YBL054W / TOD6

PAC motif binding protein involved in rRNA and ribosome biogenesis; subunit of the RPD3L histone deacetylase complex; Myb-like HTH transcription factor; hypophosphorylated by rapamycin treatment in a Sch9p-dependent manner; TOD6 has a paralog, DOT6, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YBL054W / TOD6

Click on Significant Values for Screen Details ID:SGTC_127|Compound:0180-0333|FD-Score:3.43|P-value:3.76E-4 ID:SGTC_155|Compound:k072-0202|FD-Score:3.23|P-value:7.48E-4 ID:SGTC_843|Compound:0310-0051|FD-Score:4.65|P-value:2.68E-6 ID:SGTC_873|Compound:0591-4978|FD-Score:4.17|P-value:2.14E-5 ID:SGTC_1019|Compound:4262-0212|FD-Score:4.61|P-value:3.16E-6 ID:SGTC_1108|Compound:betulinic acid|FD-Score:4.10|P-value:2.93E-5 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:-3.29|P-value:8.46E-4 ID:SGTC_1168|Compound:k815-0004|FD-Score:4.26|P-value:1.49E-5 ID:SGTC_1252|Compound:0493-0875|FD-Score:-3.38|P-value:6.32E-4 ID:SGTC_1339|Compound:1486-1321|FD-Score:5.63|P-value:1.83E-8 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:-3.40|P-value:5.87E-4 ID:SGTC_1635|Compound:st007035|FD-Score:-3.42|P-value:5.51E-4 ID:SGTC_1637|Compound:st007924|FD-Score:3.63|P-value:1.81E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:3.74|P-value:1.23E-4 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:3.58|P-value:2.22E-4 ID:SGTC_1803|Compound:st050068|FD-Score:3.93|P-value:5.70E-5 ID:SGTC_2055|Compound:5235184|FD-Score:-3.38|P-value:6.27E-4 ID:SGTC_2057|Compound:5236571|FD-Score:3.42|P-value:3.82E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:4.74|P-value:1.76E-6 ID:SGTC_2264|Compound:7948757|FD-Score:3.92|P-value:6.09E-5 ID:SGTC_2271|Compound:7849410|FD-Score:-3.98|P-value:7.09E-5 ID:SGTC_2375|Compound:9072683|FD-Score:3.78|P-value:1.04E-4 ID:SGTC_2434|Compound:5670830|FD-Score:3.62|P-value:1.90E-4 ID:SGTC_2444|Compound:5485484|FD-Score:3.22|P-value:7.66E-4 ID:SGTC_2624|Compound:nerol|FD-Score:-4.42|P-value:1.14E-5 ID:SGTC_2690|Compound:usnic acid|FD-Score:5.99|P-value:2.42E-9 ID:SGTC_2702|Compound:st077768|FD-Score:5.71|P-value:1.20E-8 ID:SGTC_2753|Compound:fluvastatin|FD-Score:4.55|P-value:4.22E-6 ID:SGTC_2756|Compound:carbadox|FD-Score:4.79|P-value:1.41E-6 ID:SGTC_2759|Compound:disulfiram|FD-Score:3.77|P-value:1.06E-4 ID:SGTC_2776|Compound:terbinafine|FD-Score:3.27|P-value:6.46E-4 ID:SGTC_2803|Compound:7707263|FD-Score:3.30|P-value:5.94E-4 ID:SGTC_2822|Compound:7994718|FD-Score:4.43|P-value:7.21E-6 ID:SGTC_2833|Compound:9001315|FD-Score:3.68|P-value:1.53E-4 ID:SGTC_127|Compound:0180-0333|FD-Score:3.43|P-value:3.76E-4 ID:SGTC_155|Compound:k072-0202|FD-Score:3.23|P-value:7.48E-4 ID:SGTC_843|Compound:0310-0051|FD-Score:4.65|P-value:2.68E-6 ID:SGTC_873|Compound:0591-4978|FD-Score:4.17|P-value:2.14E-5 ID:SGTC_1019|Compound:4262-0212|FD-Score:4.61|P-value:3.16E-6 ID:SGTC_1108|Compound:betulinic acid|FD-Score:4.10|P-value:2.93E-5 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:-3.29|P-value:8.46E-4 ID:SGTC_1168|Compound:k815-0004|FD-Score:4.26|P-value:1.49E-5 ID:SGTC_1252|Compound:0493-0875|FD-Score:-3.38|P-value:6.32E-4 ID:SGTC_1339|Compound:1486-1321|FD-Score:5.63|P-value:1.83E-8 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:-3.40|P-value:5.87E-4 ID:SGTC_1635|Compound:st007035|FD-Score:-3.42|P-value:5.51E-4 ID:SGTC_1637|Compound:st007924|FD-Score:3.63|P-value:1.81E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:3.74|P-value:1.23E-4 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:3.58|P-value:2.22E-4 ID:SGTC_1803|Compound:st050068|FD-Score:3.93|P-value:5.70E-5 ID:SGTC_2055|Compound:5235184|FD-Score:-3.38|P-value:6.27E-4 ID:SGTC_2057|Compound:5236571|FD-Score:3.42|P-value:3.82E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:4.74|P-value:1.76E-6 ID:SGTC_2264|Compound:7948757|FD-Score:3.92|P-value:6.09E-5 ID:SGTC_2271|Compound:7849410|FD-Score:-3.98|P-value:7.09E-5 ID:SGTC_2375|Compound:9072683|FD-Score:3.78|P-value:1.04E-4 ID:SGTC_2434|Compound:5670830|FD-Score:3.62|P-value:1.90E-4 ID:SGTC_2444|Compound:5485484|FD-Score:3.22|P-value:7.66E-4 ID:SGTC_2624|Compound:nerol|FD-Score:-4.42|P-value:1.14E-5 ID:SGTC_2690|Compound:usnic acid|FD-Score:5.99|P-value:2.42E-9 ID:SGTC_2702|Compound:st077768|FD-Score:5.71|P-value:1.20E-8 ID:SGTC_2753|Compound:fluvastatin|FD-Score:4.55|P-value:4.22E-6 ID:SGTC_2756|Compound:carbadox|FD-Score:4.79|P-value:1.41E-6 ID:SGTC_2759|Compound:disulfiram|FD-Score:3.77|P-value:1.06E-4 ID:SGTC_2776|Compound:terbinafine|FD-Score:3.27|P-value:6.46E-4 ID:SGTC_2803|Compound:7707263|FD-Score:3.30|P-value:5.94E-4 ID:SGTC_2822|Compound:7994718|FD-Score:4.43|P-value:7.21E-6 ID:SGTC_2833|Compound:9001315|FD-Score:3.68|P-value:1.53E-4

Top fitness defect scores for YBL054W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2690 usnic acid 5.99 100.0 µM 2.42E-9 5 1.04E-9
2 SGTC_2702 st077768 5.71 96.8 µM 1.20E-8 3 5.63E-9
3 SGTC_1339 1486-1321 5.63 22.7 µM 1.83E-8 ERG2 3 8.79E-9
4 SGTC_2756 carbadox 4.79 75.1 µM 1.41E-6 39 8.54E-7
5 SGTC_2249 haloperidol 4.74 116.4 µM 1.76E-6 ergosterol depletion effects on membrane 74 1.08E-6
6 SGTC_843 0310-0051 4.65 143.0 µM 2.68E-6 5 1.68E-6
7 SGTC_1019 4262-0212 4.61 3.4 µM 3.16E-6 ergosterol depletion effects on membrane 39 2.00E-6
8 SGTC_2753 fluvastatin 4.55 17.1 µM 4.22E-6 azole & statin 19 2.71E-6
9 SGTC_2822 7994718 4.43 71.4 µM 7.21E-6 11 4.76E-6
10 SGTC_1168 k815-0004 4.26 80.5 µM 1.49E-5 DNA damage response 13 1.02E-5
11 SGTC_873 0591-4978 4.17 488.0 µM 2.14E-5 15 1.49E-5
12 SGTC_1108 betulinic acid 4.10 729.1 nM 2.93E-5 12 2.08E-5
13 SGTC_1803 st050068 3.93 52.4 µM 5.70E-5 NEO1-PIK1 182 4.18E-5
14 SGTC_2264 7948757 3.92 110.8 µM 6.09E-5 14 4.48E-5
15 SGTC_2375 9072683 3.78 200.0 µM 1.04E-4 mitochondrial processes 25 7.84E-5
16 SGTC_2759 disulfiram 3.77 3.4 µM 1.06E-4 43 8.05E-5
17 SGTC_1679 4130-1276 3.74 6.7 µM 1.23E-4 Golgi 75 9.37E-5
18 SGTC_2833 9001315 3.68 45.5 µM 1.53E-4 amide catabolism 68 1.18E-4
19 SGTC_1637 st007924 3.63 17.4 µM 1.81E-4 33 1.41E-4
20 SGTC_2434 5670830 3.62 169.9 µM 1.90E-4 34 1.48E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.104 1.67E-9 YIL109C SEC24 het Component of the Sec23p-Sec24p heterodimer of the COPII vesicle coat, required for cargo selection during vesicle formation in ER to Golgi transport; homologous to Sfb2p and Sfb3p
0.103 2.36E-9 YOR030W DFG16 hom Probable multiple transmembrane protein; involved in diploid invasive and pseudohyphal growth upon nitrogen starvation; is glycosylated and phosphorylated; interacts with Rim21p and Rim9p in the plasma membrane to form a pH-sensing complex in the Rim101 pathway and is required to maintain Rim21p levels; required for accumulation of processed Rim101p
0.102 2.69E-9 YNL183C NPR1 hom Protein kinase that stabilizes several plasma membrane amino acid transporters by antagonizing their ubiquitin-mediated degradation; phosphorylates Aly2p; negatively regulates Ldb19p-mediated endocytosis through phosphorylation of Ldb19p, which prevents its association with the plasma membrane; Npr1p activity is negatively regulated via phosphorylation by the TOR complex
0.102 3.35E-9 YMR061W RNA14 het Component of the cleavage and polyadenylation factor I (CF I); CF 1, composed of the CF 1A complex (Rna14p, Rna15p, Clp1p, Pcf11p) and Hrp1, is involved in cleavage and polyadenylation of mRNA 3' ends; bridges interaction between Rna15p and Hrp1p in the CF I complex; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay; required for gene looping
0.101 4.54E-9 YDR213W UPC2 hom Sterol regulatory element binding protein; induces transcription of sterol biosynthetic genes and of DAN/TIR gene products; relocates from intracellular membranes to perinuclear foci on sterol depletion; UPC2 has a paralog, ECM22, that arose from the whole genome duplication
0.097 1.98E-8 YKL217W JEN1 hom Monocarboxylate/proton symporter of the plasma membrane; transport activity is dependent on the pH gradient across the membrane; mediates high-affinity uptake of carbon sources lactate, pyuvate, and acetate, and also of the micronutrient selenite, whose structure mimics that of monocarboxylates; expression and localization are tightly regulated, with transcription repression, mRNA degradation, and protein endocytosis and degradation all occurring in the presence of glucose
0.092 9.26E-8 YBR103W SIF2 hom WD40 repeat-containing subunit of the Set3C histone deacetylase complex, which represses early/middle sporulation genes; antagonizes telomeric silencing; binds specifically to the Sir4p N-terminus
0.088 3.75E-7 YPR092W_d YPR092W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.088 3.67E-7 YMR079W SEC14 het Phosphatidylinositol/phosphatidylcholine transfer protein; involved in regulating PtdIns, PtdCho, and ceramide metabolism, products of which regulate intracellular transport and UPR; has a role in localization of lipid raft proteins; functionally homologous to mammalian PITPs
0.086 6.04E-7 YBL009W ALK2 hom Protein kinase; accumulation and phosphorylation are periodic during the cell cycle; phosphorylated in response to DNA damage; contains characteristic motifs for degradation via the APC pathway; ALK2 has a paralog, ALK1, that arose from the whole genome duplication; similar to mammalian haspins
0.085 8.49E-7 YPR095C SYT1 hom Guanine nucleotide exchange factor (GEF) for Arf proteins; promotes activation of Arl1p, which recruits Imh1p to the Golgi; involved in vesicular transport; member of the Sec7-domain family; contains a PH domain
0.083 1.34E-6 YNL006W LST8 het Protein required for the transport of amino acid permease Gap1p from the Golgi to the cell surface; component of the TOR signaling pathway; associates with both Tor1p and Tor2p; contains a WD-repeat
0.083 1.66E-6 YNL294C RIM21 hom pH sensor molecule, component of the RIM101 pathway; has a role in cell wall construction and alkaline pH response; is glycosylated and phosphorylated; interacts with Dfg16p and Rim9p to form a pH-sensing complex; localization to the plasma membrane is dependent on Dfg16p and Rim9p; has similarity to A. nidulans PalH
0.082 1.75E-6 YOL114C_p YOL114C_p hom Putative protein of unknown function with similarity to human ICT1 and prokaryotic factors that may function in translation termination; YOL114C is not an essential gene
0.082 2.03E-6 YOR115C TRS33 hom One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic