YBL084C / CDC27

Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition

Zygosity: Heterozygous strain
fixedexpanded
Profile for YBL084C / CDC27

Click on Significant Values for Screen Details ID:SGTC_40|Compound:0327-0103|FD-Score:5.25|P-value:8.29E-7 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.40|P-value:8.97E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:-7.66|P-value:1.07E-12 ID:SGTC_119|Compound:0121-0043|FD-Score:4.15|P-value:7.57E-5 ID:SGTC_161|Compound:4065-0411|FD-Score:-4.12|P-value:7.66E-5 ID:SGTC_163|Compound:1327-0036|FD-Score:-5.71|P-value:8.01E-8 ID:SGTC_216|Compound:k038-0035|FD-Score:-3.46|P-value:7.38E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:3.74|P-value:3.29E-4 ID:SGTC_566|Compound:0958-0068|FD-Score:-3.58|P-value:4.99E-4 ID:SGTC_582|Compound:0987-0078|FD-Score:4.21|P-value:6.11E-5 ID:SGTC_638|Compound:3970-0837|FD-Score:-3.49|P-value:6.83E-4 ID:SGTC_659|Compound:k018-0002|FD-Score:4.17|P-value:7.15E-5 ID:SGTC_661|Compound:1304-0007|FD-Score:5.23|P-value:8.99E-7 ID:SGTC_765|Compound:1319-0117|FD-Score:3.59|P-value:5.26E-4 ID:SGTC_866|Compound:0495-0101|FD-Score:4.59|P-value:1.39E-5 ID:SGTC_910|Compound:3454-3003|FD-Score:-3.56|P-value:5.41E-4 ID:SGTC_925|Compound:2064-1272|FD-Score:-5.12|P-value:1.34E-6 ID:SGTC_933|Compound:2914-0560|FD-Score:-3.85|P-value:2.06E-4 ID:SGTC_937|Compound:3122-0005|FD-Score:-3.54|P-value:5.85E-4 ID:SGTC_960|Compound:1222-0186|FD-Score:5.15|P-value:1.29E-6 ID:SGTC_1025|Compound:k007-0731|FD-Score:5.17|P-value:1.19E-6 ID:SGTC_1038|Compound:k292-0204|FD-Score:3.92|P-value:1.77E-4 ID:SGTC_1892|Compound:st058411|FD-Score:-3.70|P-value:3.38E-4 ID:SGTC_1935|Compound:st074532|FD-Score:-3.76|P-value:2.82E-4 ID:SGTC_1993|Compound:st073995|FD-Score:5.57|P-value:1.83E-7 ID:SGTC_2154|Compound:5570129|FD-Score:3.81|P-value:2.58E-4 ID:SGTC_2283|Compound:7944793|FD-Score:3.44|P-value:8.41E-4 ID:SGTC_2340|Compound:7987427|FD-Score:4.17|P-value:6.97E-5 ID:SGTC_2407|Compound:paclitaxel|FD-Score:-4.90|P-value:3.54E-6 ID:SGTC_2463|Compound:5473429|FD-Score:-4.42|P-value:2.50E-5 ID:SGTC_2754|Compound:granisetron|FD-Score:-3.37|P-value:9.96E-4 ID:SGTC_3028|Compound:9087778|FD-Score:4.73|P-value:7.89E-6 ID:SGTC_3130|Compound:9127414|FD-Score:3.72|P-value:3.46E-4 ID:SGTC_3223|Compound:9129970|FD-Score:4.10|P-value:9.18E-5 ID:SGTC_3320|Compound:9137005|FD-Score:3.40|P-value:9.60E-4 ID:SGTC_40|Compound:0327-0103|FD-Score:5.25|P-value:8.29E-7 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.40|P-value:8.97E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:-7.66|P-value:1.07E-12 ID:SGTC_119|Compound:0121-0043|FD-Score:4.15|P-value:7.57E-5 ID:SGTC_161|Compound:4065-0411|FD-Score:-4.12|P-value:7.66E-5 ID:SGTC_163|Compound:1327-0036|FD-Score:-5.71|P-value:8.01E-8 ID:SGTC_216|Compound:k038-0035|FD-Score:-3.46|P-value:7.38E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:3.74|P-value:3.29E-4 ID:SGTC_566|Compound:0958-0068|FD-Score:-3.58|P-value:4.99E-4 ID:SGTC_582|Compound:0987-0078|FD-Score:4.21|P-value:6.11E-5 ID:SGTC_638|Compound:3970-0837|FD-Score:-3.49|P-value:6.83E-4 ID:SGTC_659|Compound:k018-0002|FD-Score:4.17|P-value:7.15E-5 ID:SGTC_661|Compound:1304-0007|FD-Score:5.23|P-value:8.99E-7 ID:SGTC_765|Compound:1319-0117|FD-Score:3.59|P-value:5.26E-4 ID:SGTC_866|Compound:0495-0101|FD-Score:4.59|P-value:1.39E-5 ID:SGTC_910|Compound:3454-3003|FD-Score:-3.56|P-value:5.41E-4 ID:SGTC_925|Compound:2064-1272|FD-Score:-5.12|P-value:1.34E-6 ID:SGTC_933|Compound:2914-0560|FD-Score:-3.85|P-value:2.06E-4 ID:SGTC_937|Compound:3122-0005|FD-Score:-3.54|P-value:5.85E-4 ID:SGTC_960|Compound:1222-0186|FD-Score:5.15|P-value:1.29E-6 ID:SGTC_1025|Compound:k007-0731|FD-Score:5.17|P-value:1.19E-6 ID:SGTC_1038|Compound:k292-0204|FD-Score:3.92|P-value:1.77E-4 ID:SGTC_1892|Compound:st058411|FD-Score:-3.70|P-value:3.38E-4 ID:SGTC_1935|Compound:st074532|FD-Score:-3.76|P-value:2.82E-4 ID:SGTC_1993|Compound:st073995|FD-Score:5.57|P-value:1.83E-7 ID:SGTC_2154|Compound:5570129|FD-Score:3.81|P-value:2.58E-4 ID:SGTC_2283|Compound:7944793|FD-Score:3.44|P-value:8.41E-4 ID:SGTC_2340|Compound:7987427|FD-Score:4.17|P-value:6.97E-5 ID:SGTC_2407|Compound:paclitaxel|FD-Score:-4.90|P-value:3.54E-6 ID:SGTC_2463|Compound:5473429|FD-Score:-4.42|P-value:2.50E-5 ID:SGTC_2754|Compound:granisetron|FD-Score:-3.37|P-value:9.96E-4 ID:SGTC_3028|Compound:9087778|FD-Score:4.73|P-value:7.89E-6 ID:SGTC_3130|Compound:9127414|FD-Score:3.72|P-value:3.46E-4 ID:SGTC_3223|Compound:9129970|FD-Score:4.10|P-value:9.18E-5 ID:SGTC_3320|Compound:9137005|FD-Score:3.40|P-value:9.60E-4

Top fitness defect scores for YBL084C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1993 st073995 5.57 70.8 µM 1.83E-7 2 1.28E-8 0.85
2 SGTC_40 0327-0103 5.25 19.8 µM 8.29E-7 3 7.69E-8 0.59
3 SGTC_661 1304-0007 5.23 33.6 µM 8.99E-7 2 8.48E-8 1.12
4 SGTC_1025 k007-0731 5.17 70.0 µM 1.19E-6 1 1.18E-7 0.71
5 SGTC_960 1222-0186 5.15 7.7 µM 1.29E-6 4 1.30E-7 0.57
6 SGTC_3028 9087778 4.73 49.5 µM 7.89E-6 1 1.12E-6 0.58
7 SGTC_866 0495-0101 4.59 262.0 µM 1.39E-5 60S ribosome export 5 2.19E-6 0.40
8 SGTC_582 0987-0078 4.21 156.0 µM 6.11E-5 calcium & mitochondrial duress 9 1.27E-5 0.43
9 SGTC_2340 7987427 4.17 183.4 µM 6.97E-5 6 1.49E-5 0.48
10 SGTC_659 k018-0002 4.17 107.0 µM 7.15E-5 5 1.54E-5 0.32
11 SGTC_119 0121-0043 4.15 24.8 µM 7.57E-5 mitochondrial stress 17 1.65E-5 0.01
12 SGTC_3223 9129970 4.10 49.5 µM 9.18E-5 4 2.07E-5 0.01
13 SGTC_1038 k292-0204 3.92 154.0 µM 1.77E-4 6 4.51E-5 0.14
14 SGTC_2154 5570129 3.81 200.0 µM 2.58E-4 2 7.04E-5 0.21
15 SGTC_451 chloral hydrate 3.74 100.0 µM 3.29E-4 21 9.38E-5 0.06
16 SGTC_3130 9127414 3.72 49.5 µM 3.46E-4 5 9.96E-5 0.18
17 SGTC_765 1319-0117 3.59 244.0 µM 5.26E-4 60S ribosome export 10 1.64E-4 0.15
18 SGTC_2283 7944793 3.44 200.0 µM 8.41E-4 11 2.86E-4 0.05
19 SGTC_3320 9137005 3.40 35.1 µM 9.60E-4 endomembrane recycling 5 3.34E-4 0.07
20 SGTC_1027 k015-0025 3.37 8.7 µM 0.00105 9 3.70E-4 0.12

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.127 1.44E-13 YDL153C SAS10 het Essential subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit; disrupts silencing when overproduced; mutant has increased aneuploidy tolerance
0.115 3.04E-11 YHR019C DED81 het Cytosolic asparaginyl-tRNA synthetase, required for protein synthesis, catalyzes the specific attachment of asparagine to its cognate tRNA
0.111 1.26E-10 YLR195C NMT1 het N-myristoyl transferase, catalyzes the cotranslational, covalent attachment of myristic acid to the N-terminal glycine residue of several proteins involved in cellular growth and signal transduction
0.107 4.76E-10 YBR155W CNS1 het TPR-containing co-chaperone; binds both Hsp82p (Hsp90) and Ssa1p (Hsp70) and stimulates the ATPase activity of SSA1, ts mutants reduce Hsp82p function while over expression suppresses the phenotypes of an HSP82 ts allele and a cpr7 deletion
0.104 1.72E-9 YDR235W PRP42 het U1 snRNP protein involved in splicing, required for U1 snRNP biogenesis; contains multiple tetriatricopeptide repeats
0.102 3.25E-9 YER043C SAH1 het S-adenosyl-L-homocysteine hydrolase, catabolizes S-adenosyl-L-homocysteine which is formed after donation of the activated methyl group of S-adenosyl-L-methionine (AdoMet) to an acceptor
0.101 4.06E-9 YGL015C_p YGL015C_p hom Putative protein of unknown function; null mutants accumulate cargo in the Golgi
0.101 4.41E-9 YIR011C STS1 het Protein required for localizing proteasomes to the nucleus; interacts with the karyopherin Srp1p; involved in ubiquitin-mediated protein degradation
0.087 4.24E-7 YNL163C RIA1 het Cytoplasmic GTPase/eEF2-like factor involved in ribosomal biogenesis; with Sdo1p, promotes release of Tif6p from 60S ribosomal subunits in the cytoplasm so that they can assemble with 40S subunits to generate mature ribosomes; required for quality control check of newly made large ribosomal subunits before they are released into the pool of translating ribosomes
0.087 5.10E-7 YOR181W LAS17 het Actin assembly factor, activates the Arp2/3 protein complex that nucleates branched actin filaments; localizes with the Arp2/3 complex to actin patches; homolog of the human Wiskott-Aldrich syndrome protein (WASP)
0.083 1.54E-6 YGR145W ENP2 het Essential nucleolar protein, required for biogenesis of the small ribosomal subunit; contains WD repeats, interacts with Mpp10p and Bfr2p, and has homology to Spb1p
0.083 1.67E-6 YDR287W INM2 hom Inositol monophosphatase, involved in biosynthesis of inositol; enzymatic activity requires magnesium ions and is inhibited by lithium and sodium ions; inm1 inm2 double mutant lacks inositol auxotrophy
0.081 2.34E-6 YBL044W_p YBL044W_p hom Putative protein of unknown function; YBL044W is not an essential protein
0.080 3.36E-6 YOR063W RPL3 het Ribosomal 60S subunit protein L3; homologous to mammalian ribosomal protein L3 and bacterial L3; involved in the replication and maintenance of killer double stranded RNA virus
0.080 3.60E-6 YKL142W MRP8 hom Protein of unknown function; undergoes sumoylation; transcription induced under cell wall stress; protein levels are reduced under anaerobic conditions; protein abundance increases in response to DNA replication stress; originally thought to be a mitochondrial ribosomal protein based on sequence analysis