YBL077W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene ILS1/YBL076C

Zygosity: Heterozygous strain
fixedexpanded
Profile for YBL077W / YBL077W

Click on Significant Values for Screen Details ID:SGTC_125|Compound:0133-0007|FD-Score:-2.99|P-value:6.29E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:-3.29|P-value:1.92E-4 ID:SGTC_195|Compound:4234-0266|FD-Score:-2.94|P-value:7.54E-4 ID:SGTC_290|Compound:2043-6722|FD-Score:2.95|P-value:7.62E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:5.24|P-value:8.45E-9 ID:SGTC_353|Compound:1988-1175|FD-Score:4.39|P-value:1.17E-6 ID:SGTC_378|Compound:3970-0959|FD-Score:3.13|P-value:3.83E-4 ID:SGTC_395|Compound:anisomycin|FD-Score:4.74|P-value:1.73E-7 ID:SGTC_408|Compound:cantharidin|FD-Score:4.18|P-value:3.50E-6 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:-3.40|P-value:1.23E-4 ID:SGTC_507|Compound:nimesulide|FD-Score:-3.07|P-value:4.68E-4 ID:SGTC_638|Compound:3970-0837|FD-Score:-2.98|P-value:6.62E-4 ID:SGTC_652|Compound:0437-0092|FD-Score:3.02|P-value:5.77E-4 ID:SGTC_664|Compound:1222-0054|FD-Score:-2.90|P-value:8.72E-4 ID:SGTC_705|Compound:1124-0212|FD-Score:4.52|P-value:5.76E-7 ID:SGTC_756|Compound:0508-1999|FD-Score:3.63|P-value:4.65E-5 ID:SGTC_814|Compound:3342-0569|FD-Score:3.01|P-value:6.15E-4 ID:SGTC_874|Compound:0599-0792|FD-Score:3.28|P-value:2.08E-4 ID:SGTC_1080|Compound:nisoldipine|FD-Score:-2.98|P-value:6.48E-4 ID:SGTC_1084|Compound:voriconazole|FD-Score:4.47|P-value:7.82E-7 ID:SGTC_1085|Compound:doxorubicin|FD-Score:3.16|P-value:3.34E-4 ID:SGTC_1089|Compound:terbinafine|FD-Score:4.55|P-value:4.95E-7 ID:SGTC_1129|Compound:3453-1384|FD-Score:3.57|P-value:6.20E-5 ID:SGTC_1142|Compound:3253-1408|FD-Score:3.76|P-value:2.64E-5 ID:SGTC_1178|Compound:0988-0033|FD-Score:2.89|P-value:9.44E-4 ID:SGTC_1205|Compound:4161-2785|FD-Score:2.98|P-value:6.91E-4 ID:SGTC_1277|Compound:0873-0036|FD-Score:-2.92|P-value:8.16E-4 ID:SGTC_1392|Compound:3455-1037|FD-Score:3.33|P-value:1.71E-4 ID:SGTC_1418|Compound:3966-3099|FD-Score:2.96|P-value:7.43E-4 ID:SGTC_1454|Compound:4239-0054|FD-Score:-3.13|P-value:3.66E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-2.97|P-value:6.74E-4 ID:SGTC_1551|Compound:6-bromo-3'-methylflavone|FD-Score:-3.16|P-value:3.29E-4 ID:SGTC_1583|Compound:clindamycin|FD-Score:-3.27|P-value:2.12E-4 ID:SGTC_1587|Compound:estradiol valerate|FD-Score:-4.27|P-value:2.07E-6 ID:SGTC_1748|Compound:st037455|FD-Score:-3.06|P-value:4.95E-4 ID:SGTC_1800|Compound:st050079|FD-Score:3.44|P-value:1.07E-4 ID:SGTC_1810|Compound:st050138|FD-Score:3.87|P-value:1.55E-5 ID:SGTC_1821|Compound:st053465|FD-Score:3.46|P-value:1.01E-4 ID:SGTC_1867|Compound:st057372|FD-Score:-3.49|P-value:8.63E-5 ID:SGTC_1992|Compound:st073643|FD-Score:5.02|P-value:3.34E-8 ID:SGTC_2033|Compound:5192550|FD-Score:-3.10|P-value:4.19E-4 ID:SGTC_2127|Compound:5253358|FD-Score:3.37|P-value:1.48E-4 ID:SGTC_2209|Compound:5-(5-methyl-2-thenylidene)-Barbituric acid|FD-Score:4.07|P-value:6.14E-6 ID:SGTC_2221|Compound:6807166|FD-Score:3.88|P-value:1.52E-5 ID:SGTC_2246|Compound:7293507|FD-Score:3.72|P-value:3.24E-5 ID:SGTC_2385|Compound:9074692|FD-Score:3.31|P-value:1.83E-4 ID:SGTC_2401|Compound:5128683|FD-Score:3.24|P-value:2.47E-4 ID:SGTC_2402|Compound:5553605|FD-Score:3.07|P-value:4.88E-4 ID:SGTC_2409|Compound:alverine citrate|FD-Score:-3.83|P-value:1.86E-5 ID:SGTC_2417|Compound:cerulenin|FD-Score:-3.04|P-value:5.26E-4 ID:SGTC_2489|Compound:cantharidin|FD-Score:3.54|P-value:6.97E-5 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:3.36|P-value:1.49E-4 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:4.52|P-value:5.92E-7 ID:SGTC_2581|Compound:avocatin a|FD-Score:3.46|P-value:1.01E-4 ID:SGTC_2594|Compound:a-mangostin|FD-Score:3.05|P-value:5.13E-4 ID:SGTC_2643|Compound:anethole|FD-Score:3.94|P-value:1.13E-5 ID:SGTC_2674|Compound:ligustilide|FD-Score:3.43|P-value:1.11E-4 ID:SGTC_2753|Compound:fluvastatin|FD-Score:5.26|P-value:7.77E-9 ID:SGTC_2754|Compound:granisetron|FD-Score:3.07|P-value:4.82E-4 ID:SGTC_2799|Compound:7812892|FD-Score:5.77|P-value:2.66E-10 ID:SGTC_2831|Compound:7999036|FD-Score:-4.18|P-value:3.37E-6 ID:SGTC_2834|Compound:9001755|FD-Score:-3.62|P-value:4.75E-5 ID:SGTC_2841|Compound:9004761|FD-Score:4.92|P-value:6.13E-8 ID:SGTC_2906|Compound:7926292|FD-Score:-3.45|P-value:9.91E-5 ID:SGTC_2935|Compound:9038016|FD-Score:-3.07|P-value:4.72E-4 ID:SGTC_2953|Compound:9074162|FD-Score:3.18|P-value:3.15E-4 ID:SGTC_2982|Compound:9019404|FD-Score:4.50|P-value:6.40E-7 ID:SGTC_2988|Compound:9073640|FD-Score:3.39|P-value:1.35E-4 ID:SGTC_3205|Compound:9113483|FD-Score:3.33|P-value:1.75E-4 ID:SGTC_3207|Compound:9114163|FD-Score:4.69|P-value:2.30E-7 ID:SGTC_125|Compound:0133-0007|FD-Score:-2.99|P-value:6.29E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:-3.29|P-value:1.92E-4 ID:SGTC_195|Compound:4234-0266|FD-Score:-2.94|P-value:7.54E-4 ID:SGTC_290|Compound:2043-6722|FD-Score:2.95|P-value:7.62E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:5.24|P-value:8.45E-9 ID:SGTC_353|Compound:1988-1175|FD-Score:4.39|P-value:1.17E-6 ID:SGTC_378|Compound:3970-0959|FD-Score:3.13|P-value:3.83E-4 ID:SGTC_395|Compound:anisomycin|FD-Score:4.74|P-value:1.73E-7 ID:SGTC_408|Compound:cantharidin|FD-Score:4.18|P-value:3.50E-6 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:-3.40|P-value:1.23E-4 ID:SGTC_507|Compound:nimesulide|FD-Score:-3.07|P-value:4.68E-4 ID:SGTC_638|Compound:3970-0837|FD-Score:-2.98|P-value:6.62E-4 ID:SGTC_652|Compound:0437-0092|FD-Score:3.02|P-value:5.77E-4 ID:SGTC_664|Compound:1222-0054|FD-Score:-2.90|P-value:8.72E-4 ID:SGTC_705|Compound:1124-0212|FD-Score:4.52|P-value:5.76E-7 ID:SGTC_756|Compound:0508-1999|FD-Score:3.63|P-value:4.65E-5 ID:SGTC_814|Compound:3342-0569|FD-Score:3.01|P-value:6.15E-4 ID:SGTC_874|Compound:0599-0792|FD-Score:3.28|P-value:2.08E-4 ID:SGTC_1080|Compound:nisoldipine|FD-Score:-2.98|P-value:6.48E-4 ID:SGTC_1084|Compound:voriconazole|FD-Score:4.47|P-value:7.82E-7 ID:SGTC_1085|Compound:doxorubicin|FD-Score:3.16|P-value:3.34E-4 ID:SGTC_1089|Compound:terbinafine|FD-Score:4.55|P-value:4.95E-7 ID:SGTC_1129|Compound:3453-1384|FD-Score:3.57|P-value:6.20E-5 ID:SGTC_1142|Compound:3253-1408|FD-Score:3.76|P-value:2.64E-5 ID:SGTC_1178|Compound:0988-0033|FD-Score:2.89|P-value:9.44E-4 ID:SGTC_1205|Compound:4161-2785|FD-Score:2.98|P-value:6.91E-4 ID:SGTC_1277|Compound:0873-0036|FD-Score:-2.92|P-value:8.16E-4 ID:SGTC_1392|Compound:3455-1037|FD-Score:3.33|P-value:1.71E-4 ID:SGTC_1418|Compound:3966-3099|FD-Score:2.96|P-value:7.43E-4 ID:SGTC_1454|Compound:4239-0054|FD-Score:-3.13|P-value:3.66E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-2.97|P-value:6.74E-4 ID:SGTC_1551|Compound:6-bromo-3'-methylflavone|FD-Score:-3.16|P-value:3.29E-4 ID:SGTC_1583|Compound:clindamycin|FD-Score:-3.27|P-value:2.12E-4 ID:SGTC_1587|Compound:estradiol valerate|FD-Score:-4.27|P-value:2.07E-6 ID:SGTC_1748|Compound:st037455|FD-Score:-3.06|P-value:4.95E-4 ID:SGTC_1800|Compound:st050079|FD-Score:3.44|P-value:1.07E-4 ID:SGTC_1810|Compound:st050138|FD-Score:3.87|P-value:1.55E-5 ID:SGTC_1821|Compound:st053465|FD-Score:3.46|P-value:1.01E-4 ID:SGTC_1867|Compound:st057372|FD-Score:-3.49|P-value:8.63E-5 ID:SGTC_1992|Compound:st073643|FD-Score:5.02|P-value:3.34E-8 ID:SGTC_2033|Compound:5192550|FD-Score:-3.10|P-value:4.19E-4 ID:SGTC_2127|Compound:5253358|FD-Score:3.37|P-value:1.48E-4 ID:SGTC_2209|Compound:5-(5-methyl-2-thenylidene)-Barbituric acid|FD-Score:4.07|P-value:6.14E-6 ID:SGTC_2221|Compound:6807166|FD-Score:3.88|P-value:1.52E-5 ID:SGTC_2246|Compound:7293507|FD-Score:3.72|P-value:3.24E-5 ID:SGTC_2385|Compound:9074692|FD-Score:3.31|P-value:1.83E-4 ID:SGTC_2401|Compound:5128683|FD-Score:3.24|P-value:2.47E-4 ID:SGTC_2402|Compound:5553605|FD-Score:3.07|P-value:4.88E-4 ID:SGTC_2409|Compound:alverine citrate|FD-Score:-3.83|P-value:1.86E-5 ID:SGTC_2417|Compound:cerulenin|FD-Score:-3.04|P-value:5.26E-4 ID:SGTC_2489|Compound:cantharidin|FD-Score:3.54|P-value:6.97E-5 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:3.36|P-value:1.49E-4 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:4.52|P-value:5.92E-7 ID:SGTC_2581|Compound:avocatin a|FD-Score:3.46|P-value:1.01E-4 ID:SGTC_2594|Compound:a-mangostin|FD-Score:3.05|P-value:5.13E-4 ID:SGTC_2643|Compound:anethole|FD-Score:3.94|P-value:1.13E-5 ID:SGTC_2674|Compound:ligustilide|FD-Score:3.43|P-value:1.11E-4 ID:SGTC_2753|Compound:fluvastatin|FD-Score:5.26|P-value:7.77E-9 ID:SGTC_2754|Compound:granisetron|FD-Score:3.07|P-value:4.82E-4 ID:SGTC_2799|Compound:7812892|FD-Score:5.77|P-value:2.66E-10 ID:SGTC_2831|Compound:7999036|FD-Score:-4.18|P-value:3.37E-6 ID:SGTC_2834|Compound:9001755|FD-Score:-3.62|P-value:4.75E-5 ID:SGTC_2841|Compound:9004761|FD-Score:4.92|P-value:6.13E-8 ID:SGTC_2906|Compound:7926292|FD-Score:-3.45|P-value:9.91E-5 ID:SGTC_2935|Compound:9038016|FD-Score:-3.07|P-value:4.72E-4 ID:SGTC_2953|Compound:9074162|FD-Score:3.18|P-value:3.15E-4 ID:SGTC_2982|Compound:9019404|FD-Score:4.50|P-value:6.40E-7 ID:SGTC_2988|Compound:9073640|FD-Score:3.39|P-value:1.35E-4 ID:SGTC_3205|Compound:9113483|FD-Score:3.33|P-value:1.75E-4 ID:SGTC_3207|Compound:9114163|FD-Score:4.69|P-value:2.30E-7

Top fitness defect scores for YBL077W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2799 7812892 5.77 81.8 µM 2.66E-10 superoxide 7 3.90E-9 0.38
2 SGTC_2753 fluvastatin 5.26 17.1 µM 7.77E-9 azole & statin 5 7.28E-8 0.58
3 SGTC_341 1486-1430 5.24 230.0 µM 8.45E-9 11 7.82E-8 0.06
4 SGTC_1992 st073643 5.02 23.3 µM 3.34E-8 mitochondrial processes 3 2.57E-7 0.10
5 SGTC_2841 9004761 4.92 39.0 µM 6.13E-8 amide catabolism 5 4.37E-7 0.66
6 SGTC_395 anisomycin 4.74 6.2 µM 1.73E-7 2 1.07E-6 0.89
7 SGTC_3207 9114163 4.69 49.5 µM 2.30E-7 6 1.38E-6 0.47
8 SGTC_1089 terbinafine 4.55 2.2 µM 4.95E-7 5 2.68E-6 0.84
9 SGTC_705 1124-0212 4.52 310.0 µM 5.76E-7 3 3.05E-6 0.28
10 SGTC_2506 ethyl hematommate 4.52 54.2 µM 5.92E-7 RPP1 & pyrimidine depletion 3 3.13E-6 0.69
11 SGTC_2982 9019404 4.50 26.0 µM 6.40E-7 2 3.35E-6 0.01
12 SGTC_1084 voriconazole 4.47 435.0 nM 7.82E-7 azole & statin 7 3.98E-6 0.33
13 SGTC_353 1988-1175 4.39 58.3 µM 1.17E-6 unfolded protein response 7 5.66E-6 0.27
14 SGTC_408 cantharidin 4.18 100.0 µM 3.50E-6 cell wall signaling 6 1.47E-5 0.04
15 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 4.07 122.8 µM 6.14E-6 6 2.39E-5 0.01
16 SGTC_2643 anethole 3.94 100.0 µM 1.13E-5 2 4.07E-5 0.08
17 SGTC_2221 6807166 3.88 181.1 µM 1.52E-5 2 5.25E-5 0.82
18 SGTC_1810 st050138 3.87 53.0 µM 1.55E-5 PDR1 4 5.34E-5 0.39
19 SGTC_1142 3253-1408 3.76 9.8 µM 2.64E-5 2 8.49E-5 0.52
20 SGTC_2246 7293507 3.72 91.6 µM 3.24E-5 13 1.02E-4 0.13

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.097 1.59E-8 YHR209W CRG1 hom S-AdoMet-dependent methyltransferase involved in lipid homeostasis; mediates resistance to a drug cantharidin
0.094 5.40E-8 YPL099C AIM43 hom Protein of unknown function; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss
0.093 8.47E-8 YLR244C MAP1 hom Methionine aminopeptidase, catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides; function is partially redundant with that of Map2p
0.090 1.96E-7 YML075C HMG1 hom HMG-CoA reductase; catalyzes the conversion of HMG-CoA to mevalonate, which is a rate-limiting step in sterol biosynthesis; one of two isozymes; localizes to the nuclear envelope; overproduction induces the formation of karmellae; forms foci at the nuclear periphery upon DNA replication stress
0.086 5.25E-7 YKL202W_d YKL202W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.086 6.19E-7 YLL036C PRP19 het Splicing factor associated with the spliceosome; contains a U-box, a motif found in a class of ubiquitin ligases, and a WD40 domain
0.086 7.14E-7 YLR343W GAS2 hom 1,3-beta-glucanosyltransferase, involved with Gas4p in spore wall assembly; has similarity to Gas1p
0.084 1.25E-6 YLR428C_d YLR428C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CRN1
0.083 1.60E-6 YBL086C_p YBL086C_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.082 2.15E-6 YPL210C SRP72 het Core component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane
0.080 3.32E-6 YOL153C YOL153C hom Hypothetical protein
0.079 4.23E-6 YDL008W APC11 het Catalytic core subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; contains a RING-H2 domain that is required for activity
0.078 5.42E-6 YPL089C RLM1 hom MADS-box transcription factor; component of the protein kinase C-mediated MAP kinase pathway involved in the maintenance of cell integrity; phosphorylated and activated by the MAP-kinase Slt2p; RLM1 has a paralog, SMP1, that arose from the whole genome duplication
0.078 5.91E-6 YLR221C RSA3 hom Protein with a likely role in ribosomal maturation, required for accumulation of wild-type levels of large (60S) ribosomal subunits; binds to the helicase Dbp6p in pre-60S ribosomal particles in the nucleolus
0.078 6.84E-6 YOL057W YOL057W hom Dipeptidyl-peptidase III; cleaves dipeptides from the amino terminus of target proteins; highly active on synthetic substrate Arg-Arg-2-naphthylamide; mammalian ortholog may be a biomarker for some cancers