YBL080C / PET112

Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; mutation is functionally complemented by the bacterial GatB ortholog

Zygosity: Homozygous strain
fixedexpanded
Profile for YBL080C / PET112

Click on Significant Values for Screen Details ID:SGTC_116|Compound:0155-0182|FD-Score:4.62|P-value:2.65E-5 ID:SGTC_118|Compound:0083-0097|FD-Score:5.22|P-value:2.57E-6 ID:SGTC_127|Compound:0180-0333|FD-Score:3.56|P-value:9.45E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:13.20|P-value:2.98E-31 ID:SGTC_151|Compound:3013-0144|FD-Score:-4.15|P-value:1.38E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:4.88|P-value:1.01E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:17.30|P-value:8.37E-52 ID:SGTC_275|Compound:trichlorophene|FD-Score:20.60|P-value:8.73E-73 ID:SGTC_310|Compound:1273-0058|FD-Score:8.21|P-value:3.42E-13 ID:SGTC_386|Compound:1509-0011|FD-Score:4.89|P-value:9.75E-6 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:4.19|P-value:1.23E-4 ID:SGTC_650|Compound:1328-0195|FD-Score:4.16|P-value:1.38E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:4.72|P-value:1.83E-5 ID:SGTC_1054|Compound:3429-0080|FD-Score:4.84|P-value:1.17E-5 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:4.25|P-value:1.03E-4 ID:SGTC_1236|Compound:0330-0013|FD-Score:3.73|P-value:5.54E-4 ID:SGTC_1274|Compound:0865-0114|FD-Score:4.56|P-value:3.36E-5 ID:SGTC_1291|Compound:0993-0025|FD-Score:4.99|P-value:6.57E-6 ID:SGTC_1468|Compound:k284-1086|FD-Score:4.55|P-value:3.44E-5 ID:SGTC_1490|Compound:4089-0339|FD-Score:7.95|P-value:1.82E-12 ID:SGTC_1542|Compound:7-hydroxy-3'-methoxyflavone|FD-Score:3.88|P-value:3.52E-4 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:3.70|P-value:6.21E-4 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:3.70|P-value:6.20E-4 ID:SGTC_1622|Compound:st003707|FD-Score:4.83|P-value:1.21E-5 ID:SGTC_1623|Compound:st003709|FD-Score:6.11|P-value:4.67E-8 ID:SGTC_1635|Compound:st007035|FD-Score:5.57|P-value:5.67E-7 ID:SGTC_1727|Compound:st034309|FD-Score:5.60|P-value:4.93E-7 ID:SGTC_1730|Compound:st033808|FD-Score:3.97|P-value:2.59E-4 ID:SGTC_1887|Compound:st057648|FD-Score:3.61|P-value:8.15E-4 ID:SGTC_1912|Compound:st060209|FD-Score:3.54|P-value:9.83E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-5.73|P-value:2.54E-7 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:3.67|P-value:6.66E-4 ID:SGTC_1936|Compound:st074407|FD-Score:-3.86|P-value:3.58E-4 ID:SGTC_2083|Compound:5306046|FD-Score:4.51|P-value:4.02E-5 ID:SGTC_2085|Compound:5307070|FD-Score:-3.80|P-value:4.40E-4 ID:SGTC_2086|Compound:5274770|FD-Score:-5.40|P-value:1.12E-6 ID:SGTC_2088|Compound:5278280|FD-Score:3.57|P-value:8.94E-4 ID:SGTC_2096|Compound:5468907|FD-Score:-4.45|P-value:4.85E-5 ID:SGTC_2131|Compound:toluylene red|FD-Score:3.88|P-value:3.52E-4 ID:SGTC_2166|Compound:5933061|FD-Score:4.10|P-value:1.68E-4 ID:SGTC_2205|Compound:7238770|FD-Score:4.76|P-value:1.59E-5 ID:SGTC_2239|Compound:6685329|FD-Score:-4.20|P-value:1.17E-4 ID:SGTC_2261|Compound:9010538|FD-Score:4.13|P-value:1.54E-4 ID:SGTC_2276|Compound:7947513|FD-Score:3.55|P-value:9.48E-4 ID:SGTC_2403|Compound:6032726|FD-Score:3.85|P-value:3.89E-4 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:3.66|P-value:6.84E-4 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:5.09|P-value:4.24E-6 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:3.64|P-value:7.34E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:-5.46|P-value:8.44E-7 ID:SGTC_2715|Compound:st079500|FD-Score:4.32|P-value:8.11E-5 ID:SGTC_2810|Compound:7959871|FD-Score:-5.70|P-value:2.97E-7 ID:SGTC_2813|Compound:7971799|FD-Score:-5.14|P-value:3.38E-6 ID:SGTC_2814|Compound:7977482|FD-Score:4.76|P-value:1.61E-5 ID:SGTC_2830|Compound:7992007|FD-Score:4.98|P-value:6.62E-6 ID:SGTC_2832|Compound:7992762|FD-Score:-5.87|P-value:1.39E-7 ID:SGTC_3076|Compound:9116187|FD-Score:-3.90|P-value:3.19E-4 ID:SGTC_3143|Compound:9086658|FD-Score:4.29|P-value:8.71E-5 ID:SGTC_3199|Compound:9111318|FD-Score:-3.54|P-value:9.68E-4 ID:SGTC_3296|Compound:9122258|FD-Score:4.85|P-value:1.11E-5 ID:SGTC_116|Compound:0155-0182|FD-Score:4.62|P-value:2.65E-5 ID:SGTC_118|Compound:0083-0097|FD-Score:5.22|P-value:2.57E-6 ID:SGTC_127|Compound:0180-0333|FD-Score:3.56|P-value:9.45E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:13.20|P-value:2.98E-31 ID:SGTC_151|Compound:3013-0144|FD-Score:-4.15|P-value:1.38E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:4.88|P-value:1.01E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:17.30|P-value:8.37E-52 ID:SGTC_275|Compound:trichlorophene|FD-Score:20.60|P-value:8.73E-73 ID:SGTC_310|Compound:1273-0058|FD-Score:8.21|P-value:3.42E-13 ID:SGTC_386|Compound:1509-0011|FD-Score:4.89|P-value:9.75E-6 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:4.19|P-value:1.23E-4 ID:SGTC_650|Compound:1328-0195|FD-Score:4.16|P-value:1.38E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:4.72|P-value:1.83E-5 ID:SGTC_1054|Compound:3429-0080|FD-Score:4.84|P-value:1.17E-5 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:4.25|P-value:1.03E-4 ID:SGTC_1236|Compound:0330-0013|FD-Score:3.73|P-value:5.54E-4 ID:SGTC_1274|Compound:0865-0114|FD-Score:4.56|P-value:3.36E-5 ID:SGTC_1291|Compound:0993-0025|FD-Score:4.99|P-value:6.57E-6 ID:SGTC_1468|Compound:k284-1086|FD-Score:4.55|P-value:3.44E-5 ID:SGTC_1490|Compound:4089-0339|FD-Score:7.95|P-value:1.82E-12 ID:SGTC_1542|Compound:7-hydroxy-3'-methoxyflavone|FD-Score:3.88|P-value:3.52E-4 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:3.70|P-value:6.21E-4 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:3.70|P-value:6.20E-4 ID:SGTC_1622|Compound:st003707|FD-Score:4.83|P-value:1.21E-5 ID:SGTC_1623|Compound:st003709|FD-Score:6.11|P-value:4.67E-8 ID:SGTC_1635|Compound:st007035|FD-Score:5.57|P-value:5.67E-7 ID:SGTC_1727|Compound:st034309|FD-Score:5.60|P-value:4.93E-7 ID:SGTC_1730|Compound:st033808|FD-Score:3.97|P-value:2.59E-4 ID:SGTC_1887|Compound:st057648|FD-Score:3.61|P-value:8.15E-4 ID:SGTC_1912|Compound:st060209|FD-Score:3.54|P-value:9.83E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-5.73|P-value:2.54E-7 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:3.67|P-value:6.66E-4 ID:SGTC_1936|Compound:st074407|FD-Score:-3.86|P-value:3.58E-4 ID:SGTC_2083|Compound:5306046|FD-Score:4.51|P-value:4.02E-5 ID:SGTC_2085|Compound:5307070|FD-Score:-3.80|P-value:4.40E-4 ID:SGTC_2086|Compound:5274770|FD-Score:-5.40|P-value:1.12E-6 ID:SGTC_2088|Compound:5278280|FD-Score:3.57|P-value:8.94E-4 ID:SGTC_2096|Compound:5468907|FD-Score:-4.45|P-value:4.85E-5 ID:SGTC_2131|Compound:toluylene red|FD-Score:3.88|P-value:3.52E-4 ID:SGTC_2166|Compound:5933061|FD-Score:4.10|P-value:1.68E-4 ID:SGTC_2205|Compound:7238770|FD-Score:4.76|P-value:1.59E-5 ID:SGTC_2239|Compound:6685329|FD-Score:-4.20|P-value:1.17E-4 ID:SGTC_2261|Compound:9010538|FD-Score:4.13|P-value:1.54E-4 ID:SGTC_2276|Compound:7947513|FD-Score:3.55|P-value:9.48E-4 ID:SGTC_2403|Compound:6032726|FD-Score:3.85|P-value:3.89E-4 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:3.66|P-value:6.84E-4 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:5.09|P-value:4.24E-6 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:3.64|P-value:7.34E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:-5.46|P-value:8.44E-7 ID:SGTC_2715|Compound:st079500|FD-Score:4.32|P-value:8.11E-5 ID:SGTC_2810|Compound:7959871|FD-Score:-5.70|P-value:2.97E-7 ID:SGTC_2813|Compound:7971799|FD-Score:-5.14|P-value:3.38E-6 ID:SGTC_2814|Compound:7977482|FD-Score:4.76|P-value:1.61E-5 ID:SGTC_2830|Compound:7992007|FD-Score:4.98|P-value:6.62E-6 ID:SGTC_2832|Compound:7992762|FD-Score:-5.87|P-value:1.39E-7 ID:SGTC_3076|Compound:9116187|FD-Score:-3.90|P-value:3.19E-4 ID:SGTC_3143|Compound:9086658|FD-Score:4.29|P-value:8.71E-5 ID:SGTC_3199|Compound:9111318|FD-Score:-3.54|P-value:9.68E-4 ID:SGTC_3296|Compound:9122258|FD-Score:4.85|P-value:1.11E-5

Top fitness defect scores for YBL080C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_275 trichlorophene 20.60 5.7 µM 8.73E-73 mitochondrial stress 4 2.06E-94
2 SGTC_236 1509-0011 17.30 5.3 µM 8.37E-52 74 4.93E-67
3 SGTC_134 0269-0018 13.20 6.9 µM 2.98E-31 26 3.17E-40
4 SGTC_310 1273-0058 8.21 1.1 µM 3.42E-13 mitochondrial stress 83 1.08E-16
5 SGTC_1490 4089-0339 7.95 670.0 nM 1.82E-12 1 9.51E-16
6 SGTC_1623 st003709 6.11 20.3 µM 4.67E-8 calcium & mitochondrial duress 12 5.09E-10
7 SGTC_1727 st034309 5.60 9.9 µM 4.93E-7 12 1.08E-8
8 SGTC_1635 st007035 5.57 42.4 µM 5.67E-7 145 1.30E-8
9 SGTC_118 0083-0097 5.22 135.3 µM 2.57E-6 translation 46 9.18E-8
10 SGTC_2572 astragaloside iv 5.09 100.0 µM 4.24E-6 8 1.76E-7
11 SGTC_1291 0993-0025 4.99 5.8 µM 6.57E-6 5 3.10E-7
12 SGTC_2830 7992007 4.98 71.4 µM 6.62E-6 8 3.13E-7
13 SGTC_386 1509-0011 4.89 3.1 µM 9.75E-6 112 5.16E-7
14 SGTC_173 1273-0061 4.88 2.7 µM 1.01E-5 mitochondrial stress 154 5.43E-7
15 SGTC_3296 9122258 4.85 64.0 µM 1.11E-5 redox potentiating 13 6.12E-7
16 SGTC_1054 3429-0080 4.84 167.0 µM 1.17E-5 18 6.53E-7
17 SGTC_1622 st003707 4.83 19.4 µM 1.21E-5 calcium & mitochondrial duress 17 6.84E-7
18 SGTC_2205 7238770 4.76 200.0 µM 1.59E-5 3 9.74E-7
19 SGTC_2814 7977482 4.76 43.0 µM 1.61E-5 28 9.83E-7
20 SGTC_908 3448-7491 4.72 47.7 µM 1.83E-5 mitochondrial stress 88 1.17E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.530 2.85E-242 YDR518W EUG1 hom Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.493 8.88E-205 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.480 2.39E-193 YDR079W PET100 hom Chaperone that specifically facilitates the assembly of cytochrome c oxidase, integral to the mitochondrial inner membrane; interacts with a subcomplex of subunits VII, VIIa, and VIII (Cox7p, Cox9p, and Cox8p) but not with the holoenzyme
0.473 7.30E-187 YGR220C MRPL9 hom Mitochondrial ribosomal protein of the large subunit
0.468 7.72E-182 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.451 3.60E-168 YPR166C MRP2 hom Mitochondrial ribosomal protein of the small subunit
0.448 1.64E-165 YNL213C RRG9 hom Protein of unknown function; null mutant lacks mitochondrial DNA and cannot grow on glycerol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.444 4.72E-162 YNL252C MRPL17 hom Mitochondrial ribosomal protein of the large subunit
0.441 7.90E-160 YGL107C RMD9 hom Mitochondrial protein required for respiratory growth; mutant phenotype and genetic interactions suggest a role in delivering mt mRNAs to ribosomes; located on matrix face of the inner membrane and loosely associated with mitoribosomes
0.441 9.41E-160 YDR462W MRPL28 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.440 3.08E-159 YKL068W-A_p YKL068W-A_p hom Putative protein of unknown function; identified by homology to Ashbya gossypii
0.436 3.37E-156 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.435 1.19E-154 YGR150C CCM1 hom Mitochondrial 15s rRNA-binding protein; required for intron removal of COB and COX1 pre-mRNAs; contains pentatricopeptide repeat (PPR) motifs; mutant is respiratory deficient and has defective plasma membrane electron transport
0.435 7.86E-155 YDR231C COX20 hom Mitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase
0.431 6.93E-152 YDR237W MRPL7 hom Mitochondrial ribosomal protein of the large subunit; MRPL7 produces both YmL5 and YmL7, which are two different modified forms of the same protein