YBL085W / BOI1

Protein implicated in polar growth; functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; relocalizes from bud neck to cytoplasm upon DNA replication stress; BOI1 has a paralog, BOI2, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YBL085W / BOI1

Click on Significant Values for Screen Details ID:SGTC_285|Compound:1486-1325|FD-Score:2.97|P-value:9.32E-4 ID:SGTC_294|Compound:k038-0071|FD-Score:4.24|P-value:4.14E-6 ID:SGTC_304|Compound:1310-0298|FD-Score:6.09|P-value:7.38E-11 ID:SGTC_447|Compound:ml7|FD-Score:3.03|P-value:7.55E-4 ID:SGTC_484|Compound:loperamide|FD-Score:3.52|P-value:1.09E-4 ID:SGTC_488|Compound:nitrendipine|FD-Score:3.30|P-value:2.69E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:19.10|P-value:3.27E-90 ID:SGTC_516|Compound:3992-2719|FD-Score:-4.33|P-value:2.18E-6 ID:SGTC_521|Compound:r062-0005|FD-Score:-3.04|P-value:5.96E-4 ID:SGTC_636|Compound:0kpi-0074|FD-Score:-2.94|P-value:8.86E-4 ID:SGTC_658|Compound:3253-0951|FD-Score:4.13|P-value:7.03E-6 ID:SGTC_780|Compound:0109-0199|FD-Score:3.63|P-value:7.00E-5 ID:SGTC_813|Compound:k007-0158|FD-Score:3.02|P-value:7.82E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:3.61|P-value:7.50E-5 ID:SGTC_993|Compound:3909-8757|FD-Score:-3.42|P-value:1.37E-4 ID:SGTC_1093|Compound:fluphenazine|FD-Score:3.72|P-value:4.65E-5 ID:SGTC_1096|Compound:rimcazole|FD-Score:3.97|P-value:1.51E-5 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:6.35|P-value:1.19E-11 ID:SGTC_1122|Compound:capsaicin|FD-Score:-2.98|P-value:7.59E-4 ID:SGTC_1139|Compound:k015-0024|FD-Score:3.71|P-value:4.88E-5 ID:SGTC_1150|Compound:3909-7983|FD-Score:-3.36|P-value:1.74E-4 ID:SGTC_1213|Compound:1315-0166|FD-Score:2.95|P-value:9.82E-4 ID:SGTC_1247|Compound:0448-0043|FD-Score:3.59|P-value:8.36E-5 ID:SGTC_1269|Compound:0831-0796|FD-Score:-4.90|P-value:1.01E-7 ID:SGTC_1274|Compound:0865-0114|FD-Score:-2.97|P-value:7.95E-4 ID:SGTC_1294|Compound:1000-1494|FD-Score:-3.28|P-value:2.43E-4 ID:SGTC_1318|Compound:1280-3875|FD-Score:-3.49|P-value:1.03E-4 ID:SGTC_1430|Compound:4049-0248|FD-Score:3.42|P-value:1.67E-4 ID:SGTC_1443|Compound:4112-3303|FD-Score:3.08|P-value:6.27E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:5.88|P-value:2.95E-10 ID:SGTC_1712|Compound:st032288|FD-Score:4.55|P-value:8.69E-7 ID:SGTC_1988|Compound:st071872|FD-Score:3.37|P-value:2.07E-4 ID:SGTC_1994|Compound:st072947|FD-Score:2.97|P-value:9.08E-4 ID:SGTC_2146|Compound:5545642|FD-Score:-3.58|P-value:7.05E-5 ID:SGTC_2173|Compound:5763948|FD-Score:-3.25|P-value:2.68E-4 ID:SGTC_2333|Compound:9017922|FD-Score:3.81|P-value:3.20E-5 ID:SGTC_2375|Compound:9072683|FD-Score:2.99|P-value:8.61E-4 ID:SGTC_2376|Compound:9072922|FD-Score:-5.63|P-value:1.16E-9 ID:SGTC_2377|Compound:9073351|FD-Score:-3.76|P-value:3.23E-5 ID:SGTC_2384|Compound:9036245|FD-Score:-3.32|P-value:2.06E-4 ID:SGTC_2385|Compound:9074692|FD-Score:4.26|P-value:3.81E-6 ID:SGTC_2387|Compound:9077560|FD-Score:3.33|P-value:2.40E-4 ID:SGTC_2397|Compound:5161689|FD-Score:3.17|P-value:4.45E-4 ID:SGTC_2415|Compound:st077333|FD-Score:3.19|P-value:4.15E-4 ID:SGTC_2474|Compound:5321570|FD-Score:3.44|P-value:1.52E-4 ID:SGTC_2483|Compound:5729050|FD-Score:3.91|P-value:2.03E-5 ID:SGTC_2563|Compound:tomatine|FD-Score:3.99|P-value:1.37E-5 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:3.04|P-value:7.13E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-4.73|P-value:2.51E-7 ID:SGTC_2584|Compound:androsterone|FD-Score:17.30|P-value:9.62E-75 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:3.54|P-value:9.93E-5 ID:SGTC_2619|Compound:obliquin|FD-Score:5.76|P-value:6.56E-10 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:-4.23|P-value:3.58E-6 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:-3.50|P-value:9.74E-5 ID:SGTC_2694|Compound:st077685|FD-Score:-3.01|P-value:6.67E-4 ID:SGTC_2935|Compound:9038016|FD-Score:3.31|P-value:2.60E-4 ID:SGTC_3010|Compound:9080089|FD-Score:3.30|P-value:2.71E-4 ID:SGTC_3037|Compound:9091026|FD-Score:4.57|P-value:7.56E-7 ID:SGTC_3077|Compound:9117319|FD-Score:-3.41|P-value:1.44E-4 ID:SGTC_3204|Compound:9114183|FD-Score:4.73|P-value:3.35E-7 ID:SGTC_3209|Compound:9113616|FD-Score:3.30|P-value:2.70E-4 ID:SGTC_3212|Compound:9128307|FD-Score:4.29|P-value:3.27E-6 ID:SGTC_3266|Compound:9136860|FD-Score:3.94|P-value:1.74E-5 ID:SGTC_3275|Compound:9138069|FD-Score:-3.82|P-value:2.49E-5 ID:SGTC_3311|Compound:9131146|FD-Score:4.39|P-value:2.01E-6 ID:SGTC_3321|Compound:9137793|FD-Score:4.10|P-value:8.22E-6 ID:SGTC_285|Compound:1486-1325|FD-Score:2.97|P-value:9.32E-4 ID:SGTC_294|Compound:k038-0071|FD-Score:4.24|P-value:4.14E-6 ID:SGTC_304|Compound:1310-0298|FD-Score:6.09|P-value:7.38E-11 ID:SGTC_447|Compound:ml7|FD-Score:3.03|P-value:7.55E-4 ID:SGTC_484|Compound:loperamide|FD-Score:3.52|P-value:1.09E-4 ID:SGTC_488|Compound:nitrendipine|FD-Score:3.30|P-value:2.69E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:19.10|P-value:3.27E-90 ID:SGTC_516|Compound:3992-2719|FD-Score:-4.33|P-value:2.18E-6 ID:SGTC_521|Compound:r062-0005|FD-Score:-3.04|P-value:5.96E-4 ID:SGTC_636|Compound:0kpi-0074|FD-Score:-2.94|P-value:8.86E-4 ID:SGTC_658|Compound:3253-0951|FD-Score:4.13|P-value:7.03E-6 ID:SGTC_780|Compound:0109-0199|FD-Score:3.63|P-value:7.00E-5 ID:SGTC_813|Compound:k007-0158|FD-Score:3.02|P-value:7.82E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:3.61|P-value:7.50E-5 ID:SGTC_993|Compound:3909-8757|FD-Score:-3.42|P-value:1.37E-4 ID:SGTC_1093|Compound:fluphenazine|FD-Score:3.72|P-value:4.65E-5 ID:SGTC_1096|Compound:rimcazole|FD-Score:3.97|P-value:1.51E-5 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:6.35|P-value:1.19E-11 ID:SGTC_1122|Compound:capsaicin|FD-Score:-2.98|P-value:7.59E-4 ID:SGTC_1139|Compound:k015-0024|FD-Score:3.71|P-value:4.88E-5 ID:SGTC_1150|Compound:3909-7983|FD-Score:-3.36|P-value:1.74E-4 ID:SGTC_1213|Compound:1315-0166|FD-Score:2.95|P-value:9.82E-4 ID:SGTC_1247|Compound:0448-0043|FD-Score:3.59|P-value:8.36E-5 ID:SGTC_1269|Compound:0831-0796|FD-Score:-4.90|P-value:1.01E-7 ID:SGTC_1274|Compound:0865-0114|FD-Score:-2.97|P-value:7.95E-4 ID:SGTC_1294|Compound:1000-1494|FD-Score:-3.28|P-value:2.43E-4 ID:SGTC_1318|Compound:1280-3875|FD-Score:-3.49|P-value:1.03E-4 ID:SGTC_1430|Compound:4049-0248|FD-Score:3.42|P-value:1.67E-4 ID:SGTC_1443|Compound:4112-3303|FD-Score:3.08|P-value:6.27E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:5.88|P-value:2.95E-10 ID:SGTC_1712|Compound:st032288|FD-Score:4.55|P-value:8.69E-7 ID:SGTC_1988|Compound:st071872|FD-Score:3.37|P-value:2.07E-4 ID:SGTC_1994|Compound:st072947|FD-Score:2.97|P-value:9.08E-4 ID:SGTC_2146|Compound:5545642|FD-Score:-3.58|P-value:7.05E-5 ID:SGTC_2173|Compound:5763948|FD-Score:-3.25|P-value:2.68E-4 ID:SGTC_2333|Compound:9017922|FD-Score:3.81|P-value:3.20E-5 ID:SGTC_2375|Compound:9072683|FD-Score:2.99|P-value:8.61E-4 ID:SGTC_2376|Compound:9072922|FD-Score:-5.63|P-value:1.16E-9 ID:SGTC_2377|Compound:9073351|FD-Score:-3.76|P-value:3.23E-5 ID:SGTC_2384|Compound:9036245|FD-Score:-3.32|P-value:2.06E-4 ID:SGTC_2385|Compound:9074692|FD-Score:4.26|P-value:3.81E-6 ID:SGTC_2387|Compound:9077560|FD-Score:3.33|P-value:2.40E-4 ID:SGTC_2397|Compound:5161689|FD-Score:3.17|P-value:4.45E-4 ID:SGTC_2415|Compound:st077333|FD-Score:3.19|P-value:4.15E-4 ID:SGTC_2474|Compound:5321570|FD-Score:3.44|P-value:1.52E-4 ID:SGTC_2483|Compound:5729050|FD-Score:3.91|P-value:2.03E-5 ID:SGTC_2563|Compound:tomatine|FD-Score:3.99|P-value:1.37E-5 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:3.04|P-value:7.13E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-4.73|P-value:2.51E-7 ID:SGTC_2584|Compound:androsterone|FD-Score:17.30|P-value:9.62E-75 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:3.54|P-value:9.93E-5 ID:SGTC_2619|Compound:obliquin|FD-Score:5.76|P-value:6.56E-10 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:-4.23|P-value:3.58E-6 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:-3.50|P-value:9.74E-5 ID:SGTC_2694|Compound:st077685|FD-Score:-3.01|P-value:6.67E-4 ID:SGTC_2935|Compound:9038016|FD-Score:3.31|P-value:2.60E-4 ID:SGTC_3010|Compound:9080089|FD-Score:3.30|P-value:2.71E-4 ID:SGTC_3037|Compound:9091026|FD-Score:4.57|P-value:7.56E-7 ID:SGTC_3077|Compound:9117319|FD-Score:-3.41|P-value:1.44E-4 ID:SGTC_3204|Compound:9114183|FD-Score:4.73|P-value:3.35E-7 ID:SGTC_3209|Compound:9113616|FD-Score:3.30|P-value:2.70E-4 ID:SGTC_3212|Compound:9128307|FD-Score:4.29|P-value:3.27E-6 ID:SGTC_3266|Compound:9136860|FD-Score:3.94|P-value:1.74E-5 ID:SGTC_3275|Compound:9138069|FD-Score:-3.82|P-value:2.49E-5 ID:SGTC_3311|Compound:9131146|FD-Score:4.39|P-value:2.01E-6 ID:SGTC_3321|Compound:9137793|FD-Score:4.10|P-value:8.22E-6

Top fitness defect scores for YBL085W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_514 4466-0038 19.10 2.6 nM 3.27E-90 cell wall 2 3.11E-81
2 SGTC_2584 androsterone 17.30 48.7 µM 9.62E-75 cell wall 3 2.36E-67
3 SGTC_1116 jasmonic acid 6.35 1.6 µM 1.19E-11 2 1.10E-10
4 SGTC_304 1310-0298 6.09 97.0 µM 7.38E-11 cell wall 18 5.73E-10
5 SGTC_1679 4130-1276 5.88 6.7 µM 2.95E-10 Golgi 24 2.00E-9
6 SGTC_2619 obliquin 5.76 87.9 µM 6.56E-10 cell wall 83 4.11E-9
7 SGTC_3204 9114183 4.73 49.5 µM 3.35E-7 15 1.14E-6
8 SGTC_3037 9091026 4.57 49.5 µM 7.56E-7 NEO1-PIK1 90 2.38E-6
9 SGTC_1712 st032288 4.55 53.4 µM 8.69E-7 calcium & mitochondrial duress 139 2.70E-6
10 SGTC_3311 9131146 4.39 2.9 µM 2.01E-6 cell wall 106 5.77E-6
11 SGTC_3212 9128307 4.29 49.5 µM 3.27E-6 37 8.95E-6
12 SGTC_2385 9074692 4.26 200.0 µM 3.81E-6 35 1.03E-5
13 SGTC_294 k038-0071 4.24 157.0 µM 4.14E-6 ubiquinone biosynthesis & proteasome 52 1.11E-5
14 SGTC_658 3253-0951 4.13 102.0 µM 7.03E-6 calcium & mitochondrial duress 54 1.79E-5
15 SGTC_3321 9137793 4.10 26.8 µM 8.22E-6 cell wall 70 2.06E-5
16 SGTC_2563 tomatine 3.99 8.5 µM 1.37E-5 45 3.27E-5
17 SGTC_1096 rimcazole 3.97 32.2 µM 1.51E-5 9 3.58E-5
18 SGTC_3266 9136860 3.94 49.5 µM 1.74E-5 cell wall 46 4.07E-5
19 SGTC_2483 5729050 3.91 27.2 µM 2.03E-5 26 4.66E-5
20 SGTC_2333 9017922 3.81 200.0 µM 3.20E-5 31 7.06E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.487 1.29E-199 YLL032C YLL032C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene
0.430 2.73E-151 YMR036C MIH1 hom Protein tyrosine phosphatase involved in cell cycle control; regulates the phosphorylation state of Cdc28p; homolog of S. pombe cdc25
0.389 2.24E-121 YLR102C APC9 hom Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition
0.366 1.36E-106 YDR121W DPB4 hom Subunit of DNA pol epsilon and of ISW2 chromatin accessibility complex; involved in both chromosomal DNA replication and inheritance of telomeric silencing; stabilizes the interaction of Pol epsilon with primer-template DNA, positively affecting the processivity of the polymerase and exonuclease activities of Pol epsilon; interacts with extranucleosomal DNA and acts as anchor point for ISW2 complex that retains its position on DNA during nucleosome mobilization
0.353 2.47E-99 YOL003C PFA4 hom Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases
0.332 2.67E-87 YMR124W_p YMR124W_p hom Protein of unknown function; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W is not an essential gene; predicted to have a role in organelle organization
0.327 1.20E-84 YGL033W HOP2 hom Meiosis-specific protein that localizes to chromosomes, preventing synapsis between nonhomologous chromosomes and ensuring synapsis between homologs; complexes with Mnd1p to promote homolog pairing and meiotic double-strand break repair
0.326 5.08E-84 YML119W_p YML119W_p hom Putative protein of unknown function; YML119W is not an essential gene; potential Cdc28p substrate
0.323 2.58E-82 YOR195W SLK19 hom Kinetochore-associated protein required for normal segregation of chromosomes in meiosis and mitosis; component of the FEAR regulatory network, which promotes Cdc14p release from the nucleolus during anaphase; potential Cdc28p substrate
0.319 3.38E-80 YBR134W_d YBR134W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.312 7.52E-77 YKL035W UGP1 het UDP-glucose pyrophosphorylase (UGPase); catalyses the reversible formation of UDP-Glc from glucose 1-phosphate and UTP, involved in a wide variety of metabolic pathways, expression modulated by Pho85p through Pho4p; UGP1 has a paralog, YHL012W, that arose from the whole genome duplication
0.296 6.05E-69 YMR121C RPL15B hom Ribosomal 60S subunit protein L15B; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L15, no bacterial homolog; RPL15B has a paralog, RPL15A, that arose from the whole genome duplication; relocalizes from nucleus to nucleolus upon DNA replication stress
0.290 3.78E-66 YJL159W HSP150 hom O-mannosylated heat shock protein; secreted and covalently attached to the cell wall via beta-1,3-glucan and disulfide bridges; required for cell wall stability; induced by heat shock, oxidative stress, and nitrogen limitation; HSP150 has a paralog, PIR3, that arose from the whole genome duplication
0.284 3.92E-63 YCL005W LDB16 hom Protein of unknown function; null mutants have decreased net negative cell surface charge; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; native protein is detected in purified mitochondria
0.272 6.55E-58 YOR091W TMA46 hom Protein of unknown function that associates with translating ribosomes; interacts with GTPase Rbg1p