YBL059W_p

Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YBL059W has a paralog, YER093C-A, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YBL059W / YBL059W

Click on Significant Values for Screen Details ID:SGTC_149|Compound:3970-0822|FD-Score:3.36|P-value:8.00E-4 ID:SGTC_189|Compound:3970-0742|FD-Score:4.49|P-value:1.20E-5 ID:SGTC_252|Compound:miconazole|FD-Score:3.32|P-value:9.26E-4 ID:SGTC_285|Compound:1486-1325|FD-Score:3.44|P-value:6.18E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:3.48|P-value:5.44E-4 ID:SGTC_493|Compound:zm226600|FD-Score:5.30|P-value:3.10E-7 ID:SGTC_587|Compound:k089-0003|FD-Score:-3.47|P-value:5.16E-4 ID:SGTC_667|Compound:1498-1044|FD-Score:4.08|P-value:6.39E-5 ID:SGTC_769|Compound:0302-0231|FD-Score:3.81|P-value:1.73E-4 ID:SGTC_802|Compound:4112-3352|FD-Score:5.64|P-value:5.75E-8 ID:SGTC_936|Compound:3005-4620|FD-Score:5.41|P-value:1.79E-7 ID:SGTC_1104|Compound:tacrolimus|FD-Score:4.71|P-value:4.70E-6 ID:SGTC_1109|Compound:tnp00067|FD-Score:4.04|P-value:7.31E-5 ID:SGTC_1112|Compound:tnp00069|FD-Score:3.63|P-value:3.26E-4 ID:SGTC_1163|Compound:k060-0048|FD-Score:4.15|P-value:4.75E-5 ID:SGTC_1253|Compound:0550-0034|FD-Score:3.92|P-value:1.17E-4 ID:SGTC_1422|Compound:4031-0024|FD-Score:4.46|P-value:1.40E-5 ID:SGTC_1435|Compound:4092-0789|FD-Score:-3.51|P-value:4.38E-4 ID:SGTC_1436|Compound:4092-1007|FD-Score:4.21|P-value:3.82E-5 ID:SGTC_1711|Compound:st032263|FD-Score:-3.50|P-value:4.58E-4 ID:SGTC_1827|Compound:berberine|FD-Score:3.84|P-value:1.52E-4 ID:SGTC_1959|Compound:st077091|FD-Score:5.11|P-value:7.77E-7 ID:SGTC_1982|Compound:st072467|FD-Score:3.70|P-value:2.51E-4 ID:SGTC_2123|Compound:5259487|FD-Score:3.42|P-value:6.57E-4 ID:SGTC_2157|Compound:5649910|FD-Score:3.94|P-value:1.07E-4 ID:SGTC_2199|Compound:6590217|FD-Score:3.43|P-value:6.29E-4 ID:SGTC_2385|Compound:9074692|FD-Score:4.43|P-value:1.57E-5 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:3.48|P-value:5.36E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:6.95|P-value:3.05E-11 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:13.50|P-value:3.99E-37 ID:SGTC_2950|Compound:9072895|FD-Score:3.50|P-value:5.01E-4 ID:SGTC_2963|Compound:9082507|FD-Score:5.13|P-value:7.16E-7 ID:SGTC_2965|Compound:9082772|FD-Score:5.58|P-value:7.57E-8 ID:SGTC_2985|Compound:9022375|FD-Score:-3.66|P-value:2.65E-4 ID:SGTC_3029|Compound:9088683|FD-Score:-3.62|P-value:3.01E-4 ID:SGTC_3037|Compound:9091026|FD-Score:3.70|P-value:2.58E-4 ID:SGTC_3038|Compound:9091290|FD-Score:3.35|P-value:8.21E-4 ID:SGTC_3073|Compound:9114972|FD-Score:-5.59|P-value:6.27E-8 ID:SGTC_3109|Compound:9122853|FD-Score:3.52|P-value:4.68E-4 ID:SGTC_3207|Compound:9114163|FD-Score:-3.82|P-value:1.49E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:3.36|P-value:8.00E-4 ID:SGTC_189|Compound:3970-0742|FD-Score:4.49|P-value:1.20E-5 ID:SGTC_252|Compound:miconazole|FD-Score:3.32|P-value:9.26E-4 ID:SGTC_285|Compound:1486-1325|FD-Score:3.44|P-value:6.18E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:3.48|P-value:5.44E-4 ID:SGTC_493|Compound:zm226600|FD-Score:5.30|P-value:3.10E-7 ID:SGTC_587|Compound:k089-0003|FD-Score:-3.47|P-value:5.16E-4 ID:SGTC_667|Compound:1498-1044|FD-Score:4.08|P-value:6.39E-5 ID:SGTC_769|Compound:0302-0231|FD-Score:3.81|P-value:1.73E-4 ID:SGTC_802|Compound:4112-3352|FD-Score:5.64|P-value:5.75E-8 ID:SGTC_936|Compound:3005-4620|FD-Score:5.41|P-value:1.79E-7 ID:SGTC_1104|Compound:tacrolimus|FD-Score:4.71|P-value:4.70E-6 ID:SGTC_1109|Compound:tnp00067|FD-Score:4.04|P-value:7.31E-5 ID:SGTC_1112|Compound:tnp00069|FD-Score:3.63|P-value:3.26E-4 ID:SGTC_1163|Compound:k060-0048|FD-Score:4.15|P-value:4.75E-5 ID:SGTC_1253|Compound:0550-0034|FD-Score:3.92|P-value:1.17E-4 ID:SGTC_1422|Compound:4031-0024|FD-Score:4.46|P-value:1.40E-5 ID:SGTC_1435|Compound:4092-0789|FD-Score:-3.51|P-value:4.38E-4 ID:SGTC_1436|Compound:4092-1007|FD-Score:4.21|P-value:3.82E-5 ID:SGTC_1711|Compound:st032263|FD-Score:-3.50|P-value:4.58E-4 ID:SGTC_1827|Compound:berberine|FD-Score:3.84|P-value:1.52E-4 ID:SGTC_1959|Compound:st077091|FD-Score:5.11|P-value:7.77E-7 ID:SGTC_1982|Compound:st072467|FD-Score:3.70|P-value:2.51E-4 ID:SGTC_2123|Compound:5259487|FD-Score:3.42|P-value:6.57E-4 ID:SGTC_2157|Compound:5649910|FD-Score:3.94|P-value:1.07E-4 ID:SGTC_2199|Compound:6590217|FD-Score:3.43|P-value:6.29E-4 ID:SGTC_2385|Compound:9074692|FD-Score:4.43|P-value:1.57E-5 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:3.48|P-value:5.36E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:6.95|P-value:3.05E-11 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:13.50|P-value:3.99E-37 ID:SGTC_2950|Compound:9072895|FD-Score:3.50|P-value:5.01E-4 ID:SGTC_2963|Compound:9082507|FD-Score:5.13|P-value:7.16E-7 ID:SGTC_2965|Compound:9082772|FD-Score:5.58|P-value:7.57E-8 ID:SGTC_2985|Compound:9022375|FD-Score:-3.66|P-value:2.65E-4 ID:SGTC_3029|Compound:9088683|FD-Score:-3.62|P-value:3.01E-4 ID:SGTC_3037|Compound:9091026|FD-Score:3.70|P-value:2.58E-4 ID:SGTC_3038|Compound:9091290|FD-Score:3.35|P-value:8.21E-4 ID:SGTC_3073|Compound:9114972|FD-Score:-5.59|P-value:6.27E-8 ID:SGTC_3109|Compound:9122853|FD-Score:3.52|P-value:4.68E-4 ID:SGTC_3207|Compound:9114163|FD-Score:-3.82|P-value:1.49E-4

Top fitness defect scores for YBL059W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2615 purpurogallin-4-carboxylic acid 13.50 100.0 µM 3.99E-37 redox potentiating 5 1.40E-41
2 SGTC_2607 solasodine 6.95 47.4 µM 3.05E-11 21 1.81E-12
3 SGTC_802 4112-3352 5.64 742.0 µM 5.75E-8 4 8.69E-9
4 SGTC_2965 9082772 5.58 38.6 µM 7.57E-8 mitochondrial response to ROS 13 1.18E-8
5 SGTC_936 3005-4620 5.41 401.0 µM 1.79E-7 5 3.11E-8
6 SGTC_493 zm226600 5.30 134.0 µM 3.10E-7 mitochondrial processes 5 5.76E-8
7 SGTC_2963 9082507 5.13 9.0 µM 7.16E-7 9 1.48E-7
8 SGTC_1959 st077091 5.11 55.8 µM 7.77E-7 RPP1 & pyrimidine depletion 22 1.62E-7
9 SGTC_1104 tacrolimus 4.71 29.8 µM 4.70E-6 23 1.22E-6
10 SGTC_189 3970-0742 4.49 2.1 µM 1.20E-5 6 3.50E-6
11 SGTC_1422 4031-0024 4.46 15.5 µM 1.40E-5 iron homeostasis 10 4.14E-6
12 SGTC_2385 9074692 4.43 200.0 µM 1.57E-5 33 4.73E-6
13 SGTC_1436 4092-1007 4.21 8.3 µM 3.82E-5 9 1.28E-5
14 SGTC_1163 k060-0048 4.15 49.9 µM 4.75E-5 19 1.64E-5
15 SGTC_667 1498-1044 4.08 59.0 µM 6.39E-5 RPP1 & pyrimidine depletion 13 2.28E-5
16 SGTC_1109 tnp00067 4.04 928.3 nM 7.31E-5 15 2.65E-5
17 SGTC_2157 5649910 3.94 96.4 µM 1.07E-4 25 4.08E-5
18 SGTC_1253 0550-0034 3.92 176.0 µM 1.17E-4 21 4.48E-5
19 SGTC_1827 berberine 3.84 7.2 µM 1.52E-4 60S ribosome export 20 6.05E-5
20 SGTC_769 0302-0231 3.81 76.0 µM 1.73E-4 45 6.97E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.196 2.18E-30 YGR197C SNG1 hom Protein involved in resistance to nitrosoguanidine (MNNG) and 6-azauracil (6-AU); expression is regulated by transcription factors involved in multidrug resistance
0.189 2.55E-28 YJR046W TAH11 het DNA replication licensing factor, required for pre-replication complex assembly
0.188 4.73E-28 YOR162C YRR1 hom Zn2-Cys6 zinc-finger transcription factor; activates genes involved in multidrug resistance; paralog of Yrm1p, acting on an overlapping set of target genes; YRR1 has a paralog, PDR8, that arose from the whole genome duplication
0.156 1.35E-19 YPL222W_p FMP40_p hom Putative protein of unknown function; proposed to be involved in responding to environmental stresses; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.135 4.78E-15 YDR315C IPK1 hom Inositol 1,3,4,5,6-pentakisphosphate 2-kinase, nuclear protein required for synthesis of 1,2,3,4,5,6-hexakisphosphate (phytate), which is integral to cell function; has 2 motifs conserved in other fungi; ipk1 gle1 double mutant is inviable
0.132 1.69E-14 YOR382W FIT2 hom Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
0.131 2.83E-14 YBR157C ICS2 hom Protein of unknown function; null mutation does not confer any obvious defects in growth, spore germination, viability, or carbohydrate utilization
0.121 2.30E-12 YBR151W APD1 hom Protein of unknown function, required for normal localization of actin patches and for normal tolerance of sodium ions and hydrogen peroxide; localizes to both cytoplasm and nucleus
0.119 4.55E-12 YOL052C SPE2 hom S-adenosylmethionine decarboxylase, required for the biosynthesis of spermidine and spermine; cells lacking Spe2p require spermine or spermidine for growth in the presence of oxygen but not when grown anaerobically
0.107 4.47E-10 YOR164C GET4 hom Protein with a role in insertion of tail-anchored proteins into the ER membrane; forms a complex with Mdy2p; highly conserved across species and homologous to human gene C7orf20
0.096 2.27E-8 YDR464W SPP41 het Protein involved in negative regulation of expression of spliceosome components PRP4 and PRP3
0.096 2.40E-8 YJR125C ENT3 hom Protein containing an N-terminal epsin-like domain involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2p
0.095 3.39E-8 YMR279C YMR279C hom Putative boron transporter involved in boron efflux and resistance; overexpression mutant but not null mutant displays boron tolerance phenotype; identified as a heat-induced gene in a high-throughout screen; YMR279C is not an essential gene; YMR279C has a paralog, ATR1, that arose from the whole genome duplication
0.095 3.50E-8 YDR173C ARG82 hom Inositol polyphosphate multikinase (IPMK), sequentially phosphorylates Ins(1,4,5)P3 to form Ins(1,3,4,5,6)P5; also has diphosphoinositol polyphosphate synthase activity; regulates arginine-, phosphate-, and nitrogen-responsive genes
0.094 4.39E-8 YFL041W-A_p YFL041W-A_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR