YBL075C / SSA3

ATPase involved in protein folding and the response to stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the heat shock protein 70 (HSP70) family; localized to the cytoplasm; SSA3 has a paralog, SSA4, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YBL075C / SSA3

Click on Significant Values for Screen Details ID:SGTC_45|Compound:0kpi-0036|FD-Score:3.72|P-value:1.54E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:4.11|P-value:3.21E-5 ID:SGTC_153|Compound:4077-0274|FD-Score:4.40|P-value:9.37E-6 ID:SGTC_275|Compound:trichlorophene|FD-Score:3.44|P-value:4.17E-4 ID:SGTC_355|Compound:1311-2252|FD-Score:5.07|P-value:4.08E-7 ID:SGTC_544|Compound:k015-0020|FD-Score:4.25|P-value:1.80E-5 ID:SGTC_572|Compound:0960-0087|FD-Score:3.94|P-value:6.54E-5 ID:SGTC_583|Compound:1488-1091|FD-Score:3.68|P-value:1.75E-4 ID:SGTC_628|Compound:1636-0253|FD-Score:3.85|P-value:9.32E-5 ID:SGTC_666|Compound:0272-0154|FD-Score:3.40|P-value:4.91E-4 ID:SGTC_668|Compound:1682-0499|FD-Score:4.59|P-value:4.16E-6 ID:SGTC_712|Compound:r015-0009|FD-Score:3.69|P-value:1.69E-4 ID:SGTC_774|Compound:k060-0086|FD-Score:11.00|P-value:2.69E-27 ID:SGTC_797|Compound:k781-0471|FD-Score:4.86|P-value:1.17E-6 ID:SGTC_895|Compound:0964-0006|FD-Score:4.40|P-value:9.56E-6 ID:SGTC_904|Compound:1141-0088|FD-Score:3.58|P-value:2.58E-4 ID:SGTC_975|Compound:1335-0046|FD-Score:3.24|P-value:8.30E-4 ID:SGTC_1048|Compound:3161-0300|FD-Score:4.55|P-value:4.88E-6 ID:SGTC_1053|Compound:3366-3204|FD-Score:3.91|P-value:7.32E-5 ID:SGTC_1073|Compound:triclabendazole|FD-Score:3.37|P-value:5.28E-4 ID:SGTC_1077|Compound:5-fluorocytosine|FD-Score:4.05|P-value:4.09E-5 ID:SGTC_1272|Compound:0839-0021|FD-Score:3.38|P-value:5.18E-4 ID:SGTC_1305|Compound:1181-0477|FD-Score:4.22|P-value:2.06E-5 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:3.25|P-value:8.18E-4 ID:SGTC_1685|Compound:st024049|FD-Score:3.68|P-value:1.78E-4 ID:SGTC_1687|Compound:st020778|FD-Score:6.32|P-value:3.90E-10 ID:SGTC_1695|Compound:st026914|FD-Score:4.67|P-value:2.89E-6 ID:SGTC_1728|Compound:st035614|FD-Score:3.86|P-value:9.03E-5 ID:SGTC_1744|Compound:st037937|FD-Score:4.14|P-value:2.90E-5 ID:SGTC_1756|Compound:st041558|FD-Score:4.58|P-value:4.28E-6 ID:SGTC_1804|Compound:st050076|FD-Score:3.31|P-value:6.56E-4 ID:SGTC_1905|Compound:st060207|FD-Score:3.36|P-value:5.49E-4 ID:SGTC_1939|Compound:st074455|FD-Score:4.97|P-value:6.79E-7 ID:SGTC_1963|Compound:st076565|FD-Score:4.48|P-value:6.72E-6 ID:SGTC_1981|Compound:st071826|FD-Score:4.41|P-value:9.26E-6 ID:SGTC_1983|Compound:st071813|FD-Score:3.50|P-value:3.35E-4 ID:SGTC_1989|Compound:st071868|FD-Score:3.58|P-value:2.56E-4 ID:SGTC_2057|Compound:5236571|FD-Score:-3.84|P-value:8.64E-5 ID:SGTC_2064|Compound:5220758|FD-Score:4.41|P-value:9.19E-6 ID:SGTC_2160|Compound:5660466|FD-Score:3.63|P-value:2.11E-4 ID:SGTC_2161|Compound:5662504|FD-Score:3.32|P-value:6.34E-4 ID:SGTC_2201|Compound:6605497|FD-Score:3.84|P-value:9.60E-5 ID:SGTC_2268|Compound:7933382|FD-Score:3.96|P-value:5.92E-5 ID:SGTC_2326|Compound:6164455|FD-Score:3.43|P-value:4.30E-4 ID:SGTC_2365|Compound:9042475|FD-Score:-3.17|P-value:9.49E-4 ID:SGTC_2452|Compound:5863136|FD-Score:6.72|P-value:3.20E-11 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:3.56|P-value:2.71E-4 ID:SGTC_2517|Compound:totarol|FD-Score:4.13|P-value:2.98E-5 ID:SGTC_2600|Compound:tangeritin|FD-Score:9.32|P-value:5.87E-20 ID:SGTC_2629|Compound:bisabolol|FD-Score:3.47|P-value:3.81E-4 ID:SGTC_2639|Compound:lactacystin|FD-Score:3.22|P-value:8.88E-4 ID:SGTC_2729|Compound:fluphenazine|FD-Score:3.25|P-value:8.07E-4 ID:SGTC_2736|Compound:butenafine|FD-Score:3.25|P-value:7.93E-4 ID:SGTC_2788|Compound:5282734|FD-Score:3.95|P-value:6.25E-5 ID:SGTC_2789|Compound:5281112|FD-Score:3.47|P-value:3.84E-4 ID:SGTC_2858|Compound:9025781|FD-Score:3.44|P-value:4.14E-4 ID:SGTC_2873|Compound:9040596|FD-Score:-3.54|P-value:2.60E-4 ID:SGTC_2875|Compound:9039966|FD-Score:3.90|P-value:7.53E-5 ID:SGTC_2906|Compound:7926292|FD-Score:4.18|P-value:2.44E-5 ID:SGTC_2973|Compound:9094665|FD-Score:3.66|P-value:1.89E-4 ID:SGTC_2980|Compound:9014342|FD-Score:3.43|P-value:4.37E-4 ID:SGTC_3026|Compound:9090633|FD-Score:3.30|P-value:6.79E-4 ID:SGTC_3029|Compound:9088683|FD-Score:5.86|P-value:5.99E-9 ID:SGTC_3049|Compound:9092223|FD-Score:5.60|P-value:2.64E-8 ID:SGTC_3068|Compound:9116768|FD-Score:3.32|P-value:6.36E-4 ID:SGTC_3083|Compound:9117465|FD-Score:3.59|P-value:2.44E-4 ID:SGTC_3088|Compound:9117578|FD-Score:3.73|P-value:1.46E-4 ID:SGTC_3200|Compound:9114385|FD-Score:3.38|P-value:5.26E-4 ID:SGTC_3202|Compound:9113761|FD-Score:-3.30|P-value:6.06E-4 ID:SGTC_3281|Compound:9140613|FD-Score:-3.26|P-value:6.93E-4 ID:SGTC_3301|Compound:9125354|FD-Score:3.76|P-value:1.32E-4 ID:SGTC_3333|Compound:9141820|FD-Score:6.17|P-value:9.65E-10 ID:SGTC_45|Compound:0kpi-0036|FD-Score:3.72|P-value:1.54E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:4.11|P-value:3.21E-5 ID:SGTC_153|Compound:4077-0274|FD-Score:4.40|P-value:9.37E-6 ID:SGTC_275|Compound:trichlorophene|FD-Score:3.44|P-value:4.17E-4 ID:SGTC_355|Compound:1311-2252|FD-Score:5.07|P-value:4.08E-7 ID:SGTC_544|Compound:k015-0020|FD-Score:4.25|P-value:1.80E-5 ID:SGTC_572|Compound:0960-0087|FD-Score:3.94|P-value:6.54E-5 ID:SGTC_583|Compound:1488-1091|FD-Score:3.68|P-value:1.75E-4 ID:SGTC_628|Compound:1636-0253|FD-Score:3.85|P-value:9.32E-5 ID:SGTC_666|Compound:0272-0154|FD-Score:3.40|P-value:4.91E-4 ID:SGTC_668|Compound:1682-0499|FD-Score:4.59|P-value:4.16E-6 ID:SGTC_712|Compound:r015-0009|FD-Score:3.69|P-value:1.69E-4 ID:SGTC_774|Compound:k060-0086|FD-Score:11.00|P-value:2.69E-27 ID:SGTC_797|Compound:k781-0471|FD-Score:4.86|P-value:1.17E-6 ID:SGTC_895|Compound:0964-0006|FD-Score:4.40|P-value:9.56E-6 ID:SGTC_904|Compound:1141-0088|FD-Score:3.58|P-value:2.58E-4 ID:SGTC_975|Compound:1335-0046|FD-Score:3.24|P-value:8.30E-4 ID:SGTC_1048|Compound:3161-0300|FD-Score:4.55|P-value:4.88E-6 ID:SGTC_1053|Compound:3366-3204|FD-Score:3.91|P-value:7.32E-5 ID:SGTC_1073|Compound:triclabendazole|FD-Score:3.37|P-value:5.28E-4 ID:SGTC_1077|Compound:5-fluorocytosine|FD-Score:4.05|P-value:4.09E-5 ID:SGTC_1272|Compound:0839-0021|FD-Score:3.38|P-value:5.18E-4 ID:SGTC_1305|Compound:1181-0477|FD-Score:4.22|P-value:2.06E-5 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:3.25|P-value:8.18E-4 ID:SGTC_1685|Compound:st024049|FD-Score:3.68|P-value:1.78E-4 ID:SGTC_1687|Compound:st020778|FD-Score:6.32|P-value:3.90E-10 ID:SGTC_1695|Compound:st026914|FD-Score:4.67|P-value:2.89E-6 ID:SGTC_1728|Compound:st035614|FD-Score:3.86|P-value:9.03E-5 ID:SGTC_1744|Compound:st037937|FD-Score:4.14|P-value:2.90E-5 ID:SGTC_1756|Compound:st041558|FD-Score:4.58|P-value:4.28E-6 ID:SGTC_1804|Compound:st050076|FD-Score:3.31|P-value:6.56E-4 ID:SGTC_1905|Compound:st060207|FD-Score:3.36|P-value:5.49E-4 ID:SGTC_1939|Compound:st074455|FD-Score:4.97|P-value:6.79E-7 ID:SGTC_1963|Compound:st076565|FD-Score:4.48|P-value:6.72E-6 ID:SGTC_1981|Compound:st071826|FD-Score:4.41|P-value:9.26E-6 ID:SGTC_1983|Compound:st071813|FD-Score:3.50|P-value:3.35E-4 ID:SGTC_1989|Compound:st071868|FD-Score:3.58|P-value:2.56E-4 ID:SGTC_2057|Compound:5236571|FD-Score:-3.84|P-value:8.64E-5 ID:SGTC_2064|Compound:5220758|FD-Score:4.41|P-value:9.19E-6 ID:SGTC_2160|Compound:5660466|FD-Score:3.63|P-value:2.11E-4 ID:SGTC_2161|Compound:5662504|FD-Score:3.32|P-value:6.34E-4 ID:SGTC_2201|Compound:6605497|FD-Score:3.84|P-value:9.60E-5 ID:SGTC_2268|Compound:7933382|FD-Score:3.96|P-value:5.92E-5 ID:SGTC_2326|Compound:6164455|FD-Score:3.43|P-value:4.30E-4 ID:SGTC_2365|Compound:9042475|FD-Score:-3.17|P-value:9.49E-4 ID:SGTC_2452|Compound:5863136|FD-Score:6.72|P-value:3.20E-11 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:3.56|P-value:2.71E-4 ID:SGTC_2517|Compound:totarol|FD-Score:4.13|P-value:2.98E-5 ID:SGTC_2600|Compound:tangeritin|FD-Score:9.32|P-value:5.87E-20 ID:SGTC_2629|Compound:bisabolol|FD-Score:3.47|P-value:3.81E-4 ID:SGTC_2639|Compound:lactacystin|FD-Score:3.22|P-value:8.88E-4 ID:SGTC_2729|Compound:fluphenazine|FD-Score:3.25|P-value:8.07E-4 ID:SGTC_2736|Compound:butenafine|FD-Score:3.25|P-value:7.93E-4 ID:SGTC_2788|Compound:5282734|FD-Score:3.95|P-value:6.25E-5 ID:SGTC_2789|Compound:5281112|FD-Score:3.47|P-value:3.84E-4 ID:SGTC_2858|Compound:9025781|FD-Score:3.44|P-value:4.14E-4 ID:SGTC_2873|Compound:9040596|FD-Score:-3.54|P-value:2.60E-4 ID:SGTC_2875|Compound:9039966|FD-Score:3.90|P-value:7.53E-5 ID:SGTC_2906|Compound:7926292|FD-Score:4.18|P-value:2.44E-5 ID:SGTC_2973|Compound:9094665|FD-Score:3.66|P-value:1.89E-4 ID:SGTC_2980|Compound:9014342|FD-Score:3.43|P-value:4.37E-4 ID:SGTC_3026|Compound:9090633|FD-Score:3.30|P-value:6.79E-4 ID:SGTC_3029|Compound:9088683|FD-Score:5.86|P-value:5.99E-9 ID:SGTC_3049|Compound:9092223|FD-Score:5.60|P-value:2.64E-8 ID:SGTC_3068|Compound:9116768|FD-Score:3.32|P-value:6.36E-4 ID:SGTC_3083|Compound:9117465|FD-Score:3.59|P-value:2.44E-4 ID:SGTC_3088|Compound:9117578|FD-Score:3.73|P-value:1.46E-4 ID:SGTC_3200|Compound:9114385|FD-Score:3.38|P-value:5.26E-4 ID:SGTC_3202|Compound:9113761|FD-Score:-3.30|P-value:6.06E-4 ID:SGTC_3281|Compound:9140613|FD-Score:-3.26|P-value:6.93E-4 ID:SGTC_3301|Compound:9125354|FD-Score:3.76|P-value:1.32E-4 ID:SGTC_3333|Compound:9141820|FD-Score:6.17|P-value:9.65E-10

Top fitness defect scores for YBL075C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_774 k060-0086 11.00 136.0 µM 2.69E-27 1 1.11E-28
2 SGTC_2600 tangeritin 9.32 88.0 µM 5.87E-20 3 5.90E-21
3 SGTC_2452 5863136 6.72 48.4 µM 3.20E-11 3 9.31E-12
4 SGTC_1687 st020778 6.32 55.4 µM 3.90E-10 103 1.30E-10
5 SGTC_3333 9141820 6.17 12.1 µM 9.65E-10 3 3.36E-10
6 SGTC_3029 9088683 5.86 49.5 µM 5.99E-9 6 2.30E-9
7 SGTC_3049 9092223 5.60 49.5 µM 2.64E-8 1 1.10E-8
8 SGTC_355 1311-2252 5.07 105.0 µM 4.08E-7 4 1.96E-7
9 SGTC_1939 st074455 4.97 53.6 µM 6.79E-7 13 3.35E-7
10 SGTC_797 k781-0471 4.86 270.0 µM 1.17E-6 RPP1 & pyrimidine depletion 6 5.94E-7
11 SGTC_1695 st026914 4.67 34.5 µM 2.89E-6 5 1.54E-6
12 SGTC_668 1682-0499 4.59 62.6 µM 4.16E-6 13 2.26E-6
13 SGTC_1756 st041558 4.58 35.5 µM 4.28E-6 3 2.33E-6
14 SGTC_1048 3161-0300 4.55 24.5 µM 4.88E-6 15 2.67E-6
15 SGTC_1963 st076565 4.48 50.3 µM 6.72E-6 4 3.74E-6
16 SGTC_2064 5220758 4.41 200.0 µM 9.19E-6 22 5.20E-6
17 SGTC_1981 st071826 4.41 47.0 µM 9.26E-6 8 5.24E-6
18 SGTC_153 4077-0274 4.40 519.7 µM 9.37E-6 12 5.31E-6
19 SGTC_895 0964-0006 4.40 13.7 µM 9.56E-6 6 5.42E-6
20 SGTC_544 k015-0020 4.25 52.4 µM 1.80E-5 8 1.06E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.133 8.54E-15 YOR095C RKI1 het Ribose-5-phosphate ketol-isomerase, catalyzes the interconversion of ribose 5-phosphate and ribulose 5-phosphate in the pentose phosphate pathway; participates in pyridoxine biosynthesis
0.118 7.86E-12 YHR117W TOM71 hom Mitochondrial outer membrane protein; probable minor component of the TOM (translocase of outer membrane) complex responsible for recognition and import of mitochondrially directed proteins; TOM71 has a paralog, TOM70, that arose from the whole genome duplication
0.104 1.37E-9 YPR159C-A_p YPR159C-A_p hom Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.103 2.50E-9 YLR132C USB1 het Putative phosphodiesterase specific for U6 snRNA 3' end modification; trims the 3' poly(u) tract to leave a terminal 3' phosphate; human homolog, hUSB1 (aka C16orf57) produces a 2',3' cyclic phosphate; mutations in hUSB1 are associated with a rare skin condition (OMIM 604173); essential protein that localizes to the nucleus and mitochondria; overexpression suppresses the respiratory defects of oxa1 and mtf2 mutants
0.089 2.47E-7 YML001W YPT7 hom Rab family GTPase; GTP-binding protein of the rab family; required for homotypic fusion event in vacuole inheritance, for endosome-endosome fusion; interacts with the cargo selection/retromer complex for retrograde sorting; similar to mammalian Rab7
0.088 3.63E-7 YBR053C_p YBR053C_p hom Putative protein of unknown function; induced by cell wall perturbation
0.082 1.83E-6 YPL037C EGD1 hom Subunit beta1 of the nascent polypeptide-associated complex (NAC) involved in protein targeting, associated with cytoplasmic ribosomes; enhances DNA binding of the Gal4p activator; homolog of human BTF3b
0.079 5.24E-6 YJR033C RAV1 hom Subunit of the RAVE complex (Rav1p, Rav2p, Skp1p), which promotes assembly of the V-ATPase holoenzyme; required for transport between the early and late endosome/PVC and for localization of TGN membrane proteins; potential Cdc28p substrate
0.074 1.88E-5 YOL050C_d YOL050C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps verified gene GAL11; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
0.074 1.89E-5 YJL064W_d YJL064W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene YJL065C/DLS1
0.074 1.94E-5 YJR025C BNA1 hom 3-hydroxyanthranilic acid dioxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p
0.073 2.55E-5 YGL194C HOS2 hom Histone deacetylase and subunit of Set3 and Rpd3L complexes; required for gene activation via specific deacetylation of lysines in H3 and H4 histone tails; subunit of the Set3 complex, a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity; co-localizes with Cmr1p in nuclear foci in response to DNA damage by MMS
0.073 2.62E-5 YLR087C CSF1 hom Protein required for fermentation at low temperature; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.072 2.71E-5 YGL001C ERG26 het C-3 sterol dehydrogenase, catalyzes the second of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis
0.071 3.54E-5 YGL096W TOS8 hom Homeodomain-containing protein and putative transcription factor; found associated with chromatin; target of SBF transcription factor; induced during meiosis and under cell-damaging conditions; TOS8 has a paralog, CUP9, that arose from the whole genome duplication