YBL057C / PTH2

One of two (see also PTH1) mitochondrially-localized peptidyl-tRNA hydrolases; negatively regulates the ubiquitin-proteasome pathway via interactions with ubiquitin-like ubiquitin-associated proteins; dispensable for cell growth

Zygosity: Homozygous strain
fixedexpanded
Profile for YBL057C / PTH2

Click on Significant Values for Screen Details ID:SGTC_101|Compound:0490-5701|FD-Score:3.51|P-value:3.88E-4 ID:SGTC_174|Compound:3553-0389|FD-Score:3.43|P-value:5.21E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:-4.12|P-value:2.89E-5 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:3.90|P-value:9.26E-5 ID:SGTC_432|Compound:NS 1619|FD-Score:4.42|P-value:1.13E-5 ID:SGTC_519|Compound:k048-0011|FD-Score:3.43|P-value:5.22E-4 ID:SGTC_864|Compound:0469-0573|FD-Score:3.49|P-value:4.24E-4 ID:SGTC_1014|Compound:4130-3005|FD-Score:4.88|P-value:1.39E-6 ID:SGTC_1024|Compound:4507-0395|FD-Score:3.57|P-value:3.22E-4 ID:SGTC_1054|Compound:3429-0080|FD-Score:3.50|P-value:4.07E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:3.31|P-value:7.86E-4 ID:SGTC_1151|Compound:3909-8316|FD-Score:4.29|P-value:1.99E-5 ID:SGTC_1408|Compound:3909-7976|FD-Score:3.57|P-value:3.20E-4 ID:SGTC_1486|Compound:3970-0793|FD-Score:4.04|P-value:5.31E-5 ID:SGTC_1489|Compound:4065-0444|FD-Score:4.03|P-value:5.70E-5 ID:SGTC_1603|Compound:st002045|FD-Score:3.24|P-value:9.63E-4 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:5.41|P-value:9.85E-8 ID:SGTC_2009|Compound:4012297|FD-Score:3.93|P-value:8.25E-5 ID:SGTC_2160|Compound:5660466|FD-Score:4.02|P-value:5.85E-5 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:-3.18|P-value:9.14E-4 ID:SGTC_2180|Compound:6301957|FD-Score:3.37|P-value:6.25E-4 ID:SGTC_2184|Compound:6075246|FD-Score:4.51|P-value:7.72E-6 ID:SGTC_2185|Compound:6113692|FD-Score:-3.56|P-value:2.49E-4 ID:SGTC_2247|Compound:cerulenin|FD-Score:3.45|P-value:4.89E-4 ID:SGTC_2351|Compound:9026858|FD-Score:3.25|P-value:9.58E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:5.87|P-value:8.58E-9 ID:SGTC_2584|Compound:androsterone|FD-Score:-3.29|P-value:6.46E-4 ID:SGTC_2587|Compound:piperic acid|FD-Score:-4.88|P-value:9.54E-7 ID:SGTC_2762|Compound:leflunomide|FD-Score:3.43|P-value:5.15E-4 ID:SGTC_2780|Compound:5215298|FD-Score:3.40|P-value:5.64E-4 ID:SGTC_2832|Compound:7992762|FD-Score:3.36|P-value:6.64E-4 ID:SGTC_2868|Compound:9035608|FD-Score:3.47|P-value:4.43E-4 ID:SGTC_2948|Compound:9070189|FD-Score:3.41|P-value:5.60E-4 ID:SGTC_2959|Compound:9079155|FD-Score:3.93|P-value:8.18E-5 ID:SGTC_3099|Compound:9120367|FD-Score:3.34|P-value:6.94E-4 ID:SGTC_3110|Compound:9122132|FD-Score:3.95|P-value:7.69E-5 ID:SGTC_3116|Compound:9124943|FD-Score:3.68|P-value:2.14E-4 ID:SGTC_3158|Compound:9100007|FD-Score:3.25|P-value:9.47E-4 ID:SGTC_3218|Compound:9131285|FD-Score:-3.51|P-value:2.97E-4 ID:SGTC_3315|Compound:9136395|FD-Score:5.00|P-value:8.00E-7 ID:SGTC_101|Compound:0490-5701|FD-Score:3.51|P-value:3.88E-4 ID:SGTC_174|Compound:3553-0389|FD-Score:3.43|P-value:5.21E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:-4.12|P-value:2.89E-5 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:3.90|P-value:9.26E-5 ID:SGTC_432|Compound:NS 1619|FD-Score:4.42|P-value:1.13E-5 ID:SGTC_519|Compound:k048-0011|FD-Score:3.43|P-value:5.22E-4 ID:SGTC_864|Compound:0469-0573|FD-Score:3.49|P-value:4.24E-4 ID:SGTC_1014|Compound:4130-3005|FD-Score:4.88|P-value:1.39E-6 ID:SGTC_1024|Compound:4507-0395|FD-Score:3.57|P-value:3.22E-4 ID:SGTC_1054|Compound:3429-0080|FD-Score:3.50|P-value:4.07E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:3.31|P-value:7.86E-4 ID:SGTC_1151|Compound:3909-8316|FD-Score:4.29|P-value:1.99E-5 ID:SGTC_1408|Compound:3909-7976|FD-Score:3.57|P-value:3.20E-4 ID:SGTC_1486|Compound:3970-0793|FD-Score:4.04|P-value:5.31E-5 ID:SGTC_1489|Compound:4065-0444|FD-Score:4.03|P-value:5.70E-5 ID:SGTC_1603|Compound:st002045|FD-Score:3.24|P-value:9.63E-4 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:5.41|P-value:9.85E-8 ID:SGTC_2009|Compound:4012297|FD-Score:3.93|P-value:8.25E-5 ID:SGTC_2160|Compound:5660466|FD-Score:4.02|P-value:5.85E-5 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:-3.18|P-value:9.14E-4 ID:SGTC_2180|Compound:6301957|FD-Score:3.37|P-value:6.25E-4 ID:SGTC_2184|Compound:6075246|FD-Score:4.51|P-value:7.72E-6 ID:SGTC_2185|Compound:6113692|FD-Score:-3.56|P-value:2.49E-4 ID:SGTC_2247|Compound:cerulenin|FD-Score:3.45|P-value:4.89E-4 ID:SGTC_2351|Compound:9026858|FD-Score:3.25|P-value:9.58E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:5.87|P-value:8.58E-9 ID:SGTC_2584|Compound:androsterone|FD-Score:-3.29|P-value:6.46E-4 ID:SGTC_2587|Compound:piperic acid|FD-Score:-4.88|P-value:9.54E-7 ID:SGTC_2762|Compound:leflunomide|FD-Score:3.43|P-value:5.15E-4 ID:SGTC_2780|Compound:5215298|FD-Score:3.40|P-value:5.64E-4 ID:SGTC_2832|Compound:7992762|FD-Score:3.36|P-value:6.64E-4 ID:SGTC_2868|Compound:9035608|FD-Score:3.47|P-value:4.43E-4 ID:SGTC_2948|Compound:9070189|FD-Score:3.41|P-value:5.60E-4 ID:SGTC_2959|Compound:9079155|FD-Score:3.93|P-value:8.18E-5 ID:SGTC_3099|Compound:9120367|FD-Score:3.34|P-value:6.94E-4 ID:SGTC_3110|Compound:9122132|FD-Score:3.95|P-value:7.69E-5 ID:SGTC_3116|Compound:9124943|FD-Score:3.68|P-value:2.14E-4 ID:SGTC_3158|Compound:9100007|FD-Score:3.25|P-value:9.47E-4 ID:SGTC_3218|Compound:9131285|FD-Score:-3.51|P-value:2.97E-4 ID:SGTC_3315|Compound:9136395|FD-Score:5.00|P-value:8.00E-7

Top fitness defect scores for YBL057C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2564 betulinic acid 5.87 100.0 µM 8.58E-9 8 2.24E-9
2 SGTC_1680 diphenhydramine 5.41 100.0 µM 9.85E-8 NEO1 9 3.07E-8
3 SGTC_3315 9136395 5.00 68.5 µM 8.00E-7 3 2.90E-7
4 SGTC_1014 4130-3005 4.88 69.3 µM 1.39E-6 7 5.25E-7
5 SGTC_2184 6075246 4.51 200.0 µM 7.72E-6 15 3.31E-6
6 SGTC_432 NS 1619 4.42 61.3 µM 1.13E-5 19 4.97E-6
7 SGTC_1151 3909-8316 4.29 15.3 µM 1.99E-5 12 9.14E-6
8 SGTC_1486 3970-0793 4.04 4.5 µM 5.31E-5 7 2.62E-5
9 SGTC_1489 4065-0444 4.03 182.0 µM 5.70E-5 18 2.83E-5
10 SGTC_2160 5660466 4.02 132.9 µM 5.85E-5 60S ribosome export 13 2.91E-5
11 SGTC_3110 9122132 3.95 49.5 µM 7.69E-5 redox potentiating 19 3.90E-5
12 SGTC_2959 9079155 3.93 11.0 µM 8.18E-5 25 4.17E-5
13 SGTC_2009 4012297 3.93 12.1 µM 8.25E-5 cell wall signaling 60 4.20E-5
14 SGTC_402 epigallocatechin gallate 3.90 10.0 µM 9.26E-5 26 4.76E-5
15 SGTC_3116 9124943 3.68 49.5 µM 2.14E-4 24 1.17E-4
16 SGTC_1408 3909-7976 3.57 48.8 µM 3.20E-4 Golgi 34 1.80E-4
17 SGTC_1024 4507-0395 3.57 26.0 µM 3.22E-4 TSC3-RPN4 36 1.81E-4
18 SGTC_101 0490-5701 3.51 117.5 µM 3.88E-4 25 2.22E-4
19 SGTC_1054 3429-0080 3.50 167.0 µM 4.07E-4 40 2.33E-4
20 SGTC_864 0469-0573 3.49 172.0 µM 4.24E-4 35 2.44E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.113 4.56E-11 YBR070C ALG14 het Component of UDP-GlcNAc transferase required for the second step of dolichyl-linked oligosaccharide synthesis; anchors the catalytic subunit Alg13p to the ER membrane; similar to bacterial and human glycosyltransferases
0.099 8.37E-9 YPL251W_d YPL251W_d het Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified, essential gene YAH1/YPL252C
0.094 5.20E-8 YCR088W ABP1 hom Actin-binding protein of the cortical actin cytoskeleton, important for activation of the Arp2/3 complex that plays a key role actin in cytoskeleton organization; phosphorylation within its PRR (Proline-Rich Region), mediated by Cdc28p and Pho85p, protects Abp1p from proteolysis mediated by its own PEST sequences
0.090 1.75E-7 YDL149W ATG9 hom Transmembrane protein involved in forming Cvt and autophagic vesicles; cycles between the phagophore assembly site (PAS) and other cytosolic punctate structures, not found in autophagosomes; may be involved in membrane delivery to the PAS
0.088 2.95E-7 YPL252C YAH1 het Ferredoxin of the mitochondrial matrix required for formation of cellular iron-sulfur proteins; involved in heme A biosynthesis; homologous to human adrenodoxin
0.083 1.61E-6 YPR045C THP3 hom Protein that forms a complex with Csn12p that is recruited to transcribed genes and may have a role in transcription elongation; possibly involved in splicing based on pre-mRNA accumulation defect for many intron-containing genes
0.082 2.18E-6 YJL158C CIS3 hom Mannose-containing glycoprotein constituent of the cell wall; member of the PIR (proteins with internal repeats) family
0.080 3.26E-6 YIL146C ATG32 hom Mitochondrial outer membrane protein required to initiate mitophagy; recruits the autophagy adaptor protein Atg11p and the ubiquitin-like protein Atg8p to the mitochondrial surface to initiate mitophagy, the selective vacuolar degradation of mitochondria in response to starvation; can promote pexophagy when placed ectopically in the peroxisomal membrane
0.080 3.67E-6 YDR431W_d YDR431W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.080 3.83E-6 YBR089W_d YBR089W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps the verified gene POL30
0.079 5.19E-6 YBR033W_p EDS1_p hom Putative zinc cluster protein, predicted to be a transcription factor; not an essential gene; EDS1 has a paralog, RGT1, that arose from the whole genome duplication
0.078 5.44E-6 YJL162C JJJ2 hom Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
0.078 6.43E-6 YMR240C CUS1 het Protein required for assembly of U2 snRNP into the spliceosome, forms a complex with Hsh49p and Hsh155p
0.077 9.04E-6 YBR211C AME1 het Essential kinetochore protein associated with microtubules and SPBs; component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p); involved in spindle checkpoint maintenance; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-U and fission yeast Mis17; relative distribution to the nucleus increases upon DNA replication stress
0.074 1.59E-5 YLR385C SWC7 hom Protein of unknown function, component of the Swr1p complex that incorporates Htz1p into chromatin