YBL065W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF SEF1/YBL066C; YBL065W is a non-essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YBL065W / YBL065W

Click on Significant Values for Screen Details ID:SGTC_39|Compound:0986-0283|FD-Score:4.63|P-value:3.41E-6 ID:SGTC_42|Compound:0133-0086|FD-Score:3.30|P-value:7.04E-4 ID:SGTC_52|Compound:0329-0193|FD-Score:3.54|P-value:3.03E-4 ID:SGTC_181|Compound:1447-1644|FD-Score:3.33|P-value:6.21E-4 ID:SGTC_264|Compound:promethazine|FD-Score:3.45|P-value:4.08E-4 ID:SGTC_461|Compound:N-acetylfarnesylcysteine|FD-Score:-3.26|P-value:6.22E-4 ID:SGTC_699|Compound:0375-0592|FD-Score:3.89|P-value:8.11E-5 ID:SGTC_705|Compound:1124-0212|FD-Score:3.51|P-value:3.29E-4 ID:SGTC_989|Compound:1501-0895|FD-Score:-3.63|P-value:1.68E-4 ID:SGTC_990|Compound:3985-0011|FD-Score:3.82|P-value:1.04E-4 ID:SGTC_998|Compound:3996-0085|FD-Score:-3.45|P-value:3.24E-4 ID:SGTC_1001|Compound:4048-4355|FD-Score:5.66|P-value:1.79E-8 ID:SGTC_1207|Compound:2099-0101|FD-Score:3.38|P-value:5.20E-4 ID:SGTC_1231|Compound:0242-0792|FD-Score:3.32|P-value:6.50E-4 ID:SGTC_1260|Compound:0700-1617|FD-Score:4.31|P-value:1.40E-5 ID:SGTC_1652|Compound:st011932|FD-Score:-3.55|P-value:2.24E-4 ID:SGTC_1659|Compound:st012954|FD-Score:-3.49|P-value:2.81E-4 ID:SGTC_1727|Compound:st034309|FD-Score:-3.68|P-value:1.37E-4 ID:SGTC_1732|Compound:st034308|FD-Score:-3.55|P-value:2.21E-4 ID:SGTC_1737|Compound:st035557|FD-Score:-7.18|P-value:7.79E-13 ID:SGTC_1747|Compound:st037496|FD-Score:4.22|P-value:2.11E-5 ID:SGTC_1916|Compound:st067606|FD-Score:-3.62|P-value:1.72E-4 ID:SGTC_1925|Compound:st057770|FD-Score:-3.50|P-value:2.72E-4 ID:SGTC_1933|Compound:st074711|FD-Score:-3.39|P-value:4.04E-4 ID:SGTC_2026|Compound:5148700|FD-Score:-5.22|P-value:1.33E-7 ID:SGTC_2029|Compound:5175081|FD-Score:-3.53|P-value:2.36E-4 ID:SGTC_2033|Compound:5192550|FD-Score:-3.42|P-value:3.55E-4 ID:SGTC_2035|Compound:5154463|FD-Score:3.38|P-value:5.22E-4 ID:SGTC_2053|Compound:5265679|FD-Score:3.88|P-value:8.39E-5 ID:SGTC_2342|Compound:7990637|FD-Score:3.47|P-value:3.82E-4 ID:SGTC_2397|Compound:5161689|FD-Score:3.97|P-value:5.71E-5 ID:SGTC_2414|Compound:st077232|FD-Score:3.62|P-value:2.25E-4 ID:SGTC_2417|Compound:cerulenin|FD-Score:3.25|P-value:8.24E-4 ID:SGTC_2638|Compound:epoxomicin|FD-Score:-3.26|P-value:6.20E-4 ID:SGTC_2717|Compound:st081029|FD-Score:-3.24|P-value:6.62E-4 ID:SGTC_2872|Compound:9044037|FD-Score:3.26|P-value:7.83E-4 ID:SGTC_2874|Compound:9043904|FD-Score:-8.06|P-value:1.13E-15 ID:SGTC_2878|Compound:9043973|FD-Score:-6.23|P-value:4.11E-10 ID:SGTC_2919|Compound:7978188|FD-Score:-3.45|P-value:3.16E-4 ID:SGTC_2969|Compound:9091408|FD-Score:3.34|P-value:6.07E-4 ID:SGTC_3125|Compound:9127534|FD-Score:-3.63|P-value:1.63E-4 ID:SGTC_3175|Compound:9106517|FD-Score:4.09|P-value:3.57E-5 ID:SGTC_3185|Compound:9108267|FD-Score:3.32|P-value:6.51E-4 ID:SGTC_39|Compound:0986-0283|FD-Score:4.63|P-value:3.41E-6 ID:SGTC_42|Compound:0133-0086|FD-Score:3.30|P-value:7.04E-4 ID:SGTC_52|Compound:0329-0193|FD-Score:3.54|P-value:3.03E-4 ID:SGTC_181|Compound:1447-1644|FD-Score:3.33|P-value:6.21E-4 ID:SGTC_264|Compound:promethazine|FD-Score:3.45|P-value:4.08E-4 ID:SGTC_461|Compound:N-acetylfarnesylcysteine|FD-Score:-3.26|P-value:6.22E-4 ID:SGTC_699|Compound:0375-0592|FD-Score:3.89|P-value:8.11E-5 ID:SGTC_705|Compound:1124-0212|FD-Score:3.51|P-value:3.29E-4 ID:SGTC_989|Compound:1501-0895|FD-Score:-3.63|P-value:1.68E-4 ID:SGTC_990|Compound:3985-0011|FD-Score:3.82|P-value:1.04E-4 ID:SGTC_998|Compound:3996-0085|FD-Score:-3.45|P-value:3.24E-4 ID:SGTC_1001|Compound:4048-4355|FD-Score:5.66|P-value:1.79E-8 ID:SGTC_1207|Compound:2099-0101|FD-Score:3.38|P-value:5.20E-4 ID:SGTC_1231|Compound:0242-0792|FD-Score:3.32|P-value:6.50E-4 ID:SGTC_1260|Compound:0700-1617|FD-Score:4.31|P-value:1.40E-5 ID:SGTC_1652|Compound:st011932|FD-Score:-3.55|P-value:2.24E-4 ID:SGTC_1659|Compound:st012954|FD-Score:-3.49|P-value:2.81E-4 ID:SGTC_1727|Compound:st034309|FD-Score:-3.68|P-value:1.37E-4 ID:SGTC_1732|Compound:st034308|FD-Score:-3.55|P-value:2.21E-4 ID:SGTC_1737|Compound:st035557|FD-Score:-7.18|P-value:7.79E-13 ID:SGTC_1747|Compound:st037496|FD-Score:4.22|P-value:2.11E-5 ID:SGTC_1916|Compound:st067606|FD-Score:-3.62|P-value:1.72E-4 ID:SGTC_1925|Compound:st057770|FD-Score:-3.50|P-value:2.72E-4 ID:SGTC_1933|Compound:st074711|FD-Score:-3.39|P-value:4.04E-4 ID:SGTC_2026|Compound:5148700|FD-Score:-5.22|P-value:1.33E-7 ID:SGTC_2029|Compound:5175081|FD-Score:-3.53|P-value:2.36E-4 ID:SGTC_2033|Compound:5192550|FD-Score:-3.42|P-value:3.55E-4 ID:SGTC_2035|Compound:5154463|FD-Score:3.38|P-value:5.22E-4 ID:SGTC_2053|Compound:5265679|FD-Score:3.88|P-value:8.39E-5 ID:SGTC_2342|Compound:7990637|FD-Score:3.47|P-value:3.82E-4 ID:SGTC_2397|Compound:5161689|FD-Score:3.97|P-value:5.71E-5 ID:SGTC_2414|Compound:st077232|FD-Score:3.62|P-value:2.25E-4 ID:SGTC_2417|Compound:cerulenin|FD-Score:3.25|P-value:8.24E-4 ID:SGTC_2638|Compound:epoxomicin|FD-Score:-3.26|P-value:6.20E-4 ID:SGTC_2717|Compound:st081029|FD-Score:-3.24|P-value:6.62E-4 ID:SGTC_2872|Compound:9044037|FD-Score:3.26|P-value:7.83E-4 ID:SGTC_2874|Compound:9043904|FD-Score:-8.06|P-value:1.13E-15 ID:SGTC_2878|Compound:9043973|FD-Score:-6.23|P-value:4.11E-10 ID:SGTC_2919|Compound:7978188|FD-Score:-3.45|P-value:3.16E-4 ID:SGTC_2969|Compound:9091408|FD-Score:3.34|P-value:6.07E-4 ID:SGTC_3125|Compound:9127534|FD-Score:-3.63|P-value:1.63E-4 ID:SGTC_3175|Compound:9106517|FD-Score:4.09|P-value:3.57E-5 ID:SGTC_3185|Compound:9108267|FD-Score:3.32|P-value:6.51E-4

Top fitness defect scores for YBL065W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1001 4048-4355 5.66 44.4 µM 1.79E-8 copper-dependent oxidative stress 15 7.51E-9
2 SGTC_39 0986-0283 4.63 58.4 µM 3.41E-6 calcium & mitochondrial duress 17 1.84E-6
3 SGTC_1260 0700-1617 4.31 7.8 µM 1.40E-5 calcium & mitochondrial duress 25 8.07E-6
4 SGTC_1747 st037496 4.22 66.6 µM 2.11E-5 14 1.24E-5
5 SGTC_3175 9106517 4.09 49.5 µM 3.57E-5 iron homeostasis 17 2.15E-5
6 SGTC_2397 5161689 3.97 200.0 µM 5.71E-5 33 3.52E-5
7 SGTC_699 0375-0592 3.89 111.0 µM 8.11E-5 iron homeostasis 21 5.09E-5
8 SGTC_2053 5265679 3.88 138.0 µM 8.39E-5 27 5.27E-5
9 SGTC_990 3985-0011 3.82 41.3 µM 1.04E-4 amide catabolism 24 6.61E-5
10 SGTC_2414 st077232 3.62 92.9 µM 2.25E-4 34 1.49E-4
11 SGTC_52 0329-0193 3.54 875.0 nM 3.03E-4 TSC3-RPN4 51 2.03E-4
12 SGTC_705 1124-0212 3.51 310.0 µM 3.29E-4 28 2.21E-4
13 SGTC_2342 7990637 3.47 118.9 µM 3.82E-4 RNA processing & uracil transport 57 2.58E-4
14 SGTC_264 promethazine 3.45 12.5 mM 4.08E-4 DNA intercalators 75 2.77E-4
15 SGTC_1207 2099-0101 3.38 141.0 µM 5.20E-4 40 3.57E-4
16 SGTC_2035 5154463 3.38 94.6 µM 5.22E-4 30 3.59E-4
17 SGTC_2969 9091408 3.34 28.7 µM 6.07E-4 57 4.21E-4
18 SGTC_181 1447-1644 3.33 8.1 µM 6.21E-4 endomembrane recycling 55 4.31E-4
19 SGTC_1231 0242-0792 3.32 125.0 µM 6.50E-4 40 4.52E-4
20 SGTC_3185 9108267 3.32 49.5 µM 6.51E-4 60S ribosome export 45 4.52E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.251 1.08E-48 YOR092W ECM3 hom Non-essential protein of unknown function; involved in signal transduction and the genotoxic response; induced rapidly in response to treatment with 8-methoxypsoralen and UVA irradiation; relocalizes from ER to cytoplasm upon DNA replication stress; ECM3 has a paralog, YNL095C, that arose from the whole genome duplication
0.222 2.37E-38 YMR119W-A_d YMR119W-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.199 4.88E-31 YDR171W HSP42 hom Small heat shock protein (sHSP) with chaperone activity; forms barrel-shaped oligomers that suppress unfolded protein aggregation; involved in cytoskeleton reorganization after heat shock; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress
0.196 5.22E-30 YDR291W HRQ1 hom 3'-5'DNA helicase that has DNA strand annealing activity; helicase activity is stimulated by fork structure and 3'-tail length of substrates; belongs to the widely conserved RecQ family of proteins which are involved in maintaining genomic integrity; similar to the human RecQ4p implicated in Rothmund-Thomson syndrome(RTS)
0.168 2.14E-22 YOR234C RPL33B hom Ribosomal 60S subunit protein L33B; rpl33b null mutant exhibits normal growth while rpl33a rpl33b double null mutant is inviable; homologous to mammalian ribosomal protein L35A, no bacterial homolog; RPL33B has a paralog, RPL33A, that arose from the whole genome duplication
0.158 6.71E-20 YGR295C COS6 hom Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
0.155 2.67E-19 YDR314C RAD34 hom Protein involved in nucleotide excision repair (NER); homologous to RAD4
0.152 1.33E-18 YMR114C YMR114C hom Protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; YMR114C is not an essential gene
0.149 6.70E-18 YDL010W GRX6 hom Cis-golgi localized monothiol glutaredoxin, binds Fe-S cluster; more similar in activity to dithiol than other monothiol glutaredoxins; involved in the oxidative stress response; GRX6 has a paralog, GRX7, that arose from the whole genome duplication
0.145 4.19E-17 YDR090C_p YDR090C_p hom Putative protein of unknown function
0.143 1.40E-16 YCR007C_p YCR007C_p hom Putative integral membrane protein, member of DUP240 gene family; YCR007C is not an essential gene
0.137 1.95E-15 YGR067C_p YGR067C_p hom Putative protein of unknown function; contains a zinc finger motif similar to that of Adr1p
0.136 3.68E-15 YBR170C NPL4 hom Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase; assists Cdc48p in the dislocation of misfolded, polyubiquitinated ERAD substrates that are subsequently delivered to the proteasome for degradation; also involved in the regulated destruction of resident ER membrane proteins, such as HMG-CoA reductase (Hmg1/2p) and cytoplasmic proteins (Fbp1p); role in mobilizing membrane bound transcription factors by regulated ubiquitin/proteasome-dependent processing (RUP)
0.133 1.26E-14 YOL102C TPT1 het tRNA 2'-phosphotransferase, catalyzes the final step in yeast tRNA splicing: the transfer of the 2'-PO(4) from the splice junction to NAD(+) to form ADP-ribose 1''-2''cyclic phosphate and nicotinamide
0.129 9.09E-14 YHL006C SHU1 hom Component of the Shu complex, which promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p function