YBL064C / PRX1

Mitochondrial peroxiredoxin with thioredoxin peroxidase activity; has a role in reduction of hydroperoxides; reactivation requires Trr2p and glutathione; induced during respiratory growth and oxidative stress; phosphorylated; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YBL064C / PRX1

Click on Significant Values for Screen Details ID:SGTC_140|Compound:0062-0056|FD-Score:-2.97|P-value:2.24E-4 ID:SGTC_182|Compound:3448-4371|FD-Score:2.76|P-value:4.78E-4 ID:SGTC_249|Compound:wiskostatin|FD-Score:2.78|P-value:4.46E-4 ID:SGTC_266|Compound:formosanin C|FD-Score:3.29|P-value:4.16E-5 ID:SGTC_407|Compound:eburnamonine|FD-Score:-3.06|P-value:1.48E-4 ID:SGTC_650|Compound:1328-0195|FD-Score:3.43|P-value:2.07E-5 ID:SGTC_663|Compound:1486-0733|FD-Score:5.47|P-value:3.32E-11 ID:SGTC_675|Compound:1309-0189|FD-Score:-3.18|P-value:8.47E-5 ID:SGTC_679|Compound:0422-0091|FD-Score:-3.09|P-value:1.26E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:-2.91|P-value:2.93E-4 ID:SGTC_739|Compound:1486-1183|FD-Score:2.79|P-value:4.22E-4 ID:SGTC_743|Compound:1275-0778|FD-Score:2.93|P-value:2.32E-4 ID:SGTC_833|Compound:3852-0053|FD-Score:2.65|P-value:7.58E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:2.82|P-value:3.81E-4 ID:SGTC_1142|Compound:3253-1408|FD-Score:2.69|P-value:6.58E-4 ID:SGTC_1159|Compound:4092-0538|FD-Score:-2.67|P-value:7.88E-4 ID:SGTC_1245|Compound:0418-0076|FD-Score:3.61|P-value:8.06E-6 ID:SGTC_1270|Compound:0831-1170|FD-Score:2.85|P-value:3.31E-4 ID:SGTC_1285|Compound:0929-0069|FD-Score:-2.88|P-value:3.27E-4 ID:SGTC_1453|Compound:4237-0541|FD-Score:2.70|P-value:6.27E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.12|P-value:1.11E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.25|P-value:5.90E-5 ID:SGTC_1564|Compound:D-Arginine|FD-Score:-2.88|P-value:3.32E-4 ID:SGTC_1619|Compound:st003326|FD-Score:2.67|P-value:6.94E-4 ID:SGTC_1676|Compound:st018489|FD-Score:-2.98|P-value:2.15E-4 ID:SGTC_1681|Compound:tripelennamine|FD-Score:-2.65|P-value:8.80E-4 ID:SGTC_1725|Compound:st036284|FD-Score:4.03|P-value:7.42E-7 ID:SGTC_1726|Compound:st035556|FD-Score:3.24|P-value:5.40E-5 ID:SGTC_1734|Compound:st037168|FD-Score:4.06|P-value:6.34E-7 ID:SGTC_1735|Compound:st034310|FD-Score:4.74|P-value:8.04E-9 ID:SGTC_1736|Compound:st036774|FD-Score:6.22|P-value:6.11E-14 ID:SGTC_1779|Compound:st039427|FD-Score:2.89|P-value:2.81E-4 ID:SGTC_2121|Compound:5257820|FD-Score:3.17|P-value:7.44E-5 ID:SGTC_2164|Compound:5685496|FD-Score:4.21|P-value:2.56E-7 ID:SGTC_2191|Compound:5911152|FD-Score:-2.93|P-value:2.59E-4 ID:SGTC_2327|Compound:6189656|FD-Score:4.13|P-value:4.04E-7 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:2.64|P-value:7.89E-4 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:3.54|P-value:1.18E-5 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:-3.97|P-value:1.30E-6 ID:SGTC_2619|Compound:obliquin|FD-Score:-3.18|P-value:8.21E-5 ID:SGTC_2620|Compound:irigenin|FD-Score:-3.95|P-value:1.45E-6 ID:SGTC_2628|Compound:lathosterol|FD-Score:-3.32|P-value:4.28E-5 ID:SGTC_2630|Compound:antimycin a|FD-Score:-4.77|P-value:8.04E-9 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:-2.98|P-value:2.08E-4 ID:SGTC_2640|Compound:pentamidine|FD-Score:4.72|P-value:8.76E-9 ID:SGTC_2749|Compound:bexarotene|FD-Score:-2.74|P-value:6.03E-4 ID:SGTC_2848|Compound:9016370|FD-Score:3.90|P-value:1.57E-6 ID:SGTC_2852|Compound:9023854|FD-Score:6.02|P-value:3.65E-13 ID:SGTC_2858|Compound:9025781|FD-Score:6.79|P-value:2.87E-16 ID:SGTC_2864|Compound:9034755|FD-Score:-2.76|P-value:5.45E-4 ID:SGTC_2938|Compound:9059746|FD-Score:2.84|P-value:3.38E-4 ID:SGTC_3206|Compound:9114350|FD-Score:-3.23|P-value:6.55E-5 ID:SGTC_3287|Compound:9117173|FD-Score:2.58|P-value:9.99E-4 ID:SGTC_3297|Compound:9117502|FD-Score:2.65|P-value:7.69E-4 ID:SGTC_140|Compound:0062-0056|FD-Score:-2.97|P-value:2.24E-4 ID:SGTC_182|Compound:3448-4371|FD-Score:2.76|P-value:4.78E-4 ID:SGTC_249|Compound:wiskostatin|FD-Score:2.78|P-value:4.46E-4 ID:SGTC_266|Compound:formosanin C|FD-Score:3.29|P-value:4.16E-5 ID:SGTC_407|Compound:eburnamonine|FD-Score:-3.06|P-value:1.48E-4 ID:SGTC_650|Compound:1328-0195|FD-Score:3.43|P-value:2.07E-5 ID:SGTC_663|Compound:1486-0733|FD-Score:5.47|P-value:3.32E-11 ID:SGTC_675|Compound:1309-0189|FD-Score:-3.18|P-value:8.47E-5 ID:SGTC_679|Compound:0422-0091|FD-Score:-3.09|P-value:1.26E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:-2.91|P-value:2.93E-4 ID:SGTC_739|Compound:1486-1183|FD-Score:2.79|P-value:4.22E-4 ID:SGTC_743|Compound:1275-0778|FD-Score:2.93|P-value:2.32E-4 ID:SGTC_833|Compound:3852-0053|FD-Score:2.65|P-value:7.58E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:2.82|P-value:3.81E-4 ID:SGTC_1142|Compound:3253-1408|FD-Score:2.69|P-value:6.58E-4 ID:SGTC_1159|Compound:4092-0538|FD-Score:-2.67|P-value:7.88E-4 ID:SGTC_1245|Compound:0418-0076|FD-Score:3.61|P-value:8.06E-6 ID:SGTC_1270|Compound:0831-1170|FD-Score:2.85|P-value:3.31E-4 ID:SGTC_1285|Compound:0929-0069|FD-Score:-2.88|P-value:3.27E-4 ID:SGTC_1453|Compound:4237-0541|FD-Score:2.70|P-value:6.27E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.12|P-value:1.11E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.25|P-value:5.90E-5 ID:SGTC_1564|Compound:D-Arginine|FD-Score:-2.88|P-value:3.32E-4 ID:SGTC_1619|Compound:st003326|FD-Score:2.67|P-value:6.94E-4 ID:SGTC_1676|Compound:st018489|FD-Score:-2.98|P-value:2.15E-4 ID:SGTC_1681|Compound:tripelennamine|FD-Score:-2.65|P-value:8.80E-4 ID:SGTC_1725|Compound:st036284|FD-Score:4.03|P-value:7.42E-7 ID:SGTC_1726|Compound:st035556|FD-Score:3.24|P-value:5.40E-5 ID:SGTC_1734|Compound:st037168|FD-Score:4.06|P-value:6.34E-7 ID:SGTC_1735|Compound:st034310|FD-Score:4.74|P-value:8.04E-9 ID:SGTC_1736|Compound:st036774|FD-Score:6.22|P-value:6.11E-14 ID:SGTC_1779|Compound:st039427|FD-Score:2.89|P-value:2.81E-4 ID:SGTC_2121|Compound:5257820|FD-Score:3.17|P-value:7.44E-5 ID:SGTC_2164|Compound:5685496|FD-Score:4.21|P-value:2.56E-7 ID:SGTC_2191|Compound:5911152|FD-Score:-2.93|P-value:2.59E-4 ID:SGTC_2327|Compound:6189656|FD-Score:4.13|P-value:4.04E-7 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:2.64|P-value:7.89E-4 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:3.54|P-value:1.18E-5 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:-3.97|P-value:1.30E-6 ID:SGTC_2619|Compound:obliquin|FD-Score:-3.18|P-value:8.21E-5 ID:SGTC_2620|Compound:irigenin|FD-Score:-3.95|P-value:1.45E-6 ID:SGTC_2628|Compound:lathosterol|FD-Score:-3.32|P-value:4.28E-5 ID:SGTC_2630|Compound:antimycin a|FD-Score:-4.77|P-value:8.04E-9 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:-2.98|P-value:2.08E-4 ID:SGTC_2640|Compound:pentamidine|FD-Score:4.72|P-value:8.76E-9 ID:SGTC_2749|Compound:bexarotene|FD-Score:-2.74|P-value:6.03E-4 ID:SGTC_2848|Compound:9016370|FD-Score:3.90|P-value:1.57E-6 ID:SGTC_2852|Compound:9023854|FD-Score:6.02|P-value:3.65E-13 ID:SGTC_2858|Compound:9025781|FD-Score:6.79|P-value:2.87E-16 ID:SGTC_2864|Compound:9034755|FD-Score:-2.76|P-value:5.45E-4 ID:SGTC_2938|Compound:9059746|FD-Score:2.84|P-value:3.38E-4 ID:SGTC_3206|Compound:9114350|FD-Score:-3.23|P-value:6.55E-5 ID:SGTC_3287|Compound:9117173|FD-Score:2.58|P-value:9.99E-4 ID:SGTC_3297|Compound:9117502|FD-Score:2.65|P-value:7.69E-4

Top fitness defect scores for YBL064C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2858 9025781 6.79 9.0 µM 2.87E-16 sphingolipid biosynthesis & PDR1 38 5.55E-12
2 SGTC_1736 st036774 6.22 51.0 µM 6.11E-14 6 2.49E-10
3 SGTC_2852 9023854 6.02 52.0 µM 3.65E-13 8 8.87E-10
4 SGTC_663 1486-0733 5.47 13.9 µM 3.32E-11 cell wall signaling 25 2.19E-8
5 SGTC_1735 st034310 4.74 56.8 µM 8.04E-9 Golgi 11 1.09E-6
6 SGTC_2640 pentamidine 4.72 10.4 µM 8.76E-9 mitochondrial processes 14 1.16E-6
7 SGTC_2164 5685496 4.21 200.0 µM 2.56E-7 19 1.29E-5
8 SGTC_2327 6189656 4.13 200.0 µM 4.04E-7 19 1.79E-5
9 SGTC_1734 st037168 4.06 69.4 µM 6.34E-7 21 2.47E-5
10 SGTC_1725 st036284 4.03 20.6 µM 7.42E-7 25 2.76E-5
11 SGTC_2848 9016370 3.90 26.0 µM 1.57E-6 26 4.73E-5
12 SGTC_1245 0418-0076 3.61 17.2 µM 8.06E-6 ERG2 42 1.52E-4
13 SGTC_2598 perillyl alcohol 3.54 100.0 µM 1.18E-5 49 2.01E-4
14 SGTC_650 1328-0195 3.43 38.0 µM 2.07E-5 34 2.99E-4
15 SGTC_266 formosanin C 3.29 406.0 nM 4.16E-5 sphingolipid biosynthesis & PDR1 92 4.94E-4
16 SGTC_1726 st035556 3.24 14.6 µM 5.40E-5 73 5.97E-4
17 SGTC_2121 5257820 3.17 149.6 µM 7.44E-5 33 7.50E-4
18 SGTC_743 1275-0778 2.93 158.0 µM 2.32E-4 excess fatty acid 97 0.00170
19 SGTC_1779 st039427 2.89 55.0 µM 2.81E-4 95 0.00195
20 SGTC_1270 0831-1170 2.85 17.3 µM 3.31E-4 60 0.00220

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.190 1.76E-28 YGL066W SGF73 hom SAGA complex subunit; has a role in anchoring the deubiquitination module into SAGA and SLIK complexes; involved in preinitiation complex assembly at promoters; human ortholog ataxin-7 is associated with spinocerebellar ataxia diseases; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay
0.181 5.31E-26 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.178 2.31E-25 YPL057C SUR1 hom Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit; forms a complex with regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Csh1p; SUR1 has a paralog, CSH1, that arose from the whole genome duplication
0.172 9.46E-24 YMR322C_p SNO4_p hom Possible chaperone and cysteine protease, similar to bacterial Hsp31 and yeast Hsp31p, Hsp32p, and Hsp33p; DJ-1/ThiJ/PfpI superfamily member; predicted involvement in pyridoxine metabolism; induced by mild heat stress and copper deprivation
0.171 1.71E-23 YJR005C-A_p YJR005C-A_p hom Putative protein of unknown function; originally identified as a syntenic homolog of an Ashbya gossypii gene; YJR005C-A has a paralog, YGR169C-A, that arose from the whole genome duplication
0.169 6.81E-23 YEL060C PRB1 hom Vacuolar proteinase B (yscB); serine protease of the subtilisin family; involved in protein degradation in the vacuole and required for full protein degradation during sporulation; activity inhibited by Pbi2p; protein abundance increases in response to DNA replication stress
0.151 1.45E-18 YER075C PTP3 hom Phosphotyrosine-specific protein phosphatase involved in the inactivation of mitogen-activated protein kinase (MAPK) during osmolarity sensing; dephosporylates Hog1p MAPK and regulates its localization; localized to the cytoplasm
0.149 3.33E-18 YDL029W ARP2 het Essential component of the Arp2/3 complex, which is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity
0.147 1.15E-17 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.146 2.47E-17 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.140 3.43E-16 YGR136W LSB1 hom Protein containing an N-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; protein increases in abundance and forms nuclear foci in response to DNA replication stress
0.138 1.23E-15 YLR055C SPT8 hom Subunit of the SAGA transcriptional regulatory complex but not present in SAGA-like complex SLIK/SALSA, required for SAGA-mediated inhibition at some promoters
0.135 5.09E-15 YNL166C BNI5 hom Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.131 2.42E-14 YBR274W CHK1 hom Serine/threonine kinase and DNA damage checkpoint effector, mediates cell cycle arrest via phosphorylation of Pds1p; phosphorylated by checkpoint signal transducer Mec1p; homolog of S. pombe and mammalian Chk1 checkpoint kinase
0.129 8.20E-14 YDR521W_d YDR521W_d hom Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol