YBL055C

3'-->5' exonuclease and endonuclease with a possible role in apoptosis; has similarity to mammalian and C. elegans apoptotic nucleases

Zygosity: Homozygous strain
fixedexpanded
Profile for YBL055C / YBL055C

Click on Significant Values for Screen Details ID:SGTC_159|Compound:3970-0959|FD-Score:3.40|P-value:1.03E-4 ID:SGTC_170|Compound:4197-0004|FD-Score:-3.91|P-value:9.68E-6 ID:SGTC_244|Compound:nsc-207895|FD-Score:-3.11|P-value:3.42E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:3.47|P-value:7.46E-5 ID:SGTC_469|Compound:w7|FD-Score:-3.25|P-value:1.96E-4 ID:SGTC_482|Compound:fipronil|FD-Score:2.94|P-value:6.57E-4 ID:SGTC_489|Compound:paxilline|FD-Score:-3.88|P-value:1.17E-5 ID:SGTC_656|Compound:4090-1979|FD-Score:2.96|P-value:6.21E-4 ID:SGTC_709|Compound:3807-1509|FD-Score:-3.12|P-value:3.33E-4 ID:SGTC_740|Compound:k014-0057|FD-Score:3.12|P-value:3.21E-4 ID:SGTC_933|Compound:2914-0560|FD-Score:3.11|P-value:3.47E-4 ID:SGTC_1009|Compound:4106-0057|FD-Score:3.30|P-value:1.56E-4 ID:SGTC_1010|Compound:4112-3296|FD-Score:5.47|P-value:1.14E-9 ID:SGTC_1041|Compound:0206-0046|FD-Score:3.04|P-value:4.49E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:3.86|P-value:1.22E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.05|P-value:5.04E-6 ID:SGTC_1153|Compound:4055-0057|FD-Score:3.15|P-value:2.86E-4 ID:SGTC_1252|Compound:0493-0875|FD-Score:-3.58|P-value:4.72E-5 ID:SGTC_1294|Compound:1000-1494|FD-Score:3.95|P-value:8.04E-6 ID:SGTC_1295|Compound:1013-0063|FD-Score:3.48|P-value:7.06E-5 ID:SGTC_1317|Compound:1273-0028|FD-Score:3.05|P-value:4.29E-4 ID:SGTC_1401|Compound:3807-4679|FD-Score:-3.05|P-value:4.41E-4 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:-3.06|P-value:4.20E-4 ID:SGTC_1579|Compound:chlormadinone acetate|FD-Score:3.72|P-value:2.43E-5 ID:SGTC_1594|Compound:piperine|FD-Score:3.62|P-value:3.85E-5 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:4.72|P-value:1.25E-7 ID:SGTC_1649|Compound:st011737|FD-Score:3.13|P-value:3.14E-4 ID:SGTC_1717|Compound:st033143|FD-Score:-3.34|P-value:1.32E-4 ID:SGTC_1719|Compound:st032227|FD-Score:-3.04|P-value:4.62E-4 ID:SGTC_1724|Compound:st037281|FD-Score:3.24|P-value:1.99E-4 ID:SGTC_1809|Compound:st050081|FD-Score:2.90|P-value:7.77E-4 ID:SGTC_1853|Compound:st056710|FD-Score:-2.86|P-value:9.06E-4 ID:SGTC_1859|Compound:st055998|FD-Score:3.13|P-value:3.18E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-5.05|P-value:1.75E-8 ID:SGTC_1966|Compound:st070145|FD-Score:-5.11|P-value:1.22E-8 ID:SGTC_1988|Compound:st071872|FD-Score:4.16|P-value:2.83E-6 ID:SGTC_2017|Compound:5132927|FD-Score:-3.35|P-value:1.28E-4 ID:SGTC_2159|Compound:5658611|FD-Score:3.32|P-value:1.45E-4 ID:SGTC_2170|Compound:morpholine|FD-Score:4.66|P-value:1.75E-7 ID:SGTC_2174|Compound:5790901|FD-Score:5.26|P-value:4.76E-9 ID:SGTC_2206|Compound:7254556|FD-Score:-2.91|P-value:7.49E-4 ID:SGTC_2251|Compound:lansoprazole|FD-Score:-2.89|P-value:8.00E-4 ID:SGTC_2308|Compound:7584454|FD-Score:3.30|P-value:1.54E-4 ID:SGTC_2353|Compound:9059630|FD-Score:3.18|P-value:2.60E-4 ID:SGTC_2363|Compound:9053361|FD-Score:2.83|P-value:9.79E-4 ID:SGTC_2389|Compound:9091542|FD-Score:-3.02|P-value:4.97E-4 ID:SGTC_2437|Compound:5741531|FD-Score:2.98|P-value:5.66E-4 ID:SGTC_2521|Compound:angolensin|FD-Score:-3.39|P-value:1.06E-4 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:-2.85|P-value:9.30E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:5.58|P-value:5.70E-10 ID:SGTC_2564|Compound:betulinic acid|FD-Score:4.99|P-value:2.48E-8 ID:SGTC_2589|Compound:lobaric acid|FD-Score:-3.44|P-value:8.64E-5 ID:SGTC_2594|Compound:a-mangostin|FD-Score:-3.64|P-value:3.55E-5 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:2.91|P-value:7.46E-4 ID:SGTC_2750|Compound:bromebric acid|FD-Score:3.68|P-value:2.93E-5 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:2.90|P-value:7.62E-4 ID:SGTC_2761|Compound:levamisole|FD-Score:2.84|P-value:9.63E-4 ID:SGTC_2764|Compound:methyldopa|FD-Score:3.25|P-value:1.94E-4 ID:SGTC_2791|Compound:5663188|FD-Score:3.39|P-value:1.07E-4 ID:SGTC_2848|Compound:9016370|FD-Score:3.51|P-value:6.18E-5 ID:SGTC_2957|Compound:9076800|FD-Score:-4.84|P-value:6.33E-8 ID:SGTC_2964|Compound:9083345|FD-Score:-4.73|P-value:1.25E-7 ID:SGTC_2998|Compound:9066762|FD-Score:3.31|P-value:1.52E-4 ID:SGTC_3016|Compound:9080866|FD-Score:3.02|P-value:4.91E-4 ID:SGTC_3058|Compound:9093861|FD-Score:3.92|P-value:9.35E-6 ID:SGTC_3217|Compound:9129673|FD-Score:2.93|P-value:6.73E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:3.40|P-value:1.03E-4 ID:SGTC_170|Compound:4197-0004|FD-Score:-3.91|P-value:9.68E-6 ID:SGTC_244|Compound:nsc-207895|FD-Score:-3.11|P-value:3.42E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:3.47|P-value:7.46E-5 ID:SGTC_469|Compound:w7|FD-Score:-3.25|P-value:1.96E-4 ID:SGTC_482|Compound:fipronil|FD-Score:2.94|P-value:6.57E-4 ID:SGTC_489|Compound:paxilline|FD-Score:-3.88|P-value:1.17E-5 ID:SGTC_656|Compound:4090-1979|FD-Score:2.96|P-value:6.21E-4 ID:SGTC_709|Compound:3807-1509|FD-Score:-3.12|P-value:3.33E-4 ID:SGTC_740|Compound:k014-0057|FD-Score:3.12|P-value:3.21E-4 ID:SGTC_933|Compound:2914-0560|FD-Score:3.11|P-value:3.47E-4 ID:SGTC_1009|Compound:4106-0057|FD-Score:3.30|P-value:1.56E-4 ID:SGTC_1010|Compound:4112-3296|FD-Score:5.47|P-value:1.14E-9 ID:SGTC_1041|Compound:0206-0046|FD-Score:3.04|P-value:4.49E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:3.86|P-value:1.22E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.05|P-value:5.04E-6 ID:SGTC_1153|Compound:4055-0057|FD-Score:3.15|P-value:2.86E-4 ID:SGTC_1252|Compound:0493-0875|FD-Score:-3.58|P-value:4.72E-5 ID:SGTC_1294|Compound:1000-1494|FD-Score:3.95|P-value:8.04E-6 ID:SGTC_1295|Compound:1013-0063|FD-Score:3.48|P-value:7.06E-5 ID:SGTC_1317|Compound:1273-0028|FD-Score:3.05|P-value:4.29E-4 ID:SGTC_1401|Compound:3807-4679|FD-Score:-3.05|P-value:4.41E-4 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:-3.06|P-value:4.20E-4 ID:SGTC_1579|Compound:chlormadinone acetate|FD-Score:3.72|P-value:2.43E-5 ID:SGTC_1594|Compound:piperine|FD-Score:3.62|P-value:3.85E-5 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:4.72|P-value:1.25E-7 ID:SGTC_1649|Compound:st011737|FD-Score:3.13|P-value:3.14E-4 ID:SGTC_1717|Compound:st033143|FD-Score:-3.34|P-value:1.32E-4 ID:SGTC_1719|Compound:st032227|FD-Score:-3.04|P-value:4.62E-4 ID:SGTC_1724|Compound:st037281|FD-Score:3.24|P-value:1.99E-4 ID:SGTC_1809|Compound:st050081|FD-Score:2.90|P-value:7.77E-4 ID:SGTC_1853|Compound:st056710|FD-Score:-2.86|P-value:9.06E-4 ID:SGTC_1859|Compound:st055998|FD-Score:3.13|P-value:3.18E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-5.05|P-value:1.75E-8 ID:SGTC_1966|Compound:st070145|FD-Score:-5.11|P-value:1.22E-8 ID:SGTC_1988|Compound:st071872|FD-Score:4.16|P-value:2.83E-6 ID:SGTC_2017|Compound:5132927|FD-Score:-3.35|P-value:1.28E-4 ID:SGTC_2159|Compound:5658611|FD-Score:3.32|P-value:1.45E-4 ID:SGTC_2170|Compound:morpholine|FD-Score:4.66|P-value:1.75E-7 ID:SGTC_2174|Compound:5790901|FD-Score:5.26|P-value:4.76E-9 ID:SGTC_2206|Compound:7254556|FD-Score:-2.91|P-value:7.49E-4 ID:SGTC_2251|Compound:lansoprazole|FD-Score:-2.89|P-value:8.00E-4 ID:SGTC_2308|Compound:7584454|FD-Score:3.30|P-value:1.54E-4 ID:SGTC_2353|Compound:9059630|FD-Score:3.18|P-value:2.60E-4 ID:SGTC_2363|Compound:9053361|FD-Score:2.83|P-value:9.79E-4 ID:SGTC_2389|Compound:9091542|FD-Score:-3.02|P-value:4.97E-4 ID:SGTC_2437|Compound:5741531|FD-Score:2.98|P-value:5.66E-4 ID:SGTC_2521|Compound:angolensin|FD-Score:-3.39|P-value:1.06E-4 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:-2.85|P-value:9.30E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:5.58|P-value:5.70E-10 ID:SGTC_2564|Compound:betulinic acid|FD-Score:4.99|P-value:2.48E-8 ID:SGTC_2589|Compound:lobaric acid|FD-Score:-3.44|P-value:8.64E-5 ID:SGTC_2594|Compound:a-mangostin|FD-Score:-3.64|P-value:3.55E-5 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:2.91|P-value:7.46E-4 ID:SGTC_2750|Compound:bromebric acid|FD-Score:3.68|P-value:2.93E-5 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:2.90|P-value:7.62E-4 ID:SGTC_2761|Compound:levamisole|FD-Score:2.84|P-value:9.63E-4 ID:SGTC_2764|Compound:methyldopa|FD-Score:3.25|P-value:1.94E-4 ID:SGTC_2791|Compound:5663188|FD-Score:3.39|P-value:1.07E-4 ID:SGTC_2848|Compound:9016370|FD-Score:3.51|P-value:6.18E-5 ID:SGTC_2957|Compound:9076800|FD-Score:-4.84|P-value:6.33E-8 ID:SGTC_2964|Compound:9083345|FD-Score:-4.73|P-value:1.25E-7 ID:SGTC_2998|Compound:9066762|FD-Score:3.31|P-value:1.52E-4 ID:SGTC_3016|Compound:9080866|FD-Score:3.02|P-value:4.91E-4 ID:SGTC_3058|Compound:9093861|FD-Score:3.92|P-value:9.35E-6 ID:SGTC_3217|Compound:9129673|FD-Score:2.93|P-value:6.73E-4

Top fitness defect scores for YBL055C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2563 tomatine 5.58 8.5 µM 5.70E-10 14 1.24E-8
2 SGTC_1010 4112-3296 5.47 15.2 µM 1.14E-9 8 2.21E-8
3 SGTC_2174 5790901 5.26 200.0 µM 4.76E-9 tubulin folding & SWR complex 19 7.39E-8
4 SGTC_2564 betulinic acid 4.99 100.0 µM 2.48E-8 13 2.97E-7
5 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 4.72 67.5 µM 1.25E-7 22 1.16E-6
6 SGTC_2170 morpholine 4.66 200.0 µM 1.75E-7 5 1.55E-6
7 SGTC_1988 st071872 4.16 53.4 µM 2.83E-6 7 1.62E-5
8 SGTC_1294 1000-1494 3.95 117.0 µM 8.04E-6 24 3.92E-5
9 SGTC_3058 9093861 3.92 49.5 µM 9.35E-6 16 4.45E-5
10 SGTC_1083 didemethylchlorpromazine sulfoxide 3.86 707.4 nM 1.22E-5 redox potentiating 89 5.57E-5
11 SGTC_1579 chlormadinone acetate 3.72 49.4 µM 2.43E-5 13 9.98E-5
12 SGTC_2750 bromebric acid 3.68 70.2 µM 2.93E-5 41 1.17E-4
13 SGTC_1594 piperine 3.62 70.1 µM 3.85E-5 21 1.47E-4
14 SGTC_2848 9016370 3.51 26.0 µM 6.18E-5 42 2.20E-4
15 SGTC_1295 1013-0063 3.48 9.8 µM 7.06E-5 25 2.46E-4
16 SGTC_372 0155-0182 3.47 15.9 µM 7.46E-5 mitochondrial response to ROS 43 2.58E-4
17 SGTC_159 3970-0959 3.40 50.0 µM 1.03E-4 115 3.38E-4
18 SGTC_2791 5663188 3.39 71.4 µM 1.07E-4 RPP1 & pyrimidine depletion 40 3.49E-4
19 SGTC_2159 5658611 3.32 73.8 µM 1.45E-4 19 4.54E-4
20 SGTC_2998 9066762 3.31 71.4 µM 1.52E-4 RPP1 & pyrimidine depletion 49 4.73E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.165 8.41E-22 YBL063W KIP1 hom Kinesin-related motor protein required for mitotic spindle assembly, chromosome segregation, and 2 micron plasmid partitioning; functionally redundant with Cin8p for chromosomal but not plasmid functions
0.137 1.70E-15 YDL207W GLE1 het Cytoplasmic nucleoporin required for polyadenylated RNA export; not essential for protein import; contains a nuclear export signal; when bound to inositol hexakisphosphate (IP6), functions as an activator for the Dbp5p ATPase activity at the nuclear pore complex during mRNA export
0.131 2.25E-14 YLR203C MSS51 hom Specific translational activator for the mitochondrial COX1 mRNA; loosely associated with the matrix face of the mitochondrial inner membrane; influences both COX1 mRNA translation and Cox1p assembly into cytochrome c oxidase; binds to heme B, which may be a mechanism for sensing oxygen levels in order to regulate cytochrome c oxidase biogenesis
0.129 6.92E-14 YNR032C-A HUB1 hom Ubiquitin-like protein modifier; promotes alternative splicing of SRC1 pre-mRNA; binds non-covalently to the HIND domain of Snu66, may function in modification of Sph1p and Hbt1p, functionally complemented by the human or S. pombe ortholog; mechanism of Hub1p adduct formation not yet clear
0.129 7.37E-14 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.127 1.59E-13 YLL012W YEH1 hom Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes
0.127 1.80E-13 YKL220C FRE2 hom Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low iron levels but not by low copper levels
0.123 9.71E-13 YDR110W FOB1 hom Nucleolar protein that binds the rDNA replication fork barrier (RFB) site; required for replication fork blocking, recombinational hotspot activity, condensin recruitment to RFB and rDNA repeat segregation; related to retroviral integrases
0.121 2.36E-12 YDR299W BFR2 het Essential protein that is a component of 90S preribosomes; may be involved in rRNA processing; multicopy suppressor of sensitivity to Brefeldin A; expression is induced during lag phase and also by cold shock
0.117 1.14E-11 YPL251W_d YPL251W_d het Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified, essential gene YAH1/YPL252C
0.116 1.89E-11 YER064C VHR2 hom Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.113 5.16E-11 YMR184W ADD37 hom Protein of unknown function; involved in ER-associated protein degradation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YMR184W is not an essential gene; protein abundance increases in response to DNA replication stress
0.111 1.29E-10 YOR082C_d YOR082C_d hom Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene YOR083W
0.109 2.26E-10 YBR085W AAC3 hom Mitochondrial inner membrane ADP/ATP translocator; exchanges cytosolic ADP for mitochondrially synthesized ATP; expressed under anaerobic conditions; similar to Aac1p; has roles in maintenance of viability and in respiration; AAC3 has a paralog, PET9, that arose from the whole genome duplication
0.109 2.36E-10 YGR097W ASK10 hom Component of RNA polymerase II holoenzyme; phosphorylated in response to oxidative stress; has a role in destruction of Ssn8p; proposed to function in activation of the glycerol channel Fps1p; ASK10 has a paralog, RGC1, that arose from the whole genome duplication