7 het Lanosterol synthase, an essential enzyme that catalyzes the cyclization of squalene 2,3-epoxide, a step in ergosterol biosynthesis
0.101 4.12E-9 YKL202W_d YKL202W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.092 9.03E-8 YOR214C_p YOR214C_p hom Putative protein of unknown function; YOR214C is not an essential gene
0.089 2.12E-7 YHR122W CIA2 het Component of cytosolic iron-sulfur protein assembly (CIA) machinery; acts at a late step of Fe-S cluster assembly; forms the CIA targeting complex with Cia1p and Met18p that directs Fe-S cluster incorporation into a subset of proteins involved in methionine biosynthesis, DNA replication and repair, transcription, and telomere maintenance; ortholog of human FAM96B
0.087 4.23E-7 YDR089W YDR089W hom Protein of unknown function; deletion confers resistance to nickel; contains an SPX domain, which is found in proteins involved in phosphate homeostasis; relocalizes from vacuole to cytoplasm upon DNA replication stress
0.087 5.12E-7 YMR080C NAM7 hom ATP-dependent RNA helicase of the SFI superfamily; involved in nonsense mediated mRNA decay; required for efficient translation termination at nonsense codons and targeting of NMD substrates to P-bodies; involved in telomere maintenance; forms cytoplasmic foci upon DNA replication stress
0.086 5.30E-7 YML050W AIM32 hom Putative protein of unknown function; null mutant is viable and displays elevated frequency of mitochondrial genome loss
0.085 8.74E-7 YLL036C PRP19 het Splicing factor associated with the spliceosome; contains a U-box, a motif found in a class of ubiquitin ligases, and a WD40 domain
0.085 8.78E-7 YJR010W MET3 hom ATP sulfurylase, catalyzes the primary step of intracellular sulfate activation, essential for assimilatory reduction of sulfate to sulfide, involved in methionine metabolism
0.084 1.00E-6 YGR275W RTT102 hom Component of both the SWI/SNF and RSC chromatin remodeling complexes; suggested role in chromosome maintenance; possible weak regulator of Ty1 transposition; protein abundance increases in response to DNA replication stress
0.084 1.29E-6 YJR073C OPI3 hom Phospholipid methyltransferase (methylene-fatty-acyl-phospholipid synthase), catalyzes the last two steps in phosphatidylcholine biosynthesis
0.083 1.54E-6 YLR095C IOC2 hom Member of a complex (Isw1b) with Isw1p and Ioc4p that exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing, contains a PHD finger motif
0.081 2.35E-6 YDR446W ECM11 hom Non-essential protein apparently involved in meiosis, GFP fusion protein is present in discrete clusters in the nucleus throughout mitosis; may be involved in maintaining chromatin structure
0.080 3.47E-6 YER071C_p TDA2_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; null mutant is sensitive to expression of the top1-T722A allele
0.080 3.44E-6 YLR346C_p YLR346C_p hom Putative protein of unknown function found in mitochondria; expression is regulated by transcription factors involved in pleiotropic drug resistance, Pdr1p and Yrr1p; YLR346C is not an essential gene