YBL062W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YBL062W / YBL062W

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:3.45|P-value:6.53E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:8.30|P-value:2.92E-15 ID:SGTC_184|Compound:1494-0393|FD-Score:-3.23|P-value:9.23E-4 ID:SGTC_275|Compound:trichlorophene|FD-Score:3.99|P-value:9.56E-5 ID:SGTC_351|Compound:caspofungin|FD-Score:5.70|P-value:4.54E-8 ID:SGTC_354|Compound:2783-3500|FD-Score:6.35|P-value:1.27E-9 ID:SGTC_367|Compound:0335-0881|FD-Score:-3.93|P-value:7.97E-5 ID:SGTC_391|Compound:gliotoxin|FD-Score:3.93|P-value:1.23E-4 ID:SGTC_464|Compound:bw-b 70c|FD-Score:6.22|P-value:2.68E-9 ID:SGTC_586|Compound:0957-0265|FD-Score:4.14|P-value:5.38E-5 ID:SGTC_627|Compound:1391-0720|FD-Score:5.30|P-value:3.46E-7 ID:SGTC_863|Compound:0466-0191|FD-Score:7.74|P-value:1.67E-13 ID:SGTC_866|Compound:0495-0101|FD-Score:3.85|P-value:1.64E-4 ID:SGTC_871|Compound:0574-0004|FD-Score:3.48|P-value:5.86E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:3.38|P-value:8.13E-4 ID:SGTC_1012|Compound:4112-3522|FD-Score:4.56|P-value:9.76E-6 ID:SGTC_1483|Compound:3453-0561|FD-Score:3.96|P-value:1.07E-4 ID:SGTC_1622|Compound:st003707|FD-Score:3.38|P-value:8.24E-4 ID:SGTC_1727|Compound:st034309|FD-Score:3.45|P-value:6.53E-4 ID:SGTC_1801|Compound:st050089|FD-Score:4.04|P-value:8.08E-5 ID:SGTC_1894|Compound:3',6'-dihydroxyflavone|FD-Score:3.77|P-value:2.14E-4 ID:SGTC_1935|Compound:st074532|FD-Score:4.34|P-value:2.51E-5 ID:SGTC_1987|Compound:st072290|FD-Score:-3.27|P-value:8.15E-4 ID:SGTC_1993|Compound:st073995|FD-Score:5.44|P-value:1.70E-7 ID:SGTC_2278|Compound:7948257|FD-Score:-5.08|P-value:5.59E-7 ID:SGTC_2288|Compound:7946289|FD-Score:-3.39|P-value:5.43E-4 ID:SGTC_2400|Compound:5203494|FD-Score:4.00|P-value:9.21E-5 ID:SGTC_2459|Compound:5811157|FD-Score:4.12|P-value:5.88E-5 ID:SGTC_2508|Compound:celastrol|FD-Score:3.58|P-value:4.15E-4 ID:SGTC_2512|Compound:diallyl trisulfide|FD-Score:3.35|P-value:8.88E-4 ID:SGTC_2610|Compound:ononetin|FD-Score:3.89|P-value:1.41E-4 ID:SGTC_2643|Compound:anethole|FD-Score:6.06|P-value:6.39E-9 ID:SGTC_2652|Compound:actinonin|FD-Score:3.55|P-value:4.62E-4 ID:SGTC_2770|Compound:toltrazuril|FD-Score:4.64|P-value:7.02E-6 ID:SGTC_2774|Compound:tamoxifen|FD-Score:3.48|P-value:5.93E-4 ID:SGTC_2819|Compound:7996655|FD-Score:4.08|P-value:6.82E-5 ID:SGTC_2841|Compound:9004761|FD-Score:3.76|P-value:2.25E-4 ID:SGTC_2843|Compound:9000894|FD-Score:4.66|P-value:6.39E-6 ID:SGTC_2873|Compound:9040596|FD-Score:4.86|P-value:2.66E-6 ID:SGTC_2912|Compound:7964298|FD-Score:5.38|P-value:2.27E-7 ID:SGTC_2921|Compound:7974240|FD-Score:3.81|P-value:1.91E-4 ID:SGTC_2928|Compound:9011484|FD-Score:3.58|P-value:4.26E-4 ID:SGTC_3045|Compound:9092950|FD-Score:5.16|P-value:6.75E-7 ID:SGTC_3168|Compound:9103419|FD-Score:3.48|P-value:5.90E-4 ID:SGTC_3203|Compound:9113543|FD-Score:-4.26|P-value:2.19E-5 ID:SGTC_3251|Compound:9135047|FD-Score:3.41|P-value:7.37E-4 ID:SGTC_3266|Compound:9136860|FD-Score:4.59|P-value:8.68E-6 ID:SGTC_3311|Compound:9131146|FD-Score:8.27|P-value:3.56E-15 ID:SGTC_3315|Compound:9136395|FD-Score:-3.49|P-value:3.87E-4 ID:SGTC_3321|Compound:9137793|FD-Score:7.48|P-value:1.01E-12 ID:SGTC_58|Compound:0957-0393|FD-Score:3.45|P-value:6.53E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:8.30|P-value:2.92E-15 ID:SGTC_184|Compound:1494-0393|FD-Score:-3.23|P-value:9.23E-4 ID:SGTC_275|Compound:trichlorophene|FD-Score:3.99|P-value:9.56E-5 ID:SGTC_351|Compound:caspofungin|FD-Score:5.70|P-value:4.54E-8 ID:SGTC_354|Compound:2783-3500|FD-Score:6.35|P-value:1.27E-9 ID:SGTC_367|Compound:0335-0881|FD-Score:-3.93|P-value:7.97E-5 ID:SGTC_391|Compound:gliotoxin|FD-Score:3.93|P-value:1.23E-4 ID:SGTC_464|Compound:bw-b 70c|FD-Score:6.22|P-value:2.68E-9 ID:SGTC_586|Compound:0957-0265|FD-Score:4.14|P-value:5.38E-5 ID:SGTC_627|Compound:1391-0720|FD-Score:5.30|P-value:3.46E-7 ID:SGTC_863|Compound:0466-0191|FD-Score:7.74|P-value:1.67E-13 ID:SGTC_866|Compound:0495-0101|FD-Score:3.85|P-value:1.64E-4 ID:SGTC_871|Compound:0574-0004|FD-Score:3.48|P-value:5.86E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:3.38|P-value:8.13E-4 ID:SGTC_1012|Compound:4112-3522|FD-Score:4.56|P-value:9.76E-6 ID:SGTC_1483|Compound:3453-0561|FD-Score:3.96|P-value:1.07E-4 ID:SGTC_1622|Compound:st003707|FD-Score:3.38|P-value:8.24E-4 ID:SGTC_1727|Compound:st034309|FD-Score:3.45|P-value:6.53E-4 ID:SGTC_1801|Compound:st050089|FD-Score:4.04|P-value:8.08E-5 ID:SGTC_1894|Compound:3',6'-dihydroxyflavone|FD-Score:3.77|P-value:2.14E-4 ID:SGTC_1935|Compound:st074532|FD-Score:4.34|P-value:2.51E-5 ID:SGTC_1987|Compound:st072290|FD-Score:-3.27|P-value:8.15E-4 ID:SGTC_1993|Compound:st073995|FD-Score:5.44|P-value:1.70E-7 ID:SGTC_2278|Compound:7948257|FD-Score:-5.08|P-value:5.59E-7 ID:SGTC_2288|Compound:7946289|FD-Score:-3.39|P-value:5.43E-4 ID:SGTC_2400|Compound:5203494|FD-Score:4.00|P-value:9.21E-5 ID:SGTC_2459|Compound:5811157|FD-Score:4.12|P-value:5.88E-5 ID:SGTC_2508|Compound:celastrol|FD-Score:3.58|P-value:4.15E-4 ID:SGTC_2512|Compound:diallyl trisulfide|FD-Score:3.35|P-value:8.88E-4 ID:SGTC_2610|Compound:ononetin|FD-Score:3.89|P-value:1.41E-4 ID:SGTC_2643|Compound:anethole|FD-Score:6.06|P-value:6.39E-9 ID:SGTC_2652|Compound:actinonin|FD-Score:3.55|P-value:4.62E-4 ID:SGTC_2770|Compound:toltrazuril|FD-Score:4.64|P-value:7.02E-6 ID:SGTC_2774|Compound:tamoxifen|FD-Score:3.48|P-value:5.93E-4 ID:SGTC_2819|Compound:7996655|FD-Score:4.08|P-value:6.82E-5 ID:SGTC_2841|Compound:9004761|FD-Score:3.76|P-value:2.25E-4 ID:SGTC_2843|Compound:9000894|FD-Score:4.66|P-value:6.39E-6 ID:SGTC_2873|Compound:9040596|FD-Score:4.86|P-value:2.66E-6 ID:SGTC_2912|Compound:7964298|FD-Score:5.38|P-value:2.27E-7 ID:SGTC_2921|Compound:7974240|FD-Score:3.81|P-value:1.91E-4 ID:SGTC_2928|Compound:9011484|FD-Score:3.58|P-value:4.26E-4 ID:SGTC_3045|Compound:9092950|FD-Score:5.16|P-value:6.75E-7 ID:SGTC_3168|Compound:9103419|FD-Score:3.48|P-value:5.90E-4 ID:SGTC_3203|Compound:9113543|FD-Score:-4.26|P-value:2.19E-5 ID:SGTC_3251|Compound:9135047|FD-Score:3.41|P-value:7.37E-4 ID:SGTC_3266|Compound:9136860|FD-Score:4.59|P-value:8.68E-6 ID:SGTC_3311|Compound:9131146|FD-Score:8.27|P-value:3.56E-15 ID:SGTC_3315|Compound:9136395|FD-Score:-3.49|P-value:3.87E-4 ID:SGTC_3321|Compound:9137793|FD-Score:7.48|P-value:1.01E-12

Top fitness defect scores for YBL062W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_138 0850-0259 8.30 40.9 µM 2.92E-15 cell wall 60 5.33E-17
2 SGTC_3311 9131146 8.27 2.9 µM 3.56E-15 cell wall 30 6.67E-17
3 SGTC_863 0466-0191 7.74 129.0 µM 1.67E-13 cell wall 19 4.96E-15
4 SGTC_3321 9137793 7.48 26.8 µM 1.01E-12 cell wall 14 3.74E-14
5 SGTC_354 2783-3500 6.35 4.9 µM 1.27E-9 cell wall 16 1.11E-10
6 SGTC_464 bw-b 70c 6.22 158.0 µM 2.68E-9 2 2.56E-10
7 SGTC_2643 anethole 6.06 100.0 µM 6.39E-9 2 6.77E-10
8 SGTC_351 caspofungin 5.70 25.0 nM 4.54E-8 cell wall 43 6.09E-9
9 SGTC_1993 st073995 5.44 70.8 µM 1.70E-7 5 2.68E-8
10 SGTC_2912 7964298 5.38 10.9 µM 2.27E-7 cell wall 57 3.71E-8
11 SGTC_627 1391-0720 5.30 175.0 µM 3.46E-7 1 5.94E-8
12 SGTC_3045 9092950 5.16 49.5 µM 6.75E-7 5 1.26E-7
13 SGTC_2873 9040596 4.86 71.4 µM 2.66E-6 24 5.86E-7
14 SGTC_2843 9000894 4.66 45.5 µM 6.39E-6 4 1.56E-6
15 SGTC_2770 toltrazuril 4.64 17.5 µM 7.02E-6 10 1.74E-6
16 SGTC_3266 9136860 4.59 49.5 µM 8.68E-6 cell wall 34 2.21E-6
17 SGTC_1012 4112-3522 4.56 18.0 µM 9.76E-6 16 2.52E-6
18 SGTC_1935 st074532 4.34 41.6 µM 2.51E-5 20 7.25E-6
19 SGTC_586 0957-0265 4.14 8.2 µM 5.38E-5 cell wall 40 1.71E-5
20 SGTC_2459 5811157 4.12 9.2 µM 5.88E-5 mitochondrial processes 10 1.89E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.462 3.26E-177 YJL099W CHS6 hom Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex that mediates export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; CHS6 has a paralog, BCH2, that arose from the whole genome duplication
0.370 1.27E-109 YBR023C CHS3 hom Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan
0.366 1.19E-106 YDL203C ACK1 hom Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria
0.358 5.15E-102 YLR331C_d JIP3_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2
0.335 5.73E-89 YDL066W IDP1 hom Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes
0.307 2.82E-74 YBL006C LDB7 hom Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Npl6p, and Htl1p to form a module important for a broad range of RSC functions
0.295 3.30E-68 YBL061C SKT5 hom Activator of Chs3p (chitin synthase III) during vegetative growth; recruits Chs3p to the bud neck via interaction with Bni4p; SKT5 has a paralog, SHC1, that arose from the whole genome duplication
0.294 4.07E-68 YJR142W_p YJR142W_p hom Putative protein of unknown function; GST fusion protein is a Dbf2p-Mob1p phosphorylation target in a proteome chip analysis; synthetic lethal with PH085 deletion; plays a role in restricting Ty1 transposition; nudix hydrolase family member
0.285 8.54E-64 YLL043W FPS1 hom Plasma membrane channel, member of major intrinsic protein (MIP) family; involved in efflux of glycerol and in uptake of acetic acid and the trivalent metalloids arsenite and antimonite; phosphorylated by Hog1p MAPK under acetate stress
0.282 3.32E-62 YPL115C BEM3 hom Rho GTPase activating protein (RhoGAP) involved in control of the cytoskeleton organization; targets the essential Rho-GTPase Cdc42p, which controls establishment and maintenance of cell polarity, including bud-site assembly
0.265 8.26E-55 YMR124W_p YMR124W_p hom Protein of unknown function; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W is not an essential gene; predicted to have a role in organelle organization
0.255 9.38E-51 YDR351W SBE2 hom Protein involved in the transport of cell wall components from the Golgi to the cell surface; required for bud growth
0.254 2.23E-50 YLL032C YLL032C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene
0.248 3.02E-48 YLR330W CHS5 hom Component of the exomer complex, which also contains Csh6p, Bch1p, Bch2p, and Bud7p and is involved in export of selected proteins, such as chitin synthase Chs3p, from the Golgi to the plasma membrane
0.246 2.13E-47 YLL021W SPA2 hom Component of the polarisome, which functions in actin cytoskeletal organization during polarized growth; acts as a scaffold for Mkk1p and Mpk1p cell wall integrity signaling components; potential Cdc28p substrate