YBL078C / ATG8

Component of autophagosomes and Cvt vesicles; unique ubiquitin-like protein whose conjugation target is the lipid phosphatidylethanolamine (PE); Atg8p-PE is anchored to membranes, is involved in phagophore expansion, and may mediate membrane fusion during autophagosome formation; deconjugation of Atg8p-PE is required for efficient autophagosome biogenesis

Zygosity: Homozygous strain
fixedexpanded
Profile for YBL078C / ATG8

Click on Significant Values for Screen Details ID:SGTC_123|Compound:0083-0120|FD-Score:-3.93|P-value:6.88E-5 ID:SGTC_165|Compound:k038-0023|FD-Score:-5.52|P-value:5.19E-8 ID:SGTC_169|Compound:k015-0017|FD-Score:-3.22|P-value:8.34E-4 ID:SGTC_302|Compound:1094-0063|FD-Score:3.41|P-value:8.51E-4 ID:SGTC_378|Compound:3970-0959|FD-Score:5.22|P-value:6.02E-7 ID:SGTC_382|Compound:3229-0966|FD-Score:4.11|P-value:7.11E-5 ID:SGTC_663|Compound:1486-0733|FD-Score:3.76|P-value:2.65E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:-3.40|P-value:4.61E-4 ID:SGTC_680|Compound:0417-1641|FD-Score:3.53|P-value:5.79E-4 ID:SGTC_780|Compound:0109-0199|FD-Score:4.66|P-value:7.83E-6 ID:SGTC_792|Compound:4534-1957|FD-Score:3.72|P-value:2.98E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:-3.82|P-value:1.05E-4 ID:SGTC_923|Compound:1900-2434|FD-Score:4.36|P-value:2.67E-5 ID:SGTC_934|Compound:2950-0684|FD-Score:6.12|P-value:5.68E-9 ID:SGTC_936|Compound:3005-4620|FD-Score:4.95|P-value:2.13E-6 ID:SGTC_961|Compound:1252-1571|FD-Score:4.04|P-value:9.30E-5 ID:SGTC_1098|Compound:clofazimine|FD-Score:3.92|P-value:1.47E-4 ID:SGTC_1184|Compound:1269-1718|FD-Score:4.44|P-value:1.91E-5 ID:SGTC_1255|Compound:0566-0045|FD-Score:-5.51|P-value:5.51E-8 ID:SGTC_1365|Compound:1672-3266|FD-Score:3.44|P-value:7.62E-4 ID:SGTC_1428|Compound:4049-0204|FD-Score:3.40|P-value:8.87E-4 ID:SGTC_1431|Compound:4049-0260|FD-Score:3.37|P-value:9.54E-4 ID:SGTC_1478|Compound:0453-0656|FD-Score:4.29|P-value:3.51E-5 ID:SGTC_1533|Compound:dihydroergotamine mesylate|FD-Score:5.09|P-value:1.12E-6 ID:SGTC_1649|Compound:st011737|FD-Score:6.50|P-value:6.65E-10 ID:SGTC_1685|Compound:st024049|FD-Score:8.65|P-value:2.79E-16 ID:SGTC_1687|Compound:st020778|FD-Score:3.52|P-value:5.85E-4 ID:SGTC_1714|Compound:st033236|FD-Score:4.00|P-value:1.10E-4 ID:SGTC_1726|Compound:st035556|FD-Score:4.55|P-value:1.24E-5 ID:SGTC_1733|Compound:st037357|FD-Score:3.60|P-value:4.55E-4 ID:SGTC_1835|Compound:st008666|FD-Score:4.84|P-value:3.53E-6 ID:SGTC_1868|Compound:st057644|FD-Score:6.15|P-value:5.05E-9 ID:SGTC_1920|Compound:st075728|FD-Score:-3.71|P-value:1.55E-4 ID:SGTC_1921|Compound:5740136|FD-Score:-3.95|P-value:6.40E-5 ID:SGTC_1938|Compound:st074717|FD-Score:3.38|P-value:9.30E-4 ID:SGTC_1939|Compound:st074455|FD-Score:-3.44|P-value:3.99E-4 ID:SGTC_2063|Compound:5246145|FD-Score:4.06|P-value:8.59E-5 ID:SGTC_2068|Compound:5226020|FD-Score:3.40|P-value:8.86E-4 ID:SGTC_2105|Compound:5350118|FD-Score:3.72|P-value:2.99E-4 ID:SGTC_2124|Compound:5246320|FD-Score:3.54|P-value:5.59E-4 ID:SGTC_2183|Compound:6420625|FD-Score:4.40|P-value:2.32E-5 ID:SGTC_2213|Compound:7173844|FD-Score:4.71|P-value:6.29E-6 ID:SGTC_2237|Compound:6667747|FD-Score:3.66|P-value:3.66E-4 ID:SGTC_2370|Compound:9071495|FD-Score:7.40|P-value:2.32E-12 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:4.36|P-value:2.68E-5 ID:SGTC_2480|Compound:5767542|FD-Score:4.22|P-value:4.69E-5 ID:SGTC_2485|Compound:5633444|FD-Score:6.27|P-value:2.49E-9 ID:SGTC_2486|Compound:5283202|FD-Score:-5.99|P-value:3.99E-9 ID:SGTC_2503|Compound:beta-caryophyllene alcohol|FD-Score:-4.43|P-value:8.80E-6 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:4.12|P-value:7.03E-5 ID:SGTC_2575|Compound:plumbagin|FD-Score:3.64|P-value:3.95E-4 ID:SGTC_2606|Compound:farnesol|FD-Score:-3.21|P-value:8.56E-4 ID:SGTC_2643|Compound:anethole|FD-Score:5.37|P-value:2.92E-7 ID:SGTC_2696|Compound:st077691|FD-Score:3.62|P-value:4.26E-4 ID:SGTC_2795|Compound:7780010|FD-Score:4.58|P-value:1.11E-5 ID:SGTC_2848|Compound:9016370|FD-Score:-3.22|P-value:8.36E-4 ID:SGTC_2850|Compound:9015429|FD-Score:-3.95|P-value:6.35E-5 ID:SGTC_2856|Compound:9022925|FD-Score:7.48|P-value:1.31E-12 ID:SGTC_2924|Compound:9010168|FD-Score:4.11|P-value:7.30E-5 ID:SGTC_2994|Compound:9053520|FD-Score:4.25|P-value:4.24E-5 ID:SGTC_3071|Compound:9117417|FD-Score:7.08|P-value:1.87E-11 ID:SGTC_3214|Compound:9129694|FD-Score:4.54|P-value:1.31E-5 ID:SGTC_123|Compound:0083-0120|FD-Score:-3.93|P-value:6.88E-5 ID:SGTC_165|Compound:k038-0023|FD-Score:-5.52|P-value:5.19E-8 ID:SGTC_169|Compound:k015-0017|FD-Score:-3.22|P-value:8.34E-4 ID:SGTC_302|Compound:1094-0063|FD-Score:3.41|P-value:8.51E-4 ID:SGTC_378|Compound:3970-0959|FD-Score:5.22|P-value:6.02E-7 ID:SGTC_382|Compound:3229-0966|FD-Score:4.11|P-value:7.11E-5 ID:SGTC_663|Compound:1486-0733|FD-Score:3.76|P-value:2.65E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:-3.40|P-value:4.61E-4 ID:SGTC_680|Compound:0417-1641|FD-Score:3.53|P-value:5.79E-4 ID:SGTC_780|Compound:0109-0199|FD-Score:4.66|P-value:7.83E-6 ID:SGTC_792|Compound:4534-1957|FD-Score:3.72|P-value:2.98E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:-3.82|P-value:1.05E-4 ID:SGTC_923|Compound:1900-2434|FD-Score:4.36|P-value:2.67E-5 ID:SGTC_934|Compound:2950-0684|FD-Score:6.12|P-value:5.68E-9 ID:SGTC_936|Compound:3005-4620|FD-Score:4.95|P-value:2.13E-6 ID:SGTC_961|Compound:1252-1571|FD-Score:4.04|P-value:9.30E-5 ID:SGTC_1098|Compound:clofazimine|FD-Score:3.92|P-value:1.47E-4 ID:SGTC_1184|Compound:1269-1718|FD-Score:4.44|P-value:1.91E-5 ID:SGTC_1255|Compound:0566-0045|FD-Score:-5.51|P-value:5.51E-8 ID:SGTC_1365|Compound:1672-3266|FD-Score:3.44|P-value:7.62E-4 ID:SGTC_1428|Compound:4049-0204|FD-Score:3.40|P-value:8.87E-4 ID:SGTC_1431|Compound:4049-0260|FD-Score:3.37|P-value:9.54E-4 ID:SGTC_1478|Compound:0453-0656|FD-Score:4.29|P-value:3.51E-5 ID:SGTC_1533|Compound:dihydroergotamine mesylate|FD-Score:5.09|P-value:1.12E-6 ID:SGTC_1649|Compound:st011737|FD-Score:6.50|P-value:6.65E-10 ID:SGTC_1685|Compound:st024049|FD-Score:8.65|P-value:2.79E-16 ID:SGTC_1687|Compound:st020778|FD-Score:3.52|P-value:5.85E-4 ID:SGTC_1714|Compound:st033236|FD-Score:4.00|P-value:1.10E-4 ID:SGTC_1726|Compound:st035556|FD-Score:4.55|P-value:1.24E-5 ID:SGTC_1733|Compound:st037357|FD-Score:3.60|P-value:4.55E-4 ID:SGTC_1835|Compound:st008666|FD-Score:4.84|P-value:3.53E-6 ID:SGTC_1868|Compound:st057644|FD-Score:6.15|P-value:5.05E-9 ID:SGTC_1920|Compound:st075728|FD-Score:-3.71|P-value:1.55E-4 ID:SGTC_1921|Compound:5740136|FD-Score:-3.95|P-value:6.40E-5 ID:SGTC_1938|Compound:st074717|FD-Score:3.38|P-value:9.30E-4 ID:SGTC_1939|Compound:st074455|FD-Score:-3.44|P-value:3.99E-4 ID:SGTC_2063|Compound:5246145|FD-Score:4.06|P-value:8.59E-5 ID:SGTC_2068|Compound:5226020|FD-Score:3.40|P-value:8.86E-4 ID:SGTC_2105|Compound:5350118|FD-Score:3.72|P-value:2.99E-4 ID:SGTC_2124|Compound:5246320|FD-Score:3.54|P-value:5.59E-4 ID:SGTC_2183|Compound:6420625|FD-Score:4.40|P-value:2.32E-5 ID:SGTC_2213|Compound:7173844|FD-Score:4.71|P-value:6.29E-6 ID:SGTC_2237|Compound:6667747|FD-Score:3.66|P-value:3.66E-4 ID:SGTC_2370|Compound:9071495|FD-Score:7.40|P-value:2.32E-12 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:4.36|P-value:2.68E-5 ID:SGTC_2480|Compound:5767542|FD-Score:4.22|P-value:4.69E-5 ID:SGTC_2485|Compound:5633444|FD-Score:6.27|P-value:2.49E-9 ID:SGTC_2486|Compound:5283202|FD-Score:-5.99|P-value:3.99E-9 ID:SGTC_2503|Compound:beta-caryophyllene alcohol|FD-Score:-4.43|P-value:8.80E-6 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:4.12|P-value:7.03E-5 ID:SGTC_2575|Compound:plumbagin|FD-Score:3.64|P-value:3.95E-4 ID:SGTC_2606|Compound:farnesol|FD-Score:-3.21|P-value:8.56E-4 ID:SGTC_2643|Compound:anethole|FD-Score:5.37|P-value:2.92E-7 ID:SGTC_2696|Compound:st077691|FD-Score:3.62|P-value:4.26E-4 ID:SGTC_2795|Compound:7780010|FD-Score:4.58|P-value:1.11E-5 ID:SGTC_2848|Compound:9016370|FD-Score:-3.22|P-value:8.36E-4 ID:SGTC_2850|Compound:9015429|FD-Score:-3.95|P-value:6.35E-5 ID:SGTC_2856|Compound:9022925|FD-Score:7.48|P-value:1.31E-12 ID:SGTC_2924|Compound:9010168|FD-Score:4.11|P-value:7.30E-5 ID:SGTC_2994|Compound:9053520|FD-Score:4.25|P-value:4.24E-5 ID:SGTC_3071|Compound:9117417|FD-Score:7.08|P-value:1.87E-11 ID:SGTC_3214|Compound:9129694|FD-Score:4.54|P-value:1.31E-5

Top fitness defect scores for YBL078C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1685 st024049 8.65 53.1 µM 2.79E-16 TSC3-RPN4 2 2.66E-18
2 SGTC_2856 9022925 7.48 19.5 µM 1.31E-12 2 3.61E-14
3 SGTC_2370 9071495 7.40 200.0 µM 2.32E-12 mitochondrial processes 3 6.88E-14
4 SGTC_3071 9117417 7.08 49.5 µM 1.87E-11 fatty acid desaturase (OLE1) 4 7.24E-13
5 SGTC_1649 st011737 6.50 51.3 µM 6.65E-10 14 4.05E-11
6 SGTC_2485 5633444 6.27 17.8 µM 2.49E-9 redox potentiating 11 1.80E-10
7 SGTC_1868 st057644 6.15 42.7 µM 5.05E-9 8 3.99E-10
8 SGTC_934 2950-0684 6.12 338.0 µM 5.68E-9 5 4.55E-10
9 SGTC_2643 anethole 5.37 100.0 µM 2.92E-7 4 3.89E-8
10 SGTC_378 3970-0959 5.22 8.3 µM 6.02E-7 5 8.83E-8
11 SGTC_1533 dihydroergotamine mesylate 5.09 29.4 µM 1.12E-6 DNA intercalators 5 1.79E-7
12 SGTC_936 3005-4620 4.95 401.0 µM 2.13E-6 10 3.67E-7
13 SGTC_1835 st008666 4.84 49.2 µM 3.53E-6 12 6.51E-7
14 SGTC_2213 7173844 4.71 200.0 µM 6.29E-6 7 1.25E-6
15 SGTC_780 0109-0199 4.66 192.0 µM 7.83E-6 5 1.60E-6
16 SGTC_2795 7780010 4.58 54.5 µM 1.11E-5 13 2.37E-6
17 SGTC_1726 st035556 4.55 14.6 µM 1.24E-5 24 2.69E-6
18 SGTC_3214 9129694 4.54 49.5 µM 1.31E-5 12 2.87E-6
19 SGTC_1184 1269-1718 4.44 139.0 µM 1.91E-5 16 4.40E-6
20 SGTC_2183 6420625 4.40 130.5 µM 2.32E-5 mitochondrial processes 38 5.47E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.086 6.70E-7 YOR385W_p YOR385W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YOR385W is not an essential gene
0.085 7.80E-7 YBR159W IFA38 hom Microsomal beta-keto-reductase; contains oleate response element (ORE) sequence in the promoter region; mutants exhibit reduced VLCFA synthesis, accumulate high levels of dihydrosphingosine, phytosphingosine and medium-chain ceramides
0.082 2.17E-6 YNR054C ESF2 het Essential nucleolar protein involved in pre-18S rRNA processing; binds to RNA and stimulates ATPase activity of Dbp8; involved in assembly of the small subunit (SSU) processome
0.079 4.78E-6 YOR266W PNT1 hom Mitochondrial integral inner membrane protein involved in membrane insertion of C-terminus of Cox2p, interacts genetically and physically with Cox18p; deletion mutant sensitive to the anti-Pneumocystis carinii drug pentamidine
0.077 8.49E-6 YMR194C-A_d YMR194C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.075 1.26E-5 YCL030C HIS4 hom Multifunctional enzyme containing phosphoribosyl-ATP pyrophosphatase, phosphoribosyl-AMP cyclohydrolase, and histidinol dehydrogenase activities; catalyzes the second, third, ninth and tenth steps in histidine biosynthesis
0.073 2.40E-5 YDL015C TSC13 het Enoyl reductase; catalyzes the last step in each cycle of very long chain fatty acid elongation; localizes to the ER, highly enriched in a structure marking nuclear-vacuolar junctions; coimmunoprecipitates with elongases Fen1p and Sur4p; protein increases in abundance and relative distribution to ER foci increases upon DNA replication stress
0.072 3.27E-5 YPL025C_d YPL025C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.069 6.77E-5 YEL071W DLD3 hom D-lactate dehydrogenase, part of the retrograde regulon which consists of genes whose expression is stimulated by damage to mitochondria and reduced in cells grown with glutamate as the sole nitrogen source, located in the cytoplasm
0.068 8.91E-5 YKL069W YKL069W hom Methionine-R-sulfoxide reductase; reduces the R enantiomer of free Met-SO, in contrast to Ycl033Cp which reduces Met-R-SO in a peptide linkage; has a role in protection against oxidative stress; relative distribution to the nucleus increases upon DNA replication stress
0.068 9.01E-5 YPR095C SYT1 hom Guanine nucleotide exchange factor (GEF) for Arf proteins; promotes activation of Arl1p, which recruits Imh1p to the Golgi; involved in vesicular transport; member of the Sec7-domain family; contains a PH domain
0.067 1.05E-4 YKR021W ALY1 hom Alpha arrestin that controls nutrient-mediated intracellular sorting of permease Gap1p; interacts with AP-1 subunit Apl4p; may regulate endocytosis of plasma membrane proteins by recruiting ubiquitin ligase Rsp5p to plasma membrane targets; ALY1 has a paralog, ALY2, that arose from the whole genome duplication
0.065 1.59E-4 YBR007C DSF2 hom Deletion suppressor of mpt5 mutation; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.065 1.84E-4 YBR027C_d YBR027C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.065 1.84E-4 YBR056W-A_p YBR056W-A_p hom Protein of unknown function; mRNA identified as translated by ribosome profiling data; partially overlaps the dubious ORF YBR056C-B