YBL090W / MRP21

Mitochondrial ribosomal protein of the small subunit; MRP21 exhibits genetic interactions with mutations in the COX2 and COX3 mRNA 5'-untranslated leader sequences

Zygosity: Homozygous strain
fixedexpanded
Profile for YBL090W / MRP21

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:4.39|P-value:3.75E-5 ID:SGTC_63|Compound:0099-0242|FD-Score:4.45|P-value:2.98E-5 ID:SGTC_118|Compound:0083-0097|FD-Score:3.43|P-value:9.94E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:-4.46|P-value:2.23E-5 ID:SGTC_173|Compound:1273-0061|FD-Score:6.69|P-value:7.18E-10 ID:SGTC_204|Compound:1543-0184|FD-Score:3.80|P-value:3.10E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:10.20|P-value:9.35E-21 ID:SGTC_275|Compound:trichlorophene|FD-Score:4.53|P-value:2.21E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:4.62|P-value:1.54E-5 ID:SGTC_330|Compound:1488-0319|FD-Score:4.22|P-value:7.15E-5 ID:SGTC_407|Compound:eburnamonine|FD-Score:4.43|P-value:3.15E-5 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:-3.85|P-value:2.10E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-5.76|P-value:6.97E-8 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-3.45|P-value:7.79E-4 ID:SGTC_535|Compound:2293-4129|FD-Score:-3.42|P-value:8.44E-4 ID:SGTC_578|Compound:3460-0051|FD-Score:3.55|P-value:7.00E-4 ID:SGTC_601|Compound:0986-0029|FD-Score:3.67|P-value:4.69E-4 ID:SGTC_633|Compound:0437-0093|FD-Score:3.80|P-value:3.09E-4 ID:SGTC_756|Compound:0508-1999|FD-Score:6.37|P-value:4.32E-9 ID:SGTC_767|Compound:0929-0023|FD-Score:8.14|P-value:8.58E-14 ID:SGTC_769|Compound:0302-0231|FD-Score:-4.22|P-value:5.49E-5 ID:SGTC_800|Compound:3448-7362|FD-Score:3.61|P-value:5.75E-4 ID:SGTC_845|Compound:0330-0138|FD-Score:-3.42|P-value:8.54E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:6.80|P-value:3.79E-10 ID:SGTC_906|Compound:1165-0455|FD-Score:5.18|P-value:1.44E-6 ID:SGTC_908|Compound:3448-7491|FD-Score:5.05|P-value:2.57E-6 ID:SGTC_931|Compound:2812-0076|FD-Score:3.63|P-value:5.34E-4 ID:SGTC_969|Compound:1313-0238|FD-Score:3.66|P-value:4.95E-4 ID:SGTC_980|Compound:1473-0395|FD-Score:4.08|P-value:1.17E-4 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:3.55|P-value:6.98E-4 ID:SGTC_1151|Compound:3909-8316|FD-Score:-3.66|P-value:4.00E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:-5.47|P-value:2.91E-7 ID:SGTC_1164|Compound:k060-0068|FD-Score:3.72|P-value:4.03E-4 ID:SGTC_1289|Compound:0976-0073|FD-Score:4.69|P-value:1.14E-5 ID:SGTC_1321|Compound:1326-2144|FD-Score:3.87|P-value:2.45E-4 ID:SGTC_1554|Compound:st069299|FD-Score:4.90|P-value:4.92E-6 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:5.06|P-value:2.42E-6 ID:SGTC_1627|Compound:st003713|FD-Score:5.93|P-value:4.20E-8 ID:SGTC_1707|Compound:st032323|FD-Score:-3.47|P-value:7.31E-4 ID:SGTC_1730|Compound:st033808|FD-Score:3.74|P-value:3.80E-4 ID:SGTC_1742|Compound:st038235|FD-Score:3.92|P-value:2.05E-4 ID:SGTC_1754|Compound:st042065|FD-Score:-4.57|P-value:1.45E-5 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:4.11|P-value:1.05E-4 ID:SGTC_2021|Compound:4019055|FD-Score:-4.34|P-value:3.54E-5 ID:SGTC_2097|Compound:5376186|FD-Score:3.74|P-value:3.74E-4 ID:SGTC_2283|Compound:7944793|FD-Score:4.37|P-value:4.01E-5 ID:SGTC_2342|Compound:7990637|FD-Score:3.56|P-value:6.61E-4 ID:SGTC_2389|Compound:9091542|FD-Score:-4.31|P-value:3.94E-5 ID:SGTC_2391|Compound:6285546|FD-Score:4.16|P-value:8.67E-5 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:-7.58|P-value:2.34E-12 ID:SGTC_2612|Compound:dictamnine|FD-Score:-3.41|P-value:8.91E-4 ID:SGTC_2786|Compound:7743617|FD-Score:4.92|P-value:4.37E-6 ID:SGTC_2829|Compound:7992743|FD-Score:4.56|P-value:1.95E-5 ID:SGTC_2858|Compound:9025781|FD-Score:-4.13|P-value:7.76E-5 ID:SGTC_2896|Compound:9052656|FD-Score:-3.60|P-value:4.80E-4 ID:SGTC_3002|Compound:9075603|FD-Score:3.63|P-value:5.33E-4 ID:SGTC_3059|Compound:1327-0034|FD-Score:-3.71|P-value:3.41E-4 ID:SGTC_3094|Compound:9117742|FD-Score:5.31|P-value:8.24E-7 ID:SGTC_3138|Compound:9097216|FD-Score:3.79|P-value:3.21E-4 ID:SGTC_3189|Compound:9110682|FD-Score:3.55|P-value:6.96E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-4.58|P-value:1.37E-5 ID:SGTC_3338|Compound:9144300|FD-Score:3.78|P-value:3.32E-4 ID:SGTC_3346|Compound:9158254|FD-Score:3.62|P-value:5.52E-4 ID:SGTC_10|Compound:0279-0212|FD-Score:4.39|P-value:3.75E-5 ID:SGTC_63|Compound:0099-0242|FD-Score:4.45|P-value:2.98E-5 ID:SGTC_118|Compound:0083-0097|FD-Score:3.43|P-value:9.94E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:-4.46|P-value:2.23E-5 ID:SGTC_173|Compound:1273-0061|FD-Score:6.69|P-value:7.18E-10 ID:SGTC_204|Compound:1543-0184|FD-Score:3.80|P-value:3.10E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:10.20|P-value:9.35E-21 ID:SGTC_275|Compound:trichlorophene|FD-Score:4.53|P-value:2.21E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:4.62|P-value:1.54E-5 ID:SGTC_330|Compound:1488-0319|FD-Score:4.22|P-value:7.15E-5 ID:SGTC_407|Compound:eburnamonine|FD-Score:4.43|P-value:3.15E-5 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:-3.85|P-value:2.10E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-5.76|P-value:6.97E-8 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-3.45|P-value:7.79E-4 ID:SGTC_535|Compound:2293-4129|FD-Score:-3.42|P-value:8.44E-4 ID:SGTC_578|Compound:3460-0051|FD-Score:3.55|P-value:7.00E-4 ID:SGTC_601|Compound:0986-0029|FD-Score:3.67|P-value:4.69E-4 ID:SGTC_633|Compound:0437-0093|FD-Score:3.80|P-value:3.09E-4 ID:SGTC_756|Compound:0508-1999|FD-Score:6.37|P-value:4.32E-9 ID:SGTC_767|Compound:0929-0023|FD-Score:8.14|P-value:8.58E-14 ID:SGTC_769|Compound:0302-0231|FD-Score:-4.22|P-value:5.49E-5 ID:SGTC_800|Compound:3448-7362|FD-Score:3.61|P-value:5.75E-4 ID:SGTC_845|Compound:0330-0138|FD-Score:-3.42|P-value:8.54E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:6.80|P-value:3.79E-10 ID:SGTC_906|Compound:1165-0455|FD-Score:5.18|P-value:1.44E-6 ID:SGTC_908|Compound:3448-7491|FD-Score:5.05|P-value:2.57E-6 ID:SGTC_931|Compound:2812-0076|FD-Score:3.63|P-value:5.34E-4 ID:SGTC_969|Compound:1313-0238|FD-Score:3.66|P-value:4.95E-4 ID:SGTC_980|Compound:1473-0395|FD-Score:4.08|P-value:1.17E-4 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:3.55|P-value:6.98E-4 ID:SGTC_1151|Compound:3909-8316|FD-Score:-3.66|P-value:4.00E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:-5.47|P-value:2.91E-7 ID:SGTC_1164|Compound:k060-0068|FD-Score:3.72|P-value:4.03E-4 ID:SGTC_1289|Compound:0976-0073|FD-Score:4.69|P-value:1.14E-5 ID:SGTC_1321|Compound:1326-2144|FD-Score:3.87|P-value:2.45E-4 ID:SGTC_1554|Compound:st069299|FD-Score:4.90|P-value:4.92E-6 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:5.06|P-value:2.42E-6 ID:SGTC_1627|Compound:st003713|FD-Score:5.93|P-value:4.20E-8 ID:SGTC_1707|Compound:st032323|FD-Score:-3.47|P-value:7.31E-4 ID:SGTC_1730|Compound:st033808|FD-Score:3.74|P-value:3.80E-4 ID:SGTC_1742|Compound:st038235|FD-Score:3.92|P-value:2.05E-4 ID:SGTC_1754|Compound:st042065|FD-Score:-4.57|P-value:1.45E-5 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:4.11|P-value:1.05E-4 ID:SGTC_2021|Compound:4019055|FD-Score:-4.34|P-value:3.54E-5 ID:SGTC_2097|Compound:5376186|FD-Score:3.74|P-value:3.74E-4 ID:SGTC_2283|Compound:7944793|FD-Score:4.37|P-value:4.01E-5 ID:SGTC_2342|Compound:7990637|FD-Score:3.56|P-value:6.61E-4 ID:SGTC_2389|Compound:9091542|FD-Score:-4.31|P-value:3.94E-5 ID:SGTC_2391|Compound:6285546|FD-Score:4.16|P-value:8.67E-5 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:-7.58|P-value:2.34E-12 ID:SGTC_2612|Compound:dictamnine|FD-Score:-3.41|P-value:8.91E-4 ID:SGTC_2786|Compound:7743617|FD-Score:4.92|P-value:4.37E-6 ID:SGTC_2829|Compound:7992743|FD-Score:4.56|P-value:1.95E-5 ID:SGTC_2858|Compound:9025781|FD-Score:-4.13|P-value:7.76E-5 ID:SGTC_2896|Compound:9052656|FD-Score:-3.60|P-value:4.80E-4 ID:SGTC_3002|Compound:9075603|FD-Score:3.63|P-value:5.33E-4 ID:SGTC_3059|Compound:1327-0034|FD-Score:-3.71|P-value:3.41E-4 ID:SGTC_3094|Compound:9117742|FD-Score:5.31|P-value:8.24E-7 ID:SGTC_3138|Compound:9097216|FD-Score:3.79|P-value:3.21E-4 ID:SGTC_3189|Compound:9110682|FD-Score:3.55|P-value:6.96E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-4.58|P-value:1.37E-5 ID:SGTC_3338|Compound:9144300|FD-Score:3.78|P-value:3.32E-4 ID:SGTC_3346|Compound:9158254|FD-Score:3.62|P-value:5.52E-4

Top fitness defect scores for YBL090W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 10.20 5.3 µM 9.35E-21 190 7.15E-25
2 SGTC_767 0929-0023 8.14 86.0 µM 8.58E-14 TRP & mitochondrial translation 8 1.97E-16
3 SGTC_892 0929-0076 6.80 29.0 µM 3.79E-10 TRP & mitochondrial translation 3 5.12E-12
4 SGTC_173 1273-0061 6.69 2.7 µM 7.18E-10 mitochondrial stress 93 1.11E-11
5 SGTC_756 0508-1999 6.37 28.3 µM 4.32E-9 RPP1 & pyrimidine depletion 2 9.76E-11
6 SGTC_1627 st003713 5.93 25.6 µM 4.20E-8 calcium & mitochondrial duress 31 1.53E-9
7 SGTC_3094 9117742 5.31 49.5 µM 8.24E-7 7 5.63E-8
8 SGTC_906 1165-0455 5.18 526.0 µM 1.44E-6 1 1.11E-7
9 SGTC_1597 7-benzyloxygramine 5.06 47.5 µM 2.42E-6 calcium & mitochondrial duress 69 2.08E-7
10 SGTC_908 3448-7491 5.05 47.7 µM 2.57E-6 mitochondrial stress 77 2.23E-7
11 SGTC_2786 7743617 4.92 45.5 µM 4.37E-6 9 4.23E-7
12 SGTC_1554 st069299 4.90 38.7 µM 4.92E-6 6 4.89E-7
13 SGTC_1289 0976-0073 4.69 69.1 µM 1.14E-5 5 1.35E-6
14 SGTC_310 1273-0058 4.62 1.1 µM 1.54E-5 mitochondrial stress 202 1.94E-6
15 SGTC_2829 7992743 4.56 58.4 µM 1.95E-5 24 2.59E-6
16 SGTC_275 trichlorophene 4.53 5.7 µM 2.21E-5 mitochondrial stress 199 3.01E-6
17 SGTC_63 0099-0242 4.45 26.7 µM 2.98E-5 mitochondrial stress 72 4.32E-6
18 SGTC_407 eburnamonine 4.43 100.0 µM 3.15E-5 8 4.61E-6
19 SGTC_10 0279-0212 4.39 42.6 µM 3.75E-5 TRP & mitochondrial translation 103 5.70E-6
20 SGTC_2283 7944793 4.37 200.0 µM 4.01E-5 28 6.17E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.372 3.14E-110 YMR098C ATP25 hom Mitochondrial protein required for the stability of Oli1p (Atp9p) mRNA and for the Oli1p ring formation; YMR098C is not an essential gene
0.367 2.44E-107 YOL095C HMI1 hom Mitochondrial inner membrane localized ATP-dependent DNA helicase, required for the maintenance of the mitochondrial genome; not required for mitochondrial transcription; has homology to E. coli helicase uvrD
0.366 1.17E-106 YGL064C MRH4 hom Mitochondrial ATP-dependent RNA helicase of the DEAD-box family, plays an essential role in mitochondrial function
0.365 2.87E-106 YDR114C_p YDR114C_p hom Putative protein of unknown function; deletion mutant exhibits poor growth at elevated pH and calcium
0.364 2.35E-105 YGR102C GTF1 hom Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; transposon insertion mutant is salt sensitive and null mutant has growth defects; non-tagged protein is detected in purified mitochondria
0.361 1.09E-103 YDR296W MHR1 hom Protein involved in homologous recombination in mitochondria; required for recombination-dependent mtDNA partitioning; involved in stimulation of mitochondrial DNA replication in response to oxidative stress
0.359 1.12E-102 YDR462W MRPL28 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.357 2.70E-101 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.351 4.48E-98 YGR171C MSM1 hom Mitochondrial methionyl-tRNA synthetase (MetRS), functions as a monomer in mitochondrial protein synthesis; functions similarly to cytoplasmic MetRS although the cytoplasmic form contains a zinc-binding domain not found in Msm1p
0.350 2.31E-97 YPR100W MRPL51 hom Mitochondrial ribosomal protein of the large subunit
0.347 2.01E-95 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.343 2.43E-93 YLR069C MEF1 hom Mitochondrial elongation factor involved in translational elongation
0.341 2.30E-92 YDR337W MRPS28 hom Mitochondrial ribosomal protein of the small subunit
0.338 2.42E-90 YKL170W MRPL38 hom Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL34 and YmL38) on two-dimensional SDS gels; protein abundance increases in response to DNA replication stress
0.337 3.70E-90 YDR268W MSW1 hom Mitochondrial tryptophanyl-tRNA synthetase