YBL095W_p

Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies

Zygosity: Homozygous strain
fixedexpanded
Profile for YBL095W / YBL095W

Click on Significant Values for Screen Details ID:SGTC_361|Compound:000s-0510|FD-Score:-6.17|P-value:7.82E-9 ID:SGTC_362|Compound:0310-0100|FD-Score:6.50|P-value:2.98E-10 ID:SGTC_369|Compound:0957-0393|FD-Score:-5.98|P-value:2.13E-8 ID:SGTC_388|Compound:3',4'-dichloroisocoumarin|FD-Score:-3.54|P-value:7.06E-4 ID:SGTC_607|Compound:4491-0986|FD-Score:3.59|P-value:2.63E-4 ID:SGTC_699|Compound:0375-0592|FD-Score:3.22|P-value:8.99E-4 ID:SGTC_898|Compound:1000-0849|FD-Score:3.54|P-value:3.14E-4 ID:SGTC_1054|Compound:3429-0080|FD-Score:4.93|P-value:1.17E-6 ID:SGTC_1075|Compound:aripiprazole|FD-Score:4.13|P-value:3.58E-5 ID:SGTC_1131|Compound:3454-3128|FD-Score:5.13|P-value:4.64E-7 ID:SGTC_1155|Compound:4088-0394|FD-Score:4.41|P-value:1.12E-5 ID:SGTC_1162|Compound:k048-0130|FD-Score:3.39|P-value:5.15E-4 ID:SGTC_1259|Compound:0671-0132|FD-Score:-4.18|P-value:7.41E-5 ID:SGTC_1263|Compound:0774-1208|FD-Score:-4.34|P-value:3.97E-5 ID:SGTC_1264|Compound:0783-0040|FD-Score:-3.45|P-value:9.44E-4 ID:SGTC_1300|Compound:1094-0077|FD-Score:3.81|P-value:1.20E-4 ID:SGTC_1372|Compound:2752-0194|FD-Score:-3.51|P-value:7.71E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:5.77|P-value:1.81E-8 ID:SGTC_1458|Compound:k015-0034|FD-Score:4.96|P-value:9.98E-7 ID:SGTC_1530|Compound:rhein|FD-Score:3.86|P-value:9.82E-5 ID:SGTC_1604|Compound:st002052|FD-Score:-3.61|P-value:5.51E-4 ID:SGTC_1612|Compound:st002233|FD-Score:5.02|P-value:7.71E-7 ID:SGTC_1618|Compound:st003135|FD-Score:-4.71|P-value:8.86E-6 ID:SGTC_1619|Compound:st003326|FD-Score:4.34|P-value:1.53E-5 ID:SGTC_1621|Compound:st003705|FD-Score:3.84|P-value:1.08E-4 ID:SGTC_1649|Compound:st011737|FD-Score:4.42|P-value:1.10E-5 ID:SGTC_1841|Compound:st054148|FD-Score:3.40|P-value:4.92E-4 ID:SGTC_1896|Compound:st058441|FD-Score:3.58|P-value:2.70E-4 ID:SGTC_1930|Compound:st074634|FD-Score:3.95|P-value:7.16E-5 ID:SGTC_1934|Compound:st074720|FD-Score:3.29|P-value:7.03E-4 ID:SGTC_1945|Compound:st075991|FD-Score:4.42|P-value:1.09E-5 ID:SGTC_1966|Compound:st070145|FD-Score:6.42|P-value:4.75E-10 ID:SGTC_1991|Compound:st073000|FD-Score:4.20|P-value:2.66E-5 ID:SGTC_2019|Compound:4016004|FD-Score:-4.09|P-value:1.02E-4 ID:SGTC_2122|Compound:5258151|FD-Score:3.57|P-value:2.81E-4 ID:SGTC_2394|Compound:5221648|FD-Score:4.45|P-value:9.57E-6 ID:SGTC_2414|Compound:st077232|FD-Score:5.44|P-value:1.01E-7 ID:SGTC_2445|Compound:5742597|FD-Score:4.60|P-value:5.12E-6 ID:SGTC_2456|Compound:5770359|FD-Score:3.19|P-value:9.85E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:3.40|P-value:4.99E-4 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:3.41|P-value:4.76E-4 ID:SGTC_2677|Compound:mitomycin C|FD-Score:3.75|P-value:1.48E-4 ID:SGTC_2719|Compound:novobiocin|FD-Score:3.22|P-value:9.04E-4 ID:SGTC_2920|Compound:7982904|FD-Score:-3.96|P-value:1.66E-4 ID:SGTC_2939|Compound:9044578|FD-Score:4.47|P-value:8.72E-6 ID:SGTC_2959|Compound:9079155|FD-Score:3.27|P-value:7.57E-4 ID:SGTC_2965|Compound:9082772|FD-Score:3.30|P-value:6.90E-4 ID:SGTC_3026|Compound:9090633|FD-Score:4.19|P-value:2.76E-5 ID:SGTC_3065|Compound:9113888|FD-Score:-3.81|P-value:2.85E-4 ID:SGTC_3108|Compound:9121785|FD-Score:-4.29|P-value:4.81E-5 ID:SGTC_3130|Compound:9127414|FD-Score:3.49|P-value:3.68E-4 ID:SGTC_3131|Compound:9127911|FD-Score:-5.47|P-value:2.85E-7 ID:SGTC_3134|Compound:9127454|FD-Score:3.64|P-value:2.18E-4 ID:SGTC_3137|Compound:9097352|FD-Score:4.41|P-value:1.12E-5 ID:SGTC_3151|Compound:9099821|FD-Score:-5.20|P-value:1.04E-6 ID:SGTC_3153|Compound:9100258|FD-Score:3.60|P-value:2.53E-4 ID:SGTC_3174|Compound:9107204|FD-Score:4.03|P-value:5.16E-5 ID:SGTC_3213|Compound:9129884|FD-Score:-3.57|P-value:6.35E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:-6.17|P-value:7.82E-9 ID:SGTC_362|Compound:0310-0100|FD-Score:6.50|P-value:2.98E-10 ID:SGTC_369|Compound:0957-0393|FD-Score:-5.98|P-value:2.13E-8 ID:SGTC_388|Compound:3',4'-dichloroisocoumarin|FD-Score:-3.54|P-value:7.06E-4 ID:SGTC_607|Compound:4491-0986|FD-Score:3.59|P-value:2.63E-4 ID:SGTC_699|Compound:0375-0592|FD-Score:3.22|P-value:8.99E-4 ID:SGTC_898|Compound:1000-0849|FD-Score:3.54|P-value:3.14E-4 ID:SGTC_1054|Compound:3429-0080|FD-Score:4.93|P-value:1.17E-6 ID:SGTC_1075|Compound:aripiprazole|FD-Score:4.13|P-value:3.58E-5 ID:SGTC_1131|Compound:3454-3128|FD-Score:5.13|P-value:4.64E-7 ID:SGTC_1155|Compound:4088-0394|FD-Score:4.41|P-value:1.12E-5 ID:SGTC_1162|Compound:k048-0130|FD-Score:3.39|P-value:5.15E-4 ID:SGTC_1259|Compound:0671-0132|FD-Score:-4.18|P-value:7.41E-5 ID:SGTC_1263|Compound:0774-1208|FD-Score:-4.34|P-value:3.97E-5 ID:SGTC_1264|Compound:0783-0040|FD-Score:-3.45|P-value:9.44E-4 ID:SGTC_1300|Compound:1094-0077|FD-Score:3.81|P-value:1.20E-4 ID:SGTC_1372|Compound:2752-0194|FD-Score:-3.51|P-value:7.71E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:5.77|P-value:1.81E-8 ID:SGTC_1458|Compound:k015-0034|FD-Score:4.96|P-value:9.98E-7 ID:SGTC_1530|Compound:rhein|FD-Score:3.86|P-value:9.82E-5 ID:SGTC_1604|Compound:st002052|FD-Score:-3.61|P-value:5.51E-4 ID:SGTC_1612|Compound:st002233|FD-Score:5.02|P-value:7.71E-7 ID:SGTC_1618|Compound:st003135|FD-Score:-4.71|P-value:8.86E-6 ID:SGTC_1619|Compound:st003326|FD-Score:4.34|P-value:1.53E-5 ID:SGTC_1621|Compound:st003705|FD-Score:3.84|P-value:1.08E-4 ID:SGTC_1649|Compound:st011737|FD-Score:4.42|P-value:1.10E-5 ID:SGTC_1841|Compound:st054148|FD-Score:3.40|P-value:4.92E-4 ID:SGTC_1896|Compound:st058441|FD-Score:3.58|P-value:2.70E-4 ID:SGTC_1930|Compound:st074634|FD-Score:3.95|P-value:7.16E-5 ID:SGTC_1934|Compound:st074720|FD-Score:3.29|P-value:7.03E-4 ID:SGTC_1945|Compound:st075991|FD-Score:4.42|P-value:1.09E-5 ID:SGTC_1966|Compound:st070145|FD-Score:6.42|P-value:4.75E-10 ID:SGTC_1991|Compound:st073000|FD-Score:4.20|P-value:2.66E-5 ID:SGTC_2019|Compound:4016004|FD-Score:-4.09|P-value:1.02E-4 ID:SGTC_2122|Compound:5258151|FD-Score:3.57|P-value:2.81E-4 ID:SGTC_2394|Compound:5221648|FD-Score:4.45|P-value:9.57E-6 ID:SGTC_2414|Compound:st077232|FD-Score:5.44|P-value:1.01E-7 ID:SGTC_2445|Compound:5742597|FD-Score:4.60|P-value:5.12E-6 ID:SGTC_2456|Compound:5770359|FD-Score:3.19|P-value:9.85E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:3.40|P-value:4.99E-4 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:3.41|P-value:4.76E-4 ID:SGTC_2677|Compound:mitomycin C|FD-Score:3.75|P-value:1.48E-4 ID:SGTC_2719|Compound:novobiocin|FD-Score:3.22|P-value:9.04E-4 ID:SGTC_2920|Compound:7982904|FD-Score:-3.96|P-value:1.66E-4 ID:SGTC_2939|Compound:9044578|FD-Score:4.47|P-value:8.72E-6 ID:SGTC_2959|Compound:9079155|FD-Score:3.27|P-value:7.57E-4 ID:SGTC_2965|Compound:9082772|FD-Score:3.30|P-value:6.90E-4 ID:SGTC_3026|Compound:9090633|FD-Score:4.19|P-value:2.76E-5 ID:SGTC_3065|Compound:9113888|FD-Score:-3.81|P-value:2.85E-4 ID:SGTC_3108|Compound:9121785|FD-Score:-4.29|P-value:4.81E-5 ID:SGTC_3130|Compound:9127414|FD-Score:3.49|P-value:3.68E-4 ID:SGTC_3131|Compound:9127911|FD-Score:-5.47|P-value:2.85E-7 ID:SGTC_3134|Compound:9127454|FD-Score:3.64|P-value:2.18E-4 ID:SGTC_3137|Compound:9097352|FD-Score:4.41|P-value:1.12E-5 ID:SGTC_3151|Compound:9099821|FD-Score:-5.20|P-value:1.04E-6 ID:SGTC_3153|Compound:9100258|FD-Score:3.60|P-value:2.53E-4 ID:SGTC_3174|Compound:9107204|FD-Score:4.03|P-value:5.16E-5 ID:SGTC_3213|Compound:9129884|FD-Score:-3.57|P-value:6.35E-4

Top fitness defect scores for YBL095W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_362 0310-0100 6.50 9.0 µM 2.98E-10 RPP1 & pyrimidine depletion 2 3.96E-11
2 SGTC_1966 st070145 6.42 16.1 µM 4.75E-10 6 6.68E-11
3 SGTC_1374 2889-5571 5.77 141.0 µM 1.81E-8 RSC complex & mRNA processing 13 3.93E-9
4 SGTC_2414 st077232 5.44 92.9 µM 1.01E-7 5 2.67E-8
5 SGTC_1131 3454-3128 5.13 32.3 µM 4.64E-7 13 1.47E-7
6 SGTC_1612 st002233 5.02 45.4 µM 7.71E-7 6 2.59E-7
7 SGTC_1458 k015-0034 4.96 6.3 µM 9.98E-7 9 3.45E-7
8 SGTC_1054 3429-0080 4.93 167.0 µM 1.17E-6 15 4.11E-7
9 SGTC_2445 5742597 4.60 35.6 µM 5.12E-6 22 2.13E-6
10 SGTC_2939 9044578 4.47 71.4 µM 8.72E-6 30 3.85E-6
11 SGTC_2394 5221648 4.45 200.0 µM 9.57E-6 13 4.26E-6
12 SGTC_1945 st075991 4.42 56.6 µM 1.09E-5 60S ribosome export 9 4.92E-6
13 SGTC_1649 st011737 4.42 51.3 µM 1.10E-5 25 4.98E-6
14 SGTC_1155 4088-0394 4.41 48.2 µM 1.12E-5 17 5.06E-6
15 SGTC_3137 9097352 4.41 49.5 µM 1.12E-5 27 5.08E-6
16 SGTC_1619 st003326 4.34 88.7 µM 1.53E-5 60S ribosome export 13 7.20E-6
17 SGTC_1991 st073000 4.20 8.9 µM 2.66E-5 NEO1 69 1.32E-5
18 SGTC_3026 9090633 4.19 49.5 µM 2.76E-5 17 1.38E-5
19 SGTC_1075 aripiprazole 4.13 15.2 µM 3.58E-5 23 1.84E-5
20 SGTC_3174 9107204 4.03 49.5 µM 5.16E-5 ERG2 26 2.76E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.082 2.11E-6 YFL041W FET5 hom Multicopper oxidase, integral membrane protein with similarity to Fet3p; may have a role in iron transport
0.075 1.45E-5 YJL105W SET4 hom Protein of unknown function, contains a SET domain; SET4 has a paralog, SET3, that arose from the whole genome duplication
0.074 1.71E-5 YOR208W PTP2 hom Phosphotyrosine-specific protein phosphatase involved in the inactivation of mitogen-activated protein kinase (MAPK) during osmolarity sensing; dephosporylates Hog1p MAPK and regulates its localization; localized to the nucleus
0.074 1.99E-5 YBL060W YEL1 hom Guanine nucleotide exchange factor specific for Arf3p; localized to the bud neck and tip; required for localization of Arf3p to the bud neck and tip
0.072 2.65E-5 YDL204W RTN2 hom Reticulon protein; stabilizes membrane curvature; involved in nuclear pore assembly and maintenance of tubular ER morphology; interacts with exocyst subunit Sec6p, Yip3p, and Sbh1p; much less abundant than Rtn1p; rtn1 rtn2 yop1 triple mutant lacks tubular ER; member of RTNLA (reticulon-like A) subfamily; protein increases in abundance and relocalizes to plasma membrane upon DNA replication stress; RTN2 has a paralog, RTN1, that arose from the whole genome duplication
0.071 3.58E-5 YFR028C CDC14 het Protein phosphatase required for mitotic exit; located in the nucleolus until liberated by the FEAR and Mitotic Exit Network in anaphase, enabling it to act on key substrates to effect a decrease in CDK/B-cyclin activity and mitotic exit; required for meiosis I spindle disassembly; released from nucleolus upon entry into anaphase I of meiosis, resequestered in metaphase II, then released again upon entry into anaphase II; maintained in nucleolus by Cdc55p in early meiosis
0.070 4.55E-5 YOR046C DBP5 het Cytoplasmic ATP-dependent RNA helicase of the DEAD-box family; involved in mRNA export from the nucleus; involved in translation termination; ATP/ADP cycling is regulated by Gle1p and Nup159p
0.070 4.77E-5 YER091C MET6 hom Cobalamin-independent methionine synthase, involved in methionine biosynthesis and regeneration; requires a minimum of two glutamates on the methyltetrahydrofolate substrate, similar to bacterial metE homologs
0.070 5.55E-5 YBR147W RTC2 hom Putative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; positive regulation by Lys14p suggests that lysine may be the primary substrate; member of the PQ-loop family, with seven transmembrane domains; similar to mammalian PQLC2 vacuolar transporter
0.069 6.26E-5 YPL179W PPQ1 hom Putative protein serine/threonine phosphatase; null mutation enhances efficiency of translational suppressors
0.069 6.27E-5 YGR260W TNA1 hom High affinity nicotinic acid plasma membrane permease, responsible for uptake of low levels of nicotinic acid; expression of the gene increases in the absence of extracellular nicotinic acid or para-aminobenzoate (PABA)
0.067 9.35E-5 YJL172W CPS1 hom Vacuolar carboxypeptidase yscS; expression is induced under low-nitrogen conditions
0.067 9.87E-5 YNL311C SKP2 hom F-box protein of unknown function predicted to be part of an SCF ubiquitin protease complex; involved in regulating protein levels of sulfur metabolism enzymes; may interact with ribosomes, based on co-purification experiments
0.066 1.23E-4 YOR384W FRE5 hom Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.064 1.96E-4 YOR099W KTR1 hom Alpha-1,2-mannosyltransferase; involved in O- and N-linked protein glycosylation; type II membrane protein; member of the KRE2/MNT1 mannosyltransferase family; relocalizes from vacuole to cytoplasm upon DNA replication stress