YBL093C / ROX3

Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme

Zygosity: Homozygous strain
fixedexpanded
Profile for YBL093C / ROX3

Click on Significant Values for Screen Details ID:SGTC_31|Compound:0508-1974|FD-Score:4.56|P-value:1.37E-5 ID:SGTC_61|Compound:0978-8327|FD-Score:3.40|P-value:8.84E-4 ID:SGTC_207|Compound:4185-0010|FD-Score:4.40|P-value:2.61E-5 ID:SGTC_222|Compound:nsc-310342|FD-Score:4.00|P-value:1.17E-4 ID:SGTC_240|Compound:5hr heat shock (37°C) + Streptovitacin|FD-Score:3.79|P-value:2.49E-4 ID:SGTC_458|Compound:nppb|FD-Score:4.24|P-value:4.89E-5 ID:SGTC_518|Compound:1021-0119|FD-Score:5.10|P-value:1.34E-6 ID:SGTC_520|Compound:3584-0023|FD-Score:4.32|P-value:3.56E-5 ID:SGTC_568|Compound:1193-0097|FD-Score:-3.59|P-value:4.44E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:4.45|P-value:2.10E-5 ID:SGTC_593|Compound:1203-0218|FD-Score:3.38|P-value:9.34E-4 ID:SGTC_611|Compound:3453-1652|FD-Score:-3.52|P-value:5.57E-4 ID:SGTC_723|Compound:4182-0001|FD-Score:3.46|P-value:7.33E-4 ID:SGTC_761|Compound:k216-0224|FD-Score:3.71|P-value:3.26E-4 ID:SGTC_827|Compound:3253-0474|FD-Score:4.59|P-value:1.21E-5 ID:SGTC_831|Compound:k061-1017|FD-Score:3.40|P-value:8.77E-4 ID:SGTC_856|Compound:0433-0016|FD-Score:5.63|P-value:1.08E-7 ID:SGTC_948|Compound:3448-0295|FD-Score:6.71|P-value:3.25E-10 ID:SGTC_974|Compound:1326-0144|FD-Score:4.63|P-value:1.01E-5 ID:SGTC_1082|Compound:camptothecin|FD-Score:3.56|P-value:5.39E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:5.36|P-value:4.01E-7 ID:SGTC_1313|Compound:1220-0047|FD-Score:3.61|P-value:4.55E-4 ID:SGTC_1318|Compound:1280-3875|FD-Score:3.88|P-value:1.83E-4 ID:SGTC_1379|Compound:2144-0755|FD-Score:3.70|P-value:3.34E-4 ID:SGTC_1381|Compound:2324-0066|FD-Score:4.53|P-value:1.54E-5 ID:SGTC_1417|Compound:3966-0327|FD-Score:5.19|P-value:9.00E-7 ID:SGTC_1419|Compound:3993-2473|FD-Score:4.24|P-value:4.79E-5 ID:SGTC_1423|Compound:4048-0112|FD-Score:4.34|P-value:3.29E-5 ID:SGTC_1427|Compound:4048-4900|FD-Score:3.47|P-value:7.24E-4 ID:SGTC_1446|Compound:4239-0190|FD-Score:6.28|P-value:3.79E-9 ID:SGTC_1450|Compound:4112-4260|FD-Score:-3.58|P-value:4.54E-4 ID:SGTC_1454|Compound:4239-0054|FD-Score:7.34|P-value:6.81E-12 ID:SGTC_1459|Compound:k035-0031|FD-Score:5.88|P-value:3.15E-8 ID:SGTC_1720|Compound:st037298|FD-Score:3.39|P-value:9.15E-4 ID:SGTC_1724|Compound:st037281|FD-Score:4.08|P-value:8.76E-5 ID:SGTC_2006|Compound:4011487|FD-Score:-3.39|P-value:8.47E-4 ID:SGTC_2024|Compound:5144227|FD-Score:3.38|P-value:9.58E-4 ID:SGTC_2105|Compound:5350118|FD-Score:4.20|P-value:5.65E-5 ID:SGTC_2109|Compound:5483026|FD-Score:5.53|P-value:1.79E-7 ID:SGTC_2113|Compound:5491891|FD-Score:-4.25|P-value:4.15E-5 ID:SGTC_2256|Compound:7954252|FD-Score:-4.35|P-value:2.90E-5 ID:SGTC_2315|Compound:7733312|FD-Score:5.75|P-value:6.13E-8 ID:SGTC_2330|Compound:7979373|FD-Score:3.50|P-value:6.46E-4 ID:SGTC_2336|Compound:9001819|FD-Score:4.73|P-value:6.85E-6 ID:SGTC_2379|Compound:9035213|FD-Score:4.48|P-value:1.89E-5 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:3.44|P-value:7.77E-4 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:6.05|P-value:1.28E-8 ID:SGTC_2569|Compound:tetrandrine|FD-Score:3.47|P-value:7.16E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:3.63|P-value:4.25E-4 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:-5.20|P-value:7.50E-7 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:4.76|P-value:5.89E-6 ID:SGTC_2789|Compound:5281112|FD-Score:3.64|P-value:4.04E-4 ID:SGTC_2907|Compound:7721985|FD-Score:3.80|P-value:2.41E-4 ID:SGTC_2949|Compound:9072542|FD-Score:4.78|P-value:5.50E-6 ID:SGTC_3036|Compound:9090181|FD-Score:3.51|P-value:6.21E-4 ID:SGTC_3158|Compound:9100007|FD-Score:3.61|P-value:4.56E-4 ID:SGTC_3232|Compound:9132874|FD-Score:-3.49|P-value:6.19E-4 ID:SGTC_31|Compound:0508-1974|FD-Score:4.56|P-value:1.37E-5 ID:SGTC_61|Compound:0978-8327|FD-Score:3.40|P-value:8.84E-4 ID:SGTC_207|Compound:4185-0010|FD-Score:4.40|P-value:2.61E-5 ID:SGTC_222|Compound:nsc-310342|FD-Score:4.00|P-value:1.17E-4 ID:SGTC_240|Compound:5hr heat shock (37°C) + Streptovitacin|FD-Score:3.79|P-value:2.49E-4 ID:SGTC_458|Compound:nppb|FD-Score:4.24|P-value:4.89E-5 ID:SGTC_518|Compound:1021-0119|FD-Score:5.10|P-value:1.34E-6 ID:SGTC_520|Compound:3584-0023|FD-Score:4.32|P-value:3.56E-5 ID:SGTC_568|Compound:1193-0097|FD-Score:-3.59|P-value:4.44E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:4.45|P-value:2.10E-5 ID:SGTC_593|Compound:1203-0218|FD-Score:3.38|P-value:9.34E-4 ID:SGTC_611|Compound:3453-1652|FD-Score:-3.52|P-value:5.57E-4 ID:SGTC_723|Compound:4182-0001|FD-Score:3.46|P-value:7.33E-4 ID:SGTC_761|Compound:k216-0224|FD-Score:3.71|P-value:3.26E-4 ID:SGTC_827|Compound:3253-0474|FD-Score:4.59|P-value:1.21E-5 ID:SGTC_831|Compound:k061-1017|FD-Score:3.40|P-value:8.77E-4 ID:SGTC_856|Compound:0433-0016|FD-Score:5.63|P-value:1.08E-7 ID:SGTC_948|Compound:3448-0295|FD-Score:6.71|P-value:3.25E-10 ID:SGTC_974|Compound:1326-0144|FD-Score:4.63|P-value:1.01E-5 ID:SGTC_1082|Compound:camptothecin|FD-Score:3.56|P-value:5.39E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:5.36|P-value:4.01E-7 ID:SGTC_1313|Compound:1220-0047|FD-Score:3.61|P-value:4.55E-4 ID:SGTC_1318|Compound:1280-3875|FD-Score:3.88|P-value:1.83E-4 ID:SGTC_1379|Compound:2144-0755|FD-Score:3.70|P-value:3.34E-4 ID:SGTC_1381|Compound:2324-0066|FD-Score:4.53|P-value:1.54E-5 ID:SGTC_1417|Compound:3966-0327|FD-Score:5.19|P-value:9.00E-7 ID:SGTC_1419|Compound:3993-2473|FD-Score:4.24|P-value:4.79E-5 ID:SGTC_1423|Compound:4048-0112|FD-Score:4.34|P-value:3.29E-5 ID:SGTC_1427|Compound:4048-4900|FD-Score:3.47|P-value:7.24E-4 ID:SGTC_1446|Compound:4239-0190|FD-Score:6.28|P-value:3.79E-9 ID:SGTC_1450|Compound:4112-4260|FD-Score:-3.58|P-value:4.54E-4 ID:SGTC_1454|Compound:4239-0054|FD-Score:7.34|P-value:6.81E-12 ID:SGTC_1459|Compound:k035-0031|FD-Score:5.88|P-value:3.15E-8 ID:SGTC_1720|Compound:st037298|FD-Score:3.39|P-value:9.15E-4 ID:SGTC_1724|Compound:st037281|FD-Score:4.08|P-value:8.76E-5 ID:SGTC_2006|Compound:4011487|FD-Score:-3.39|P-value:8.47E-4 ID:SGTC_2024|Compound:5144227|FD-Score:3.38|P-value:9.58E-4 ID:SGTC_2105|Compound:5350118|FD-Score:4.20|P-value:5.65E-5 ID:SGTC_2109|Compound:5483026|FD-Score:5.53|P-value:1.79E-7 ID:SGTC_2113|Compound:5491891|FD-Score:-4.25|P-value:4.15E-5 ID:SGTC_2256|Compound:7954252|FD-Score:-4.35|P-value:2.90E-5 ID:SGTC_2315|Compound:7733312|FD-Score:5.75|P-value:6.13E-8 ID:SGTC_2330|Compound:7979373|FD-Score:3.50|P-value:6.46E-4 ID:SGTC_2336|Compound:9001819|FD-Score:4.73|P-value:6.85E-6 ID:SGTC_2379|Compound:9035213|FD-Score:4.48|P-value:1.89E-5 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:3.44|P-value:7.77E-4 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:6.05|P-value:1.28E-8 ID:SGTC_2569|Compound:tetrandrine|FD-Score:3.47|P-value:7.16E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:3.63|P-value:4.25E-4 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:-5.20|P-value:7.50E-7 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:4.76|P-value:5.89E-6 ID:SGTC_2789|Compound:5281112|FD-Score:3.64|P-value:4.04E-4 ID:SGTC_2907|Compound:7721985|FD-Score:3.80|P-value:2.41E-4 ID:SGTC_2949|Compound:9072542|FD-Score:4.78|P-value:5.50E-6 ID:SGTC_3036|Compound:9090181|FD-Score:3.51|P-value:6.21E-4 ID:SGTC_3158|Compound:9100007|FD-Score:3.61|P-value:4.56E-4 ID:SGTC_3232|Compound:9132874|FD-Score:-3.49|P-value:6.19E-4

Top fitness defect scores for YBL093C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1454 4239-0054 7.34 42.6 µM 6.81E-12 1 1.05E-13
2 SGTC_948 3448-0295 6.71 75.3 µM 3.25E-10 2 9.76E-12
3 SGTC_1446 4239-0190 6.28 62.0 µM 3.79E-9 7 1.74E-10
4 SGTC_2540 epiandrosterone 6.05 100.0 µM 1.28E-8 21 7.28E-10
5 SGTC_1459 k035-0031 5.88 35.7 µM 3.15E-8 DNA intercalators 2 2.09E-9
6 SGTC_2315 7733312 5.75 200.0 µM 6.13E-8 6 4.55E-9
7 SGTC_856 0433-0016 5.63 11.3 µM 1.08E-7 2 8.86E-9
8 SGTC_2109 5483026 5.53 200.0 µM 1.79E-7 RSC complex & mRNA processing 5 1.59E-8
9 SGTC_1136 pergolide 5.36 1.1 µM 4.01E-7 9 4.12E-8
10 SGTC_1417 3966-0327 5.19 90.4 µM 9.00E-7 4 1.06E-7
11 SGTC_518 1021-0119 5.10 62.6 µM 1.34E-6 ERG2 14 1.69E-7
12 SGTC_2949 9072542 4.78 2.2 µM 5.50E-6 TSC3-RPN4 18 8.84E-7
13 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 4.76 100.0 µM 5.89E-6 11 9.57E-7
14 SGTC_2336 9001819 4.73 198.7 µM 6.85E-6 heme biosynthesis & mitochondrial translocase 29 1.14E-6
15 SGTC_974 1326-0144 4.63 138.0 µM 1.01E-5 ERG2 24 1.79E-6
16 SGTC_827 3253-0474 4.59 693.0 µM 1.21E-5 9 2.23E-6
17 SGTC_31 0508-1974 4.56 57.2 µM 1.37E-5 14 2.56E-6
18 SGTC_1381 2324-0066 4.53 62.1 µM 1.54E-5 20 2.94E-6
19 SGTC_2379 9035213 4.48 200.0 µM 1.89E-5 8 3.74E-6
20 SGTC_580 1123-0028 4.45 41.0 µM 2.10E-5 DNA damage response 23 4.24E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.115 2.40E-11 YDL233W_p MFG1_p hom Regulator of filamentous growth; interacts with FLO11 promoter and regulates FLO11 expression; binds to transcription factors Flo8p and Mss11p; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YDL233W is not an essential gene
0.099 1.08E-8 YKL009W MRT4 hom Protein involved in mRNA turnover and ribosome assembly, localizes to the nucleolus
0.097 1.68E-8 YOL130W ALR1 het Plasma membrane Mg(2+) transporter, expression and turnover are regulated by Mg(2+) concentration; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions
0.087 4.58E-7 YOL104C NDJ1 hom Meiosis-specific telomere protein, required for bouquet formation, effective homolog pairing, ordered cross-over distribution, sister chromatid cohesion at meiotic telomeres, chromosomal segregation and telomere-led rapid prophase movement
0.081 2.58E-6 YLL018C-A COX19 hom Protein required for cytochrome c oxidase assembly, located in the cytosol and mitochondrial intermembrane space; putative copper metallochaperone that delivers copper to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs
0.070 4.52E-5 YDR418W RPL12B hom Ribosomal 60S subunit protein L12B; rpl12a rpl12b double mutant exhibits slow growth and slow translation; homologous to mammalian ribosomal protein L12 and bacterial L11; RPL12B has a paralog, RPL12A, that arose from the whole genome duplication
0.069 6.69E-5 YPL079W RPL21B hom Ribosomal 60S subunit protein L21B; homologous to mammalian ribosomal protein L21, no bacterial homolog; RPL21B has a paralog, RPL21A, that arose from the whole genome duplication
0.068 7.74E-5 YCL054W SPB1 het AdoMet-dependent methyltransferase involved in rRNA processing and 60S ribosomal subunit maturation; methylates G2922 in the tRNA docking site of the large subunit rRNA and in the absence of snR52, U2921; suppressor of PAB1 mutants
0.068 8.73E-5 YMR156C TPP1 hom DNA 3'-phosphatase; functions in repair of endogenous damage of double-stranded DNA, activity is specific for removal of 3' phosphates at strand breaks; similar to the l-2-haloacid dehalogenase superfamily; homolog of human polynucleotide kinase/3′-phosphatase
0.068 8.81E-5 YKL027W YKL027W hom Protein of unknown function, localized to the mitochondrial outer membrane
0.068 8.95E-5 YDR390C UBA2 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Aos1p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.067 9.33E-5 YPL088W_p YPL088W_p hom Putative aryl alcohol dehydrogenase; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance
0.067 9.49E-5 YKR026C GCN3 hom Alpha subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a positive regulator of GCN4 expression
0.067 1.08E-4 YDR007W TRP1 hom Phosphoribosylanthranilate isomerase that catalyzes the third step in tryptophan biosynthesis; in 2004, the sequence of TRP1 from strain S228C was updated by changing the previously annotated internal STOP (TAA) to serine (TCA)
0.066 1.18E-4 YER174C GRX4 hom Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx3p and Grx5p; protects cells from oxidative damage; mutant has increased aneuploidy tolerance; transcription is regulated by Yap5