YBL091C-A / SCS22

Protein involved in regulation of phospholipid metabolism; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; similar to D. melanogaster inturned protein; SCS22 has a paralog, SCS2, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YBL091C-A / SCS22

Click on Significant Values for Screen Details ID:SGTC_93|Compound:0109-0045|FD-Score:3.88|P-value:4.30E-5 ID:SGTC_130|Compound:0136-0219|FD-Score:3.19|P-value:6.26E-4 ID:SGTC_136|Compound:0097-0015|FD-Score:3.14|P-value:7.53E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:3.85|P-value:4.92E-5 ID:SGTC_361|Compound:000s-0510|FD-Score:3.16|P-value:6.92E-4 ID:SGTC_364|Compound:0083-0097|FD-Score:-3.14|P-value:7.08E-4 ID:SGTC_368|Compound:fentichlor|FD-Score:3.50|P-value:2.04E-4 ID:SGTC_429|Compound:1112-0049|FD-Score:3.33|P-value:3.82E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:5.50|P-value:1.32E-8 ID:SGTC_455|Compound:paf C-16|FD-Score:-3.27|P-value:4.34E-4 ID:SGTC_470|Compound:aa-861|FD-Score:3.47|P-value:2.23E-4 ID:SGTC_541|Compound:4513-1321|FD-Score:-3.27|P-value:4.45E-4 ID:SGTC_577|Compound:r071-0003|FD-Score:3.74|P-value:7.67E-5 ID:SGTC_631|Compound:k072-0230|FD-Score:3.20|P-value:6.01E-4 ID:SGTC_684|Compound:1140-0066|FD-Score:3.65|P-value:1.13E-4 ID:SGTC_706|Compound:4262-0057|FD-Score:3.15|P-value:7.32E-4 ID:SGTC_793|Compound:0488-0545|FD-Score:3.26|P-value:4.95E-4 ID:SGTC_917|Compound:harmaline|FD-Score:3.67|P-value:1.02E-4 ID:SGTC_971|Compound:1315-0384|FD-Score:3.68|P-value:1.00E-4 ID:SGTC_1048|Compound:3161-0300|FD-Score:3.95|P-value:3.19E-5 ID:SGTC_1385|Compound:3091-4834|FD-Score:4.62|P-value:1.48E-6 ID:SGTC_1460|Compound:k062-0059|FD-Score:3.81|P-value:5.69E-5 ID:SGTC_1547|Compound:harmine|FD-Score:3.21|P-value:5.83E-4 ID:SGTC_1704|Compound:st028805|FD-Score:3.20|P-value:6.15E-4 ID:SGTC_1714|Compound:st033236|FD-Score:4.63|P-value:1.43E-6 ID:SGTC_1727|Compound:st034309|FD-Score:-3.05|P-value:9.50E-4 ID:SGTC_1777|Compound:st045864|FD-Score:3.42|P-value:2.72E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:3.10|P-value:8.66E-4 ID:SGTC_1868|Compound:st057644|FD-Score:6.05|P-value:4.57E-10 ID:SGTC_1912|Compound:st060209|FD-Score:4.12|P-value:1.53E-5 ID:SGTC_1917|Compound:st066507|FD-Score:3.69|P-value:9.38E-5 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:3.17|P-value:6.64E-4 ID:SGTC_2031|Compound:5180455|FD-Score:3.19|P-value:6.38E-4 ID:SGTC_2168|Compound:5727979|FD-Score:4.24|P-value:9.03E-6 ID:SGTC_2170|Compound:morpholine|FD-Score:3.75|P-value:7.42E-5 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:3.31|P-value:4.11E-4 ID:SGTC_2544|Compound:sphondin|FD-Score:3.37|P-value:3.23E-4 ID:SGTC_2606|Compound:farnesol|FD-Score:3.48|P-value:2.13E-4 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:3.48|P-value:2.17E-4 ID:SGTC_2702|Compound:st077768|FD-Score:3.21|P-value:5.83E-4 ID:SGTC_2718|Compound:lomofungin|FD-Score:3.54|P-value:1.70E-4 ID:SGTC_2735|Compound:sertaconazole|FD-Score:3.53|P-value:1.78E-4 ID:SGTC_2830|Compound:7992007|FD-Score:3.90|P-value:4.05E-5 ID:SGTC_2841|Compound:9004761|FD-Score:3.27|P-value:4.80E-4 ID:SGTC_2914|Compound:7968218|FD-Score:4.66|P-value:1.18E-6 ID:SGTC_2916|Compound:7875993|FD-Score:5.81|P-value:2.08E-9 ID:SGTC_2920|Compound:7982904|FD-Score:3.79|P-value:6.33E-5 ID:SGTC_2927|Compound:9011802|FD-Score:-3.96|P-value:2.77E-5 ID:SGTC_2958|Compound:9077254|FD-Score:-3.97|P-value:2.71E-5 ID:SGTC_2970|Compound:9090938|FD-Score:3.52|P-value:1.85E-4 ID:SGTC_3110|Compound:9122132|FD-Score:4.06|P-value:2.02E-5 ID:SGTC_3119|Compound:9125183|FD-Score:3.44|P-value:2.55E-4 ID:SGTC_3180|Compound:9109287|FD-Score:4.07|P-value:1.91E-5 ID:SGTC_3235|Compound:9132602|FD-Score:3.96|P-value:3.13E-5 ID:SGTC_93|Compound:0109-0045|FD-Score:3.88|P-value:4.30E-5 ID:SGTC_130|Compound:0136-0219|FD-Score:3.19|P-value:6.26E-4 ID:SGTC_136|Compound:0097-0015|FD-Score:3.14|P-value:7.53E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:3.85|P-value:4.92E-5 ID:SGTC_361|Compound:000s-0510|FD-Score:3.16|P-value:6.92E-4 ID:SGTC_364|Compound:0083-0097|FD-Score:-3.14|P-value:7.08E-4 ID:SGTC_368|Compound:fentichlor|FD-Score:3.50|P-value:2.04E-4 ID:SGTC_429|Compound:1112-0049|FD-Score:3.33|P-value:3.82E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:5.50|P-value:1.32E-8 ID:SGTC_455|Compound:paf C-16|FD-Score:-3.27|P-value:4.34E-4 ID:SGTC_470|Compound:aa-861|FD-Score:3.47|P-value:2.23E-4 ID:SGTC_541|Compound:4513-1321|FD-Score:-3.27|P-value:4.45E-4 ID:SGTC_577|Compound:r071-0003|FD-Score:3.74|P-value:7.67E-5 ID:SGTC_631|Compound:k072-0230|FD-Score:3.20|P-value:6.01E-4 ID:SGTC_684|Compound:1140-0066|FD-Score:3.65|P-value:1.13E-4 ID:SGTC_706|Compound:4262-0057|FD-Score:3.15|P-value:7.32E-4 ID:SGTC_793|Compound:0488-0545|FD-Score:3.26|P-value:4.95E-4 ID:SGTC_917|Compound:harmaline|FD-Score:3.67|P-value:1.02E-4 ID:SGTC_971|Compound:1315-0384|FD-Score:3.68|P-value:1.00E-4 ID:SGTC_1048|Compound:3161-0300|FD-Score:3.95|P-value:3.19E-5 ID:SGTC_1385|Compound:3091-4834|FD-Score:4.62|P-value:1.48E-6 ID:SGTC_1460|Compound:k062-0059|FD-Score:3.81|P-value:5.69E-5 ID:SGTC_1547|Compound:harmine|FD-Score:3.21|P-value:5.83E-4 ID:SGTC_1704|Compound:st028805|FD-Score:3.20|P-value:6.15E-4 ID:SGTC_1714|Compound:st033236|FD-Score:4.63|P-value:1.43E-6 ID:SGTC_1727|Compound:st034309|FD-Score:-3.05|P-value:9.50E-4 ID:SGTC_1777|Compound:st045864|FD-Score:3.42|P-value:2.72E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:3.10|P-value:8.66E-4 ID:SGTC_1868|Compound:st057644|FD-Score:6.05|P-value:4.57E-10 ID:SGTC_1912|Compound:st060209|FD-Score:4.12|P-value:1.53E-5 ID:SGTC_1917|Compound:st066507|FD-Score:3.69|P-value:9.38E-5 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:3.17|P-value:6.64E-4 ID:SGTC_2031|Compound:5180455|FD-Score:3.19|P-value:6.38E-4 ID:SGTC_2168|Compound:5727979|FD-Score:4.24|P-value:9.03E-6 ID:SGTC_2170|Compound:morpholine|FD-Score:3.75|P-value:7.42E-5 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:3.31|P-value:4.11E-4 ID:SGTC_2544|Compound:sphondin|FD-Score:3.37|P-value:3.23E-4 ID:SGTC_2606|Compound:farnesol|FD-Score:3.48|P-value:2.13E-4 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:3.48|P-value:2.17E-4 ID:SGTC_2702|Compound:st077768|FD-Score:3.21|P-value:5.83E-4 ID:SGTC_2718|Compound:lomofungin|FD-Score:3.54|P-value:1.70E-4 ID:SGTC_2735|Compound:sertaconazole|FD-Score:3.53|P-value:1.78E-4 ID:SGTC_2830|Compound:7992007|FD-Score:3.90|P-value:4.05E-5 ID:SGTC_2841|Compound:9004761|FD-Score:3.27|P-value:4.80E-4 ID:SGTC_2914|Compound:7968218|FD-Score:4.66|P-value:1.18E-6 ID:SGTC_2916|Compound:7875993|FD-Score:5.81|P-value:2.08E-9 ID:SGTC_2920|Compound:7982904|FD-Score:3.79|P-value:6.33E-5 ID:SGTC_2927|Compound:9011802|FD-Score:-3.96|P-value:2.77E-5 ID:SGTC_2958|Compound:9077254|FD-Score:-3.97|P-value:2.71E-5 ID:SGTC_2970|Compound:9090938|FD-Score:3.52|P-value:1.85E-4 ID:SGTC_3110|Compound:9122132|FD-Score:4.06|P-value:2.02E-5 ID:SGTC_3119|Compound:9125183|FD-Score:3.44|P-value:2.55E-4 ID:SGTC_3180|Compound:9109287|FD-Score:4.07|P-value:1.91E-5 ID:SGTC_3235|Compound:9132602|FD-Score:3.96|P-value:3.13E-5

Top fitness defect scores for YBL091C-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1868 st057644 6.05 42.7 µM 4.57E-10 9 7.35E-10
2 SGTC_2916 7875993 5.81 68.8 µM 2.08E-9 4 3.21E-9
3 SGTC_451 chloral hydrate 5.50 100.0 µM 1.32E-8 19 1.95E-8
4 SGTC_2914 7968218 4.66 45.3 µM 1.18E-6 7 1.56E-6
5 SGTC_1714 st033236 4.63 13.6 µM 1.43E-6 11 1.87E-6
6 SGTC_1385 3091-4834 4.62 14.1 µM 1.48E-6 RPP1 & pyrimidine depletion 7 1.93E-6
7 SGTC_2168 5727979 4.24 200.0 µM 9.03E-6 13 1.13E-5
8 SGTC_1912 st060209 4.12 90.8 µM 1.53E-5 34 1.89E-5
9 SGTC_3180 9109287 4.07 49.5 µM 1.91E-5 8 2.34E-5
10 SGTC_3110 9122132 4.06 49.5 µM 2.02E-5 redox potentiating 18 2.47E-5
11 SGTC_3235 9132602 3.96 49.5 µM 3.13E-5 24 3.79E-5
12 SGTC_1048 3161-0300 3.95 24.5 µM 3.19E-5 24 3.87E-5
13 SGTC_2830 7992007 3.90 71.4 µM 4.05E-5 24 4.88E-5
14 SGTC_93 0109-0045 3.88 59.2 µM 4.30E-5 DNA damage response 50 5.18E-5
15 SGTC_178 4092-0806 3.85 87.5 µM 4.92E-5 ergosterol depletion effects on membrane 104 5.90E-5
16 SGTC_1460 k062-0059 3.81 9.2 µM 5.69E-5 Golgi 17 6.81E-5
17 SGTC_2920 7982904 3.79 15.8 µM 6.33E-5 26 7.55E-5
18 SGTC_2170 morpholine 3.75 200.0 µM 7.42E-5 13 8.82E-5
19 SGTC_577 r071-0003 3.74 38.6 µM 7.67E-5 fatty acid desaturase (OLE1) 65 9.11E-5
20 SGTC_1917 st066507 3.69 28.5 µM 9.38E-5 Golgi 48 1.11E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.094 5.02E-8 YOR224C RPB8 het RNA polymerase subunit ABC14.5, common to RNA polymerases I, II, and III
0.093 7.73E-8 YNL268W LYP1 hom Lysine permease; one of three amino acid permeases (Alp1p, Can1p, Lyp1p) responsible for uptake of cationic amino acids
0.092 1.08E-7 YHR072W ERG7 het Lanosterol synthase, an essential enzyme that catalyzes the cyclization of squalene 2,3-epoxide, a step in ergosterol biosynthesis
0.087 5.18E-7 YBR264C YPT10 hom Rab family GTP-binding protein that contains the PEST signal sequence specific for proteolytic enzymes; may be involved in vesicular transport; overexpression leads to accumulation of Golgi-like cisternae with budding vesicles
0.083 1.30E-6 YOR194C TOA1 het TFIIA large subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; homologous to largest and second largest subunits of human and Drosophila TFIIA
0.082 2.22E-6 YOR344C TYE7 hom Serine-rich protein that contains a basic-helix-loop-helix (bHLH) DNA binding motif; binds E-boxes of glycolytic genes and contributes to their activation; may function as a transcriptional activator in Ty1-mediated gene expression
0.080 3.51E-6 YPL219W PCL8 hom Cyclin, interacts with Pho85p cyclin-dependent kinase (Cdk) to phosphorylate and regulate glycogen synthase, also activates Pho85p for Glc8p phosphorylation
0.080 3.76E-6 YPL028W ERG10 het Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase), cytosolic enzyme that transfers an acetyl group from one acetyl-CoA molecule to another, forming acetoacetyl-CoA; involved in the first step in mevalonate biosynthesis
0.076 1.10E-5 YGR252W GCN5 hom Acetyltransferase, modifies N-terminal lysines on histones H2B and H3; acetylates Rsc4p, a subunit of the RSC chromatin-remodeling complex, altering replication stress tolerance; catalytic subunit of the ADA and SAGA histone acetyltransferase complexes; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay; greater involvement in repression of RNAPII-dependent transcription than in activation
0.074 1.69E-5 YKL186C MTR2 het mRNA transport regulator, essential nuclear protein; Mex67p and Mtr2p form a mRNA export complex which binds to RNA
0.072 2.83E-5 YLR040C_p YLR040C_p hom Protein of unknown function; localizes to the cell wall; predicted to be a GPI-attached protein; upregulated by Mcm1p-Alpha1p transcription factor; partially overlaps the dubious ORF YLR041W; mRNA identified as translated by ribosome profiling data; YLR040C is not essential
0.067 1.06E-4 YOR045W TOM6 hom Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex
0.065 1.75E-4 YPL190C NAB3 het RNA-binding protein, subunit of Nrd1 complex (Nrd1p-Nab3p-Sen1p); complex interacts with the exosome to mediate 3′ end formation of some mRNAs, snRNAs, snoRNAs, and CUTs; required for termination of non-poly(A) transcripts and efficient splicing
0.064 1.86E-4 YFR047C BNA6 hom Quinolinate phosphoribosyl transferase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p
0.064 2.03E-4 YOL025W LAG2 hom Protein that negatively regulates the SCF E3-ubiquitin ligase by interacting with and preventing neddyation of the cullin subunit, Cdc53p; longevity determinant that is preferentially expressed in young cells; similar to mammalian Cand1