YBL092W / RPL32

Ribosomal 60S subunit protein L32; overexpression disrupts telomeric silencing; homologous to mammalian ribosomal protein L32, no bacterial homolog

Zygosity: Heterozygous strain
fixedexpanded
Profile for YBL092W / RPL32

Click on Significant Values for Screen Details ID:SGTC_16|Compound:erodoxin|FD-Score:5.66|P-value:7.89E-6 ID:SGTC_22|Compound:0964-0034|FD-Score:13.60|P-value:2.72E-25 ID:SGTC_36|Compound:0335-0881|FD-Score:-5.42|P-value:2.09E-5 ID:SGTC_45|Compound:0kpi-0036|FD-Score:5.24|P-value:3.18E-5 ID:SGTC_70|Compound:0141-0289|FD-Score:-4.97|P-value:8.82E-5 ID:SGTC_93|Compound:0109-0045|FD-Score:5.41|P-value:1.88E-5 ID:SGTC_138|Compound:0850-0259|FD-Score:5.68|P-value:7.36E-6 ID:SGTC_157|Compound:1348-1695|FD-Score:9.45|P-value:3.30E-13 ID:SGTC_173|Compound:1273-0061|FD-Score:-6.68|P-value:2.17E-7 ID:SGTC_214|Compound:4373-3496|FD-Score:4.53|P-value:2.75E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:6.48|P-value:3.93E-7 ID:SGTC_227|Compound:fluconazole|FD-Score:6.30|P-value:7.95E-7 ID:SGTC_248|Compound:streptozotocin|FD-Score:4.77|P-value:1.39E-4 ID:SGTC_287|Compound:k060-0039|FD-Score:4.75|P-value:1.44E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:4.06|P-value:9.61E-4 ID:SGTC_332|Compound:4112-0506|FD-Score:8.89|P-value:6.68E-12 ID:SGTC_393|Compound:acivicin|FD-Score:-4.34|P-value:5.34E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:4.44|P-value:3.47E-4 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:-4.10|P-value:9.98E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:12.40|P-value:2.26E-21 ID:SGTC_451|Compound:chloral hydrate|FD-Score:4.89|P-value:9.46E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-6.05|P-value:2.37E-6 ID:SGTC_480|Compound:am 92016|FD-Score:5.44|P-value:1.66E-5 ID:SGTC_490|Compound:phenamil|FD-Score:4.98|P-value:7.24E-5 ID:SGTC_492|Compound:tmb-8|FD-Score:4.94|P-value:8.31E-5 ID:SGTC_513|Compound:4245-1575|FD-Score:-6.74|P-value:1.74E-7 ID:SGTC_514|Compound:4466-0038|FD-Score:8.94|P-value:5.05E-12 ID:SGTC_518|Compound:1021-0119|FD-Score:4.59|P-value:2.31E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:5.47|P-value:1.51E-5 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:4.59|P-value:2.29E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:4.43|P-value:3.65E-4 ID:SGTC_586|Compound:0957-0265|FD-Score:7.93|P-value:7.72E-10 ID:SGTC_673|Compound:1082-0474|FD-Score:4.69|P-value:1.73E-4 ID:SGTC_674|Compound:0498-0004|FD-Score:-4.75|P-value:1.69E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:4.44|P-value:3.54E-4 ID:SGTC_764|Compound:1951-2361|FD-Score:6.14|P-value:1.44E-6 ID:SGTC_778|Compound:3456-2434|FD-Score:-4.10|P-value:9.92E-4 ID:SGTC_796|Compound:1234-0020|FD-Score:4.90|P-value:9.35E-5 ID:SGTC_810|Compound:3825-7150|FD-Score:-4.50|P-value:3.43E-4 ID:SGTC_824|Compound:1304-0008|FD-Score:4.97|P-value:7.60E-5 ID:SGTC_829|Compound:1635-0120|FD-Score:10.40|P-value:1.20E-15 ID:SGTC_839|Compound:0122-0028|FD-Score:6.58|P-value:2.70E-7 ID:SGTC_852|Compound:0418-0143|FD-Score:-5.86|P-value:4.71E-6 ID:SGTC_871|Compound:0574-0004|FD-Score:5.05|P-value:5.79E-5 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:4.18|P-value:7.15E-4 ID:SGTC_928|Compound:2764-0428|FD-Score:5.73|P-value:6.24E-6 ID:SGTC_946|Compound:3434-1334|FD-Score:4.66|P-value:1.90E-4 ID:SGTC_964|Compound:1287-0107|FD-Score:4.61|P-value:2.16E-4 ID:SGTC_1050|Compound:3232-1156|FD-Score:5.01|P-value:6.65E-5 ID:SGTC_1074|Compound:carmofur|FD-Score:4.21|P-value:6.49E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:4.09|P-value:8.91E-4 ID:SGTC_1213|Compound:1315-0166|FD-Score:5.35|P-value:2.23E-5 ID:SGTC_1239|Compound:0337-0584|FD-Score:9.56|P-value:1.76E-13 ID:SGTC_1264|Compound:0783-0040|FD-Score:-4.98|P-value:8.57E-5 ID:SGTC_1271|Compound:0832-2808|FD-Score:4.22|P-value:6.32E-4 ID:SGTC_1274|Compound:0865-0114|FD-Score:5.10|P-value:4.99E-5 ID:SGTC_1285|Compound:0929-0069|FD-Score:-4.21|P-value:7.37E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:-5.11|P-value:5.63E-5 ID:SGTC_1374|Compound:2889-5571|FD-Score:13.70|P-value:1.37E-25 ID:SGTC_1493|Compound:4348-0038|FD-Score:5.49|P-value:1.42E-5 ID:SGTC_1556|Compound:plumbagin|FD-Score:-4.59|P-value:2.63E-4 ID:SGTC_1573|Compound:oleylamine|FD-Score:4.14|P-value:7.96E-4 ID:SGTC_1651|Compound:st011928|FD-Score:5.71|P-value:6.66E-6 ID:SGTC_1652|Compound:st011932|FD-Score:16.20|P-value:5.89E-35 ID:SGTC_1655|Compound:st012546|FD-Score:4.09|P-value:8.88E-4 ID:SGTC_1672|Compound:st016598|FD-Score:8.01|P-value:5.42E-10 ID:SGTC_1696|Compound:st025591|FD-Score:5.05|P-value:5.90E-5 ID:SGTC_1701|Compound:st028638|FD-Score:-4.73|P-value:1.76E-4 ID:SGTC_1707|Compound:st032323|FD-Score:11.80|P-value:1.44E-19 ID:SGTC_1745|Compound:st081495|FD-Score:7.28|P-value:1.48E-8 ID:SGTC_1774|Compound:st048371|FD-Score:7.13|P-value:2.80E-8 ID:SGTC_1786|Compound:berberine|FD-Score:4.16|P-value:7.44E-4 ID:SGTC_1803|Compound:st050068|FD-Score:5.32|P-value:2.51E-5 ID:SGTC_1915|Compound:st067105|FD-Score:6.54|P-value:3.18E-7 ID:SGTC_2066|Compound:5222451|FD-Score:-4.80|P-value:1.46E-4 ID:SGTC_2090|Compound:5301565|FD-Score:4.07|P-value:9.45E-4 ID:SGTC_2109|Compound:5483026|FD-Score:10.40|P-value:1.67E-15 ID:SGTC_2111|Compound:5486399|FD-Score:6.33|P-value:7.14E-7 ID:SGTC_2140|Compound:5586273|FD-Score:4.77|P-value:1.36E-4 ID:SGTC_2187|Compound:6125751|FD-Score:5.53|P-value:1.24E-5 ID:SGTC_2192|Compound:5915882|FD-Score:8.57|P-value:3.52E-11 ID:SGTC_2229|Compound:7354935|FD-Score:4.99|P-value:6.97E-5 ID:SGTC_2275|Compound:7947463|FD-Score:4.09|P-value:8.92E-4 ID:SGTC_2291|Compound:7917025|FD-Score:5.12|P-value:4.68E-5 ID:SGTC_2292|Compound:7671323|FD-Score:4.87|P-value:1.03E-4 ID:SGTC_2293|Compound:7624732|FD-Score:9.13|P-value:1.82E-12 ID:SGTC_2302|Compound:7771753|FD-Score:-4.21|P-value:7.54E-4 ID:SGTC_2344|Compound:7990960|FD-Score:-4.46|P-value:3.85E-4 ID:SGTC_2361|Compound:9034121|FD-Score:9.28|P-value:8.02E-13 ID:SGTC_2413|Compound:inermin|FD-Score:-4.16|P-value:8.60E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:-4.95|P-value:9.18E-5 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:-4.35|P-value:5.17E-4 ID:SGTC_2456|Compound:5770359|FD-Score:-4.13|P-value:9.19E-4 ID:SGTC_2466|Compound:5983409|FD-Score:4.36|P-value:4.34E-4 ID:SGTC_2467|Compound:5474540|FD-Score:4.48|P-value:3.13E-4 ID:SGTC_2477|Compound:5967686|FD-Score:5.00|P-value:6.92E-5 ID:SGTC_2485|Compound:5633444|FD-Score:4.89|P-value:9.54E-5 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:-4.48|P-value:3.60E-4 ID:SGTC_2544|Compound:sphondin|FD-Score:7.36|P-value:1.04E-8 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-5.10|P-value:5.89E-5 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:4.52|P-value:2.79E-4 ID:SGTC_2659|Compound:sanguinarine|FD-Score:-4.56|P-value:2.85E-4 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:4.28|P-value:5.43E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:4.45|P-value:3.41E-4 ID:SGTC_2686|Compound:alizarin|FD-Score:5.95|P-value:2.92E-6 ID:SGTC_2912|Compound:7964298|FD-Score:10.40|P-value:1.68E-15 ID:SGTC_2980|Compound:9014342|FD-Score:-6.13|P-value:1.79E-6 ID:SGTC_2996|Compound:9066192|FD-Score:4.06|P-value:9.70E-4 ID:SGTC_2997|Compound:9067075|FD-Score:4.97|P-value:7.49E-5 ID:SGTC_3062|Compound:9077494|FD-Score:-8.28|P-value:1.88E-10 ID:SGTC_3063|Compound:1327-0034|FD-Score:-4.76|P-value:1.64E-4 ID:SGTC_3200|Compound:9114385|FD-Score:6.23|P-value:1.03E-6 ID:SGTC_3214|Compound:9129694|FD-Score:-4.40|P-value:4.47E-4 ID:SGTC_3222|Compound:9128301|FD-Score:-5.08|P-value:6.23E-5 ID:SGTC_3247|Compound:9135149|FD-Score:5.46|P-value:1.57E-5 ID:SGTC_3249|Compound:9135183|FD-Score:-4.49|P-value:3.47E-4 ID:SGTC_3304|Compound:9125678|FD-Score:5.53|P-value:1.24E-5 ID:SGTC_3311|Compound:9131146|FD-Score:5.73|P-value:6.23E-6 ID:SGTC_3322|Compound:9139058|FD-Score:5.65|P-value:8.19E-6 ID:SGTC_3347|Compound:9188721|FD-Score:9.78|P-value:5.09E-14 ID:SGTC_16|Compound:erodoxin|FD-Score:5.66|P-value:7.89E-6 ID:SGTC_22|Compound:0964-0034|FD-Score:13.60|P-value:2.72E-25 ID:SGTC_36|Compound:0335-0881|FD-Score:-5.42|P-value:2.09E-5 ID:SGTC_45|Compound:0kpi-0036|FD-Score:5.24|P-value:3.18E-5 ID:SGTC_70|Compound:0141-0289|FD-Score:-4.97|P-value:8.82E-5 ID:SGTC_93|Compound:0109-0045|FD-Score:5.41|P-value:1.88E-5 ID:SGTC_138|Compound:0850-0259|FD-Score:5.68|P-value:7.36E-6 ID:SGTC_157|Compound:1348-1695|FD-Score:9.45|P-value:3.30E-13 ID:SGTC_173|Compound:1273-0061|FD-Score:-6.68|P-value:2.17E-7 ID:SGTC_214|Compound:4373-3496|FD-Score:4.53|P-value:2.75E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:6.48|P-value:3.93E-7 ID:SGTC_227|Compound:fluconazole|FD-Score:6.30|P-value:7.95E-7 ID:SGTC_248|Compound:streptozotocin|FD-Score:4.77|P-value:1.39E-4 ID:SGTC_287|Compound:k060-0039|FD-Score:4.75|P-value:1.44E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:4.06|P-value:9.61E-4 ID:SGTC_332|Compound:4112-0506|FD-Score:8.89|P-value:6.68E-12 ID:SGTC_393|Compound:acivicin|FD-Score:-4.34|P-value:5.34E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:4.44|P-value:3.47E-4 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:-4.10|P-value:9.98E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:12.40|P-value:2.26E-21 ID:SGTC_451|Compound:chloral hydrate|FD-Score:4.89|P-value:9.46E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-6.05|P-value:2.37E-6 ID:SGTC_480|Compound:am 92016|FD-Score:5.44|P-value:1.66E-5 ID:SGTC_490|Compound:phenamil|FD-Score:4.98|P-value:7.24E-5 ID:SGTC_492|Compound:tmb-8|FD-Score:4.94|P-value:8.31E-5 ID:SGTC_513|Compound:4245-1575|FD-Score:-6.74|P-value:1.74E-7 ID:SGTC_514|Compound:4466-0038|FD-Score:8.94|P-value:5.05E-12 ID:SGTC_518|Compound:1021-0119|FD-Score:4.59|P-value:2.31E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:5.47|P-value:1.51E-5 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:4.59|P-value:2.29E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:4.43|P-value:3.65E-4 ID:SGTC_586|Compound:0957-0265|FD-Score:7.93|P-value:7.72E-10 ID:SGTC_673|Compound:1082-0474|FD-Score:4.69|P-value:1.73E-4 ID:SGTC_674|Compound:0498-0004|FD-Score:-4.75|P-value:1.69E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:4.44|P-value:3.54E-4 ID:SGTC_764|Compound:1951-2361|FD-Score:6.14|P-value:1.44E-6 ID:SGTC_778|Compound:3456-2434|FD-Score:-4.10|P-value:9.92E-4 ID:SGTC_796|Compound:1234-0020|FD-Score:4.90|P-value:9.35E-5 ID:SGTC_810|Compound:3825-7150|FD-Score:-4.50|P-value:3.43E-4 ID:SGTC_824|Compound:1304-0008|FD-Score:4.97|P-value:7.60E-5 ID:SGTC_829|Compound:1635-0120|FD-Score:10.40|P-value:1.20E-15 ID:SGTC_839|Compound:0122-0028|FD-Score:6.58|P-value:2.70E-7 ID:SGTC_852|Compound:0418-0143|FD-Score:-5.86|P-value:4.71E-6 ID:SGTC_871|Compound:0574-0004|FD-Score:5.05|P-value:5.79E-5 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:4.18|P-value:7.15E-4 ID:SGTC_928|Compound:2764-0428|FD-Score:5.73|P-value:6.24E-6 ID:SGTC_946|Compound:3434-1334|FD-Score:4.66|P-value:1.90E-4 ID:SGTC_964|Compound:1287-0107|FD-Score:4.61|P-value:2.16E-4 ID:SGTC_1050|Compound:3232-1156|FD-Score:5.01|P-value:6.65E-5 ID:SGTC_1074|Compound:carmofur|FD-Score:4.21|P-value:6.49E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:4.09|P-value:8.91E-4 ID:SGTC_1213|Compound:1315-0166|FD-Score:5.35|P-value:2.23E-5 ID:SGTC_1239|Compound:0337-0584|FD-Score:9.56|P-value:1.76E-13 ID:SGTC_1264|Compound:0783-0040|FD-Score:-4.98|P-value:8.57E-5 ID:SGTC_1271|Compound:0832-2808|FD-Score:4.22|P-value:6.32E-4 ID:SGTC_1274|Compound:0865-0114|FD-Score:5.10|P-value:4.99E-5 ID:SGTC_1285|Compound:0929-0069|FD-Score:-4.21|P-value:7.37E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:-5.11|P-value:5.63E-5 ID:SGTC_1374|Compound:2889-5571|FD-Score:13.70|P-value:1.37E-25 ID:SGTC_1493|Compound:4348-0038|FD-Score:5.49|P-value:1.42E-5 ID:SGTC_1556|Compound:plumbagin|FD-Score:-4.59|P-value:2.63E-4 ID:SGTC_1573|Compound:oleylamine|FD-Score:4.14|P-value:7.96E-4 ID:SGTC_1651|Compound:st011928|FD-Score:5.71|P-value:6.66E-6 ID:SGTC_1652|Compound:st011932|FD-Score:16.20|P-value:5.89E-35 ID:SGTC_1655|Compound:st012546|FD-Score:4.09|P-value:8.88E-4 ID:SGTC_1672|Compound:st016598|FD-Score:8.01|P-value:5.42E-10 ID:SGTC_1696|Compound:st025591|FD-Score:5.05|P-value:5.90E-5 ID:SGTC_1701|Compound:st028638|FD-Score:-4.73|P-value:1.76E-4 ID:SGTC_1707|Compound:st032323|FD-Score:11.80|P-value:1.44E-19 ID:SGTC_1745|Compound:st081495|FD-Score:7.28|P-value:1.48E-8 ID:SGTC_1774|Compound:st048371|FD-Score:7.13|P-value:2.80E-8 ID:SGTC_1786|Compound:berberine|FD-Score:4.16|P-value:7.44E-4 ID:SGTC_1803|Compound:st050068|FD-Score:5.32|P-value:2.51E-5 ID:SGTC_1915|Compound:st067105|FD-Score:6.54|P-value:3.18E-7 ID:SGTC_2066|Compound:5222451|FD-Score:-4.80|P-value:1.46E-4 ID:SGTC_2090|Compound:5301565|FD-Score:4.07|P-value:9.45E-4 ID:SGTC_2109|Compound:5483026|FD-Score:10.40|P-value:1.67E-15 ID:SGTC_2111|Compound:5486399|FD-Score:6.33|P-value:7.14E-7 ID:SGTC_2140|Compound:5586273|FD-Score:4.77|P-value:1.36E-4 ID:SGTC_2187|Compound:6125751|FD-Score:5.53|P-value:1.24E-5 ID:SGTC_2192|Compound:5915882|FD-Score:8.57|P-value:3.52E-11 ID:SGTC_2229|Compound:7354935|FD-Score:4.99|P-value:6.97E-5 ID:SGTC_2275|Compound:7947463|FD-Score:4.09|P-value:8.92E-4 ID:SGTC_2291|Compound:7917025|FD-Score:5.12|P-value:4.68E-5 ID:SGTC_2292|Compound:7671323|FD-Score:4.87|P-value:1.03E-4 ID:SGTC_2293|Compound:7624732|FD-Score:9.13|P-value:1.82E-12 ID:SGTC_2302|Compound:7771753|FD-Score:-4.21|P-value:7.54E-4 ID:SGTC_2344|Compound:7990960|FD-Score:-4.46|P-value:3.85E-4 ID:SGTC_2361|Compound:9034121|FD-Score:9.28|P-value:8.02E-13 ID:SGTC_2413|Compound:inermin|FD-Score:-4.16|P-value:8.60E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:-4.95|P-value:9.18E-5 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:-4.35|P-value:5.17E-4 ID:SGTC_2456|Compound:5770359|FD-Score:-4.13|P-value:9.19E-4 ID:SGTC_2466|Compound:5983409|FD-Score:4.36|P-value:4.34E-4 ID:SGTC_2467|Compound:5474540|FD-Score:4.48|P-value:3.13E-4 ID:SGTC_2477|Compound:5967686|FD-Score:5.00|P-value:6.92E-5 ID:SGTC_2485|Compound:5633444|FD-Score:4.89|P-value:9.54E-5 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:-4.48|P-value:3.60E-4 ID:SGTC_2544|Compound:sphondin|FD-Score:7.36|P-value:1.04E-8 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-5.10|P-value:5.89E-5 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:4.52|P-value:2.79E-4 ID:SGTC_2659|Compound:sanguinarine|FD-Score:-4.56|P-value:2.85E-4 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:4.28|P-value:5.43E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:4.45|P-value:3.41E-4 ID:SGTC_2686|Compound:alizarin|FD-Score:5.95|P-value:2.92E-6 ID:SGTC_2912|Compound:7964298|FD-Score:10.40|P-value:1.68E-15 ID:SGTC_2980|Compound:9014342|FD-Score:-6.13|P-value:1.79E-6 ID:SGTC_2996|Compound:9066192|FD-Score:4.06|P-value:9.70E-4 ID:SGTC_2997|Compound:9067075|FD-Score:4.97|P-value:7.49E-5 ID:SGTC_3062|Compound:9077494|FD-Score:-8.28|P-value:1.88E-10 ID:SGTC_3063|Compound:1327-0034|FD-Score:-4.76|P-value:1.64E-4 ID:SGTC_3200|Compound:9114385|FD-Score:6.23|P-value:1.03E-6 ID:SGTC_3214|Compound:9129694|FD-Score:-4.40|P-value:4.47E-4 ID:SGTC_3222|Compound:9128301|FD-Score:-5.08|P-value:6.23E-5 ID:SGTC_3247|Compound:9135149|FD-Score:5.46|P-value:1.57E-5 ID:SGTC_3249|Compound:9135183|FD-Score:-4.49|P-value:3.47E-4 ID:SGTC_3304|Compound:9125678|FD-Score:5.53|P-value:1.24E-5 ID:SGTC_3311|Compound:9131146|FD-Score:5.73|P-value:6.23E-6 ID:SGTC_3322|Compound:9139058|FD-Score:5.65|P-value:8.19E-6 ID:SGTC_3347|Compound:9188721|FD-Score:9.78|P-value:5.09E-14

Top fitness defect scores for YBL092W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1652 st011932 16.20 78.0 µM 5.89E-35 RSC complex & mRNA processing 4 5.29E-59 0.25
2 SGTC_1374 2889-5571 13.70 141.0 µM 1.37E-25 RSC complex & mRNA processing 6 8.04E-43 1.23
3 SGTC_22 0964-0034 13.60 14.5 µM 2.72E-25 unfolded protein response 1 2.65E-42 2.81
4 SGTC_445 e6 berbamine 12.40 66.0 µM 2.26E-21 NEO1-PIK1 4 1.53E-35 1.13
5 SGTC_1707 st032323 11.80 6.3 µM 1.44E-19 DNA damage response 2 1.99E-32 0.41
6 SGTC_829 1635-0120 10.40 117.0 µM 1.20E-15 DNA damage response 6 1.12E-25 0.33
7 SGTC_2109 5483026 10.40 200.0 µM 1.67E-15 RSC complex & mRNA processing 7 1.99E-25 0.00
8 SGTC_2912 7964298 10.40 10.9 µM 1.68E-15 cell wall 13 2.00E-25 0.23
9 SGTC_3347 9188721 9.78 44.7 µM 5.09E-14 4 7.10E-23 0.32
10 SGTC_1239 0337-0584 9.56 35.4 µM 1.76E-13 unfolded protein response 6 6.01E-22 1.97
11 SGTC_157 1348-1695 9.45 65.8 µM 3.30E-13 iron homeostasis 6 1.76E-21 0.19
12 SGTC_2361 9034121 9.28 116.0 µM 8.02E-13 RSC complex & mRNA processing 5 8.11E-21 1.14
13 SGTC_2293 7624732 9.13 200.0 µM 1.82E-12 1 3.31E-20 2.82
14 SGTC_514 4466-0038 8.94 2.6 nM 5.05E-12 cell wall 4 1.91E-19 0.31
15 SGTC_332 4112-0506 8.89 40.9 µM 6.68E-12 2 3.09E-19 1.11
16 SGTC_2192 5915882 8.57 198.5 µM 3.52E-11 RNA processing & uracil transport 5 5.35E-18 1.51
17 SGTC_1672 st016598 8.01 6.5 µM 5.42E-10 endomembrane recycling 3 5.81E-16 0.84
18 SGTC_586 0957-0265 7.93 8.2 µM 7.72E-10 cell wall 16 1.07E-15 0.17
19 SGTC_2544 sphondin 7.36 68.5 µM 1.04E-8 RNA pol III & RNase P/MRP 14 9.14E-14 0.73
20 SGTC_1745 st081495 7.28 74.0 µM 1.48E-8 RNA processing & uracil transport 11 1.67E-13 0.99

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.575 2.22E-294 YOR236W DFR1 het Dihydrofolate reductase involved in tetrahydrofolate biosynthesis; required for respiratory metabolism
0.553 8.20E-268 YBL026W LSM2 het Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress
0.552 4.83E-267 YBR091C TIM12 het Essential protein of the inner mitochondrial membrane, peripherally localized; component of the TIM22 complex, which is a twin-pore translocase that mediates insertion of numerous multispanning inner membrane proteins
0.408 7.07E-134 YJL081C ARP4 het Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes
0.407 5.79E-134 YER165W PAB1 het Poly(A) binding protein, part of the 3'-end RNA-processing complex, mediates interactions between the 5' cap structure and the 3' mRNA poly(A) tail, involved in control of poly(A) tail length, interacts with translation factor eIF-4G
0.340 1.58E-91 YML127W RSC9 het Component of the RSC chromatin remodeling complex; DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathway
0.328 1.05E-84 YNR016C ACC1 het Acetyl-CoA carboxylase, biotin containing enzyme; catalyzes the carboxylation of cytosolic acetyl-CoA to form malonyl-CoA and regulates histone acetylation by regulating the availablity of acetyl-CoA; required for de novo biosynthesis of long-chain fatty acids;
0.309 6.62E-75 YLR321C SFH1 het Component of the RSC chromatin remodeling complex; essential gene required for cell cycle progression and maintenance of proper ploidy; phosphorylated in the G1 phase of the cell cycle; Snf5p paralog
0.302 1.82E-71 YLR033W RSC58 het Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance
0.299 3.62E-70 YFR037C RSC8 het Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters
0.273 3.35E-58 YPR104C FHL1 het Regulator of ribosomal protein (RP) transcription; has forkhead associated domain that binds phosphorylated proteins; recruits coactivator Ifh1p or corepressor Crf1p to RP gene promoters; also has forkhead DNA-binding domain though in vitro DNA binding assays give inconsistent results; computational analyses suggest it binds DNA directly at highly active RP genes and indirectly through Rap1p motifs at others; suppresses RNA pol III and splicing factor prp4 mutants
0.268 2.95E-56 YPR034W ARP7 het Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation
0.267 9.82E-56 YDR404C RPB7 het RNA polymerase II subunit B16; forms two subunit dissociable complex with Rpb4p; involved in recruitment of 3'-end processing factors to transcribing RNA polymerase II complex and in export of mRNA to cytoplasm under stress conditions; also involved in translation initiation
0.246 2.96E-47 YDR172W SUP35 het Translation termination factor eRF3, has a role in mRNA deadenylation and decay; altered protein conformation creates the [PSI(+)] prion that alters translational fidelity and results in a nonsense suppressor phenotype
0.238 1.60E-44 YOL005C RPB11 het RNA polymerase II subunit B12.5; part of central core; similar to Rpc19p and bacterial alpha subunit