YBL063W / KIP1

Kinesin-related motor protein required for mitotic spindle assembly, chromosome segregation, and 2 micron plasmid partitioning; functionally redundant with Cin8p for chromosomal but not plasmid functions

Zygosity: Homozygous strain
fixedexpanded
Profile for YBL063W / KIP1

Click on Significant Values for Screen Details ID:SGTC_167|Compound:3672-0051|FD-Score:-2.79|P-value:9.41E-4 ID:SGTC_189|Compound:3970-0742|FD-Score:3.40|P-value:7.87E-5 ID:SGTC_439|Compound:amiodarone|FD-Score:-3.53|P-value:4.24E-5 ID:SGTC_701|Compound:4424-0219|FD-Score:3.09|P-value:2.98E-4 ID:SGTC_774|Compound:k060-0086|FD-Score:2.84|P-value:8.09E-4 ID:SGTC_923|Compound:1900-2434|FD-Score:-3.16|P-value:2.24E-4 ID:SGTC_926|Compound:2268-1401|FD-Score:-3.73|P-value:1.67E-5 ID:SGTC_927|Compound:2425-1185|FD-Score:-3.20|P-value:1.88E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.54|P-value:4.16E-5 ID:SGTC_1120|Compound:ficusin|FD-Score:-3.36|P-value:9.36E-5 ID:SGTC_1125|Compound:tnp00248|FD-Score:5.24|P-value:2.79E-9 ID:SGTC_1126|Compound:isoteolin|FD-Score:3.58|P-value:3.47E-5 ID:SGTC_1220|Compound:1838-0075|FD-Score:-3.13|P-value:2.48E-4 ID:SGTC_1221|Compound:2958-7315|FD-Score:4.77|P-value:5.83E-8 ID:SGTC_1234|Compound:0326-0494|FD-Score:3.37|P-value:9.05E-5 ID:SGTC_1369|Compound:1866-0067|FD-Score:2.97|P-value:4.72E-4 ID:SGTC_1379|Compound:2144-0755|FD-Score:-2.97|P-value:4.71E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:-3.05|P-value:3.48E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.37|P-value:8.85E-5 ID:SGTC_2032|Compound:5185112|FD-Score:-3.00|P-value:4.23E-4 ID:SGTC_2048|Compound:5246248|FD-Score:2.80|P-value:9.17E-4 ID:SGTC_2084|Compound:5306078|FD-Score:-3.19|P-value:1.96E-4 ID:SGTC_2093|Compound:5331342|FD-Score:4.75|P-value:6.40E-8 ID:SGTC_2145|Compound:5634607|FD-Score:2.92|P-value:5.83E-4 ID:SGTC_2162|Compound:5663267|FD-Score:3.14|P-value:2.38E-4 ID:SGTC_2334|Compound:9017922|FD-Score:3.27|P-value:1.37E-4 ID:SGTC_2528|Compound:xanthyletin|FD-Score:3.26|P-value:1.44E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:3.74|P-value:1.64E-5 ID:SGTC_2564|Compound:betulinic acid|FD-Score:6.53|P-value:1.87E-13 ID:SGTC_2805|Compound:7950783|FD-Score:2.96|P-value:5.04E-4 ID:SGTC_2880|Compound:9042983|FD-Score:4.35|P-value:6.58E-7 ID:SGTC_2888|Compound:9058547|FD-Score:-3.01|P-value:4.11E-4 ID:SGTC_2892|Compound:9047358|FD-Score:3.62|P-value:2.79E-5 ID:SGTC_2897|Compound:9048598|FD-Score:3.55|P-value:3.94E-5 ID:SGTC_2999|Compound:9069765|FD-Score:-3.58|P-value:3.37E-5 ID:SGTC_3191|Compound:9110352|FD-Score:3.97|P-value:5.12E-6 ID:SGTC_3192|Compound:9110362|FD-Score:3.12|P-value:2.63E-4 ID:SGTC_167|Compound:3672-0051|FD-Score:-2.79|P-value:9.41E-4 ID:SGTC_189|Compound:3970-0742|FD-Score:3.40|P-value:7.87E-5 ID:SGTC_439|Compound:amiodarone|FD-Score:-3.53|P-value:4.24E-5 ID:SGTC_701|Compound:4424-0219|FD-Score:3.09|P-value:2.98E-4 ID:SGTC_774|Compound:k060-0086|FD-Score:2.84|P-value:8.09E-4 ID:SGTC_923|Compound:1900-2434|FD-Score:-3.16|P-value:2.24E-4 ID:SGTC_926|Compound:2268-1401|FD-Score:-3.73|P-value:1.67E-5 ID:SGTC_927|Compound:2425-1185|FD-Score:-3.20|P-value:1.88E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.54|P-value:4.16E-5 ID:SGTC_1120|Compound:ficusin|FD-Score:-3.36|P-value:9.36E-5 ID:SGTC_1125|Compound:tnp00248|FD-Score:5.24|P-value:2.79E-9 ID:SGTC_1126|Compound:isoteolin|FD-Score:3.58|P-value:3.47E-5 ID:SGTC_1220|Compound:1838-0075|FD-Score:-3.13|P-value:2.48E-4 ID:SGTC_1221|Compound:2958-7315|FD-Score:4.77|P-value:5.83E-8 ID:SGTC_1234|Compound:0326-0494|FD-Score:3.37|P-value:9.05E-5 ID:SGTC_1369|Compound:1866-0067|FD-Score:2.97|P-value:4.72E-4 ID:SGTC_1379|Compound:2144-0755|FD-Score:-2.97|P-value:4.71E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:-3.05|P-value:3.48E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.37|P-value:8.85E-5 ID:SGTC_2032|Compound:5185112|FD-Score:-3.00|P-value:4.23E-4 ID:SGTC_2048|Compound:5246248|FD-Score:2.80|P-value:9.17E-4 ID:SGTC_2084|Compound:5306078|FD-Score:-3.19|P-value:1.96E-4 ID:SGTC_2093|Compound:5331342|FD-Score:4.75|P-value:6.40E-8 ID:SGTC_2145|Compound:5634607|FD-Score:2.92|P-value:5.83E-4 ID:SGTC_2162|Compound:5663267|FD-Score:3.14|P-value:2.38E-4 ID:SGTC_2334|Compound:9017922|FD-Score:3.27|P-value:1.37E-4 ID:SGTC_2528|Compound:xanthyletin|FD-Score:3.26|P-value:1.44E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:3.74|P-value:1.64E-5 ID:SGTC_2564|Compound:betulinic acid|FD-Score:6.53|P-value:1.87E-13 ID:SGTC_2805|Compound:7950783|FD-Score:2.96|P-value:5.04E-4 ID:SGTC_2880|Compound:9042983|FD-Score:4.35|P-value:6.58E-7 ID:SGTC_2888|Compound:9058547|FD-Score:-3.01|P-value:4.11E-4 ID:SGTC_2892|Compound:9047358|FD-Score:3.62|P-value:2.79E-5 ID:SGTC_2897|Compound:9048598|FD-Score:3.55|P-value:3.94E-5 ID:SGTC_2999|Compound:9069765|FD-Score:-3.58|P-value:3.37E-5 ID:SGTC_3191|Compound:9110352|FD-Score:3.97|P-value:5.12E-6 ID:SGTC_3192|Compound:9110362|FD-Score:3.12|P-value:2.63E-4

Top fitness defect scores for YBL063W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2564 betulinic acid 6.53 100.0 µM 1.87E-13 5 3.22E-11
2 SGTC_1125 tnp00248 5.24 1.3 µM 2.79E-9 8 7.93E-8
3 SGTC_1221 2958-7315 4.77 257.0 µM 5.83E-8 11 9.43E-7
4 SGTC_2093 5331342 4.75 194.4 µM 6.40E-8 18 1.02E-6
5 SGTC_2880 9042983 4.35 58.4 µM 6.58E-7 fatty acid desaturase (OLE1) 15 6.79E-6
6 SGTC_3191 9110352 3.97 49.5 µM 5.12E-6 9 3.63E-5
7 SGTC_2563 tomatine 3.74 8.5 µM 1.64E-5 58 9.36E-5
8 SGTC_2892 9047358 3.62 58.4 µM 2.79E-5 14 1.45E-4
9 SGTC_1126 isoteolin 3.58 1.0 µM 3.47E-5 44 1.73E-4
10 SGTC_2897 9048598 3.55 13.0 µM 3.94E-5 26 1.92E-4
11 SGTC_189 3970-0742 3.40 2.1 µM 7.87E-5 13 3.38E-4
12 SGTC_1234 0326-0494 3.37 15.5 µM 9.05E-5 30 3.79E-4
13 SGTC_2334 9017922 3.27 200.0 µM 1.37E-4 41 5.32E-4
14 SGTC_2528 xanthyletin 3.26 44.8 µM 1.44E-4 39 5.54E-4
15 SGTC_2162 5663267 3.14 200.0 µM 2.38E-4 34 8.38E-4
16 SGTC_3192 9110362 3.12 49.5 µM 2.63E-4 mitochondrial processes 32 9.10E-4
17 SGTC_701 4424-0219 3.09 185.0 µM 2.98E-4 calcium & mitochondrial duress 48 0.00101
18 SGTC_1369 1866-0067 2.97 208.0 µM 4.72E-4 RPP1 & pyrimidine depletion 84 0.00147
19 SGTC_2805 7950783 2.96 58.4 µM 5.04E-4 74 0.00155
20 SGTC_2145 5634607 2.92 200.0 µM 5.83E-4 41 0.00175

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.171 1.60E-23 YDR411C DFM1 hom Endoplasmic reticulum (ER) localized protein involved in ER-associated protein degradation (ERAD), ER stress and homeostasis; interacts with components of ERAD-L and ERAD-C and Cdc48p; derlin-like family member similar to Der1p
0.165 8.41E-22 YBL055C YBL055C hom 3'-->5' exonuclease and endonuclease with a possible role in apoptosis; has similarity to mammalian and C. elegans apoptotic nucleases
0.162 3.07E-21 YBR085W AAC3 hom Mitochondrial inner membrane ADP/ATP translocator; exchanges cytosolic ADP for mitochondrially synthesized ATP; expressed under anaerobic conditions; similar to Aac1p; has roles in maintenance of viability and in respiration; AAC3 has a paralog, PET9, that arose from the whole genome duplication
0.161 6.62E-21 YOR012W_p YOR012W_p hom Putative protein of unknown function
0.160 1.08E-20 YDR499W LCD1 het Essential protein required for the DNA integrity checkpoint pathways; interacts physically with Mec1p; putative homolog of S. pombe Rad26 and human ATRIP; forms nuclear foci upon DNA replication stress
0.158 2.66E-20 YDR122W KIN1 hom Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin2p
0.153 5.69E-19 YGR097W ASK10 hom Component of RNA polymerase II holoenzyme; phosphorylated in response to oxidative stress; has a role in destruction of Ssn8p; proposed to function in activation of the glycerol channel Fps1p; ASK10 has a paralog, RGC1, that arose from the whole genome duplication
0.152 1.06E-18 YER064C VHR2 hom Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.148 6.63E-18 YDR299W BFR2 het Essential protein that is a component of 90S preribosomes; may be involved in rRNA processing; multicopy suppressor of sensitivity to Brefeldin A; expression is induced during lag phase and also by cold shock
0.147 1.13E-17 YBR070C ALG14 het Component of UDP-GlcNAc transferase required for the second step of dolichyl-linked oligosaccharide synthesis; anchors the catalytic subunit Alg13p to the ER membrane; similar to bacterial and human glycosyltransferases
0.143 9.59E-17 YBL044W_p YBL044W_p hom Putative protein of unknown function; YBL044W is not an essential protein
0.141 2.50E-16 YCR088W ABP1 hom Actin-binding protein of the cortical actin cytoskeleton, important for activation of the Arp2/3 complex that plays a key role actin in cytoskeleton organization; phosphorylation within its PRR (Proline-Rich Region), mediated by Cdc28p and Pho85p, protects Abp1p from proteolysis mediated by its own PEST sequences
0.140 3.06E-16 YKL220C FRE2 hom Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low iron levels but not by low copper levels
0.139 5.33E-16 YMR150C IMP1 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.134 5.82E-15 YML074C FPR3 hom Nucleolar peptidyl-prolyl cis-trans isomerase (PPIase); FK506 binding protein; phosphorylated by casein kinase II (Cka1p-Cka2p-Ckb1p-Ckb2p) and dephosphorylated by Ptp1p