YBL071C_d

Dubious open reading frame, predicted protein contains a peroxisomal targeting signal

Zygosity: Homozygous strain
fixedexpanded
Profile for YBL071C / YBL071C

Click on Significant Values for Screen Details ID:SGTC_69|Compound:0096-0274|FD-Score:7.43|P-value:2.11E-13 ID:SGTC_78|Compound:0336-0123|FD-Score:5.11|P-value:3.00E-7 ID:SGTC_221|Compound:trifluoperazine|FD-Score:3.37|P-value:4.72E-4 ID:SGTC_251|Compound:melphalan|FD-Score:3.25|P-value:7.15E-4 ID:SGTC_278|Compound:4092-0821|FD-Score:3.19|P-value:8.75E-4 ID:SGTC_419|Compound:nsc-638432|FD-Score:4.74|P-value:1.78E-6 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.73|P-value:1.71E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:-3.40|P-value:5.53E-4 ID:SGTC_544|Compound:k015-0020|FD-Score:3.21|P-value:8.26E-4 ID:SGTC_751|Compound:0833-0568|FD-Score:3.83|P-value:8.83E-5 ID:SGTC_952|Compound:1185-0122|FD-Score:3.69|P-value:1.49E-4 ID:SGTC_1027|Compound:k015-0025|FD-Score:8.39|P-value:1.41E-16 ID:SGTC_1032|Compound:k061-1018|FD-Score:3.42|P-value:3.93E-4 ID:SGTC_1040|Compound:k898-0338|FD-Score:-4.25|P-value:2.19E-5 ID:SGTC_1044|Compound:1222-0021|FD-Score:-6.15|P-value:1.52E-9 ID:SGTC_1048|Compound:3161-0300|FD-Score:3.21|P-value:8.08E-4 ID:SGTC_1049|Compound:3226-0134|FD-Score:3.96|P-value:5.30E-5 ID:SGTC_1081|Compound:sertraline|FD-Score:3.82|P-value:8.96E-5 ID:SGTC_1085|Compound:doxorubicin|FD-Score:5.36|P-value:8.22E-8 ID:SGTC_1190|Compound:1486-1332|FD-Score:3.81|P-value:9.54E-5 ID:SGTC_1209|Compound:2323-2347|FD-Score:-3.36|P-value:6.22E-4 ID:SGTC_1234|Compound:0326-0494|FD-Score:4.24|P-value:1.63E-5 ID:SGTC_1246|Compound:0422-0085|FD-Score:3.36|P-value:4.84E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:3.34|P-value:5.27E-4 ID:SGTC_1381|Compound:2324-0066|FD-Score:3.63|P-value:1.84E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:4.46|P-value:6.33E-6 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:-4.24|P-value:2.25E-5 ID:SGTC_1642|Compound:st009582|FD-Score:4.10|P-value:2.99E-5 ID:SGTC_1683|Compound:st010134|FD-Score:6.29|P-value:4.02E-10 ID:SGTC_1844|Compound:rapamycin|FD-Score:8.48|P-value:6.94E-17 ID:SGTC_1973|Compound:st070275|FD-Score:3.23|P-value:7.62E-4 ID:SGTC_2061|Compound:5245884|FD-Score:3.78|P-value:1.07E-4 ID:SGTC_2088|Compound:5278280|FD-Score:4.19|P-value:2.04E-5 ID:SGTC_2089|Compound:5281248|FD-Score:3.60|P-value:2.08E-4 ID:SGTC_2156|Compound:5649887|FD-Score:3.51|P-value:2.87E-4 ID:SGTC_2207|Compound:7258803|FD-Score:-3.23|P-value:9.76E-4 ID:SGTC_2457|Compound:5731572|FD-Score:4.17|P-value:2.25E-5 ID:SGTC_2476|Compound:5806916|FD-Score:3.15|P-value:9.81E-4 ID:SGTC_2479|Compound:5617353|FD-Score:5.41|P-value:6.26E-8 ID:SGTC_2481|Compound:5478948|FD-Score:3.30|P-value:5.99E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:3.74|P-value:1.26E-4 ID:SGTC_2592|Compound:piperlongumine|FD-Score:3.30|P-value:6.09E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:3.47|P-value:3.37E-4 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:-3.37|P-value:6.13E-4 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:3.47|P-value:3.33E-4 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:3.33|P-value:5.41E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:5.41|P-value:6.43E-8 ID:SGTC_2737|Compound:bleomycin|FD-Score:-3.23|P-value:9.71E-4 ID:SGTC_2755|Compound:lomerizine|FD-Score:3.30|P-value:5.93E-4 ID:SGTC_2860|Compound:9025725|FD-Score:3.28|P-value:6.43E-4 ID:SGTC_2873|Compound:9040596|FD-Score:4.01|P-value:4.22E-5 ID:SGTC_2938|Compound:9059746|FD-Score:4.64|P-value:2.85E-6 ID:SGTC_2982|Compound:9019404|FD-Score:3.40|P-value:4.28E-4 ID:SGTC_3008|Compound:9078912|FD-Score:4.22|P-value:1.80E-5 ID:SGTC_3100|Compound:9120536|FD-Score:-3.52|P-value:3.59E-4 ID:SGTC_3124|Compound:9127567|FD-Score:3.47|P-value:3.32E-4 ID:SGTC_3127|Compound:9126946|FD-Score:3.17|P-value:9.40E-4 ID:SGTC_3131|Compound:9127911|FD-Score:6.87|P-value:1.04E-11 ID:SGTC_3218|Compound:9131285|FD-Score:3.60|P-value:2.07E-4 ID:SGTC_3303|Compound:9125618|FD-Score:-3.32|P-value:7.25E-4 ID:SGTC_3311|Compound:9131146|FD-Score:-4.11|P-value:3.85E-5 ID:SGTC_3312|Compound:9133330|FD-Score:-3.85|P-value:1.08E-4 ID:SGTC_3337|Compound:9144342|FD-Score:4.70|P-value:2.13E-6 ID:SGTC_3347|Compound:9188721|FD-Score:3.96|P-value:5.19E-5 ID:SGTC_69|Compound:0096-0274|FD-Score:7.43|P-value:2.11E-13 ID:SGTC_78|Compound:0336-0123|FD-Score:5.11|P-value:3.00E-7 ID:SGTC_221|Compound:trifluoperazine|FD-Score:3.37|P-value:4.72E-4 ID:SGTC_251|Compound:melphalan|FD-Score:3.25|P-value:7.15E-4 ID:SGTC_278|Compound:4092-0821|FD-Score:3.19|P-value:8.75E-4 ID:SGTC_419|Compound:nsc-638432|FD-Score:4.74|P-value:1.78E-6 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.73|P-value:1.71E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:-3.40|P-value:5.53E-4 ID:SGTC_544|Compound:k015-0020|FD-Score:3.21|P-value:8.26E-4 ID:SGTC_751|Compound:0833-0568|FD-Score:3.83|P-value:8.83E-5 ID:SGTC_952|Compound:1185-0122|FD-Score:3.69|P-value:1.49E-4 ID:SGTC_1027|Compound:k015-0025|FD-Score:8.39|P-value:1.41E-16 ID:SGTC_1032|Compound:k061-1018|FD-Score:3.42|P-value:3.93E-4 ID:SGTC_1040|Compound:k898-0338|FD-Score:-4.25|P-value:2.19E-5 ID:SGTC_1044|Compound:1222-0021|FD-Score:-6.15|P-value:1.52E-9 ID:SGTC_1048|Compound:3161-0300|FD-Score:3.21|P-value:8.08E-4 ID:SGTC_1049|Compound:3226-0134|FD-Score:3.96|P-value:5.30E-5 ID:SGTC_1081|Compound:sertraline|FD-Score:3.82|P-value:8.96E-5 ID:SGTC_1085|Compound:doxorubicin|FD-Score:5.36|P-value:8.22E-8 ID:SGTC_1190|Compound:1486-1332|FD-Score:3.81|P-value:9.54E-5 ID:SGTC_1209|Compound:2323-2347|FD-Score:-3.36|P-value:6.22E-4 ID:SGTC_1234|Compound:0326-0494|FD-Score:4.24|P-value:1.63E-5 ID:SGTC_1246|Compound:0422-0085|FD-Score:3.36|P-value:4.84E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:3.34|P-value:5.27E-4 ID:SGTC_1381|Compound:2324-0066|FD-Score:3.63|P-value:1.84E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:4.46|P-value:6.33E-6 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:-4.24|P-value:2.25E-5 ID:SGTC_1642|Compound:st009582|FD-Score:4.10|P-value:2.99E-5 ID:SGTC_1683|Compound:st010134|FD-Score:6.29|P-value:4.02E-10 ID:SGTC_1844|Compound:rapamycin|FD-Score:8.48|P-value:6.94E-17 ID:SGTC_1973|Compound:st070275|FD-Score:3.23|P-value:7.62E-4 ID:SGTC_2061|Compound:5245884|FD-Score:3.78|P-value:1.07E-4 ID:SGTC_2088|Compound:5278280|FD-Score:4.19|P-value:2.04E-5 ID:SGTC_2089|Compound:5281248|FD-Score:3.60|P-value:2.08E-4 ID:SGTC_2156|Compound:5649887|FD-Score:3.51|P-value:2.87E-4 ID:SGTC_2207|Compound:7258803|FD-Score:-3.23|P-value:9.76E-4 ID:SGTC_2457|Compound:5731572|FD-Score:4.17|P-value:2.25E-5 ID:SGTC_2476|Compound:5806916|FD-Score:3.15|P-value:9.81E-4 ID:SGTC_2479|Compound:5617353|FD-Score:5.41|P-value:6.26E-8 ID:SGTC_2481|Compound:5478948|FD-Score:3.30|P-value:5.99E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:3.74|P-value:1.26E-4 ID:SGTC_2592|Compound:piperlongumine|FD-Score:3.30|P-value:6.09E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:3.47|P-value:3.37E-4 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:-3.37|P-value:6.13E-4 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:3.47|P-value:3.33E-4 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:3.33|P-value:5.41E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:5.41|P-value:6.43E-8 ID:SGTC_2737|Compound:bleomycin|FD-Score:-3.23|P-value:9.71E-4 ID:SGTC_2755|Compound:lomerizine|FD-Score:3.30|P-value:5.93E-4 ID:SGTC_2860|Compound:9025725|FD-Score:3.28|P-value:6.43E-4 ID:SGTC_2873|Compound:9040596|FD-Score:4.01|P-value:4.22E-5 ID:SGTC_2938|Compound:9059746|FD-Score:4.64|P-value:2.85E-6 ID:SGTC_2982|Compound:9019404|FD-Score:3.40|P-value:4.28E-4 ID:SGTC_3008|Compound:9078912|FD-Score:4.22|P-value:1.80E-5 ID:SGTC_3100|Compound:9120536|FD-Score:-3.52|P-value:3.59E-4 ID:SGTC_3124|Compound:9127567|FD-Score:3.47|P-value:3.32E-4 ID:SGTC_3127|Compound:9126946|FD-Score:3.17|P-value:9.40E-4 ID:SGTC_3131|Compound:9127911|FD-Score:6.87|P-value:1.04E-11 ID:SGTC_3218|Compound:9131285|FD-Score:3.60|P-value:2.07E-4 ID:SGTC_3303|Compound:9125618|FD-Score:-3.32|P-value:7.25E-4 ID:SGTC_3311|Compound:9131146|FD-Score:-4.11|P-value:3.85E-5 ID:SGTC_3312|Compound:9133330|FD-Score:-3.85|P-value:1.08E-4 ID:SGTC_3337|Compound:9144342|FD-Score:4.70|P-value:2.13E-6 ID:SGTC_3347|Compound:9188721|FD-Score:3.96|P-value:5.19E-5

Top fitness defect scores for YBL071C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1844 rapamycin 8.48 4.0 nM 6.94E-17 49 1.12E-17
2 SGTC_1027 k015-0025 8.39 8.7 µM 1.41E-16 1 2.38E-17
3 SGTC_69 0096-0274 7.43 206.7 µM 2.11E-13 mitochondrial processes 5 5.34E-14
4 SGTC_3131 9127911 6.87 49.5 µM 1.04E-11 2 3.28E-12
5 SGTC_1683 st010134 6.29 710.0 nM 4.02E-10 4 1.54E-10
6 SGTC_2479 5617353 5.41 43.9 µM 6.26E-8 11 3.15E-8
7 SGTC_2679 rapamycin 5.41 1.0 nM 6.43E-8 90 3.24E-8
8 SGTC_1085 doxorubicin 5.36 7.7 µM 8.22E-8 anthracycline transcription coupled DNA repair 1 4.20E-8
9 SGTC_78 0336-0123 5.11 156.8 µM 3.00E-7 11 1.64E-7
10 SGTC_419 nsc-638432 4.74 893.0 µM 1.78E-6 DNA damage response 4 1.07E-6
11 SGTC_3337 9144342 4.70 33.5 µM 2.13E-6 18 1.29E-6
12 SGTC_2938 9059746 4.64 27.3 µM 2.85E-6 fatty acid desaturase (OLE1) 27 1.76E-6
13 SGTC_1459 k035-0031 4.46 35.7 µM 6.33E-6 DNA intercalators 15 4.06E-6
14 SGTC_1234 0326-0494 4.24 15.5 µM 1.63E-5 10 1.10E-5
15 SGTC_3008 9078912 4.22 71.4 µM 1.80E-5 10 1.21E-5
16 SGTC_2088 5278280 4.19 127.4 µM 2.04E-5 18 1.39E-5
17 SGTC_2457 5731572 4.17 11.7 µM 2.25E-5 15 1.53E-5
18 SGTC_1642 st009582 4.10 77.7 µM 2.99E-5 RPP1 & pyrimidine depletion 12 2.07E-5
19 SGTC_2873 9040596 4.01 71.4 µM 4.22E-5 44 2.98E-5
20 SGTC_3347 9188721 3.96 44.7 µM 5.19E-5 23 3.70E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.214 4.92E-36 YKL203C TOR2 het PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis; TOR2 has a paralog, TOR1, that arose from the whole genome duplication
0.198 4.93E-31 YJR066W TOR1 hom PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis; TOR1 has a paralog, TOR2, that arose from the whole genome duplication
0.193 2.28E-29 YML121W GTR1 hom Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB
0.180 7.14E-26 YHR187W IKI1 hom Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; iki1 mutations confer resistance to the K. lactis toxin zymocin
0.175 1.79E-24 YOR274W MOD5 hom Delta 2-isopentenyl pyrophosphate:tRNA isopentenyl transferase; required for biosynthesis of the modified base isopentenyladenosine in mitochondrial and cytoplasmic tRNAs; gene is nuclear and encodes two isozymic forms; converts to a prion form, and prion conversion contributes to azole antifungal resistance by upregulating ergosterol biosynthesis
0.167 2.24E-22 YLR114C AVL9 hom Conserved protein involved in exocytic transport from the Golgi; mutation is synthetically lethal with apl2 vps1 double mutation; member of a protein superfamily with orthologs in diverse organisms; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.165 7.92E-22 YGL211W NCS6 hom Protein required for thiolation of the uridine at the wobble position of Gln, Lys, and Glu tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae
0.162 2.89E-21 YLR384C IKI3 hom Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; maintains structural integrity of Elongator; homolog of human IKAP, mutations in which cause familial dysautonomia (FD)
0.153 6.53E-19 YKL110C KTI12 hom Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p
0.152 7.52E-19 YHR186C KOG1 het Subunit of TORC1, a rapamycin-sensitive complex involved in growth control that contains Tor1p or Tor2p, Lst8p and Tco89p; contains four HEAT repeats and seven WD-40 repeats; may act as a scaffold protein to couple TOR and its effectors
0.150 1.98E-18 YGR163W GTR2 hom Putative GTP binding protein that negatively regulates Ran/Tc4 GTPase cycle; activates transcription; subunit of EGO and GSE complexes; required for sorting of Gap1p; localizes to cytoplasm and to chromatin; homolog of human RagC and RagD
0.148 6.03E-18 YNL119W NCS2 hom Protein required for thiolation of the uridine at the wobble position of Lys(UUU) and Glu(UUC) tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae
0.143 6.49E-17 YGR200C ELP2 hom Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; target of Kluyveromyces lactis zymocin
0.136 2.57E-15 YHR111W UBA4 hom Protein that activates Urm1p before its conjugation to proteins (urmylation); also acts in thiolation of the wobble base of cytoplasmic tRNAs by adenylating and then thiolating Urm1p; receives sulfur from Tum1p
0.135 4.33E-15 YFL024C EPL1 het Subunit of NuA4, an essential histone H4/H2A acetyltransferase complex; conserved region at N-terminus is essential for interaction with the NPC (nucleosome core particle); required for autophagy; homologous to Drosophila Enhancer of Polycomb