YBL072C / RPS8A

Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S8, no bacterial homolog; RPS8A has a paralog, RPS8B, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YBL072C / RPS8A

Click on Significant Values for Screen Details ID:SGTC_31|Compound:0508-1974|FD-Score:3.67|P-value:1.37E-4 ID:SGTC_147|Compound:4466-0538|FD-Score:-5.44|P-value:8.65E-8 ID:SGTC_160|Compound:3453-0671|FD-Score:-3.61|P-value:2.86E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:6.93|P-value:4.71E-12 ID:SGTC_167|Compound:3672-0051|FD-Score:6.17|P-value:6.33E-10 ID:SGTC_168|Compound:3970-0862|FD-Score:-4.98|P-value:8.91E-7 ID:SGTC_171|Compound:k064-0041|FD-Score:-6.62|P-value:9.15E-11 ID:SGTC_201|Compound:4262-0159|FD-Score:5.56|P-value:2.08E-8 ID:SGTC_204|Compound:1543-0184|FD-Score:-3.31|P-value:8.04E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:3.17|P-value:7.91E-4 ID:SGTC_527|Compound:4476-4215|FD-Score:6.01|P-value:1.63E-9 ID:SGTC_534|Compound:k292-0788|FD-Score:-3.93|P-value:8.76E-5 ID:SGTC_604|Compound:1000-0114|FD-Score:3.47|P-value:2.79E-4 ID:SGTC_655|Compound:k060-0012|FD-Score:3.34|P-value:4.42E-4 ID:SGTC_677|Compound:0929-0063|FD-Score:3.59|P-value:1.85E-4 ID:SGTC_681|Compound:1642-0006|FD-Score:3.85|P-value:6.81E-5 ID:SGTC_700|Compound:3453-2283|FD-Score:4.36|P-value:7.93E-6 ID:SGTC_725|Compound:1497-0963|FD-Score:3.84|P-value:7.00E-5 ID:SGTC_783|Compound:0848-0141|FD-Score:3.47|P-value:2.81E-4 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:3.29|P-value:5.31E-4 ID:SGTC_1001|Compound:4048-4355|FD-Score:3.60|P-value:1.75E-4 ID:SGTC_1074|Compound:carmofur|FD-Score:3.37|P-value:4.07E-4 ID:SGTC_1094|Compound:duloxetine|FD-Score:5.64|P-value:1.38E-8 ID:SGTC_1100|Compound:amiodarone|FD-Score:3.53|P-value:2.29E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:3.15|P-value:8.53E-4 ID:SGTC_1157|Compound:4092-0394|FD-Score:3.47|P-value:2.78E-4 ID:SGTC_1190|Compound:1486-1332|FD-Score:3.56|P-value:2.02E-4 ID:SGTC_1238|Compound:0333-0287|FD-Score:5.80|P-value:5.39E-9 ID:SGTC_1243|Compound:0416-0003|FD-Score:3.46|P-value:2.91E-4 ID:SGTC_1252|Compound:0493-0875|FD-Score:4.50|P-value:4.36E-6 ID:SGTC_1304|Compound:1165-0502|FD-Score:3.72|P-value:1.11E-4 ID:SGTC_1372|Compound:2752-0194|FD-Score:3.23|P-value:6.47E-4 ID:SGTC_1388|Compound:3346-4487|FD-Score:4.25|P-value:1.29E-5 ID:SGTC_1427|Compound:4048-4900|FD-Score:3.86|P-value:6.57E-5 ID:SGTC_1443|Compound:4112-3303|FD-Score:3.74|P-value:1.03E-4 ID:SGTC_1479|Compound:0549-0158|FD-Score:4.51|P-value:4.08E-6 ID:SGTC_1510|Compound:1123-0200|FD-Score:4.43|P-value:5.86E-6 ID:SGTC_1514|Compound:1189-1591|FD-Score:3.87|P-value:6.14E-5 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:3.95|P-value:4.54E-5 ID:SGTC_1685|Compound:st024049|FD-Score:3.27|P-value:5.74E-4 ID:SGTC_1700|Compound:st030840|FD-Score:4.66|P-value:2.06E-6 ID:SGTC_1737|Compound:st035557|FD-Score:3.12|P-value:9.57E-4 ID:SGTC_1744|Compound:st037937|FD-Score:4.99|P-value:4.08E-7 ID:SGTC_1757|Compound:st041620|FD-Score:3.45|P-value:3.01E-4 ID:SGTC_1761|Compound:st044296|FD-Score:3.51|P-value:2.48E-4 ID:SGTC_1781|Compound:st038725|FD-Score:3.15|P-value:8.65E-4 ID:SGTC_1801|Compound:st050089|FD-Score:3.82|P-value:7.51E-5 ID:SGTC_1813|Compound:st051246|FD-Score:-4.03|P-value:5.99E-5 ID:SGTC_1827|Compound:berberine|FD-Score:-3.79|P-value:1.51E-4 ID:SGTC_1889|Compound:st059080|FD-Score:3.39|P-value:3.70E-4 ID:SGTC_1917|Compound:st066507|FD-Score:4.65|P-value:2.18E-6 ID:SGTC_1990|Compound:st072050|FD-Score:-3.68|P-value:2.24E-4 ID:SGTC_1992|Compound:st073643|FD-Score:4.85|P-value:8.44E-7 ID:SGTC_1999|Compound:st074831|FD-Score:4.22|P-value:1.45E-5 ID:SGTC_2189|Compound:6047310|FD-Score:4.45|P-value:5.48E-6 ID:SGTC_2191|Compound:5911152|FD-Score:3.24|P-value:6.27E-4 ID:SGTC_2207|Compound:7258803|FD-Score:3.21|P-value:6.89E-4 ID:SGTC_2239|Compound:6685329|FD-Score:3.60|P-value:1.76E-4 ID:SGTC_2288|Compound:7946289|FD-Score:4.54|P-value:3.66E-6 ID:SGTC_2331|Compound:7980721|FD-Score:3.62|P-value:1.60E-4 ID:SGTC_2378|Compound:9074213|FD-Score:4.34|P-value:8.66E-6 ID:SGTC_2385|Compound:9074692|FD-Score:4.86|P-value:7.99E-7 ID:SGTC_2507|Compound:purpurin|FD-Score:4.88|P-value:7.14E-7 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:-5.96|P-value:5.04E-9 ID:SGTC_2528|Compound:xanthyletin|FD-Score:3.23|P-value:6.54E-4 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:3.30|P-value:5.07E-4 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:4.49|P-value:4.58E-6 ID:SGTC_2560|Compound:caryophyllene|FD-Score:6.69|P-value:2.39E-11 ID:SGTC_2593|Compound:nobiletin|FD-Score:3.14|P-value:8.99E-4 ID:SGTC_2594|Compound:a-mangostin|FD-Score:-3.50|P-value:4.25E-4 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:4.47|P-value:4.89E-6 ID:SGTC_2782|Compound:7736369|FD-Score:3.74|P-value:1.02E-4 ID:SGTC_2831|Compound:7999036|FD-Score:3.95|P-value:4.54E-5 ID:SGTC_2883|Compound:9059145|FD-Score:5.05|P-value:3.08E-7 ID:SGTC_2892|Compound:9047358|FD-Score:3.82|P-value:7.61E-5 ID:SGTC_3027|Compound:9089541|FD-Score:3.84|P-value:7.04E-5 ID:SGTC_3049|Compound:9092223|FD-Score:3.74|P-value:1.03E-4 ID:SGTC_3076|Compound:9116187|FD-Score:5.39|P-value:5.37E-8 ID:SGTC_3194|Compound:9111903|FD-Score:-3.30|P-value:8.51E-4 ID:SGTC_3281|Compound:9140613|FD-Score:3.82|P-value:7.45E-5 ID:SGTC_31|Compound:0508-1974|FD-Score:3.67|P-value:1.37E-4 ID:SGTC_147|Compound:4466-0538|FD-Score:-5.44|P-value:8.65E-8 ID:SGTC_160|Compound:3453-0671|FD-Score:-3.61|P-value:2.86E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:6.93|P-value:4.71E-12 ID:SGTC_167|Compound:3672-0051|FD-Score:6.17|P-value:6.33E-10 ID:SGTC_168|Compound:3970-0862|FD-Score:-4.98|P-value:8.91E-7 ID:SGTC_171|Compound:k064-0041|FD-Score:-6.62|P-value:9.15E-11 ID:SGTC_201|Compound:4262-0159|FD-Score:5.56|P-value:2.08E-8 ID:SGTC_204|Compound:1543-0184|FD-Score:-3.31|P-value:8.04E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:3.17|P-value:7.91E-4 ID:SGTC_527|Compound:4476-4215|FD-Score:6.01|P-value:1.63E-9 ID:SGTC_534|Compound:k292-0788|FD-Score:-3.93|P-value:8.76E-5 ID:SGTC_604|Compound:1000-0114|FD-Score:3.47|P-value:2.79E-4 ID:SGTC_655|Compound:k060-0012|FD-Score:3.34|P-value:4.42E-4 ID:SGTC_677|Compound:0929-0063|FD-Score:3.59|P-value:1.85E-4 ID:SGTC_681|Compound:1642-0006|FD-Score:3.85|P-value:6.81E-5 ID:SGTC_700|Compound:3453-2283|FD-Score:4.36|P-value:7.93E-6 ID:SGTC_725|Compound:1497-0963|FD-Score:3.84|P-value:7.00E-5 ID:SGTC_783|Compound:0848-0141|FD-Score:3.47|P-value:2.81E-4 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:3.29|P-value:5.31E-4 ID:SGTC_1001|Compound:4048-4355|FD-Score:3.60|P-value:1.75E-4 ID:SGTC_1074|Compound:carmofur|FD-Score:3.37|P-value:4.07E-4 ID:SGTC_1094|Compound:duloxetine|FD-Score:5.64|P-value:1.38E-8 ID:SGTC_1100|Compound:amiodarone|FD-Score:3.53|P-value:2.29E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:3.15|P-value:8.53E-4 ID:SGTC_1157|Compound:4092-0394|FD-Score:3.47|P-value:2.78E-4 ID:SGTC_1190|Compound:1486-1332|FD-Score:3.56|P-value:2.02E-4 ID:SGTC_1238|Compound:0333-0287|FD-Score:5.80|P-value:5.39E-9 ID:SGTC_1243|Compound:0416-0003|FD-Score:3.46|P-value:2.91E-4 ID:SGTC_1252|Compound:0493-0875|FD-Score:4.50|P-value:4.36E-6 ID:SGTC_1304|Compound:1165-0502|FD-Score:3.72|P-value:1.11E-4 ID:SGTC_1372|Compound:2752-0194|FD-Score:3.23|P-value:6.47E-4 ID:SGTC_1388|Compound:3346-4487|FD-Score:4.25|P-value:1.29E-5 ID:SGTC_1427|Compound:4048-4900|FD-Score:3.86|P-value:6.57E-5 ID:SGTC_1443|Compound:4112-3303|FD-Score:3.74|P-value:1.03E-4 ID:SGTC_1479|Compound:0549-0158|FD-Score:4.51|P-value:4.08E-6 ID:SGTC_1510|Compound:1123-0200|FD-Score:4.43|P-value:5.86E-6 ID:SGTC_1514|Compound:1189-1591|FD-Score:3.87|P-value:6.14E-5 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:3.95|P-value:4.54E-5 ID:SGTC_1685|Compound:st024049|FD-Score:3.27|P-value:5.74E-4 ID:SGTC_1700|Compound:st030840|FD-Score:4.66|P-value:2.06E-6 ID:SGTC_1737|Compound:st035557|FD-Score:3.12|P-value:9.57E-4 ID:SGTC_1744|Compound:st037937|FD-Score:4.99|P-value:4.08E-7 ID:SGTC_1757|Compound:st041620|FD-Score:3.45|P-value:3.01E-4 ID:SGTC_1761|Compound:st044296|FD-Score:3.51|P-value:2.48E-4 ID:SGTC_1781|Compound:st038725|FD-Score:3.15|P-value:8.65E-4 ID:SGTC_1801|Compound:st050089|FD-Score:3.82|P-value:7.51E-5 ID:SGTC_1813|Compound:st051246|FD-Score:-4.03|P-value:5.99E-5 ID:SGTC_1827|Compound:berberine|FD-Score:-3.79|P-value:1.51E-4 ID:SGTC_1889|Compound:st059080|FD-Score:3.39|P-value:3.70E-4 ID:SGTC_1917|Compound:st066507|FD-Score:4.65|P-value:2.18E-6 ID:SGTC_1990|Compound:st072050|FD-Score:-3.68|P-value:2.24E-4 ID:SGTC_1992|Compound:st073643|FD-Score:4.85|P-value:8.44E-7 ID:SGTC_1999|Compound:st074831|FD-Score:4.22|P-value:1.45E-5 ID:SGTC_2189|Compound:6047310|FD-Score:4.45|P-value:5.48E-6 ID:SGTC_2191|Compound:5911152|FD-Score:3.24|P-value:6.27E-4 ID:SGTC_2207|Compound:7258803|FD-Score:3.21|P-value:6.89E-4 ID:SGTC_2239|Compound:6685329|FD-Score:3.60|P-value:1.76E-4 ID:SGTC_2288|Compound:7946289|FD-Score:4.54|P-value:3.66E-6 ID:SGTC_2331|Compound:7980721|FD-Score:3.62|P-value:1.60E-4 ID:SGTC_2378|Compound:9074213|FD-Score:4.34|P-value:8.66E-6 ID:SGTC_2385|Compound:9074692|FD-Score:4.86|P-value:7.99E-7 ID:SGTC_2507|Compound:purpurin|FD-Score:4.88|P-value:7.14E-7 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:-5.96|P-value:5.04E-9 ID:SGTC_2528|Compound:xanthyletin|FD-Score:3.23|P-value:6.54E-4 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:3.30|P-value:5.07E-4 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:4.49|P-value:4.58E-6 ID:SGTC_2560|Compound:caryophyllene|FD-Score:6.69|P-value:2.39E-11 ID:SGTC_2593|Compound:nobiletin|FD-Score:3.14|P-value:8.99E-4 ID:SGTC_2594|Compound:a-mangostin|FD-Score:-3.50|P-value:4.25E-4 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:4.47|P-value:4.89E-6 ID:SGTC_2782|Compound:7736369|FD-Score:3.74|P-value:1.02E-4 ID:SGTC_2831|Compound:7999036|FD-Score:3.95|P-value:4.54E-5 ID:SGTC_2883|Compound:9059145|FD-Score:5.05|P-value:3.08E-7 ID:SGTC_2892|Compound:9047358|FD-Score:3.82|P-value:7.61E-5 ID:SGTC_3027|Compound:9089541|FD-Score:3.84|P-value:7.04E-5 ID:SGTC_3049|Compound:9092223|FD-Score:3.74|P-value:1.03E-4 ID:SGTC_3076|Compound:9116187|FD-Score:5.39|P-value:5.37E-8 ID:SGTC_3194|Compound:9111903|FD-Score:-3.30|P-value:8.51E-4 ID:SGTC_3281|Compound:9140613|FD-Score:3.82|P-value:7.45E-5

Top fitness defect scores for YBL072C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_163 1327-0036 6.93 7.5 µM 4.71E-12 29 2.10E-12
2 SGTC_2560 caryophyllene 6.69 100.0 µM 2.39E-11 1 1.14E-11
3 SGTC_167 3672-0051 6.17 66.2 µM 6.33E-10 12 3.50E-10
4 SGTC_527 4476-4215 6.01 268.0 µM 1.63E-9 PDR1 11 9.38E-10
5 SGTC_1238 0333-0287 5.80 48.8 µM 5.39E-9 Golgi 5 3.26E-9
6 SGTC_1094 duloxetine 5.64 25.4 µM 1.38E-8 RPP1 & pyrimidine depletion 1 8.69E-9
7 SGTC_201 4262-0159 5.56 12.8 µM 2.08E-8 ergosterol depletion effects on membrane 18 1.33E-8
8 SGTC_3076 9116187 5.39 49.5 µM 5.37E-8 4 3.57E-8
9 SGTC_2883 9059145 5.05 45.5 µM 3.08E-7 2 2.20E-7
10 SGTC_1744 st037937 4.99 38.9 µM 4.08E-7 6 2.95E-7
11 SGTC_2507 purpurin 4.88 79.7 µM 7.14E-7 copper-dependent oxidative stress 21 5.27E-7
12 SGTC_2385 9074692 4.86 200.0 µM 7.99E-7 21 5.92E-7
13 SGTC_1992 st073643 4.85 23.3 µM 8.44E-7 mitochondrial processes 4 6.27E-7
14 SGTC_1700 st030840 4.66 7.9 µM 2.06E-6 PDR1 16 1.59E-6
15 SGTC_1917 st066507 4.65 28.5 µM 2.18E-6 Golgi 25 1.68E-6
16 SGTC_2288 7946289 4.54 167.3 µM 3.66E-6 15 2.88E-6
17 SGTC_1479 0549-0158 4.51 134.0 µM 4.08E-6 11 3.22E-6
18 SGTC_1252 0493-0875 4.50 34.8 µM 4.36E-6 16 3.45E-6
19 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 4.49 100.0 µM 4.58E-6 7 3.63E-6
20 SGTC_2613 3',4'-dimethoxydalbergione 4.47 24.6 µM 4.89E-6 10 3.89E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.104 1.55E-9 YGL110C CUE3 hom Protein of unknown function; has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination
0.100 5.62E-9 YGR193C PDX1 hom Dihydrolipoamide dehydrogenase (E3)-binding protein (E3BP) of the mitochondrial pyruvate dehydrogenase (PDH) complex, plays a structural role in the complex by binding and positioning E3 to the dihydrolipoamide acetyltransferase (E2) core
0.099 9.67E-9 YIR008C PRI1 het Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair
0.089 2.69E-7 YPL229W_p YPL229W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; not an essential gene; YPL229W has a paralog, YMR181C, that arose from the whole genome duplication
0.086 6.57E-7 YER052C HOM3 hom Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
0.085 7.51E-7 YKL068W NUP100 hom FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier and is involved in gene tethering at the nuclear periphery; homologous to Nup116p
0.084 1.10E-6 YOR338W_p YOR338W_p hom Putative protein of unknown function; YOR338W transcription is regulated by Azf1p and its transcript is a specific target of the G protein effector Scp160p; identified as being required for sporulation in a high-throughput mutant screen; YOR338W has a paralog, FUN19, that arose from the whole genome duplication
0.080 3.28E-6 YDR381W YRA1 het RNA binding protein required for export of poly(A)+ mRNA from the nucleus; proposed to couple mRNA export with 3' end processing via its interactions with Mex67p and Pcf11p; functionally redundant with Yra2p, another REF family member
0.080 3.45E-6 YHR118C ORC6 het Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; phosphorylated by Cdc28p
0.078 6.87E-6 YGR081C SLX9 hom Protein required for pre-rRNA processing; associated with the 90S pre-ribosome and 43S small ribosomal subunit precursor; interacts with U3 snoRNA; deletion mutant has synthetic fitness defect with an sgs1 deletion mutant
0.074 1.67E-5 YHR172W SPC97 het Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaque
0.074 1.66E-5 YNL130C-A_p DGR1_p hom Protein of unknown function; dgr1 null mutant is resistant to 2-deoxy-D-glucose
0.073 2.36E-5 YER089C PTC2 hom Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p to limit maximal osmostress induced kinase activity; dephosphorylates Ire1p to downregulate the unfolded protein response; dephosphorylates Cdc28p; inactivates the DNA damage checkpoint; PTC2 has a paralog, PTC3, that arose from the whole genome duplication
0.073 2.40E-5 YPR120C CLB5 hom B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1 phase
0.072 3.35E-5 YOR146W_d YOR146W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene PNO1/YOR145C