YBL070C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YBL070C / YBL070C

Click on Significant Values for Screen Details ID:SGTC_119|Compound:0121-0043|FD-Score:4.37|P-value:1.19E-5 ID:SGTC_122|Compound:0236-0016|FD-Score:6.16|P-value:1.29E-9 ID:SGTC_268|Compound:camptothecin|FD-Score:3.53|P-value:3.16E-4 ID:SGTC_270|Compound:tamoxifen|FD-Score:-3.22|P-value:8.94E-4 ID:SGTC_283|Compound:0987-0079|FD-Score:-3.62|P-value:2.21E-4 ID:SGTC_421|Compound:streptovitacin|FD-Score:-5.73|P-value:1.35E-8 ID:SGTC_427|Compound:1354-0053|FD-Score:6.18|P-value:1.14E-9 ID:SGTC_428|Compound:3448-4153|FD-Score:-8.19|P-value:1.03E-15 ID:SGTC_439|Compound:amiodarone|FD-Score:-3.23|P-value:8.47E-4 ID:SGTC_545|Compound:4218-0007|FD-Score:5.95|P-value:4.31E-9 ID:SGTC_555|Compound:4296-0685|FD-Score:3.23|P-value:9.05E-4 ID:SGTC_560|Compound:2332-1943|FD-Score:3.51|P-value:3.43E-4 ID:SGTC_597|Compound:k018-0003|FD-Score:3.30|P-value:7.15E-4 ID:SGTC_624|Compound:k048-0052|FD-Score:3.24|P-value:8.79E-4 ID:SGTC_792|Compound:4534-1957|FD-Score:4.96|P-value:7.93E-7 ID:SGTC_853|Compound:0419-0306|FD-Score:3.82|P-value:1.11E-4 ID:SGTC_925|Compound:2064-1272|FD-Score:-3.95|P-value:6.29E-5 ID:SGTC_927|Compound:2425-1185|FD-Score:-3.61|P-value:2.29E-4 ID:SGTC_993|Compound:3909-8757|FD-Score:3.43|P-value:4.62E-4 ID:SGTC_1004|Compound:4084-0029|FD-Score:-3.50|P-value:3.39E-4 ID:SGTC_1124|Compound:fisetin|FD-Score:3.78|P-value:1.27E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:-3.77|P-value:1.27E-4 ID:SGTC_1535|Compound:tetrahydropapaveroline hydrobromide|FD-Score:-3.28|P-value:7.32E-4 ID:SGTC_1610|Compound:st001799|FD-Score:-4.21|P-value:2.26E-5 ID:SGTC_1648|Compound:st011736|FD-Score:3.28|P-value:7.49E-4 ID:SGTC_1683|Compound:st010134|FD-Score:3.85|P-value:9.71E-5 ID:SGTC_1684|Compound:st024538|FD-Score:3.47|P-value:3.96E-4 ID:SGTC_1701|Compound:st028638|FD-Score:4.54|P-value:5.66E-6 ID:SGTC_1705|Compound:st027868|FD-Score:-3.71|P-value:1.59E-4 ID:SGTC_1949|Compound:st076024|FD-Score:3.36|P-value:5.80E-4 ID:SGTC_1963|Compound:st076565|FD-Score:3.93|P-value:7.12E-5 ID:SGTC_2087|Compound:5276107|FD-Score:3.37|P-value:5.61E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:-3.87|P-value:8.71E-5 ID:SGTC_2750|Compound:bromebric acid|FD-Score:3.75|P-value:1.45E-4 ID:SGTC_2781|Compound:5567276|FD-Score:4.32|P-value:1.44E-5 ID:SGTC_3031|Compound:9088762|FD-Score:4.27|P-value:1.84E-5 ID:SGTC_3034|Compound:9090421|FD-Score:-3.45|P-value:4.11E-4 ID:SGTC_3183|Compound:9108214|FD-Score:-3.37|P-value:5.45E-4 ID:SGTC_3325|Compound:9138760|FD-Score:3.95|P-value:6.68E-5 ID:SGTC_119|Compound:0121-0043|FD-Score:4.37|P-value:1.19E-5 ID:SGTC_122|Compound:0236-0016|FD-Score:6.16|P-value:1.29E-9 ID:SGTC_268|Compound:camptothecin|FD-Score:3.53|P-value:3.16E-4 ID:SGTC_270|Compound:tamoxifen|FD-Score:-3.22|P-value:8.94E-4 ID:SGTC_283|Compound:0987-0079|FD-Score:-3.62|P-value:2.21E-4 ID:SGTC_421|Compound:streptovitacin|FD-Score:-5.73|P-value:1.35E-8 ID:SGTC_427|Compound:1354-0053|FD-Score:6.18|P-value:1.14E-9 ID:SGTC_428|Compound:3448-4153|FD-Score:-8.19|P-value:1.03E-15 ID:SGTC_439|Compound:amiodarone|FD-Score:-3.23|P-value:8.47E-4 ID:SGTC_545|Compound:4218-0007|FD-Score:5.95|P-value:4.31E-9 ID:SGTC_555|Compound:4296-0685|FD-Score:3.23|P-value:9.05E-4 ID:SGTC_560|Compound:2332-1943|FD-Score:3.51|P-value:3.43E-4 ID:SGTC_597|Compound:k018-0003|FD-Score:3.30|P-value:7.15E-4 ID:SGTC_624|Compound:k048-0052|FD-Score:3.24|P-value:8.79E-4 ID:SGTC_792|Compound:4534-1957|FD-Score:4.96|P-value:7.93E-7 ID:SGTC_853|Compound:0419-0306|FD-Score:3.82|P-value:1.11E-4 ID:SGTC_925|Compound:2064-1272|FD-Score:-3.95|P-value:6.29E-5 ID:SGTC_927|Compound:2425-1185|FD-Score:-3.61|P-value:2.29E-4 ID:SGTC_993|Compound:3909-8757|FD-Score:3.43|P-value:4.62E-4 ID:SGTC_1004|Compound:4084-0029|FD-Score:-3.50|P-value:3.39E-4 ID:SGTC_1124|Compound:fisetin|FD-Score:3.78|P-value:1.27E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:-3.77|P-value:1.27E-4 ID:SGTC_1535|Compound:tetrahydropapaveroline hydrobromide|FD-Score:-3.28|P-value:7.32E-4 ID:SGTC_1610|Compound:st001799|FD-Score:-4.21|P-value:2.26E-5 ID:SGTC_1648|Compound:st011736|FD-Score:3.28|P-value:7.49E-4 ID:SGTC_1683|Compound:st010134|FD-Score:3.85|P-value:9.71E-5 ID:SGTC_1684|Compound:st024538|FD-Score:3.47|P-value:3.96E-4 ID:SGTC_1701|Compound:st028638|FD-Score:4.54|P-value:5.66E-6 ID:SGTC_1705|Compound:st027868|FD-Score:-3.71|P-value:1.59E-4 ID:SGTC_1949|Compound:st076024|FD-Score:3.36|P-value:5.80E-4 ID:SGTC_1963|Compound:st076565|FD-Score:3.93|P-value:7.12E-5 ID:SGTC_2087|Compound:5276107|FD-Score:3.37|P-value:5.61E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:-3.87|P-value:8.71E-5 ID:SGTC_2750|Compound:bromebric acid|FD-Score:3.75|P-value:1.45E-4 ID:SGTC_2781|Compound:5567276|FD-Score:4.32|P-value:1.44E-5 ID:SGTC_3031|Compound:9088762|FD-Score:4.27|P-value:1.84E-5 ID:SGTC_3034|Compound:9090421|FD-Score:-3.45|P-value:4.11E-4 ID:SGTC_3183|Compound:9108214|FD-Score:-3.37|P-value:5.45E-4 ID:SGTC_3325|Compound:9138760|FD-Score:3.95|P-value:6.68E-5

Top fitness defect scores for YBL070C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_427 1354-0053 6.18 47.3 µM 1.14E-9 2 3.29E-10
2 SGTC_122 0236-0016 6.16 402.4 µM 1.29E-9 RNA processing & uracil transport 8 3.75E-10
3 SGTC_545 4218-0007 5.95 221.0 µM 4.31E-9 6 1.35E-9
4 SGTC_792 4534-1957 4.96 155.0 µM 7.93E-7 17 3.50E-7
5 SGTC_1701 st028638 4.54 40.4 µM 5.66E-6 8 2.83E-6
6 SGTC_119 0121-0043 4.37 24.8 µM 1.19E-5 mitochondrial stress 83 6.27E-6
7 SGTC_2781 5567276 4.32 71.4 µM 1.44E-5 37 7.66E-6
8 SGTC_3031 9088762 4.27 49.5 µM 1.84E-5 11 9.92E-6
9 SGTC_3325 9138760 3.95 55.2 µM 6.68E-5 Golgi 26 3.92E-5
10 SGTC_1963 st076565 3.93 50.3 µM 7.12E-5 10 4.19E-5
11 SGTC_1683 st010134 3.85 710.0 nM 9.71E-5 32 5.83E-5
12 SGTC_853 0419-0306 3.82 21.0 µM 1.11E-4 16 6.70E-5
13 SGTC_1124 fisetin 3.78 1.2 µM 1.27E-4 42 7.74E-5
14 SGTC_2750 bromebric acid 3.75 70.2 µM 1.45E-4 37 8.93E-5
15 SGTC_268 camptothecin 3.53 39.6 µM 3.16E-4 DNA damage response 92 2.04E-4
16 SGTC_560 2332-1943 3.51 155.0 µM 3.43E-4 18 2.23E-4
17 SGTC_1684 st024538 3.47 14.6 µM 3.96E-4 12 2.60E-4
18 SGTC_993 3909-8757 3.43 62.7 µM 4.62E-4 40 3.06E-4
19 SGTC_2087 5276107 3.37 200.0 µM 5.61E-4 30 3.76E-4
20 SGTC_1949 st076024 3.36 69.1 µM 5.80E-4 48 3.90E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.137 1.49E-15 YJL051W IRC8 hom Bud tip localized protein of unknown function; mRNA is targeted to the bud by a She2p dependent transport system; mRNA is cell cycle regulated via Fkh2p, peaking in G2/M phase; null mutant displays increased levels of spontaneous Rad52p foc
0.107 4.27E-10 YGR231C PHB2 hom Subunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation
0.106 7.88E-10 YDR311W TFB1 het Subunit of TFIIH and nucleotide excision repair factor 3 complexes, required for nucleotide excision repair, target for transcriptional activators
0.092 1.07E-7 YFL053W DAK2 hom Dihydroxyacetone kinase, required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation
0.089 2.60E-7 YNR029C_p YNR029C_p hom Putative protein of unknown function, deletion confers reduced fitness in saline
0.088 2.89E-7 YNR014W_p YNR014W_p hom Putative protein of unknown function; expression is cell-cycle regulated, Azf1p-dependent, and heat-inducible; YNR014W has a paralog, YMR206W, that arose from the whole genome duplication
0.088 3.02E-7 YGR132C PHB1 hom Subunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation
0.080 3.97E-6 YLR325C RPL38 hom Ribosomal 60S subunit protein L38; homologous to mammalian ribosomal protein L38, no bacterial homolog
0.079 4.16E-6 YFR017C IGD1 hom Cytoplasmic protein that inhibits Gdb1p glycogen debranching activity; required for normal intracellular accumulation of glycogen; phosphorylated in vivo; expression increases during wine fermentation; protein abundance increases in response to DNA replication stress; IGD1 has a paralog, YOL024W, that arose from the whole genome duplication
0.076 1.06E-5 YIR020C_p YIR020C_p hom Protein of unknown function; mRNA identified as translated by ribosome profiling data
0.073 2.15E-5 YGL051W MST27 hom Putative integral membrane protein, involved in vesicle formation; forms complex with Mst28p; member of DUP240 gene family; binds COPI and COPII vesicles
0.072 3.45E-5 YGR038W ORM1 hom Evolutionarily conserved protein, similar to Orm2p, required for resistance to agents that induce unfolded protein response; Orm1p and Orm2p together control membrane biogenesis by coordinating lipid homeostasis with protein quality control
0.070 5.00E-5 YOR378W_p YOR378W_p hom Putative paralog of ATR1, but not required for boron tolerance; member of the DHA2 family of drug:H+ antiporters; YOR378W is not an essential gene
0.069 6.68E-5 YMR299C DYN3 hom Dynein light intermediate chain (LIC); localizes with dynein, null mutant is defective in nuclear migration
0.068 7.20E-5 YDR411C DFM1 hom Endoplasmic reticulum (ER) localized protein involved in ER-associated protein degradation (ERAD), ER stress and homeostasis; interacts with components of ERAD-L and ERAD-C and Cdc48p; derlin-like family member similar to Der1p