YBL073W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential gene AAR2/YBL074C

Zygosity: Heterozygous strain
fixedexpanded
Profile for YBL073W / YBL073W

Click on Significant Values for Screen Details ID:SGTC_26|Compound:0302-0163|FD-Score:-3.17|P-value:3.16E-4 ID:SGTC_75|Compound:0159-0059|FD-Score:2.89|P-value:9.26E-4 ID:SGTC_283|Compound:0987-0079|FD-Score:-3.08|P-value:4.57E-4 ID:SGTC_326|Compound:k292-0812|FD-Score:-3.32|P-value:1.73E-4 ID:SGTC_328|Compound:k915-0120|FD-Score:-3.13|P-value:3.82E-4 ID:SGTC_333|Compound:3486-0131|FD-Score:-3.02|P-value:5.73E-4 ID:SGTC_335|Compound:4077-0256|FD-Score:3.07|P-value:4.65E-4 ID:SGTC_356|Compound:1634-0012|FD-Score:-3.99|P-value:8.50E-6 ID:SGTC_383|Compound:2324-0395|FD-Score:-3.20|P-value:2.88E-4 ID:SGTC_590|Compound:k048-0076|FD-Score:3.77|P-value:2.43E-5 ID:SGTC_593|Compound:1203-0218|FD-Score:4.37|P-value:1.27E-6 ID:SGTC_595|Compound:3909-8003|FD-Score:3.34|P-value:1.61E-4 ID:SGTC_601|Compound:0986-0029|FD-Score:4.28|P-value:2.06E-6 ID:SGTC_745|Compound:0469-0705|FD-Score:2.87|P-value:9.99E-4 ID:SGTC_774|Compound:k060-0086|FD-Score:3.89|P-value:1.41E-5 ID:SGTC_924|Compound:2046-0044|FD-Score:3.23|P-value:2.46E-4 ID:SGTC_952|Compound:1185-0122|FD-Score:-3.17|P-value:3.18E-4 ID:SGTC_958|Compound:1222-0007|FD-Score:3.35|P-value:1.57E-4 ID:SGTC_1219|Compound:1469-0211|FD-Score:3.99|P-value:8.59E-6 ID:SGTC_1225|Compound:1216-0074|FD-Score:5.23|P-value:9.07E-9 ID:SGTC_1254|Compound:0550-0035|FD-Score:-2.95|P-value:7.33E-4 ID:SGTC_1421|Compound:4029-0249|FD-Score:3.57|P-value:5.90E-5 ID:SGTC_1941|Compound:st076221|FD-Score:3.22|P-value:2.58E-4 ID:SGTC_2236|Compound:dapsone|FD-Score:-3.34|P-value:1.62E-4 ID:SGTC_2468|Compound:5987765|FD-Score:3.36|P-value:1.51E-4 ID:SGTC_2803|Compound:7707263|FD-Score:-2.95|P-value:7.34E-4 ID:SGTC_2805|Compound:7950783|FD-Score:-4.87|P-value:7.88E-8 ID:SGTC_2808|Compound:7946468|FD-Score:-2.89|P-value:9.32E-4 ID:SGTC_2809|Compound:7964133|FD-Score:3.86|P-value:1.61E-5 ID:SGTC_2814|Compound:7977482|FD-Score:3.71|P-value:3.22E-5 ID:SGTC_2917|Compound:7979103|FD-Score:3.06|P-value:4.87E-4 ID:SGTC_2991|Compound:9074669|FD-Score:3.81|P-value:2.02E-5 ID:SGTC_2997|Compound:9067075|FD-Score:5.46|P-value:2.10E-9 ID:SGTC_3002|Compound:9075603|FD-Score:-4.45|P-value:8.42E-7 ID:SGTC_3019|Compound:9081971|FD-Score:3.56|P-value:6.25E-5 ID:SGTC_3237|Compound:9133362|FD-Score:-3.14|P-value:3.61E-4 ID:SGTC_3330|Compound:9141424|FD-Score:-3.84|P-value:1.73E-5 ID:SGTC_3331|Compound:9141060|FD-Score:2.97|P-value:6.86E-4 ID:SGTC_3337|Compound:9144342|FD-Score:3.71|P-value:3.19E-5 ID:SGTC_3341|Compound:9147222|FD-Score:3.87|P-value:1.55E-5 ID:SGTC_26|Compound:0302-0163|FD-Score:-3.17|P-value:3.16E-4 ID:SGTC_75|Compound:0159-0059|FD-Score:2.89|P-value:9.26E-4 ID:SGTC_283|Compound:0987-0079|FD-Score:-3.08|P-value:4.57E-4 ID:SGTC_326|Compound:k292-0812|FD-Score:-3.32|P-value:1.73E-4 ID:SGTC_328|Compound:k915-0120|FD-Score:-3.13|P-value:3.82E-4 ID:SGTC_333|Compound:3486-0131|FD-Score:-3.02|P-value:5.73E-4 ID:SGTC_335|Compound:4077-0256|FD-Score:3.07|P-value:4.65E-4 ID:SGTC_356|Compound:1634-0012|FD-Score:-3.99|P-value:8.50E-6 ID:SGTC_383|Compound:2324-0395|FD-Score:-3.20|P-value:2.88E-4 ID:SGTC_590|Compound:k048-0076|FD-Score:3.77|P-value:2.43E-5 ID:SGTC_593|Compound:1203-0218|FD-Score:4.37|P-value:1.27E-6 ID:SGTC_595|Compound:3909-8003|FD-Score:3.34|P-value:1.61E-4 ID:SGTC_601|Compound:0986-0029|FD-Score:4.28|P-value:2.06E-6 ID:SGTC_745|Compound:0469-0705|FD-Score:2.87|P-value:9.99E-4 ID:SGTC_774|Compound:k060-0086|FD-Score:3.89|P-value:1.41E-5 ID:SGTC_924|Compound:2046-0044|FD-Score:3.23|P-value:2.46E-4 ID:SGTC_952|Compound:1185-0122|FD-Score:-3.17|P-value:3.18E-4 ID:SGTC_958|Compound:1222-0007|FD-Score:3.35|P-value:1.57E-4 ID:SGTC_1219|Compound:1469-0211|FD-Score:3.99|P-value:8.59E-6 ID:SGTC_1225|Compound:1216-0074|FD-Score:5.23|P-value:9.07E-9 ID:SGTC_1254|Compound:0550-0035|FD-Score:-2.95|P-value:7.33E-4 ID:SGTC_1421|Compound:4029-0249|FD-Score:3.57|P-value:5.90E-5 ID:SGTC_1941|Compound:st076221|FD-Score:3.22|P-value:2.58E-4 ID:SGTC_2236|Compound:dapsone|FD-Score:-3.34|P-value:1.62E-4 ID:SGTC_2468|Compound:5987765|FD-Score:3.36|P-value:1.51E-4 ID:SGTC_2803|Compound:7707263|FD-Score:-2.95|P-value:7.34E-4 ID:SGTC_2805|Compound:7950783|FD-Score:-4.87|P-value:7.88E-8 ID:SGTC_2808|Compound:7946468|FD-Score:-2.89|P-value:9.32E-4 ID:SGTC_2809|Compound:7964133|FD-Score:3.86|P-value:1.61E-5 ID:SGTC_2814|Compound:7977482|FD-Score:3.71|P-value:3.22E-5 ID:SGTC_2917|Compound:7979103|FD-Score:3.06|P-value:4.87E-4 ID:SGTC_2991|Compound:9074669|FD-Score:3.81|P-value:2.02E-5 ID:SGTC_2997|Compound:9067075|FD-Score:5.46|P-value:2.10E-9 ID:SGTC_3002|Compound:9075603|FD-Score:-4.45|P-value:8.42E-7 ID:SGTC_3019|Compound:9081971|FD-Score:3.56|P-value:6.25E-5 ID:SGTC_3237|Compound:9133362|FD-Score:-3.14|P-value:3.61E-4 ID:SGTC_3330|Compound:9141424|FD-Score:-3.84|P-value:1.73E-5 ID:SGTC_3331|Compound:9141060|FD-Score:2.97|P-value:6.86E-4 ID:SGTC_3337|Compound:9144342|FD-Score:3.71|P-value:3.19E-5 ID:SGTC_3341|Compound:9147222|FD-Score:3.87|P-value:1.55E-5

Top fitness defect scores for YBL073W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2997 9067075 5.46 71.4 µM 2.10E-9 unfolded protein response 11 2.45E-8 0.34
2 SGTC_1225 1216-0074 5.23 20.6 µM 9.07E-9 1 8.67E-8 1.03
3 SGTC_593 1203-0218 4.37 61.7 µM 1.27E-6 3 6.25E-6 0.79
4 SGTC_601 0986-0029 4.28 62.9 µM 2.06E-6 calcium & mitochondrial duress 15 9.54E-6 0.12
5 SGTC_1219 1469-0211 3.99 33.1 µM 8.59E-6 4 3.29E-5 0.32
6 SGTC_774 k060-0086 3.89 136.0 µM 1.41E-5 5 5.08E-5 0.17
7 SGTC_3341 9147222 3.87 25.9 µM 1.55E-5 RNA processing & uracil transport 13 5.50E-5 0.18
8 SGTC_2809 7964133 3.86 13.0 µM 1.61E-5 60S ribosome export 14 5.69E-5 0.06
9 SGTC_2991 9074669 3.81 71.4 µM 2.02E-5 azole & statin 20 6.93E-5 0.08
10 SGTC_590 k048-0076 3.77 22.4 µM 2.43E-5 RSC & ERG11 11 8.11E-5 0.11
11 SGTC_3337 9144342 3.71 33.5 µM 3.19E-5 14 1.03E-4 0.04
12 SGTC_2814 7977482 3.71 43.0 µM 3.22E-5 14 1.04E-4 0.06
13 SGTC_1421 4029-0249 3.57 71.4 µM 5.90E-5 5 1.75E-4 0.07
14 SGTC_3019 9081971 3.56 49.5 µM 6.25E-5 7 1.84E-4 0.01
15 SGTC_2468 5987765 3.36 72.9 µM 1.51E-4 9 3.97E-4 0.01
16 SGTC_958 1222-0007 3.35 33.0 µM 1.57E-4 14 4.11E-4 0.02
17 SGTC_595 3909-8003 3.34 73.7 µM 1.61E-4 6 4.20E-4 1.89E-5
18 SGTC_924 2046-0044 3.23 21.3 µM 2.46E-4 14 6.08E-4 0.03
19 SGTC_1941 st076221 3.22 61.8 µM 2.58E-4 sphingolipid biosynthesis & PDR1 19 6.33E-4 0.01
20 SGTC_335 4077-0256 3.07 27.6 µM 4.65E-4 13 0.00106 0.13

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.115 2.71E-11 YLR097C HRT3 hom Putative SCF-ubiquitin ligase F-box protein, based on both genetic and physical interactions and sequence similarity; identified in association with Cdc53p, Skp1p and Ubi4 in large and small-scale studies
0.112 8.80E-11 YOL162W_p YOL162W_p hom Putative protein of unknown function; member of the Dal5p subfamily of the major facilitator family
0.111 1.01E-10 YLR263W RED1 hom Protein component of the synaptonemal complex axial elements, involved in chromosome segregation during the first meiotic division; critical for coupling checkpoint signaling to SC formation; interacts with Hop1p, Mec3p and Ddc1p
0.110 1.55E-10 YLR452C SST2 hom GTPase-activating protein for Gpa1p, regulates desensitization to alpha factor pheromone; also required to prevent receptor-independent signaling of the mating pathway; member of the RGS (regulator of G-protein signaling) family
0.104 1.31E-9 YKL020C SPT23 hom ER membrane protein involved in regulation of OLE1 transcription, acts with homolog Mga2p; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting
0.097 1.87E-8 YDL131W LYS21 hom Homocitrate synthase isozyme; catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; LYS21 has a paralog, LYS20, that arose from the whole genome duplication
0.088 3.17E-7 YPR159C-A_p YPR159C-A_p hom Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.083 1.51E-6 YDR459C PFA5 hom Palmitoyltransferase with autoacylation activity; likely functions in pathway(s) outside Ras; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain
0.083 1.61E-6 YLR132C USB1 het Putative phosphodiesterase specific for U6 snRNA 3' end modification; trims the 3' poly(u) tract to leave a terminal 3' phosphate; human homolog, hUSB1 (aka C16orf57) produces a 2',3' cyclic phosphate; mutations in hUSB1 are associated with a rare skin condition (OMIM 604173); essential protein that localizes to the nucleus and mitochondria; overexpression suppresses the respiratory defects of oxa1 and mtf2 mutants
0.082 2.15E-6 YMR171C EAR1 hom Specificity factor required for Rsp5p-dependent ubiquitination and sorting of specific cargo proteins at the multivesicular body; mRNA is targeted to the bud via the mRNA transport system involving She2p
0.079 4.72E-6 YPL037C EGD1 hom Subunit beta1 of the nascent polypeptide-associated complex (NAC) involved in protein targeting, associated with cytoplasmic ribosomes; enhances DNA binding of the Gal4p activator; homolog of human BTF3b
0.078 5.39E-6 YNL085W MKT1 hom Protein that forms a complex with Pbp1p; complex may mediate posttranscriptional regulation of HO; involved in propagation of M2 dsRNA satellite of L-A virus; allelic variation affects mitochondrial genome stability, drug resistance, and more; forms cytoplasmic foci upon DNA replication stress
0.078 5.84E-6 YEL019C MMS21 het SUMO ligase and component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; mutants are sensitive to methyl methanesulfonate and show increased spontaneous mutation and mitotic recombination
0.076 1.01E-5 YLR323C CWC24 het Spliceosome assembly factor, essential for the first step of splicing; component of the pre-catalytic spliceosome complex containing Cef1p; has similarity to S. pombe Cwf24p
0.075 1.30E-5 YER063W THO1 hom Conserved nuclear RNA-binding protein; specifically binds to transcribed chromatin in a THO- and RNA-dependent manner, genetically interacts with shuttling hnRNP NAB2; overproduction suppresses transcriptional defect caused by hpr1 mutation