YBL071C-B_p

Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching

Zygosity: Homozygous strain
fixedexpanded
Profile for YBL071C-B / YBL071C-B

Click on Significant Values for Screen Details ID:SGTC_118|Compound:0083-0097|FD-Score:5.04|P-value:1.05E-6 ID:SGTC_176|Compound:1486-1328|FD-Score:3.96|P-value:9.54E-5 ID:SGTC_183|Compound:3914-0051|FD-Score:-4.07|P-value:5.93E-5 ID:SGTC_309|Compound:k408-0051|FD-Score:3.77|P-value:1.96E-4 ID:SGTC_394|Compound:menadione|FD-Score:-3.86|P-value:1.28E-4 ID:SGTC_398|Compound:bronopol|FD-Score:-3.42|P-value:5.95E-4 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:-3.28|P-value:9.49E-4 ID:SGTC_408|Compound:cantharidin|FD-Score:4.10|P-value:5.69E-5 ID:SGTC_431|Compound:k089-0097|FD-Score:-3.97|P-value:8.78E-5 ID:SGTC_450|Compound:aminopyrene|FD-Score:5.61|P-value:6.22E-8 ID:SGTC_625|Compound:k213-0058|FD-Score:3.61|P-value:3.40E-4 ID:SGTC_626|Compound:0214-0009|FD-Score:-3.44|P-value:5.62E-4 ID:SGTC_679|Compound:0422-0091|FD-Score:3.75|P-value:2.10E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:4.58|P-value:7.92E-6 ID:SGTC_810|Compound:3825-7150|FD-Score:-3.87|P-value:1.26E-4 ID:SGTC_936|Compound:3005-4620|FD-Score:3.47|P-value:5.45E-4 ID:SGTC_961|Compound:1252-1571|FD-Score:3.37|P-value:7.54E-4 ID:SGTC_991|Compound:3996-0057|FD-Score:4.55|P-value:9.05E-6 ID:SGTC_1007|Compound:4101-0031|FD-Score:-3.32|P-value:8.36E-4 ID:SGTC_1009|Compound:4106-0057|FD-Score:-3.42|P-value:5.97E-4 ID:SGTC_1055|Compound:3448-0672|FD-Score:-4.57|P-value:7.64E-6 ID:SGTC_1056|Compound:3448-1962|FD-Score:4.94|P-value:1.67E-6 ID:SGTC_1057|Compound:3448-5381|FD-Score:-3.66|P-value:2.63E-4 ID:SGTC_1060|Compound:3448-7350|FD-Score:-4.79|P-value:2.95E-6 ID:SGTC_1230|Compound:0170-0365|FD-Score:-4.18|P-value:3.88E-5 ID:SGTC_1249|Compound:0481-0015|FD-Score:5.44|P-value:1.50E-7 ID:SGTC_1252|Compound:0493-0875|FD-Score:4.36|P-value:2.01E-5 ID:SGTC_1315|Compound:1237-0019|FD-Score:-3.81|P-value:1.57E-4 ID:SGTC_1498|Compound:4478-3555|FD-Score:-3.43|P-value:5.92E-4 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:3.53|P-value:4.54E-4 ID:SGTC_1728|Compound:st035614|FD-Score:5.05|P-value:9.77E-7 ID:SGTC_1781|Compound:st038725|FD-Score:4.61|P-value:6.98E-6 ID:SGTC_1833|Compound:st055984|FD-Score:-3.79|P-value:1.65E-4 ID:SGTC_1920|Compound:st075728|FD-Score:5.49|P-value:1.20E-7 ID:SGTC_1935|Compound:st074532|FD-Score:3.79|P-value:1.81E-4 ID:SGTC_1954|Compound:st077032|FD-Score:3.52|P-value:4.58E-4 ID:SGTC_1981|Compound:st071826|FD-Score:3.86|P-value:1.40E-4 ID:SGTC_1989|Compound:st071868|FD-Score:3.72|P-value:2.33E-4 ID:SGTC_1991|Compound:st073000|FD-Score:3.62|P-value:3.35E-4 ID:SGTC_1998|Compound:st075797|FD-Score:4.40|P-value:1.70E-5 ID:SGTC_2071|Compound:5230951|FD-Score:3.78|P-value:1.85E-4 ID:SGTC_2073|Compound:5212005|FD-Score:-3.63|P-value:2.99E-4 ID:SGTC_2125|Compound:5246583|FD-Score:5.86|P-value:1.70E-8 ID:SGTC_2129|Compound:girgensonine|FD-Score:3.33|P-value:8.66E-4 ID:SGTC_2142|Compound:5622915|FD-Score:3.79|P-value:1.78E-4 ID:SGTC_2288|Compound:7946289|FD-Score:3.98|P-value:8.82E-5 ID:SGTC_2303|Compound:7774051|FD-Score:-3.29|P-value:9.13E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:4.18|P-value:4.13E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.94|P-value:1.62E-6 ID:SGTC_2724|Compound:maprotiline|FD-Score:-4.61|P-value:6.51E-6 ID:SGTC_2729|Compound:fluphenazine|FD-Score:3.31|P-value:9.36E-4 ID:SGTC_2766|Compound:oltipraz|FD-Score:-3.63|P-value:2.95E-4 ID:SGTC_2782|Compound:7736369|FD-Score:3.43|P-value:6.16E-4 ID:SGTC_2795|Compound:7780010|FD-Score:3.42|P-value:6.57E-4 ID:SGTC_2799|Compound:7812892|FD-Score:-3.47|P-value:5.07E-4 ID:SGTC_2802|Compound:7925815|FD-Score:4.95|P-value:1.58E-6 ID:SGTC_2803|Compound:7707263|FD-Score:3.30|P-value:9.43E-4 ID:SGTC_2832|Compound:7992762|FD-Score:4.04|P-value:7.15E-5 ID:SGTC_2834|Compound:9001755|FD-Score:3.89|P-value:1.25E-4 ID:SGTC_2925|Compound:9010536|FD-Score:-4.11|P-value:5.09E-5 ID:SGTC_2995|Compound:9067767|FD-Score:3.60|P-value:3.58E-4 ID:SGTC_2998|Compound:9066762|FD-Score:-3.74|P-value:1.98E-4 ID:SGTC_3062|Compound:9077494|FD-Score:-3.40|P-value:6.36E-4 ID:SGTC_3219|Compound:9131112|FD-Score:-3.71|P-value:2.26E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:5.04|P-value:1.05E-6 ID:SGTC_176|Compound:1486-1328|FD-Score:3.96|P-value:9.54E-5 ID:SGTC_183|Compound:3914-0051|FD-Score:-4.07|P-value:5.93E-5 ID:SGTC_309|Compound:k408-0051|FD-Score:3.77|P-value:1.96E-4 ID:SGTC_394|Compound:menadione|FD-Score:-3.86|P-value:1.28E-4 ID:SGTC_398|Compound:bronopol|FD-Score:-3.42|P-value:5.95E-4 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:-3.28|P-value:9.49E-4 ID:SGTC_408|Compound:cantharidin|FD-Score:4.10|P-value:5.69E-5 ID:SGTC_431|Compound:k089-0097|FD-Score:-3.97|P-value:8.78E-5 ID:SGTC_450|Compound:aminopyrene|FD-Score:5.61|P-value:6.22E-8 ID:SGTC_625|Compound:k213-0058|FD-Score:3.61|P-value:3.40E-4 ID:SGTC_626|Compound:0214-0009|FD-Score:-3.44|P-value:5.62E-4 ID:SGTC_679|Compound:0422-0091|FD-Score:3.75|P-value:2.10E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:4.58|P-value:7.92E-6 ID:SGTC_810|Compound:3825-7150|FD-Score:-3.87|P-value:1.26E-4 ID:SGTC_936|Compound:3005-4620|FD-Score:3.47|P-value:5.45E-4 ID:SGTC_961|Compound:1252-1571|FD-Score:3.37|P-value:7.54E-4 ID:SGTC_991|Compound:3996-0057|FD-Score:4.55|P-value:9.05E-6 ID:SGTC_1007|Compound:4101-0031|FD-Score:-3.32|P-value:8.36E-4 ID:SGTC_1009|Compound:4106-0057|FD-Score:-3.42|P-value:5.97E-4 ID:SGTC_1055|Compound:3448-0672|FD-Score:-4.57|P-value:7.64E-6 ID:SGTC_1056|Compound:3448-1962|FD-Score:4.94|P-value:1.67E-6 ID:SGTC_1057|Compound:3448-5381|FD-Score:-3.66|P-value:2.63E-4 ID:SGTC_1060|Compound:3448-7350|FD-Score:-4.79|P-value:2.95E-6 ID:SGTC_1230|Compound:0170-0365|FD-Score:-4.18|P-value:3.88E-5 ID:SGTC_1249|Compound:0481-0015|FD-Score:5.44|P-value:1.50E-7 ID:SGTC_1252|Compound:0493-0875|FD-Score:4.36|P-value:2.01E-5 ID:SGTC_1315|Compound:1237-0019|FD-Score:-3.81|P-value:1.57E-4 ID:SGTC_1498|Compound:4478-3555|FD-Score:-3.43|P-value:5.92E-4 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:3.53|P-value:4.54E-4 ID:SGTC_1728|Compound:st035614|FD-Score:5.05|P-value:9.77E-7 ID:SGTC_1781|Compound:st038725|FD-Score:4.61|P-value:6.98E-6 ID:SGTC_1833|Compound:st055984|FD-Score:-3.79|P-value:1.65E-4 ID:SGTC_1920|Compound:st075728|FD-Score:5.49|P-value:1.20E-7 ID:SGTC_1935|Compound:st074532|FD-Score:3.79|P-value:1.81E-4 ID:SGTC_1954|Compound:st077032|FD-Score:3.52|P-value:4.58E-4 ID:SGTC_1981|Compound:st071826|FD-Score:3.86|P-value:1.40E-4 ID:SGTC_1989|Compound:st071868|FD-Score:3.72|P-value:2.33E-4 ID:SGTC_1991|Compound:st073000|FD-Score:3.62|P-value:3.35E-4 ID:SGTC_1998|Compound:st075797|FD-Score:4.40|P-value:1.70E-5 ID:SGTC_2071|Compound:5230951|FD-Score:3.78|P-value:1.85E-4 ID:SGTC_2073|Compound:5212005|FD-Score:-3.63|P-value:2.99E-4 ID:SGTC_2125|Compound:5246583|FD-Score:5.86|P-value:1.70E-8 ID:SGTC_2129|Compound:girgensonine|FD-Score:3.33|P-value:8.66E-4 ID:SGTC_2142|Compound:5622915|FD-Score:3.79|P-value:1.78E-4 ID:SGTC_2288|Compound:7946289|FD-Score:3.98|P-value:8.82E-5 ID:SGTC_2303|Compound:7774051|FD-Score:-3.29|P-value:9.13E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:4.18|P-value:4.13E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.94|P-value:1.62E-6 ID:SGTC_2724|Compound:maprotiline|FD-Score:-4.61|P-value:6.51E-6 ID:SGTC_2729|Compound:fluphenazine|FD-Score:3.31|P-value:9.36E-4 ID:SGTC_2766|Compound:oltipraz|FD-Score:-3.63|P-value:2.95E-4 ID:SGTC_2782|Compound:7736369|FD-Score:3.43|P-value:6.16E-4 ID:SGTC_2795|Compound:7780010|FD-Score:3.42|P-value:6.57E-4 ID:SGTC_2799|Compound:7812892|FD-Score:-3.47|P-value:5.07E-4 ID:SGTC_2802|Compound:7925815|FD-Score:4.95|P-value:1.58E-6 ID:SGTC_2803|Compound:7707263|FD-Score:3.30|P-value:9.43E-4 ID:SGTC_2832|Compound:7992762|FD-Score:4.04|P-value:7.15E-5 ID:SGTC_2834|Compound:9001755|FD-Score:3.89|P-value:1.25E-4 ID:SGTC_2925|Compound:9010536|FD-Score:-4.11|P-value:5.09E-5 ID:SGTC_2995|Compound:9067767|FD-Score:3.60|P-value:3.58E-4 ID:SGTC_2998|Compound:9066762|FD-Score:-3.74|P-value:1.98E-4 ID:SGTC_3062|Compound:9077494|FD-Score:-3.40|P-value:6.36E-4 ID:SGTC_3219|Compound:9131112|FD-Score:-3.71|P-value:2.26E-4

Top fitness defect scores for YBL071C-B deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2125 5246583 5.86 200.0 µM 1.70E-8 tubulin folding & SWR complex 17 2.31E-9
2 SGTC_450 aminopyrene 5.61 156.0 nM 6.22E-8 10 9.93E-9
3 SGTC_1920 st075728 5.49 45.7 µM 1.20E-7 2 2.07E-8
4 SGTC_1249 0481-0015 5.44 10.2 µM 1.50E-7 10 2.66E-8
5 SGTC_1728 st035614 5.05 33.8 µM 9.77E-7 20 2.18E-7
6 SGTC_118 0083-0097 5.04 135.3 µM 1.05E-6 translation 57 2.35E-7
7 SGTC_2802 7925815 4.95 54.5 µM 1.58E-6 18 3.72E-7
8 SGTC_2688 kanamycin b 4.94 96.7 µM 1.62E-6 calcium & mitochondrial duress 249 3.84E-7
9 SGTC_1056 3448-1962 4.94 115.0 µM 1.67E-6 amide catabolism 11 3.96E-7
10 SGTC_1781 st038725 4.61 66.3 µM 6.98E-6 NEO1 82 1.97E-6
11 SGTC_800 3448-7362 4.58 155.0 µM 7.92E-6 translation 112 2.27E-6
12 SGTC_991 3996-0057 4.55 64.7 µM 9.05E-6 10 2.64E-6
13 SGTC_1998 st075797 4.40 76.8 µM 1.70E-5 mitochondrial response to ROS 10 5.34E-6
14 SGTC_1252 0493-0875 4.36 34.8 µM 2.01E-5 18 6.44E-6
15 SGTC_2679 rapamycin 4.18 1.0 nM 4.13E-5 128 1.44E-5
16 SGTC_408 cantharidin 4.10 100.0 µM 5.69E-5 cell wall signaling 19 2.07E-5
17 SGTC_2832 7992762 4.04 52.0 µM 7.15E-5 28 2.67E-5
18 SGTC_2288 7946289 3.98 167.3 µM 8.82E-5 25 3.37E-5
19 SGTC_176 1486-1328 3.96 72.8 µM 9.54E-5 51 3.68E-5
20 SGTC_2834 9001755 3.89 58.4 µM 1.25E-4 37 4.98E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.213 8.85E-36 YGR162W TIF4631 hom Translation initiation factor eIF4G; subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); interacts with Pab1p and with eIF4A (Tif1p); also has a role in biogenesis of the large ribosomal subunit; TIF4631 has a paralog, TIF4632, that arose from the whole genome duplication
0.176 1.19E-24 YJL136C RPS21B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21B has a paralog, RPS21A, that arose from the whole genome duplication
0.161 7.14E-21 YLR264C-A_p YLR264C-A_p hom Putative protein of unknown function
0.155 1.37E-19 YLR048W RPS0B hom Protein component of the small (40S) ribosomal subunit; RPS0B has a paralog, RPS0A, that arose from the whole genome duplication; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2
0.139 5.46E-16 YLR264W RPS28B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S28, no bacterial homolog; RPS28B has a paralog, RPS28A, that arose from the whole genome duplication
0.132 1.55E-14 YLR061W RPL22A hom Ribosomal 60S subunit protein L22A; required for the oxidative stress response in yeast; homologous to mammalian ribosomal protein L22, no bacterial homolog; RPL22A has a paralog, RPL22B, that arose from the whole genome duplication
0.131 2.91E-14 YJL189W RPL39 hom Ribosomal 60S subunit protein L39; required for ribosome biogenesis; loss of both Rpl31p and Rpl39p confers lethality; also exhibits genetic interactions with SIS1 and PAB1; homologous to mammalian ribosomal protein L39, no bacterial homolog
0.124 4.73E-13 YPL101W ELP4 hom Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity
0.124 5.49E-13 YDR241W_d BUD26_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 1% of ORF overlaps the verified gene SNU56; diploid mutant displays a weak budding pattern phenotype in a systematic assay
0.124 5.84E-13 YFR032C-B_p YFR032C-B_p hom Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.123 1.01E-12 YBR191W RPL21A hom Ribosomal 60S subunit protein L21A; homologous to mammalian ribosomal protein L21, no bacterial homolog; RPL21A has a paralog, RPL21B, that arose from the whole genome duplication
0.121 2.16E-12 YGR118W RPS23A hom Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit, required for translational accuracy; homologous to mammalian ribosomal protein S23 and bacterial S12; RPS23A has a paralog, RPS23B, that arose from the whole genome duplication; deletion of both RPS23A and RPS23B is lethal
0.119 5.73E-12 YOR293W RPS10A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S10, no bacterial homolog; RPS10A has a paralog, RPS10B, that arose from the whole genome duplication
0.117 9.64E-12 YJL188C_d BUD19_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 88% of ORF overlaps the verified gene RPL39; diploid mutant displays a weak budding pattern phenotype in a systematic assay
0.113 5.44E-11 YOL040C RPS15 het Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15 and bacterial S19