YBL069W / AST1

Lipid raft associated protein; interacts with the plasma membrane ATPase Pma1p and has a role in its targeting to the plasma membrane by influencing its incorporation into lipid rafts; sometimes classified in the medium-chain dehydrogenase/reductases (MDRs) superfamily; AST1 has a paralog, AST2, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YBL069W / AST1

Click on Significant Values for Screen Details ID:SGTC_107|Compound:0358-0022|FD-Score:4.11|P-value:2.55E-5 ID:SGTC_125|Compound:0133-0007|FD-Score:-4.04|P-value:9.75E-5 ID:SGTC_136|Compound:0097-0015|FD-Score:3.26|P-value:6.10E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:-3.53|P-value:6.10E-4 ID:SGTC_334|Compound:1502-1024|FD-Score:-3.48|P-value:7.08E-4 ID:SGTC_520|Compound:3584-0023|FD-Score:-3.93|P-value:1.48E-4 ID:SGTC_644|Compound:1498-1197|FD-Score:-3.51|P-value:6.55E-4 ID:SGTC_646|Compound:4092-0839|FD-Score:-3.60|P-value:4.86E-4 ID:SGTC_659|Compound:k018-0002|FD-Score:-3.65|P-value:4.07E-4 ID:SGTC_663|Compound:1486-0733|FD-Score:3.96|P-value:4.72E-5 ID:SGTC_687|Compound:k029-0044|FD-Score:6.09|P-value:1.51E-9 ID:SGTC_689|Compound:0833-0039|FD-Score:4.20|P-value:1.82E-5 ID:SGTC_854|Compound:0422-0053|FD-Score:3.74|P-value:1.11E-4 ID:SGTC_963|Compound:1269-2853|FD-Score:-3.53|P-value:6.00E-4 ID:SGTC_1053|Compound:3366-3204|FD-Score:3.46|P-value:3.05E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:3.59|P-value:1.91E-4 ID:SGTC_1225|Compound:1216-0074|FD-Score:3.96|P-value:4.72E-5 ID:SGTC_1238|Compound:0333-0287|FD-Score:4.24|P-value:1.53E-5 ID:SGTC_1339|Compound:1486-1321|FD-Score:3.94|P-value:5.12E-5 ID:SGTC_1632|Compound:st005650|FD-Score:6.23|P-value:6.69E-10 ID:SGTC_1746|Compound:st038117|FD-Score:3.93|P-value:5.35E-5 ID:SGTC_1885|Compound:st057546|FD-Score:4.27|P-value:1.32E-5 ID:SGTC_1896|Compound:st058441|FD-Score:3.45|P-value:3.18E-4 ID:SGTC_1916|Compound:st067606|FD-Score:3.23|P-value:6.60E-4 ID:SGTC_1982|Compound:st072467|FD-Score:3.33|P-value:4.81E-4 ID:SGTC_1999|Compound:st074831|FD-Score:-3.38|P-value:9.87E-4 ID:SGTC_2068|Compound:5226020|FD-Score:3.18|P-value:7.84E-4 ID:SGTC_2092|Compound:5303694|FD-Score:3.53|P-value:2.36E-4 ID:SGTC_2124|Compound:5246320|FD-Score:-3.39|P-value:9.65E-4 ID:SGTC_2219|Compound:9098279|FD-Score:-3.51|P-value:6.56E-4 ID:SGTC_2224|Compound:6650123|FD-Score:3.89|P-value:6.17E-5 ID:SGTC_2256|Compound:7954252|FD-Score:3.34|P-value:4.65E-4 ID:SGTC_2275|Compound:7947463|FD-Score:5.23|P-value:1.58E-7 ID:SGTC_2276|Compound:7947513|FD-Score:3.92|P-value:5.52E-5 ID:SGTC_2295|Compound:7971645|FD-Score:-4.18|P-value:5.73E-5 ID:SGTC_2378|Compound:9074213|FD-Score:3.13|P-value:9.30E-4 ID:SGTC_2395|Compound:5646831|FD-Score:-3.42|P-value:8.76E-4 ID:SGTC_2484|Compound:5809818|FD-Score:3.28|P-value:5.67E-4 ID:SGTC_2495|Compound:cafestol|FD-Score:4.35|P-value:9.60E-6 ID:SGTC_2556|Compound:citropten|FD-Score:5.84|P-value:6.11E-9 ID:SGTC_2576|Compound:guaiol|FD-Score:-3.56|P-value:5.52E-4 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:3.35|P-value:4.46E-4 ID:SGTC_2668|Compound:2',4'-dihydroxychalcone|FD-Score:3.82|P-value:8.25E-5 ID:SGTC_2673|Compound:kobusone|FD-Score:3.41|P-value:3.66E-4 ID:SGTC_2714|Compound:st079313|FD-Score:-3.68|P-value:3.70E-4 ID:SGTC_2760|Compound:etidronate|FD-Score:4.09|P-value:2.82E-5 ID:SGTC_2761|Compound:levamisole|FD-Score:3.39|P-value:3.88E-4 ID:SGTC_2787|Compound:5284540|FD-Score:3.14|P-value:8.99E-4 ID:SGTC_2811|Compound:7967822|FD-Score:3.72|P-value:1.19E-4 ID:SGTC_2856|Compound:9022925|FD-Score:3.72|P-value:1.20E-4 ID:SGTC_2867|Compound:9039098|FD-Score:4.09|P-value:2.77E-5 ID:SGTC_2872|Compound:9044037|FD-Score:3.28|P-value:5.72E-4 ID:SGTC_2876|Compound:9059903|FD-Score:3.29|P-value:5.52E-4 ID:SGTC_2934|Compound:9036370|FD-Score:3.27|P-value:5.81E-4 ID:SGTC_2936|Compound:9038235|FD-Score:-5.50|P-value:1.62E-7 ID:SGTC_3031|Compound:9088762|FD-Score:3.96|P-value:4.72E-5 ID:SGTC_3049|Compound:9092223|FD-Score:5.49|P-value:4.18E-8 ID:SGTC_3078|Compound:9116413|FD-Score:4.48|P-value:5.47E-6 ID:SGTC_3104|Compound:9120930|FD-Score:4.85|P-value:9.96E-7 ID:SGTC_3114|Compound:9122766|FD-Score:3.61|P-value:1.77E-4 ID:SGTC_3146|Compound:9095609|FD-Score:3.16|P-value:8.32E-4 ID:SGTC_3264|Compound:9137442|FD-Score:4.94|P-value:6.44E-7 ID:SGTC_3280|Compound:9140961|FD-Score:4.15|P-value:2.22E-5 ID:SGTC_3293|Compound:9120939|FD-Score:3.54|P-value:2.29E-4 ID:SGTC_107|Compound:0358-0022|FD-Score:4.11|P-value:2.55E-5 ID:SGTC_125|Compound:0133-0007|FD-Score:-4.04|P-value:9.75E-5 ID:SGTC_136|Compound:0097-0015|FD-Score:3.26|P-value:6.10E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:-3.53|P-value:6.10E-4 ID:SGTC_334|Compound:1502-1024|FD-Score:-3.48|P-value:7.08E-4 ID:SGTC_520|Compound:3584-0023|FD-Score:-3.93|P-value:1.48E-4 ID:SGTC_644|Compound:1498-1197|FD-Score:-3.51|P-value:6.55E-4 ID:SGTC_646|Compound:4092-0839|FD-Score:-3.60|P-value:4.86E-4 ID:SGTC_659|Compound:k018-0002|FD-Score:-3.65|P-value:4.07E-4 ID:SGTC_663|Compound:1486-0733|FD-Score:3.96|P-value:4.72E-5 ID:SGTC_687|Compound:k029-0044|FD-Score:6.09|P-value:1.51E-9 ID:SGTC_689|Compound:0833-0039|FD-Score:4.20|P-value:1.82E-5 ID:SGTC_854|Compound:0422-0053|FD-Score:3.74|P-value:1.11E-4 ID:SGTC_963|Compound:1269-2853|FD-Score:-3.53|P-value:6.00E-4 ID:SGTC_1053|Compound:3366-3204|FD-Score:3.46|P-value:3.05E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:3.59|P-value:1.91E-4 ID:SGTC_1225|Compound:1216-0074|FD-Score:3.96|P-value:4.72E-5 ID:SGTC_1238|Compound:0333-0287|FD-Score:4.24|P-value:1.53E-5 ID:SGTC_1339|Compound:1486-1321|FD-Score:3.94|P-value:5.12E-5 ID:SGTC_1632|Compound:st005650|FD-Score:6.23|P-value:6.69E-10 ID:SGTC_1746|Compound:st038117|FD-Score:3.93|P-value:5.35E-5 ID:SGTC_1885|Compound:st057546|FD-Score:4.27|P-value:1.32E-5 ID:SGTC_1896|Compound:st058441|FD-Score:3.45|P-value:3.18E-4 ID:SGTC_1916|Compound:st067606|FD-Score:3.23|P-value:6.60E-4 ID:SGTC_1982|Compound:st072467|FD-Score:3.33|P-value:4.81E-4 ID:SGTC_1999|Compound:st074831|FD-Score:-3.38|P-value:9.87E-4 ID:SGTC_2068|Compound:5226020|FD-Score:3.18|P-value:7.84E-4 ID:SGTC_2092|Compound:5303694|FD-Score:3.53|P-value:2.36E-4 ID:SGTC_2124|Compound:5246320|FD-Score:-3.39|P-value:9.65E-4 ID:SGTC_2219|Compound:9098279|FD-Score:-3.51|P-value:6.56E-4 ID:SGTC_2224|Compound:6650123|FD-Score:3.89|P-value:6.17E-5 ID:SGTC_2256|Compound:7954252|FD-Score:3.34|P-value:4.65E-4 ID:SGTC_2275|Compound:7947463|FD-Score:5.23|P-value:1.58E-7 ID:SGTC_2276|Compound:7947513|FD-Score:3.92|P-value:5.52E-5 ID:SGTC_2295|Compound:7971645|FD-Score:-4.18|P-value:5.73E-5 ID:SGTC_2378|Compound:9074213|FD-Score:3.13|P-value:9.30E-4 ID:SGTC_2395|Compound:5646831|FD-Score:-3.42|P-value:8.76E-4 ID:SGTC_2484|Compound:5809818|FD-Score:3.28|P-value:5.67E-4 ID:SGTC_2495|Compound:cafestol|FD-Score:4.35|P-value:9.60E-6 ID:SGTC_2556|Compound:citropten|FD-Score:5.84|P-value:6.11E-9 ID:SGTC_2576|Compound:guaiol|FD-Score:-3.56|P-value:5.52E-4 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:3.35|P-value:4.46E-4 ID:SGTC_2668|Compound:2',4'-dihydroxychalcone|FD-Score:3.82|P-value:8.25E-5 ID:SGTC_2673|Compound:kobusone|FD-Score:3.41|P-value:3.66E-4 ID:SGTC_2714|Compound:st079313|FD-Score:-3.68|P-value:3.70E-4 ID:SGTC_2760|Compound:etidronate|FD-Score:4.09|P-value:2.82E-5 ID:SGTC_2761|Compound:levamisole|FD-Score:3.39|P-value:3.88E-4 ID:SGTC_2787|Compound:5284540|FD-Score:3.14|P-value:8.99E-4 ID:SGTC_2811|Compound:7967822|FD-Score:3.72|P-value:1.19E-4 ID:SGTC_2856|Compound:9022925|FD-Score:3.72|P-value:1.20E-4 ID:SGTC_2867|Compound:9039098|FD-Score:4.09|P-value:2.77E-5 ID:SGTC_2872|Compound:9044037|FD-Score:3.28|P-value:5.72E-4 ID:SGTC_2876|Compound:9059903|FD-Score:3.29|P-value:5.52E-4 ID:SGTC_2934|Compound:9036370|FD-Score:3.27|P-value:5.81E-4 ID:SGTC_2936|Compound:9038235|FD-Score:-5.50|P-value:1.62E-7 ID:SGTC_3031|Compound:9088762|FD-Score:3.96|P-value:4.72E-5 ID:SGTC_3049|Compound:9092223|FD-Score:5.49|P-value:4.18E-8 ID:SGTC_3078|Compound:9116413|FD-Score:4.48|P-value:5.47E-6 ID:SGTC_3104|Compound:9120930|FD-Score:4.85|P-value:9.96E-7 ID:SGTC_3114|Compound:9122766|FD-Score:3.61|P-value:1.77E-4 ID:SGTC_3146|Compound:9095609|FD-Score:3.16|P-value:8.32E-4 ID:SGTC_3264|Compound:9137442|FD-Score:4.94|P-value:6.44E-7 ID:SGTC_3280|Compound:9140961|FD-Score:4.15|P-value:2.22E-5 ID:SGTC_3293|Compound:9120939|FD-Score:3.54|P-value:2.29E-4

Top fitness defect scores for YBL069W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1632 st005650 6.23 90.0 µM 6.69E-10 3 2.40E-10
2 SGTC_687 k029-0044 6.09 34.9 µM 1.51E-9 PDR1 4 5.77E-10
3 SGTC_2556 citropten 5.84 84.6 µM 6.11E-9 5 2.59E-9
4 SGTC_3049 9092223 5.49 49.5 µM 4.18E-8 3 2.04E-8
5 SGTC_2275 7947463 5.23 200.0 µM 1.58E-7 iron homeostasis 19 8.47E-8
6 SGTC_3264 9137442 4.94 49.5 µM 6.44E-7 5 3.83E-7
7 SGTC_3104 9120930 4.85 49.5 µM 9.96E-7 3 6.10E-7
8 SGTC_3078 9116413 4.48 49.5 µM 5.47E-6 unfolded protein response 25 3.76E-6
9 SGTC_2495 cafestol 4.35 54.5 µM 9.60E-6 Golgi 19 6.85E-6
10 SGTC_1885 st057546 4.27 99.9 µM 1.32E-5 15 9.64E-6
11 SGTC_1238 0333-0287 4.24 48.8 µM 1.53E-5 Golgi 21 1.13E-5
12 SGTC_689 0833-0039 4.20 98.0 µM 1.82E-5 ergosterol depletion effects on membrane 30 1.36E-5
13 SGTC_3280 9140961 4.15 49.5 µM 2.22E-5 60S ribosome export 11 1.67E-5
14 SGTC_107 0358-0022 4.11 2.7 µM 2.55E-5 SWF1 & branched chain AA biosynthesis 25 1.94E-5
15 SGTC_2867 9039098 4.09 71.4 µM 2.77E-5 iron homeostasis 29 2.12E-5
16 SGTC_2760 etidronate 4.09 98.0 µM 2.82E-5 23 2.16E-5
17 SGTC_1225 1216-0074 3.96 20.6 µM 4.72E-5 22 3.73E-5
18 SGTC_3031 9088762 3.96 49.5 µM 4.72E-5 19 3.73E-5
19 SGTC_663 1486-0733 3.96 13.9 µM 4.72E-5 cell wall signaling 49 3.74E-5
20 SGTC_1339 1486-1321 3.94 22.7 µM 5.12E-5 ERG2 23 4.07E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.087 4.13E-7 YLR126C YLR126C hom Putative glutamine amidotransferase; has Aft1p-binding motif in the promoter; may be involved in copper and iron homeostasis; YLR126C is not an essential protein; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress
0.081 2.66E-6 YHR126C_p ANS1_p hom Putative GPI protein; transcription dependent upon Azf1p
0.079 5.04E-6 YBL104C SEA4 hom Subunit of the SEA (Seh1-associated) complex, a coatomer-related complex that associates dynamically with the vacuole; has an N-terminal beta-propeller fold and a C-terminal RING motif; promoter contains multiple GCN4 binding sites
0.076 9.95E-6 YLR145W RMP1 het Subunit of RNase MRP, which processes pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; unlike most subunits, not shared between RNase MRP and nuclear RNase P
0.072 3.36E-5 YBR194W AIM4 hom Protein proposed to be associated with the nuclear pore complex; null mutant is viable, displays elevated frequency of mitochondrial genome loss and is sensitive to freeze-thaw stress
0.069 6.84E-5 YOL125W TRM13 hom 2'-O-methyltransferase responsible for modification of tRNA at position 4; C-terminal domain has similarity to Rossmann-fold (RFM) superfamily of RNA methyltransferases
0.069 7.21E-5 YIL097W FYV10 hom Subunit of GID complex; involved in proteasome-dependent catabolite inactivation of gluconeogenic enzymes FBPase, PEPCK, and c-MDH; forms dimer with Rmd5p that is then recruited to GID Complex by Gid8p; contains a degenerate RING finger motif needed for GID complex ubiquitin ligase activity in vivo, as well as CTLH and CRA domains; plays role in anti-apoptosis; required for survival upon exposure to K1 killer toxin
0.067 1.14E-4 YDR441C APT2 hom Potential adenine phosphoribosyltransferase; encodes a protein with similarity to adenine phosphoribosyltransferase, but artificially expressed protein exhibits no enzymatic activity; APT2 has a paralog, APT1, that arose from the whole genome duplication
0.066 1.29E-4 YKR103W NFT1 hom Putative transporter of the multidrug resistance-associated protein (MRP) subfamily; adjacent ORFs YKR103W and YKR104W are merged in different strain backgrounds.
0.065 1.68E-4 YHR075C PPE1 hom Protein with carboxyl methyl esterase activity that may have a role in demethylation of the phosphoprotein phosphatase catalytic subunit; also identified as a small subunit mitochondrial ribosomal protein
0.065 1.80E-4 YEL045C_d YEL045C_d hom Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; deletion gives MMS sensitivity, growth defect under alkaline conditions, less than optimal growth upon citric acid stress
0.064 1.89E-4 YBR125C PTC4 hom Cytoplasmic type 2C protein phosphatase (PP2C); identified as a high-copy number suppressor of cnb1 mpk1 synthetic lethality; overexpression decreases high-osmolarity induced Hog1p phosphorylation and kinase activity
0.063 2.57E-4 YIL006W YIA6 hom Mitochondrial NAD+ transporter, involved in the transport of NAD+ into the mitochondria (see also YEA6); member of the mitochondrial carrier subfamily; disputed role as a pyruvate transporter; has putative mouse and human orthologs
0.061 4.18E-4 YNL051W COG5 hom Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
0.060 4.95E-4 YMR200W ROT1 het Molecular chaperone involved in protein folding in the ER; mutation causes defects in cell wall synthesis and in lysis of autophagic bodies, suppresses tor2 mutations, and is synthetically lethal with kar2-1 and with rot2 mutations; involved in N-linked glycosylation and O-mannosylation