YBL053W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YBL053W / YBL053W

Click on Significant Values for Screen Details ID:SGTC_12|Compound:0849-0099|FD-Score:3.51|P-value:1.30E-4 ID:SGTC_90|Compound:0870-0863|FD-Score:4.20|P-value:6.28E-6 ID:SGTC_105|Compound:0111-0055|FD-Score:-3.08|P-value:5.55E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:4.36|P-value:2.90E-6 ID:SGTC_174|Compound:3553-0389|FD-Score:4.85|P-value:2.14E-7 ID:SGTC_176|Compound:1486-1328|FD-Score:3.01|P-value:9.00E-4 ID:SGTC_307|Compound:1501-1223|FD-Score:-3.30|P-value:2.44E-4 ID:SGTC_327|Compound:1273-0057|FD-Score:3.51|P-value:1.34E-4 ID:SGTC_373|Compound:0844-0104|FD-Score:2.99|P-value:9.50E-4 ID:SGTC_496|Compound:calpeptin|FD-Score:3.02|P-value:8.73E-4 ID:SGTC_572|Compound:0960-0087|FD-Score:3.40|P-value:2.08E-4 ID:SGTC_627|Compound:1391-0720|FD-Score:3.27|P-value:3.45E-4 ID:SGTC_864|Compound:0469-0573|FD-Score:4.57|P-value:9.66E-7 ID:SGTC_881|Compound:0833-0569|FD-Score:3.17|P-value:5.07E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:3.20|P-value:4.54E-4 ID:SGTC_919|Compound:tnp00227|FD-Score:3.32|P-value:2.83E-4 ID:SGTC_971|Compound:1315-0384|FD-Score:-3.46|P-value:1.27E-4 ID:SGTC_977|Compound:1348-1378|FD-Score:3.37|P-value:2.32E-4 ID:SGTC_987|Compound:1497-1013|FD-Score:3.20|P-value:4.47E-4 ID:SGTC_1029|Compound:k015-0030|FD-Score:3.09|P-value:6.80E-4 ID:SGTC_1067|Compound:clotrimazole|FD-Score:3.96|P-value:1.87E-5 ID:SGTC_1145|Compound:3546-0597|FD-Score:3.34|P-value:2.56E-4 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:3.52|P-value:1.28E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:-4.10|P-value:7.61E-6 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:-3.15|P-value:4.20E-4 ID:SGTC_1801|Compound:st050089|FD-Score:3.28|P-value:3.32E-4 ID:SGTC_1879|Compound:gemcitabine|FD-Score:-3.25|P-value:2.92E-4 ID:SGTC_1983|Compound:st071813|FD-Score:3.94|P-value:2.13E-5 ID:SGTC_2046|Compound:4110841|FD-Score:3.01|P-value:8.86E-4 ID:SGTC_2058|Compound:5236698|FD-Score:3.14|P-value:5.63E-4 ID:SGTC_2175|Compound:5807670|FD-Score:3.27|P-value:3.46E-4 ID:SGTC_2180|Compound:6301957|FD-Score:-3.89|P-value:1.97E-5 ID:SGTC_2263|Compound:7948595|FD-Score:3.18|P-value:4.78E-4 ID:SGTC_2308|Compound:7584454|FD-Score:3.27|P-value:3.44E-4 ID:SGTC_2396|Compound:5342950|FD-Score:3.19|P-value:4.67E-4 ID:SGTC_2437|Compound:5741531|FD-Score:3.25|P-value:3.67E-4 ID:SGTC_2441|Compound:5730946|FD-Score:3.22|P-value:4.21E-4 ID:SGTC_2444|Compound:5485484|FD-Score:3.20|P-value:4.39E-4 ID:SGTC_2484|Compound:5809818|FD-Score:-4.35|P-value:2.20E-6 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:3.56|P-value:1.08E-4 ID:SGTC_2766|Compound:oltipraz|FD-Score:-3.13|P-value:4.68E-4 ID:SGTC_2830|Compound:7992007|FD-Score:-4.04|P-value:9.94E-6 ID:SGTC_2831|Compound:7999036|FD-Score:3.01|P-value:8.95E-4 ID:SGTC_3211|Compound:9128781|FD-Score:-2.98|P-value:7.91E-4 ID:SGTC_12|Compound:0849-0099|FD-Score:3.51|P-value:1.30E-4 ID:SGTC_90|Compound:0870-0863|FD-Score:4.20|P-value:6.28E-6 ID:SGTC_105|Compound:0111-0055|FD-Score:-3.08|P-value:5.55E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:4.36|P-value:2.90E-6 ID:SGTC_174|Compound:3553-0389|FD-Score:4.85|P-value:2.14E-7 ID:SGTC_176|Compound:1486-1328|FD-Score:3.01|P-value:9.00E-4 ID:SGTC_307|Compound:1501-1223|FD-Score:-3.30|P-value:2.44E-4 ID:SGTC_327|Compound:1273-0057|FD-Score:3.51|P-value:1.34E-4 ID:SGTC_373|Compound:0844-0104|FD-Score:2.99|P-value:9.50E-4 ID:SGTC_496|Compound:calpeptin|FD-Score:3.02|P-value:8.73E-4 ID:SGTC_572|Compound:0960-0087|FD-Score:3.40|P-value:2.08E-4 ID:SGTC_627|Compound:1391-0720|FD-Score:3.27|P-value:3.45E-4 ID:SGTC_864|Compound:0469-0573|FD-Score:4.57|P-value:9.66E-7 ID:SGTC_881|Compound:0833-0569|FD-Score:3.17|P-value:5.07E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:3.20|P-value:4.54E-4 ID:SGTC_919|Compound:tnp00227|FD-Score:3.32|P-value:2.83E-4 ID:SGTC_971|Compound:1315-0384|FD-Score:-3.46|P-value:1.27E-4 ID:SGTC_977|Compound:1348-1378|FD-Score:3.37|P-value:2.32E-4 ID:SGTC_987|Compound:1497-1013|FD-Score:3.20|P-value:4.47E-4 ID:SGTC_1029|Compound:k015-0030|FD-Score:3.09|P-value:6.80E-4 ID:SGTC_1067|Compound:clotrimazole|FD-Score:3.96|P-value:1.87E-5 ID:SGTC_1145|Compound:3546-0597|FD-Score:3.34|P-value:2.56E-4 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:3.52|P-value:1.28E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:-4.10|P-value:7.61E-6 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:-3.15|P-value:4.20E-4 ID:SGTC_1801|Compound:st050089|FD-Score:3.28|P-value:3.32E-4 ID:SGTC_1879|Compound:gemcitabine|FD-Score:-3.25|P-value:2.92E-4 ID:SGTC_1983|Compound:st071813|FD-Score:3.94|P-value:2.13E-5 ID:SGTC_2046|Compound:4110841|FD-Score:3.01|P-value:8.86E-4 ID:SGTC_2058|Compound:5236698|FD-Score:3.14|P-value:5.63E-4 ID:SGTC_2175|Compound:5807670|FD-Score:3.27|P-value:3.46E-4 ID:SGTC_2180|Compound:6301957|FD-Score:-3.89|P-value:1.97E-5 ID:SGTC_2263|Compound:7948595|FD-Score:3.18|P-value:4.78E-4 ID:SGTC_2308|Compound:7584454|FD-Score:3.27|P-value:3.44E-4 ID:SGTC_2396|Compound:5342950|FD-Score:3.19|P-value:4.67E-4 ID:SGTC_2437|Compound:5741531|FD-Score:3.25|P-value:3.67E-4 ID:SGTC_2441|Compound:5730946|FD-Score:3.22|P-value:4.21E-4 ID:SGTC_2444|Compound:5485484|FD-Score:3.20|P-value:4.39E-4 ID:SGTC_2484|Compound:5809818|FD-Score:-4.35|P-value:2.20E-6 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:3.56|P-value:1.08E-4 ID:SGTC_2766|Compound:oltipraz|FD-Score:-3.13|P-value:4.68E-4 ID:SGTC_2830|Compound:7992007|FD-Score:-4.04|P-value:9.94E-6 ID:SGTC_2831|Compound:7999036|FD-Score:3.01|P-value:8.95E-4 ID:SGTC_3211|Compound:9128781|FD-Score:-2.98|P-value:7.91E-4

Top fitness defect scores for YBL053W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_174 3553-0389 4.85 74.3 µM 2.14E-7 8 6.06E-7
2 SGTC_864 0469-0573 4.57 172.0 µM 9.66E-7 9 2.42E-6
3 SGTC_173 1273-0061 4.36 2.7 µM 2.90E-6 mitochondrial stress 171 6.64E-6
4 SGTC_90 0870-0863 4.20 4.6 µM 6.28E-6 41 1.35E-5
5 SGTC_1067 clotrimazole 3.96 1.4 µM 1.87E-5 azole & statin 43 3.69E-5
6 SGTC_1983 st071813 3.94 46.9 µM 2.13E-5 RPP1 & pyrimidine depletion 21 4.15E-5
7 SGTC_2634 4'-methoxyflavone 3.56 100.0 µM 1.08E-4 46 1.85E-4
8 SGTC_1309 pyrazolanthrone 3.52 13.4 µM 1.28E-4 31 2.18E-4
9 SGTC_12 0849-0099 3.51 9.3 µM 1.30E-4 30 2.21E-4
10 SGTC_327 1273-0057 3.51 4.0 µM 1.34E-4 azole & statin 44 2.26E-4
11 SGTC_572 0960-0087 3.40 17.7 µM 2.08E-4 53 3.39E-4
12 SGTC_977 1348-1378 3.37 135.0 µM 2.32E-4 36 3.76E-4
13 SGTC_1145 3546-0597 3.34 10.2 µM 2.56E-4 mitochondrial processes 37 4.12E-4
14 SGTC_919 tnp00227 3.32 403.6 nM 2.83E-4 RNA pol III & RNase P/MRP 67 4.51E-4
15 SGTC_1801 st050089 3.28 28.4 µM 3.32E-4 NEO1-PIK1 172 5.23E-4
16 SGTC_2308 7584454 3.27 197.6 µM 3.44E-4 57 5.40E-4
17 SGTC_627 1391-0720 3.27 175.0 µM 3.45E-4 30 5.41E-4
18 SGTC_2175 5807670 3.27 165.3 µM 3.46E-4 42 5.43E-4
19 SGTC_2437 5741531 3.25 144.2 µM 3.67E-4 69 5.74E-4
20 SGTC_2441 5730946 3.22 39.1 µM 4.21E-4 43 6.50E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.128 8.59E-14 YOR378W_p YOR378W_p hom Putative paralog of ATR1, but not required for boron tolerance; member of the DHA2 family of drug:H+ antiporters; YOR378W is not an essential gene
0.101 4.05E-9 YKL170W MRPL38 hom Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL34 and YmL38) on two-dimensional SDS gels; protein abundance increases in response to DNA replication stress
0.091 1.10E-7 YIL107C PFK26 hom 6-phosphofructo-2-kinase, inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate; has negligible fructose-2,6-bisphosphatase activity; transcriptional regulation involves protein kinase A
0.088 3.26E-7 YPL142C_d YPL142C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF RPL33A/YPL143W, a component of the large (60S) ribosomal subunit
0.086 7.10E-7 YMR124W_p YMR124W_p hom Protein of unknown function; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W is not an essential gene; predicted to have a role in organelle organization
0.085 9.04E-7 YDR053W_d YDR053W_d het Putative protein of unknown function; open reading frame overlaps 5' end of essential DBF4 gene encoding the regulatory subunit of the Cdc7p-Dbf4p kinase complex
0.082 2.14E-6 YOL004W SIN3 hom Component of the Sin3p-Rpd3p histone deacetylase complex, involved in transcriptional repression and activation of diverse processes, including mating-type switching and meiosis; involved in the maintenance of chromosomal integrity
0.080 3.11E-6 YLR006C SSK1 hom Cytoplasmic response regulator; part of a two-component signal transducer that mediates osmosensing via a phosphorelay mechanism; required for mitophagy; dephosphorylated form is degraded by the ubiquitin-proteasome system; potential Cdc28p substrate
0.079 5.17E-6 YIL090W ICE2 hom Integral ER membrane protein with type-III transmembrane domains; required for maintenance of ER zinc homeostasis; necessary for efficient targeting of Trm1p tRNA methyltransferase to inner nuclear membrane; mutations cause defects in cortical ER morphology in both the mother and daughter cells
0.078 6.09E-6 YPL242C IQG1 het Essential protein required for determination of budding pattern; promotes localization of axial markers Bud4p and Cdc12p and functionally interacts with Sec3p, localizes to the contractile ring during anaphase, member of the IQGAP family; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.077 8.77E-6 YGR277C CAB4 het Probable pantetheine-phosphate adenylyltransferase (PPAT), which catalyzes the fourth step in the biosynthesis of coenzyme A from pantothenate; null mutant lethality is complemented by E. coli coaD (encoding PPAT); widely conserved
0.075 1.23E-5 YPR194C OPT2 hom Oligopeptide transporter; member of the OPT family, with potential orthologs in S. pombe and C. albicans; also plays a role in formation of mature vacuoles
0.074 1.61E-5 YJR083C ACF4 hom Protein of unknown function, computational analysis of large-scale protein-protein interaction data suggests a possible role in actin cytoskeleton organization; potential Cdc28p substrate
0.074 1.71E-5 YNL139C THO2 hom Subunit of the THO complex, which is required for efficient transcription elongation and involved in transcriptional elongation-associated recombination; required for LacZ RNA expression from certain plasmids
0.074 2.04E-5 YGR102C GTF1 hom Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; transposon insertion mutant is salt sensitive and null mutant has growth defects; non-tagged protein is detected in purified mitochondria