YBL060W / YEL1

Guanine nucleotide exchange factor specific for Arf3p; localized to the bud neck and tip; required for localization of Arf3p to the bud neck and tip

Zygosity: Homozygous strain
fixedexpanded
Profile for YBL060W / YEL1

Click on Significant Values for Screen Details ID:SGTC_119|Compound:0121-0043|FD-Score:3.74|P-value:1.43E-4 ID:SGTC_130|Compound:0136-0219|FD-Score:-4.23|P-value:1.72E-5 ID:SGTC_134|Compound:0269-0018|FD-Score:-4.45|P-value:6.75E-6 ID:SGTC_557|Compound:1315-0110|FD-Score:3.25|P-value:8.30E-4 ID:SGTC_648|Compound:0375-0473|FD-Score:3.25|P-value:8.41E-4 ID:SGTC_741|Compound:4582-0002|FD-Score:-3.44|P-value:3.70E-4 ID:SGTC_851|Compound:0394-0702|FD-Score:3.27|P-value:7.84E-4 ID:SGTC_944|Compound:3370-0224|FD-Score:5.31|P-value:1.27E-7 ID:SGTC_974|Compound:1326-0144|FD-Score:-3.96|P-value:5.18E-5 ID:SGTC_1054|Compound:3429-0080|FD-Score:3.68|P-value:1.83E-4 ID:SGTC_1078|Compound:idebenone|FD-Score:3.27|P-value:7.85E-4 ID:SGTC_1108|Compound:betulinic acid|FD-Score:-4.88|P-value:8.89E-7 ID:SGTC_1111|Compound:tnp00062|FD-Score:-4.28|P-value:1.40E-5 ID:SGTC_1131|Compound:3454-3128|FD-Score:4.31|P-value:1.44E-5 ID:SGTC_1219|Compound:1469-0211|FD-Score:3.33|P-value:6.31E-4 ID:SGTC_1410|Compound:3909-8106|FD-Score:3.21|P-value:9.37E-4 ID:SGTC_1524|Compound:corynanthine|FD-Score:5.95|P-value:3.86E-9 ID:SGTC_1638|Compound:st008370|FD-Score:4.97|P-value:7.23E-7 ID:SGTC_1729|Compound:st035615|FD-Score:-3.66|P-value:1.67E-4 ID:SGTC_1732|Compound:st034308|FD-Score:-3.75|P-value:1.19E-4 ID:SGTC_1749|Compound:st037932|FD-Score:5.13|P-value:3.22E-7 ID:SGTC_1779|Compound:st039427|FD-Score:-3.40|P-value:4.33E-4 ID:SGTC_1841|Compound:st054148|FD-Score:3.42|P-value:4.70E-4 ID:SGTC_1849|Compound:st056239|FD-Score:3.42|P-value:4.66E-4 ID:SGTC_1854|Compound:st056233|FD-Score:-3.44|P-value:3.79E-4 ID:SGTC_1945|Compound:st075991|FD-Score:4.79|P-value:1.67E-6 ID:SGTC_2049|Compound:5262831|FD-Score:3.94|P-value:6.61E-5 ID:SGTC_2054|Compound:5233173|FD-Score:3.59|P-value:2.56E-4 ID:SGTC_2135|Compound:5326629|FD-Score:3.73|P-value:1.51E-4 ID:SGTC_2198|Compound:6589944|FD-Score:-3.82|P-value:9.14E-5 ID:SGTC_2297|Compound:7971671|FD-Score:3.72|P-value:1.59E-4 ID:SGTC_2344|Compound:7990960|FD-Score:3.55|P-value:2.92E-4 ID:SGTC_2377|Compound:9073351|FD-Score:4.89|P-value:1.07E-6 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:3.66|P-value:1.94E-4 ID:SGTC_2593|Compound:nobiletin|FD-Score:3.44|P-value:4.28E-4 ID:SGTC_2594|Compound:a-mangostin|FD-Score:5.05|P-value:4.89E-7 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:-3.96|P-value:5.27E-5 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:7.21|P-value:1.27E-12 ID:SGTC_2808|Compound:7946468|FD-Score:4.24|P-value:1.97E-5 ID:SGTC_2866|Compound:9034245|FD-Score:4.21|P-value:2.20E-5 ID:SGTC_2993|Compound:9054257|FD-Score:3.87|P-value:8.97E-5 ID:SGTC_3171|Compound:9103192|FD-Score:6.16|P-value:1.13E-9 ID:SGTC_3173|Compound:9105693|FD-Score:3.35|P-value:5.95E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:3.74|P-value:1.43E-4 ID:SGTC_130|Compound:0136-0219|FD-Score:-4.23|P-value:1.72E-5 ID:SGTC_134|Compound:0269-0018|FD-Score:-4.45|P-value:6.75E-6 ID:SGTC_557|Compound:1315-0110|FD-Score:3.25|P-value:8.30E-4 ID:SGTC_648|Compound:0375-0473|FD-Score:3.25|P-value:8.41E-4 ID:SGTC_741|Compound:4582-0002|FD-Score:-3.44|P-value:3.70E-4 ID:SGTC_851|Compound:0394-0702|FD-Score:3.27|P-value:7.84E-4 ID:SGTC_944|Compound:3370-0224|FD-Score:5.31|P-value:1.27E-7 ID:SGTC_974|Compound:1326-0144|FD-Score:-3.96|P-value:5.18E-5 ID:SGTC_1054|Compound:3429-0080|FD-Score:3.68|P-value:1.83E-4 ID:SGTC_1078|Compound:idebenone|FD-Score:3.27|P-value:7.85E-4 ID:SGTC_1108|Compound:betulinic acid|FD-Score:-4.88|P-value:8.89E-7 ID:SGTC_1111|Compound:tnp00062|FD-Score:-4.28|P-value:1.40E-5 ID:SGTC_1131|Compound:3454-3128|FD-Score:4.31|P-value:1.44E-5 ID:SGTC_1219|Compound:1469-0211|FD-Score:3.33|P-value:6.31E-4 ID:SGTC_1410|Compound:3909-8106|FD-Score:3.21|P-value:9.37E-4 ID:SGTC_1524|Compound:corynanthine|FD-Score:5.95|P-value:3.86E-9 ID:SGTC_1638|Compound:st008370|FD-Score:4.97|P-value:7.23E-7 ID:SGTC_1729|Compound:st035615|FD-Score:-3.66|P-value:1.67E-4 ID:SGTC_1732|Compound:st034308|FD-Score:-3.75|P-value:1.19E-4 ID:SGTC_1749|Compound:st037932|FD-Score:5.13|P-value:3.22E-7 ID:SGTC_1779|Compound:st039427|FD-Score:-3.40|P-value:4.33E-4 ID:SGTC_1841|Compound:st054148|FD-Score:3.42|P-value:4.70E-4 ID:SGTC_1849|Compound:st056239|FD-Score:3.42|P-value:4.66E-4 ID:SGTC_1854|Compound:st056233|FD-Score:-3.44|P-value:3.79E-4 ID:SGTC_1945|Compound:st075991|FD-Score:4.79|P-value:1.67E-6 ID:SGTC_2049|Compound:5262831|FD-Score:3.94|P-value:6.61E-5 ID:SGTC_2054|Compound:5233173|FD-Score:3.59|P-value:2.56E-4 ID:SGTC_2135|Compound:5326629|FD-Score:3.73|P-value:1.51E-4 ID:SGTC_2198|Compound:6589944|FD-Score:-3.82|P-value:9.14E-5 ID:SGTC_2297|Compound:7971671|FD-Score:3.72|P-value:1.59E-4 ID:SGTC_2344|Compound:7990960|FD-Score:3.55|P-value:2.92E-4 ID:SGTC_2377|Compound:9073351|FD-Score:4.89|P-value:1.07E-6 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:3.66|P-value:1.94E-4 ID:SGTC_2593|Compound:nobiletin|FD-Score:3.44|P-value:4.28E-4 ID:SGTC_2594|Compound:a-mangostin|FD-Score:5.05|P-value:4.89E-7 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:-3.96|P-value:5.27E-5 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:7.21|P-value:1.27E-12 ID:SGTC_2808|Compound:7946468|FD-Score:4.24|P-value:1.97E-5 ID:SGTC_2866|Compound:9034245|FD-Score:4.21|P-value:2.20E-5 ID:SGTC_2993|Compound:9054257|FD-Score:3.87|P-value:8.97E-5 ID:SGTC_3171|Compound:9103192|FD-Score:6.16|P-value:1.13E-9 ID:SGTC_3173|Compound:9105693|FD-Score:3.35|P-value:5.95E-4

Top fitness defect scores for YBL060W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2621 lithochol-11-enic acid 7.21 100.0 µM 1.27E-12 2 2.87E-13
2 SGTC_3171 9103192 6.16 49.5 µM 1.13E-9 1 3.72E-10
3 SGTC_1524 corynanthine 5.95 62.1 µM 3.86E-9 6 1.36E-9
4 SGTC_944 3370-0224 5.31 231.0 µM 1.27E-7 6 5.42E-8
5 SGTC_1749 st037932 5.13 54.2 µM 3.22E-7 16 1.45E-7
6 SGTC_2594 a-mangostin 5.05 100.0 µM 4.89E-7 15 2.26E-7
7 SGTC_1638 st008370 4.97 60.6 µM 7.23E-7 ergosterol biosynthesis 14 3.41E-7
8 SGTC_2377 9073351 4.89 62.6 µM 1.07E-6 ergosterol biosynthesis 12 5.15E-7
9 SGTC_1945 st075991 4.79 56.6 µM 1.67E-6 60S ribosome export 6 8.24E-7
10 SGTC_1131 3454-3128 4.31 32.3 µM 1.44E-5 28 7.99E-6
11 SGTC_2808 7946468 4.24 45.5 µM 1.97E-5 15 1.12E-5
12 SGTC_2866 9034245 4.21 58.4 µM 2.20E-5 5 1.26E-5
13 SGTC_2049 5262831 3.94 67.2 µM 6.61E-5 27 4.01E-5
14 SGTC_2993 9054257 3.87 71.4 µM 8.97E-5 fatty acid desaturase (OLE1) 46 5.53E-5
15 SGTC_119 0121-0043 3.74 24.8 µM 1.43E-4 mitochondrial stress 130 9.06E-5
16 SGTC_2135 5326629 3.73 150.4 µM 1.51E-4 RPP1 & pyrimidine depletion 33 9.57E-5
17 SGTC_2297 7971671 3.72 152.3 µM 1.59E-4 RNA processing & uracil transport 36 1.01E-4
18 SGTC_1054 3429-0080 3.68 167.0 µM 1.83E-4 32 1.17E-4
19 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 3.66 100.0 µM 1.94E-4 60S ribosome export 29 1.25E-4
20 SGTC_2054 5233173 3.59 129.0 µM 2.56E-4 mitochondrial response to ROS 69 1.67E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.104 1.55E-9 YKL130C SHE2 hom RNA-binding protein that binds specific mRNAs and interacts with She3p; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud
0.102 3.46E-9 YNL305C BXI1 hom Protein involved in apoptosis; variously described as containing a BCL-2 homology (BH3) domain or as a member of the BAX inhibitor family; reported to promote apoptosis under some conditions and to inhibit it in others; localizes to ER and vacuole; may link the unfolded protein response to apoptosis via regulation of calcium-mediated signaling; translocates to mitochondria under apoptosis-inducing conditions in a process involving Mir1p and Cor1p
0.098 1.14E-8 YLR432W IMD3 hom Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, member of a four-gene family in S. cerevisiae, constitutively expressed
0.097 1.75E-8 YOR248W_d YOR248W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.091 1.22E-7 YLR309C IMH1 hom Protein involved in vesicular transport, mediates transport between an endosomal compartment and the Golgi, contains a Golgi-localization (GRIP) domain that interacts with activated Arl1p-GTP to localize Imh1p to the Golgi
0.089 2.08E-7 YGR204W ADE3 hom Cytoplasmic trifunctional enzyme C1-tetrahydrofolate synthase, involved in single carbon metabolism and required for biosynthesis of purines, thymidylate, methionine, and histidine; null mutation causes auxotrophy for adenine and histidine
0.089 2.52E-7 YGL234W ADE5,7 hom Bifunctional enzyme of the 'de novo' purine nucleotide biosynthetic pathway, contains aminoimidazole ribotide synthetase and glycinamide ribotide synthetase activities
0.079 4.87E-6 YAL034W-A MTW1 het Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; critical to kinetochore assembly
0.077 6.96E-6 YFR006W_p YFR006W_p hom Putative X-Pro aminopeptidase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YFR006W is not an essential gene
0.077 8.30E-6 YOL022C TSR4 het Cytoplasmic protein required for correct processing of the 20S pre-rRNA at site D to generate mature 18S rRNA; essential gene in S288C background but not in CEN.PK2
0.076 1.14E-5 YBR234C ARC40 het Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches
0.075 1.33E-5 YFR017C IGD1 hom Cytoplasmic protein that inhibits Gdb1p glycogen debranching activity; required for normal intracellular accumulation of glycogen; phosphorylated in vivo; expression increases during wine fermentation; protein abundance increases in response to DNA replication stress; IGD1 has a paralog, YOL024W, that arose from the whole genome duplication
0.074 1.61E-5 YMR196W_p YMR196W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR196W is not an essential gene
0.074 1.71E-5 YIR038C GTT1 hom ER associated glutathione S-transferase capable of homodimerization; expression induced during the diauxic shift and throughout stationary phase; functional overlap with Gtt2p, Grx1p, and Grx2p
0.074 1.99E-5 YBL095W_p YBL095W_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies