YBL071W-A / KTI11

Zn-ribbon protein that co-purifies with Dph1 and Dph2 in a complex required for synthesis of diphthamide on translation factor eEF2 and with Elongator subunits Iki3p, Elp2p, and Elp3p involved in modification of wobble nucleosides in tRNAs

Zygosity: Homozygous strain
fixedexpanded
Profile for YBL071W-A / KTI11

Click on Significant Values for Screen Details ID:SGTC_100|Compound:0086-0128|FD-Score:4.04|P-value:1.77E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-4.66|P-value:8.09E-6 ID:SGTC_359|Compound:0081-0058|FD-Score:5.45|P-value:6.15E-7 ID:SGTC_374|Compound:0880-0231|FD-Score:-5.25|P-value:6.22E-7 ID:SGTC_393|Compound:acivicin|FD-Score:-3.92|P-value:1.33E-4 ID:SGTC_426|Compound:0988-0037|FD-Score:-4.02|P-value:9.22E-5 ID:SGTC_431|Compound:k089-0097|FD-Score:-6.55|P-value:8.18E-10 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-6.91|P-value:1.01E-10 ID:SGTC_568|Compound:1193-0097|FD-Score:-5.68|P-value:7.89E-8 ID:SGTC_616|Compound:4092-0450|FD-Score:3.66|P-value:6.33E-4 ID:SGTC_675|Compound:1309-0189|FD-Score:5.23|P-value:1.67E-6 ID:SGTC_708|Compound:3448-5400|FD-Score:4.53|P-value:3.02E-5 ID:SGTC_711|Compound:k292-0785|FD-Score:3.58|P-value:8.04E-4 ID:SGTC_763|Compound:3453-1109|FD-Score:-3.41|P-value:7.34E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:3.59|P-value:7.87E-4 ID:SGTC_865|Compound:0488-0499|FD-Score:-3.48|P-value:5.76E-4 ID:SGTC_907|Compound:3448-6986|FD-Score:4.40|P-value:4.89E-5 ID:SGTC_957|Compound:1187-1561|FD-Score:4.44|P-value:4.14E-5 ID:SGTC_1030|Compound:k029-0042|FD-Score:4.59|P-value:2.35E-5 ID:SGTC_1091|Compound:telmisartan|FD-Score:-4.25|P-value:3.94E-5 ID:SGTC_1184|Compound:1269-1718|FD-Score:4.66|P-value:1.81E-5 ID:SGTC_1211|Compound:1056-0033|FD-Score:-3.72|P-value:2.63E-4 ID:SGTC_1328|Compound:1441-0025|FD-Score:3.74|P-value:4.89E-4 ID:SGTC_1348|Compound:1493-0373|FD-Score:3.74|P-value:4.93E-4 ID:SGTC_1365|Compound:1672-3266|FD-Score:3.58|P-value:8.09E-4 ID:SGTC_1396|Compound:3511-0007|FD-Score:3.68|P-value:5.90E-4 ID:SGTC_1418|Compound:3966-3099|FD-Score:-3.53|P-value:5.02E-4 ID:SGTC_1632|Compound:st005650|FD-Score:3.98|P-value:2.18E-4 ID:SGTC_1633|Compound:st005664|FD-Score:3.63|P-value:6.93E-4 ID:SGTC_1754|Compound:st042065|FD-Score:4.36|P-value:5.65E-5 ID:SGTC_1760|Compound:st045453|FD-Score:4.29|P-value:7.38E-5 ID:SGTC_1790|Compound:st045711|FD-Score:-4.51|P-value:1.48E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:4.44|P-value:4.25E-5 ID:SGTC_2242|Compound:6630449|FD-Score:4.47|P-value:3.74E-5 ID:SGTC_2267|Compound:7931562|FD-Score:4.37|P-value:5.45E-5 ID:SGTC_2309|Compound:7664088|FD-Score:3.94|P-value:2.53E-4 ID:SGTC_2310|Compound:7668677|FD-Score:3.72|P-value:5.20E-4 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:3.89|P-value:2.96E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:4.03|P-value:1.84E-4 ID:SGTC_2760|Compound:etidronate|FD-Score:5.31|P-value:1.19E-6 ID:SGTC_2762|Compound:leflunomide|FD-Score:4.03|P-value:1.88E-4 ID:SGTC_2764|Compound:methyldopa|FD-Score:-4.35|P-value:2.73E-5 ID:SGTC_2896|Compound:9052656|FD-Score:-5.79|P-value:4.72E-8 ID:SGTC_2944|Compound:9067346|FD-Score:5.26|P-value:1.47E-6 ID:SGTC_2950|Compound:9072895|FD-Score:3.69|P-value:5.66E-4 ID:SGTC_2959|Compound:9079155|FD-Score:-3.64|P-value:3.44E-4 ID:SGTC_3018|Compound:9082602|FD-Score:-4.09|P-value:7.33E-5 ID:SGTC_3058|Compound:9093861|FD-Score:-3.56|P-value:4.50E-4 ID:SGTC_3094|Compound:9117742|FD-Score:3.71|P-value:5.38E-4 ID:SGTC_3150|Compound:9097574|FD-Score:3.84|P-value:3.52E-4 ID:SGTC_3210|Compound:9128157|FD-Score:3.71|P-value:5.31E-4 ID:SGTC_3216|Compound:9129716|FD-Score:3.53|P-value:9.51E-4 ID:SGTC_100|Compound:0086-0128|FD-Score:4.04|P-value:1.77E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-4.66|P-value:8.09E-6 ID:SGTC_359|Compound:0081-0058|FD-Score:5.45|P-value:6.15E-7 ID:SGTC_374|Compound:0880-0231|FD-Score:-5.25|P-value:6.22E-7 ID:SGTC_393|Compound:acivicin|FD-Score:-3.92|P-value:1.33E-4 ID:SGTC_426|Compound:0988-0037|FD-Score:-4.02|P-value:9.22E-5 ID:SGTC_431|Compound:k089-0097|FD-Score:-6.55|P-value:8.18E-10 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-6.91|P-value:1.01E-10 ID:SGTC_568|Compound:1193-0097|FD-Score:-5.68|P-value:7.89E-8 ID:SGTC_616|Compound:4092-0450|FD-Score:3.66|P-value:6.33E-4 ID:SGTC_675|Compound:1309-0189|FD-Score:5.23|P-value:1.67E-6 ID:SGTC_708|Compound:3448-5400|FD-Score:4.53|P-value:3.02E-5 ID:SGTC_711|Compound:k292-0785|FD-Score:3.58|P-value:8.04E-4 ID:SGTC_763|Compound:3453-1109|FD-Score:-3.41|P-value:7.34E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:3.59|P-value:7.87E-4 ID:SGTC_865|Compound:0488-0499|FD-Score:-3.48|P-value:5.76E-4 ID:SGTC_907|Compound:3448-6986|FD-Score:4.40|P-value:4.89E-5 ID:SGTC_957|Compound:1187-1561|FD-Score:4.44|P-value:4.14E-5 ID:SGTC_1030|Compound:k029-0042|FD-Score:4.59|P-value:2.35E-5 ID:SGTC_1091|Compound:telmisartan|FD-Score:-4.25|P-value:3.94E-5 ID:SGTC_1184|Compound:1269-1718|FD-Score:4.66|P-value:1.81E-5 ID:SGTC_1211|Compound:1056-0033|FD-Score:-3.72|P-value:2.63E-4 ID:SGTC_1328|Compound:1441-0025|FD-Score:3.74|P-value:4.89E-4 ID:SGTC_1348|Compound:1493-0373|FD-Score:3.74|P-value:4.93E-4 ID:SGTC_1365|Compound:1672-3266|FD-Score:3.58|P-value:8.09E-4 ID:SGTC_1396|Compound:3511-0007|FD-Score:3.68|P-value:5.90E-4 ID:SGTC_1418|Compound:3966-3099|FD-Score:-3.53|P-value:5.02E-4 ID:SGTC_1632|Compound:st005650|FD-Score:3.98|P-value:2.18E-4 ID:SGTC_1633|Compound:st005664|FD-Score:3.63|P-value:6.93E-4 ID:SGTC_1754|Compound:st042065|FD-Score:4.36|P-value:5.65E-5 ID:SGTC_1760|Compound:st045453|FD-Score:4.29|P-value:7.38E-5 ID:SGTC_1790|Compound:st045711|FD-Score:-4.51|P-value:1.48E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:4.44|P-value:4.25E-5 ID:SGTC_2242|Compound:6630449|FD-Score:4.47|P-value:3.74E-5 ID:SGTC_2267|Compound:7931562|FD-Score:4.37|P-value:5.45E-5 ID:SGTC_2309|Compound:7664088|FD-Score:3.94|P-value:2.53E-4 ID:SGTC_2310|Compound:7668677|FD-Score:3.72|P-value:5.20E-4 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:3.89|P-value:2.96E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:4.03|P-value:1.84E-4 ID:SGTC_2760|Compound:etidronate|FD-Score:5.31|P-value:1.19E-6 ID:SGTC_2762|Compound:leflunomide|FD-Score:4.03|P-value:1.88E-4 ID:SGTC_2764|Compound:methyldopa|FD-Score:-4.35|P-value:2.73E-5 ID:SGTC_2896|Compound:9052656|FD-Score:-5.79|P-value:4.72E-8 ID:SGTC_2944|Compound:9067346|FD-Score:5.26|P-value:1.47E-6 ID:SGTC_2950|Compound:9072895|FD-Score:3.69|P-value:5.66E-4 ID:SGTC_2959|Compound:9079155|FD-Score:-3.64|P-value:3.44E-4 ID:SGTC_3018|Compound:9082602|FD-Score:-4.09|P-value:7.33E-5 ID:SGTC_3058|Compound:9093861|FD-Score:-3.56|P-value:4.50E-4 ID:SGTC_3094|Compound:9117742|FD-Score:3.71|P-value:5.38E-4 ID:SGTC_3150|Compound:9097574|FD-Score:3.84|P-value:3.52E-4 ID:SGTC_3210|Compound:9128157|FD-Score:3.71|P-value:5.31E-4 ID:SGTC_3216|Compound:9129716|FD-Score:3.53|P-value:9.51E-4

Top fitness defect scores for YBL071W-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_359 0081-0058 5.45 15.9 µM 6.15E-7 60S ribosome export 13 2.48E-8
2 SGTC_2760 etidronate 5.31 98.0 µM 1.19E-6 6 5.59E-8
3 SGTC_2944 9067346 5.26 25.6 µM 1.47E-6 9 7.23E-8
4 SGTC_675 1309-0189 5.23 238.0 µM 1.67E-6 3 8.48E-8
5 SGTC_1184 1269-1718 4.66 139.0 µM 1.81E-5 14 1.60E-6
6 SGTC_1030 k029-0042 4.59 36.7 µM 2.35E-5 TSC3-RPN4 12 2.19E-6
7 SGTC_708 3448-5400 4.53 146.0 µM 3.02E-5 28 3.00E-6
8 SGTC_2242 6630449 4.47 61.3 µM 3.74E-5 Golgi 34 3.89E-6
9 SGTC_957 1187-1561 4.44 14.1 µM 4.14E-5 12 4.41E-6
10 SGTC_1844 rapamycin 4.44 4.0 nM 4.25E-5 131 4.56E-6
11 SGTC_907 3448-6986 4.40 75.5 µM 4.89E-5 17 5.42E-6
12 SGTC_2267 7931562 4.37 200.0 µM 5.45E-5 11 6.19E-6
13 SGTC_1754 st042065 4.36 16.1 µM 5.65E-5 NEO1-PIK1 156 6.48E-6
14 SGTC_1760 st045453 4.29 10.4 µM 7.38E-5 NEO1-PIK1 131 8.99E-6
15 SGTC_100 0086-0128 4.04 49.6 µM 1.77E-4 copper-dependent oxidative stress 48 2.65E-5
16 SGTC_2679 rapamycin 4.03 1.0 nM 1.84E-4 139 2.78E-5
17 SGTC_2762 leflunomide 4.03 42.1 µM 1.88E-4 24 2.84E-5
18 SGTC_1632 st005650 3.98 90.0 µM 2.18E-4 30 3.41E-5
19 SGTC_2309 7664088 3.94 163.9 µM 2.53E-4 32 4.11E-5
20 SGTC_2571 chrysanthemic acid 3.89 100.0 µM 2.96E-4 19 4.98E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.223 5.41E-39 YHR187W IKI1 hom Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; iki1 mutations confer resistance to the K. lactis toxin zymocin
0.212 1.95E-35 YGL211W NCS6 hom Protein required for thiolation of the uridine at the wobble position of Gln, Lys, and Glu tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae
0.198 4.08E-31 YGR200C ELP2 hom Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; target of Kluyveromyces lactis zymocin
0.193 1.36E-29 YGR159C NSR1 hom Nucleolar protein that binds nuclear localization sequences, required for pre-rRNA processing and ribosome biogenesis
0.175 1.40E-24 YBR189W RPS9B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S9 and bacterial S4; RPS9B has a paralog, RPS9A, that arose from the whole genome duplication
0.162 3.12E-21 YHR186C KOG1 het Subunit of TORC1, a rapamycin-sensitive complex involved in growth control that contains Tor1p or Tor2p, Lst8p and Tco89p; contains four HEAT repeats and seven WD-40 repeats; may act as a scaffold protein to couple TOR and its effectors
0.155 1.61E-19 YGL188C-A_p YGL188C-A_p hom Putative protein of unknown function
0.151 1.19E-18 YML121W GTR1 hom Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB
0.149 4.09E-18 YGR163W GTR2 hom Putative GTP binding protein that negatively regulates Ran/Tc4 GTPase cycle; activates transcription; subunit of EGO and GSE complexes; required for sorting of Gap1p; localizes to cytoplasm and to chromatin; homolog of human RagC and RagD
0.147 1.02E-17 YFL001W DEG1 hom tRNA:pseudouridine synthase, introduces pseudouridines at position 38 or 39 in tRNA, important for maintenance of translation efficiency and normal cell growth, localizes to both the nucleus and cytoplasm; non-essential for viability
0.147 1.29E-17 YML097C VPS9 hom A guanine nucleotide exchange factor involved in vesicle-mediated vacuolar protein transport; specifically stimulates the intrinsic guanine nucleotide exchange activity of Vps21p/Rab5: similar to mammalian ras inhibitors; binds ubiquitin
0.146 1.54E-17 YJR066W TOR1 hom PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis; TOR1 has a paralog, TOR2, that arose from the whole genome duplication
0.146 1.64E-17 YKL203C TOR2 het PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis; TOR2 has a paralog, TOR1, that arose from the whole genome duplication
0.139 6.88E-16 YDR417C_d YDR417C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RPL12B/YDR418W
0.136 2.69E-15 YPL005W AEP3 hom Protein that may facilitate use of unformylated tRNA-Met in mitochondrial translation initiation; localized to the matrix face of the mitochondrial inner membrane; stabilizes the bicistronic AAP1-ATP6 mRNA