YBL074C / AAR2

Component of the U5 snRNP, required for splicing of U3 precursors; originally described as a splicing factor specifically required for splicing pre-mRNA of the MATa1 cistron

Zygosity: Heterozygous strain
fixedexpanded
Profile for YBL074C / AAR2

Click on Significant Values for Screen Details ID:SGTC_96|Compound:0929-0093|FD-Score:-3.27|P-value:4.00E-4 ID:SGTC_133|Compound:0724-0033|FD-Score:4.82|P-value:5.06E-7 ID:SGTC_135|Compound:0933-0004|FD-Score:3.80|P-value:5.93E-5 ID:SGTC_137|Compound:0438-0332|FD-Score:-5.22|P-value:4.74E-8 ID:SGTC_139|Compound:0099-0334|FD-Score:3.33|P-value:3.81E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:3.87|P-value:4.38E-5 ID:SGTC_151|Compound:3013-0144|FD-Score:3.32|P-value:3.86E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:3.46|P-value:2.30E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:3.51|P-value:1.90E-4 ID:SGTC_281|Compound:1672-3440|FD-Score:3.41|P-value:2.80E-4 ID:SGTC_551|Compound:k048-0028|FD-Score:3.64|P-value:1.16E-4 ID:SGTC_556|Compound:4058-0063|FD-Score:4.45|P-value:3.26E-6 ID:SGTC_770|Compound:0389-1121|FD-Score:3.12|P-value:7.95E-4 ID:SGTC_868|Compound:0527-0199|FD-Score:-3.43|P-value:2.19E-4 ID:SGTC_871|Compound:0574-0004|FD-Score:3.31|P-value:4.13E-4 ID:SGTC_889|Compound:0919-1524|FD-Score:3.07|P-value:9.41E-4 ID:SGTC_940|Compound:3232-1287|FD-Score:5.43|P-value:1.87E-8 ID:SGTC_946|Compound:3434-1334|FD-Score:-3.93|P-value:2.87E-5 ID:SGTC_1010|Compound:4112-3296|FD-Score:3.24|P-value:5.29E-4 ID:SGTC_1018|Compound:4259-0013|FD-Score:4.37|P-value:4.81E-6 ID:SGTC_1131|Compound:3454-3128|FD-Score:4.02|P-value:2.32E-5 ID:SGTC_1133|Compound:3473-0247|FD-Score:4.66|P-value:1.19E-6 ID:SGTC_1147|Compound:3809-1045|FD-Score:-3.44|P-value:2.11E-4 ID:SGTC_1186|Compound:1319-0216|FD-Score:3.25|P-value:5.01E-4 ID:SGTC_1194|Compound:1488-0194|FD-Score:3.20|P-value:6.03E-4 ID:SGTC_1196|Compound:1588-0294|FD-Score:5.65|P-value:4.91E-9 ID:SGTC_1266|Compound:0828-0227|FD-Score:3.55|P-value:1.66E-4 ID:SGTC_1278|Compound:0874-0585|FD-Score:-3.23|P-value:4.58E-4 ID:SGTC_1286|Compound:0929-0070|FD-Score:-3.51|P-value:1.60E-4 ID:SGTC_1386|Compound:3228-0095|FD-Score:-3.46|P-value:1.98E-4 ID:SGTC_1390|Compound:3413-2614|FD-Score:3.77|P-value:6.78E-5 ID:SGTC_1417|Compound:3966-0327|FD-Score:3.11|P-value:8.30E-4 ID:SGTC_1611|Compound:st001856|FD-Score:3.44|P-value:2.54E-4 ID:SGTC_1732|Compound:st034308|FD-Score:4.27|P-value:7.50E-6 ID:SGTC_1735|Compound:st034310|FD-Score:4.65|P-value:1.25E-6 ID:SGTC_1797|Compound:st048695|FD-Score:4.55|P-value:1.96E-6 ID:SGTC_1931|Compound:st074438|FD-Score:-3.30|P-value:3.55E-4 ID:SGTC_1967|Compound:st070177|FD-Score:3.66|P-value:1.05E-4 ID:SGTC_1978|Compound:st071761|FD-Score:3.92|P-value:3.63E-5 ID:SGTC_2033|Compound:5192550|FD-Score:3.06|P-value:9.79E-4 ID:SGTC_2080|Compound:5212524|FD-Score:3.39|P-value:3.00E-4 ID:SGTC_2093|Compound:5331342|FD-Score:3.20|P-value:5.95E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:5.30|P-value:3.86E-8 ID:SGTC_2131|Compound:toluylene red|FD-Score:3.48|P-value:2.12E-4 ID:SGTC_2178|Compound:5812956|FD-Score:3.11|P-value:8.26E-4 ID:SGTC_2329|Compound:6138490|FD-Score:9.97|P-value:1.95E-24 ID:SGTC_2334|Compound:9017922|FD-Score:-3.15|P-value:6.19E-4 ID:SGTC_2335|Compound:9018011|FD-Score:5.66|P-value:4.76E-9 ID:SGTC_2357|Compound:9067248|FD-Score:3.37|P-value:3.27E-4 ID:SGTC_2394|Compound:5221648|FD-Score:3.25|P-value:5.12E-4 ID:SGTC_2397|Compound:5161689|FD-Score:3.61|P-value:1.27E-4 ID:SGTC_2681|Compound:menadione|FD-Score:-3.09|P-value:7.61E-4 ID:SGTC_2782|Compound:7736369|FD-Score:-3.18|P-value:5.52E-4 ID:SGTC_2916|Compound:7875993|FD-Score:4.82|P-value:5.23E-7 ID:SGTC_2929|Compound:9013348|FD-Score:5.16|P-value:8.52E-8 ID:SGTC_2936|Compound:9038235|FD-Score:3.77|P-value:6.73E-5 ID:SGTC_2940|Compound:9060638|FD-Score:6.28|P-value:9.50E-11 ID:SGTC_2953|Compound:9074162|FD-Score:3.35|P-value:3.53E-4 ID:SGTC_3062|Compound:9077494|FD-Score:-3.50|P-value:1.67E-4 ID:SGTC_3144|Compound:9087057|FD-Score:3.24|P-value:5.17E-4 ID:SGTC_3193|Compound:9111931|FD-Score:3.40|P-value:2.91E-4 ID:SGTC_96|Compound:0929-0093|FD-Score:-3.27|P-value:4.00E-4 ID:SGTC_133|Compound:0724-0033|FD-Score:4.82|P-value:5.06E-7 ID:SGTC_135|Compound:0933-0004|FD-Score:3.80|P-value:5.93E-5 ID:SGTC_137|Compound:0438-0332|FD-Score:-5.22|P-value:4.74E-8 ID:SGTC_139|Compound:0099-0334|FD-Score:3.33|P-value:3.81E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:3.87|P-value:4.38E-5 ID:SGTC_151|Compound:3013-0144|FD-Score:3.32|P-value:3.86E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:3.46|P-value:2.30E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:3.51|P-value:1.90E-4 ID:SGTC_281|Compound:1672-3440|FD-Score:3.41|P-value:2.80E-4 ID:SGTC_551|Compound:k048-0028|FD-Score:3.64|P-value:1.16E-4 ID:SGTC_556|Compound:4058-0063|FD-Score:4.45|P-value:3.26E-6 ID:SGTC_770|Compound:0389-1121|FD-Score:3.12|P-value:7.95E-4 ID:SGTC_868|Compound:0527-0199|FD-Score:-3.43|P-value:2.19E-4 ID:SGTC_871|Compound:0574-0004|FD-Score:3.31|P-value:4.13E-4 ID:SGTC_889|Compound:0919-1524|FD-Score:3.07|P-value:9.41E-4 ID:SGTC_940|Compound:3232-1287|FD-Score:5.43|P-value:1.87E-8 ID:SGTC_946|Compound:3434-1334|FD-Score:-3.93|P-value:2.87E-5 ID:SGTC_1010|Compound:4112-3296|FD-Score:3.24|P-value:5.29E-4 ID:SGTC_1018|Compound:4259-0013|FD-Score:4.37|P-value:4.81E-6 ID:SGTC_1131|Compound:3454-3128|FD-Score:4.02|P-value:2.32E-5 ID:SGTC_1133|Compound:3473-0247|FD-Score:4.66|P-value:1.19E-6 ID:SGTC_1147|Compound:3809-1045|FD-Score:-3.44|P-value:2.11E-4 ID:SGTC_1186|Compound:1319-0216|FD-Score:3.25|P-value:5.01E-4 ID:SGTC_1194|Compound:1488-0194|FD-Score:3.20|P-value:6.03E-4 ID:SGTC_1196|Compound:1588-0294|FD-Score:5.65|P-value:4.91E-9 ID:SGTC_1266|Compound:0828-0227|FD-Score:3.55|P-value:1.66E-4 ID:SGTC_1278|Compound:0874-0585|FD-Score:-3.23|P-value:4.58E-4 ID:SGTC_1286|Compound:0929-0070|FD-Score:-3.51|P-value:1.60E-4 ID:SGTC_1386|Compound:3228-0095|FD-Score:-3.46|P-value:1.98E-4 ID:SGTC_1390|Compound:3413-2614|FD-Score:3.77|P-value:6.78E-5 ID:SGTC_1417|Compound:3966-0327|FD-Score:3.11|P-value:8.30E-4 ID:SGTC_1611|Compound:st001856|FD-Score:3.44|P-value:2.54E-4 ID:SGTC_1732|Compound:st034308|FD-Score:4.27|P-value:7.50E-6 ID:SGTC_1735|Compound:st034310|FD-Score:4.65|P-value:1.25E-6 ID:SGTC_1797|Compound:st048695|FD-Score:4.55|P-value:1.96E-6 ID:SGTC_1931|Compound:st074438|FD-Score:-3.30|P-value:3.55E-4 ID:SGTC_1967|Compound:st070177|FD-Score:3.66|P-value:1.05E-4 ID:SGTC_1978|Compound:st071761|FD-Score:3.92|P-value:3.63E-5 ID:SGTC_2033|Compound:5192550|FD-Score:3.06|P-value:9.79E-4 ID:SGTC_2080|Compound:5212524|FD-Score:3.39|P-value:3.00E-4 ID:SGTC_2093|Compound:5331342|FD-Score:3.20|P-value:5.95E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:5.30|P-value:3.86E-8 ID:SGTC_2131|Compound:toluylene red|FD-Score:3.48|P-value:2.12E-4 ID:SGTC_2178|Compound:5812956|FD-Score:3.11|P-value:8.26E-4 ID:SGTC_2329|Compound:6138490|FD-Score:9.97|P-value:1.95E-24 ID:SGTC_2334|Compound:9017922|FD-Score:-3.15|P-value:6.19E-4 ID:SGTC_2335|Compound:9018011|FD-Score:5.66|P-value:4.76E-9 ID:SGTC_2357|Compound:9067248|FD-Score:3.37|P-value:3.27E-4 ID:SGTC_2394|Compound:5221648|FD-Score:3.25|P-value:5.12E-4 ID:SGTC_2397|Compound:5161689|FD-Score:3.61|P-value:1.27E-4 ID:SGTC_2681|Compound:menadione|FD-Score:-3.09|P-value:7.61E-4 ID:SGTC_2782|Compound:7736369|FD-Score:-3.18|P-value:5.52E-4 ID:SGTC_2916|Compound:7875993|FD-Score:4.82|P-value:5.23E-7 ID:SGTC_2929|Compound:9013348|FD-Score:5.16|P-value:8.52E-8 ID:SGTC_2936|Compound:9038235|FD-Score:3.77|P-value:6.73E-5 ID:SGTC_2940|Compound:9060638|FD-Score:6.28|P-value:9.50E-11 ID:SGTC_2953|Compound:9074162|FD-Score:3.35|P-value:3.53E-4 ID:SGTC_3062|Compound:9077494|FD-Score:-3.50|P-value:1.67E-4 ID:SGTC_3144|Compound:9087057|FD-Score:3.24|P-value:5.17E-4 ID:SGTC_3193|Compound:9111931|FD-Score:3.40|P-value:2.91E-4

Top fitness defect scores for YBL074C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2329 6138490 9.97 200.0 µM 1.95E-24 1 9.85E-24 3.92
2 SGTC_2940 9060638 6.28 45.9 µM 9.50E-11 amide catabolism 1 1.73E-10 1.26
3 SGTC_2335 9018011 5.66 154.2 µM 4.76E-9 3 7.66E-9 0.67
4 SGTC_1196 1588-0294 5.65 184.0 µM 4.91E-9 1 7.89E-9 0.77
5 SGTC_940 3232-1287 5.43 54.8 µM 1.87E-8 NEO1 3 2.88E-8 2.02
6 SGTC_2129 girgensonine 5.30 121.0 µM 3.86E-8 heme biosynthesis & mitochondrial translocase 12 5.82E-8 0.09
7 SGTC_2929 9013348 5.16 24.6 µM 8.52E-8 2 1.26E-7 1.14
8 SGTC_133 0724-0033 4.82 378.9 µM 5.06E-7 5 7.06E-7 0.04
9 SGTC_2916 7875993 4.82 68.8 µM 5.23E-7 1 7.29E-7 0.36
10 SGTC_1133 3473-0247 4.66 50.0 µM 1.19E-6 RSC complex & mRNA processing 37 1.62E-6 0.03
11 SGTC_1735 st034310 4.65 56.8 µM 1.25E-6 Golgi 4 1.70E-6 0.30
12 SGTC_1797 st048695 4.55 56.8 µM 1.96E-6 NEO1 10 2.63E-6 0.28
13 SGTC_556 4058-0063 4.45 51.5 µM 3.26E-6 1 4.30E-6 0.35
14 SGTC_1018 4259-0013 4.37 28.1 µM 4.81E-6 5 6.28E-6 0.46
15 SGTC_1732 st034308 4.27 51.8 µM 7.50E-6 6 9.66E-6 0.06
16 SGTC_1131 3454-3128 4.02 32.3 µM 2.32E-5 13 2.89E-5 0.07
17 SGTC_1978 st071761 3.92 42.0 µM 3.63E-5 TSC3-RPN4 8 4.46E-5 0.37
18 SGTC_141 0443-0274 3.87 32.3 µM 4.38E-5 mitochondrial response to ROS 5 5.35E-5 0.41
19 SGTC_135 0933-0004 3.80 26.4 µM 5.93E-5 60S ribosome export 7 7.19E-5 0.06
20 SGTC_2936 9038235 3.77 15.6 µM 6.73E-5 9 8.13E-5 0.15

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.137 1.82E-15 YLR327C TMA10 hom Protein of unknown function that associates with ribosomes; putative homolog of the F1F0-ATPase synthase regulator Stf2p; protein abundance increases in response to DNA replication stress
0.137 1.72E-15 YOR177C MPC54 hom Component of the meiotic outer plaque, a membrane-organizing center which is assembled on the cytoplasmic face of the spindle pole body during meiosis II and triggers the formation of the prospore membrane; potential Cdc28p substrate
0.129 6.47E-14 YLR317W_d YLR317W_d het Dubious open reading frame; may be part of a bicistronic transcript with NKP2/YLR315W; overlaps the verified ORF TAD3/YLR316C
0.127 1.45E-13 YJL079C PRY1 hom Sterol binding protein involved in the export of acetylated sterols; secreted glycoprotein and member of the CAP protein superfamily (cysteine-rich secretory proteins (CRISP), antigen 5, and pathogenesis related 1 proteins); sterol export function is redundant with that of PRY2; may be involved in detoxification of hydrophobic compounds; PRY1 has a paralog, PRY2, that arose from the whole genome duplication
0.097 2.03E-8 YCR064C_d YCR064C_d hom Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene BUD31
0.097 2.09E-8 YJL203W PRP21 het Subunit of the SF3a splicing factor complex, required for spliceosome assembly
0.095 4.07E-8 YGL157W ARI1 hom NADPH-dependent aldehyde reductase, utilizes aromatic and alophatic aldehyde substrates; member of the short-chain dehydrogenase/reductase superfamily
0.095 4.15E-8 YDR468C TLG1 het Essential t-SNARE that forms a complex with Tlg2p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; binds the docking complex VFT (Vps fifty-three) through interaction with Vps51p
0.094 4.33E-8 YAL027W SAW1 hom 5'- and 3'-flap DNA binding protein; stimulates the endonuclease activity of Rad1/Rad10p; involved in Rad1p/Rad10p-dependent removal of 3'-nonhomologous tails during double-strand break repair via single-strand annealing; green fluorescent protein (GFP)-fusion protein localizes to the nucleus
0.088 2.94E-7 YMR111C YMR111C hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YMR111C is not an essential gene; forms nuclear foci upon DNA replication stress
0.088 3.55E-7 YMR158W-B_d YMR158W-B_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene ATG16/YMR159C
0.083 1.30E-6 YDR172W SUP35 het Translation termination factor eRF3, has a role in mRNA deadenylation and decay; altered protein conformation creates the [PSI(+)] prion that alters translational fidelity and results in a nonsense suppressor phenotype
0.083 1.46E-6 YKL171W NNK1 hom Protein kinase; implicated in proteasome function; interacts with TORC1, Ure2 and Gdh2; overexpression leads to hypersensitivity to rapamycin and nuclear accumulation of Gln3; epitope-tagged protein localizes to the cytoplasm
0.081 2.78E-6 YBR236C ABD1 het Methyltransferase, catalyzes the transfer of a methyl group from S-adenosylmethionine to the GpppN terminus of capped mRNA
0.081 2.84E-6 YDR531W CAB1 het Pantothenate kinase (ATP:D-pantothenate 4'-phosphotransferase, EC 2.7.1.33); catalyzes the first committed step in the universal biosynthetic pathway for synthesis of coenzyme A (CoA); transcriptionally regulated by Upc2p via a sterol response element