YBL067C / UBP13

Putative ubiquitin-specific protease that cleaves Ub-protein fusions; UBP13 has a paralog, UBP9, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YBL067C / UBP13

Click on Significant Values for Screen Details ID:SGTC_72|Compound:0744-0168|FD-Score:4.61|P-value:4.82E-6 ID:SGTC_74|Compound:000s-0487|FD-Score:-4.63|P-value:3.69E-6 ID:SGTC_77|Compound:0828-0286|FD-Score:3.90|P-value:8.86E-5 ID:SGTC_87|Compound:0100-0052|FD-Score:3.23|P-value:9.73E-4 ID:SGTC_121|Compound:0557-0495|FD-Score:4.58|P-value:5.32E-6 ID:SGTC_122|Compound:0236-0016|FD-Score:7.66|P-value:8.52E-14 ID:SGTC_127|Compound:0180-0333|FD-Score:3.74|P-value:1.62E-4 ID:SGTC_133|Compound:0724-0033|FD-Score:4.69|P-value:3.31E-6 ID:SGTC_134|Compound:0269-0018|FD-Score:3.43|P-value:5.03E-4 ID:SGTC_187|Compound:1488-2104|FD-Score:4.35|P-value:1.48E-5 ID:SGTC_188|Compound:3229-0966|FD-Score:3.54|P-value:3.41E-4 ID:SGTC_202|Compound:3594-0513|FD-Score:-4.23|P-value:2.17E-5 ID:SGTC_211|Compound:3455-0679|FD-Score:-3.53|P-value:3.21E-4 ID:SGTC_252|Compound:miconazole|FD-Score:3.28|P-value:8.30E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:6.14|P-value:1.73E-9 ID:SGTC_467|Compound:ro 31-8220|FD-Score:5.69|P-value:2.25E-8 ID:SGTC_528|Compound:3492-0019|FD-Score:3.40|P-value:5.45E-4 ID:SGTC_585|Compound:0kpi-0023|FD-Score:-3.25|P-value:8.28E-4 ID:SGTC_656|Compound:4090-1979|FD-Score:3.44|P-value:4.76E-4 ID:SGTC_799|Compound:1310-0557|FD-Score:3.37|P-value:6.07E-4 ID:SGTC_872|Compound:0588-0139|FD-Score:3.89|P-value:9.28E-5 ID:SGTC_878|Compound:0828-0289|FD-Score:3.48|P-value:4.22E-4 ID:SGTC_891|Compound:0929-0073|FD-Score:-3.22|P-value:9.10E-4 ID:SGTC_899|Compound:1083-0020|FD-Score:3.48|P-value:4.16E-4 ID:SGTC_954|Compound:1189-0853|FD-Score:-6.38|P-value:3.44E-10 ID:SGTC_960|Compound:1222-0186|FD-Score:-5.43|P-value:7.75E-8 ID:SGTC_966|Compound:1300-0360|FD-Score:-3.40|P-value:4.99E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.10|P-value:3.68E-5 ID:SGTC_1167|Compound:k781-0610|FD-Score:5.06|P-value:5.73E-7 ID:SGTC_1175|Compound:0741-0056|FD-Score:4.35|P-value:1.45E-5 ID:SGTC_1183|Compound:1254-0324|FD-Score:3.23|P-value:9.75E-4 ID:SGTC_1202|Compound:1988-0068|FD-Score:3.77|P-value:1.46E-4 ID:SGTC_1247|Compound:0448-0043|FD-Score:7.28|P-value:1.21E-12 ID:SGTC_1459|Compound:k035-0031|FD-Score:-3.37|P-value:5.42E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:4.03|P-value:5.33E-5 ID:SGTC_1745|Compound:st081495|FD-Score:3.51|P-value:3.82E-4 ID:SGTC_1750|Compound:st081859|FD-Score:5.02|P-value:7.09E-7 ID:SGTC_1909|Compound:st060837|FD-Score:3.27|P-value:8.38E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.65|P-value:2.02E-4 ID:SGTC_2016|Compound:5121758|FD-Score:-3.81|P-value:1.15E-4 ID:SGTC_2021|Compound:4019055|FD-Score:4.53|P-value:6.81E-6 ID:SGTC_2128|Compound:5255449|FD-Score:-5.47|P-value:6.09E-8 ID:SGTC_2131|Compound:toluylene red|FD-Score:-4.74|P-value:2.32E-6 ID:SGTC_2220|Compound:6782180|FD-Score:3.80|P-value:1.34E-4 ID:SGTC_2245|Compound:6637752|FD-Score:3.26|P-value:8.82E-4 ID:SGTC_2308|Compound:7584454|FD-Score:-3.55|P-value:2.92E-4 ID:SGTC_2341|Compound:7987486|FD-Score:4.15|P-value:3.42E-5 ID:SGTC_2342|Compound:7990637|FD-Score:6.57|P-value:1.32E-10 ID:SGTC_2351|Compound:9026858|FD-Score:5.06|P-value:5.91E-7 ID:SGTC_2393|Compound:9031399|FD-Score:5.01|P-value:7.52E-7 ID:SGTC_2413|Compound:inermin|FD-Score:3.39|P-value:5.73E-4 ID:SGTC_2437|Compound:5741531|FD-Score:5.17|P-value:3.40E-7 ID:SGTC_2438|Compound:5259590|FD-Score:5.92|P-value:6.32E-9 ID:SGTC_2441|Compound:5730946|FD-Score:6.98|P-value:9.22E-12 ID:SGTC_2446|Compound:5162541|FD-Score:4.05|P-value:5.05E-5 ID:SGTC_2448|Compound:5185112|FD-Score:-5.08|P-value:4.48E-7 ID:SGTC_2453|Compound:5731132|FD-Score:5.95|P-value:5.29E-9 ID:SGTC_2468|Compound:5987765|FD-Score:3.51|P-value:3.74E-4 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:3.66|P-value:2.24E-4 ID:SGTC_2518|Compound:prenyletin|FD-Score:4.22|P-value:2.56E-5 ID:SGTC_2651|Compound:1327-0036|FD-Score:3.34|P-value:6.64E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:11.40|P-value:2.36E-28 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:5.56|P-value:4.54E-8 ID:SGTC_2756|Compound:carbadox|FD-Score:3.98|P-value:6.63E-5 ID:SGTC_2778|Compound:tioconazole|FD-Score:7.05|P-value:5.97E-12 ID:SGTC_2789|Compound:5281112|FD-Score:3.89|P-value:9.40E-5 ID:SGTC_2806|Compound:7952793|FD-Score:-4.39|P-value:1.07E-5 ID:SGTC_2880|Compound:9042983|FD-Score:3.81|P-value:1.25E-4 ID:SGTC_2896|Compound:9052656|FD-Score:3.82|P-value:1.21E-4 ID:SGTC_2953|Compound:9074162|FD-Score:3.57|P-value:3.09E-4 ID:SGTC_3056|Compound:9094900|FD-Score:3.43|P-value:5.05E-4 ID:SGTC_3089|Compound:9117425|FD-Score:3.25|P-value:9.06E-4 ID:SGTC_3149|Compound:9097855|FD-Score:4.59|P-value:5.07E-6 ID:SGTC_3201|Compound:9113999|FD-Score:3.98|P-value:6.71E-5 ID:SGTC_3339|Compound:9145883|FD-Score:-3.39|P-value:5.17E-4 ID:SGTC_3341|Compound:9147222|FD-Score:4.22|P-value:2.48E-5 ID:SGTC_72|Compound:0744-0168|FD-Score:4.61|P-value:4.82E-6 ID:SGTC_74|Compound:000s-0487|FD-Score:-4.63|P-value:3.69E-6 ID:SGTC_77|Compound:0828-0286|FD-Score:3.90|P-value:8.86E-5 ID:SGTC_87|Compound:0100-0052|FD-Score:3.23|P-value:9.73E-4 ID:SGTC_121|Compound:0557-0495|FD-Score:4.58|P-value:5.32E-6 ID:SGTC_122|Compound:0236-0016|FD-Score:7.66|P-value:8.52E-14 ID:SGTC_127|Compound:0180-0333|FD-Score:3.74|P-value:1.62E-4 ID:SGTC_133|Compound:0724-0033|FD-Score:4.69|P-value:3.31E-6 ID:SGTC_134|Compound:0269-0018|FD-Score:3.43|P-value:5.03E-4 ID:SGTC_187|Compound:1488-2104|FD-Score:4.35|P-value:1.48E-5 ID:SGTC_188|Compound:3229-0966|FD-Score:3.54|P-value:3.41E-4 ID:SGTC_202|Compound:3594-0513|FD-Score:-4.23|P-value:2.17E-5 ID:SGTC_211|Compound:3455-0679|FD-Score:-3.53|P-value:3.21E-4 ID:SGTC_252|Compound:miconazole|FD-Score:3.28|P-value:8.30E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:6.14|P-value:1.73E-9 ID:SGTC_467|Compound:ro 31-8220|FD-Score:5.69|P-value:2.25E-8 ID:SGTC_528|Compound:3492-0019|FD-Score:3.40|P-value:5.45E-4 ID:SGTC_585|Compound:0kpi-0023|FD-Score:-3.25|P-value:8.28E-4 ID:SGTC_656|Compound:4090-1979|FD-Score:3.44|P-value:4.76E-4 ID:SGTC_799|Compound:1310-0557|FD-Score:3.37|P-value:6.07E-4 ID:SGTC_872|Compound:0588-0139|FD-Score:3.89|P-value:9.28E-5 ID:SGTC_878|Compound:0828-0289|FD-Score:3.48|P-value:4.22E-4 ID:SGTC_891|Compound:0929-0073|FD-Score:-3.22|P-value:9.10E-4 ID:SGTC_899|Compound:1083-0020|FD-Score:3.48|P-value:4.16E-4 ID:SGTC_954|Compound:1189-0853|FD-Score:-6.38|P-value:3.44E-10 ID:SGTC_960|Compound:1222-0186|FD-Score:-5.43|P-value:7.75E-8 ID:SGTC_966|Compound:1300-0360|FD-Score:-3.40|P-value:4.99E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.10|P-value:3.68E-5 ID:SGTC_1167|Compound:k781-0610|FD-Score:5.06|P-value:5.73E-7 ID:SGTC_1175|Compound:0741-0056|FD-Score:4.35|P-value:1.45E-5 ID:SGTC_1183|Compound:1254-0324|FD-Score:3.23|P-value:9.75E-4 ID:SGTC_1202|Compound:1988-0068|FD-Score:3.77|P-value:1.46E-4 ID:SGTC_1247|Compound:0448-0043|FD-Score:7.28|P-value:1.21E-12 ID:SGTC_1459|Compound:k035-0031|FD-Score:-3.37|P-value:5.42E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:4.03|P-value:5.33E-5 ID:SGTC_1745|Compound:st081495|FD-Score:3.51|P-value:3.82E-4 ID:SGTC_1750|Compound:st081859|FD-Score:5.02|P-value:7.09E-7 ID:SGTC_1909|Compound:st060837|FD-Score:3.27|P-value:8.38E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.65|P-value:2.02E-4 ID:SGTC_2016|Compound:5121758|FD-Score:-3.81|P-value:1.15E-4 ID:SGTC_2021|Compound:4019055|FD-Score:4.53|P-value:6.81E-6 ID:SGTC_2128|Compound:5255449|FD-Score:-5.47|P-value:6.09E-8 ID:SGTC_2131|Compound:toluylene red|FD-Score:-4.74|P-value:2.32E-6 ID:SGTC_2220|Compound:6782180|FD-Score:3.80|P-value:1.34E-4 ID:SGTC_2245|Compound:6637752|FD-Score:3.26|P-value:8.82E-4 ID:SGTC_2308|Compound:7584454|FD-Score:-3.55|P-value:2.92E-4 ID:SGTC_2341|Compound:7987486|FD-Score:4.15|P-value:3.42E-5 ID:SGTC_2342|Compound:7990637|FD-Score:6.57|P-value:1.32E-10 ID:SGTC_2351|Compound:9026858|FD-Score:5.06|P-value:5.91E-7 ID:SGTC_2393|Compound:9031399|FD-Score:5.01|P-value:7.52E-7 ID:SGTC_2413|Compound:inermin|FD-Score:3.39|P-value:5.73E-4 ID:SGTC_2437|Compound:5741531|FD-Score:5.17|P-value:3.40E-7 ID:SGTC_2438|Compound:5259590|FD-Score:5.92|P-value:6.32E-9 ID:SGTC_2441|Compound:5730946|FD-Score:6.98|P-value:9.22E-12 ID:SGTC_2446|Compound:5162541|FD-Score:4.05|P-value:5.05E-5 ID:SGTC_2448|Compound:5185112|FD-Score:-5.08|P-value:4.48E-7 ID:SGTC_2453|Compound:5731132|FD-Score:5.95|P-value:5.29E-9 ID:SGTC_2468|Compound:5987765|FD-Score:3.51|P-value:3.74E-4 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:3.66|P-value:2.24E-4 ID:SGTC_2518|Compound:prenyletin|FD-Score:4.22|P-value:2.56E-5 ID:SGTC_2651|Compound:1327-0036|FD-Score:3.34|P-value:6.64E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:11.40|P-value:2.36E-28 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:5.56|P-value:4.54E-8 ID:SGTC_2756|Compound:carbadox|FD-Score:3.98|P-value:6.63E-5 ID:SGTC_2778|Compound:tioconazole|FD-Score:7.05|P-value:5.97E-12 ID:SGTC_2789|Compound:5281112|FD-Score:3.89|P-value:9.40E-5 ID:SGTC_2806|Compound:7952793|FD-Score:-4.39|P-value:1.07E-5 ID:SGTC_2880|Compound:9042983|FD-Score:3.81|P-value:1.25E-4 ID:SGTC_2896|Compound:9052656|FD-Score:3.82|P-value:1.21E-4 ID:SGTC_2953|Compound:9074162|FD-Score:3.57|P-value:3.09E-4 ID:SGTC_3056|Compound:9094900|FD-Score:3.43|P-value:5.05E-4 ID:SGTC_3089|Compound:9117425|FD-Score:3.25|P-value:9.06E-4 ID:SGTC_3149|Compound:9097855|FD-Score:4.59|P-value:5.07E-6 ID:SGTC_3201|Compound:9113999|FD-Score:3.98|P-value:6.71E-5 ID:SGTC_3339|Compound:9145883|FD-Score:-3.39|P-value:5.17E-4 ID:SGTC_3341|Compound:9147222|FD-Score:4.22|P-value:2.48E-5

Top fitness defect scores for YBL067C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2688 kanamycin b 11.40 96.7 µM 2.36E-28 calcium & mitochondrial duress 16 1.95E-30
2 SGTC_122 0236-0016 7.66 402.4 µM 8.52E-14 RNA processing & uracil transport 5 9.26E-15
3 SGTC_1247 0448-0043 7.28 5.8 µM 1.21E-12 ERG2 4 1.61E-13
4 SGTC_2778 tioconazole 7.05 65.1 nM 5.97E-12 ergosterol depletion effects on membrane 25 9.00E-13
5 SGTC_2441 5730946 6.98 39.1 µM 9.22E-12 1 1.44E-12
6 SGTC_2342 7990637 6.57 118.9 µM 1.32E-10 RNA processing & uracil transport 3 2.52E-11
7 SGTC_453 enantio-paf c16 6.14 10.0 µM 1.73E-9 41 4.03E-10
8 SGTC_2453 5731132 5.95 22.2 µM 5.29E-9 2 1.34E-9
9 SGTC_2438 5259590 5.92 200.0 µM 6.32E-9 5 1.62E-9
10 SGTC_467 ro 31-8220 5.69 72.8 µM 2.25E-8 calcium & mitochondrial duress 33 6.39E-9
11 SGTC_2697 mebhydrolin 5.56 72.4 µM 4.54E-8 NEO1 37 1.36E-8
12 SGTC_2437 5741531 5.17 144.2 µM 3.40E-7 19 1.19E-7
13 SGTC_1167 k781-0610 5.06 148.0 µM 5.73E-7 RNA processing & uracil transport 9 2.08E-7
14 SGTC_2351 9026858 5.06 72.3 µM 5.91E-7 RNA processing & uracil transport 13 2.15E-7
15 SGTC_1750 st081859 5.02 2.4 µM 7.09E-7 endomembrane recycling 137 2.62E-7
16 SGTC_2393 9031399 5.01 185.9 µM 7.52E-7 RNA processing & uracil transport 12 2.78E-7
17 SGTC_133 0724-0033 4.69 378.9 µM 3.31E-6 13 1.37E-6
18 SGTC_72 0744-0168 4.61 198.4 µM 4.82E-6 RPP1 & pyrimidine depletion 20 2.06E-6
19 SGTC_3149 9097855 4.59 49.5 µM 5.07E-6 Golgi 14 2.17E-6
20 SGTC_121 0557-0495 4.58 61.3 µM 5.32E-6 calcium & mitochondrial duress 39 2.29E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.217 5.93E-37 YDR290W_d YDR290W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RTT103
0.210 8.45E-35 YGL079W_p KXD1_p hom Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; null mutant is sensitive to drug inducing secretion of vacuolar cargo; GFP-fusion protein localizes to the endosome
0.193 1.83E-29 YBR021W FUR4 hom Plasma membrane localized uracil permease; expression is tightly regulated by uracil levels and environmental cues; conformational alterations induced by unfolding or substrate binding result in Rsp5p-mediated ubiquitination and degradation
0.191 7.23E-29 YJL165C HAL5 hom Putative protein kinase; overexpression increases sodium and lithium tolerance, whereas gene disruption increases cation and low pH sensitivity and impairs potassium uptake, suggesting a role in regulation of Trk1p and/or Trk2p transporters; HAL5 has a paralog, KKQ8, that arose from the whole genome duplication
0.184 8.27E-27 YAL038W CDC19 het Pyruvate kinase; functions as a homotetramer in glycolysis to convert phosphoenolpyruvate to pyruvate, the input for aerobic (TCA cycle) or anaerobic (glucose fermentation) respiration; regulated via allosteric activation by fructose bisphosphate; CDC19 has a paralog, PYK2, that arose from the whole genome duplication
0.172 8.05E-24 YDL021W GPM2 hom Homolog of Gpm1p phosphoglycerate mutase, which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional derivative of a gene duplication event
0.168 1.30E-22 YIL105C SLM1 hom Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm2p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; phosphorylated by the TORC2 complex; protein abundance increases in response to DNA replication stress; SLM1 has a paralog, SLM2, that arose from the whole genome duplication
0.165 6.07E-22 YNL307C MCK1 hom Protein serine/threonine/tyrosine (dual-specificity) kinase; involved in control of chromosome segregation and in regulating entry into meiosis; interacts with Clb2p and Mih1p; inhibits Clb2p-Cdk1 activity; related to mammalian glycogen synthase kinases of the GSK-3 family
0.160 9.96E-21 YCR008W SAT4 hom Ser/Thr protein kinase involved in salt tolerance; funtions in regulation of Trk1p-Trk2p potassium transporter; partially redundant with Hal5p; has similarity to Npr1p
0.158 4.36E-20 YKL061W_p BLI1_p hom Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to the endosome
0.156 1.01E-19 YJL129C TRK1 hom Component of the Trk1p-Trk2p potassium transport system; 180 kDa high affinity potassium transporter; phosphorylated in vivo and interacts physically with the phosphatase Ppz1p, suggesting Trk1p acitivy is regulated by phosphorylation; TRK1 has a paralog, TRK2, that arose from the whole genome duplication
0.155 1.78E-19 YBR287W_p YBR287W_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the ER; YBR287W is not an essential gene
0.152 7.33E-19 YKL051W SFK1 hom Plasma membrane protein that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, at least partially mediates proper localization of Stt4p to the plasma membrane
0.152 7.69E-19 YOL016C CMK2 hom Calmodulin-dependent protein kinase; may play a role in stress response, many CA++/calmodulan dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to mammalian Cam Kinase II; CMK2 has a paralog, CMK1, that arose from the whole genome duplication
0.149 3.90E-18 YDR475C JIP4 hom Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence