HIPHOP chemogenomics database

YBL096C_d

Non-essential protein of unknown function

Zygosity: Homozygous strain

fixedexpanded
Profile for YBL096C / YBL096C

Click on Significant Values for Screen Details

Top fitness defect scores for YBL096C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_954	1189-0853	4.77	2.9 µM	1.15E-7	endomembrane recycling	22	9.14E-7
2	SGTC_2573	2',4'-dihydroxychalcone	4.73	15.0 µM	1.47E-7		26	1.13E-6
3	SGTC_2597	laccaic acid a	4.39	100.0 µM	9.57E-7		26	5.60E-6
4	SGTC_1199	1638-0010	4.34	4.5 µM	1.28E-6	endomembrane recycling	13	7.20E-6
5	SGTC_2412	st077135	4.32	33.4 µM	1.39E-6		15	7.72E-6
6	SGTC_1120	ficusin	4.24	1.8 µM	2.11E-6		17	1.10E-5
7	SGTC_935	2996-0153	4.22	430.0 µM	2.33E-6	PDR1	16	1.20E-5
8	SGTC_1487	3970-0795	4.10	2.8 µM	4.31E-6	DNA intercalators	5	2.03E-5
9	SGTC_23	0213-0011	4.05	40.0 µM	5.57E-6	copper-dependent oxidative stress	23	2.53E-5
10	SGTC_1922	5578187	3.92	25.0 µM	1.05E-5	TRP & mitochondrial translation	34	4.37E-5
11	SGTC_1919	st067113	3.90	52.3 µM	1.19E-5	TSC3-RPN4	30	4.86E-5
12	SGTC_658	3253-0951	3.53	102.0 µM	6.53E-5	calcium & mitochondrial duress	80	2.08E-4
13	SGTC_1851	st056236	3.49	18.9 µM	7.89E-5		26	2.45E-4
14	SGTC_1115	galangin	3.45	695.7 nM	9.40E-5	RPP1 & pyrimidine depletion	27	2.85E-4
15	SGTC_1138	3761-0006	3.43	1.0 µM	1.01E-4		13	3.04E-4
16	SGTC_781	4335-2806	3.36	94.4 µM	1.33E-4		37	3.84E-4
17	SGTC_2815	7968870	3.32	71.4 µM	1.58E-4		53	4.44E-4
18	SGTC_1824	st053723	3.29	68.6 µM	1.85E-4		54	5.09E-4
19	SGTC_2838	9002687	3.26	71.4 µM	2.08E-4	fatty acid desaturase (OLE1)	45	5.63E-4
20	SGTC_134	0269-0018	3.25	6.9 µM	2.14E-4		173	5.78E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.105	9.28E-10	YGL232W	TAN1	hom	Putative tRNA acetyltransferase; RNA-binding protein required for the formation of the modified nucleoside N(4)-acetylcytidine in serine and leucine tRNAs but not required for the same modification in 18S rRNA; protein abundance increases in response to DNA replication stress
0.103	2.52E-9	YPR085C	ASA1	het	Subunit of the ASTRA complex, involved in chromatin remodeling; telomere length regulator involved in the stability or biogenesis of PIKKs such as TORC1
0.102	2.65E-9	YKL120W	OAC1	hom	Mitochondrial inner membrane transporter, transports oxaloacetate, sulfate, thiosulfate, and isopropylmalate; member of the mitochondrial carrier family
0.097	1.68E-8	YNL159C	ASI2	hom	Integral inner nuclear membrane protein that acts with Asi1p and Asi3p to ensure the fidelity of SPS-sensor signalling by maintaining the dormant repressed state of gene expression in the absence of inducing signals
0.094	5.53E-8	YHR189W	PTH1	hom	One of two (see also PTH2) mitochondrially-localized peptidyl-tRNA hydrolases; dispensable for respiratory growth on rich medium, but required for respiratory growth on minimal medium
0.093	6.16E-8	YMR162C	DNF3	hom	Aminophospholipid translocase (flippase) that maintains membrane lipid asymmetry in post-Golgi secretory vesicles; localizes to the trans-Golgi network; likely involved in protein transport; type 4 P-type ATPase
0.089	2.31E-7	YOR305W	RRG7	hom	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO); YOR305W is not an essential gene
0.083	1.28E-6	YFR032C-A	RPL29	hom	Ribosomal 60S subunit protein L29; not essential for translation, but required for proper joining of large and small ribosomal subunits and for normal translation rate; homologous to mammalian ribosomal protein L29, no bacterial homolog
0.082	2.09E-6	YEL060C	PRB1	hom	Vacuolar proteinase B (yscB); serine protease of the subtilisin family; involved in protein degradation in the vacuole and required for full protein degradation during sporulation; activity inhibited by Pbi2p; protein abundance increases in response to DNA replication stress
0.081	2.74E-6	YBR225W_p	YBR225W_p	hom	Putative protein of unknown function; non-essential gene identified in a screen for mutants affected in mannosylphophorylation of cell wall components
0.079	4.84E-6	YKL068W-A_p	YKL068W-A_p	hom	Putative protein of unknown function; identified by homology to Ashbya gossypii
0.079	4.94E-6	YGR161C_p	RTS3_p	hom	Putative component of the protein phosphatase type 2A complex
0.077	8.87E-6	YIL121W	QDR2	hom	Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; exports copper; has broad substrate specificity and can transport many mono- and divalent cations; transports a variety of drugs and is required for resistance to quinidine, barban, cisplatin, and bleomycin; contributes to potassium homeostasis; expression is regulated by copper
0.076	1.05E-5	YMR143W	RPS16A	hom	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S16 and bacterial S9; RPS16A has a paralog, RPS16B, that arose from the whole genome duplication
0.075	1.25E-5	YMR140W	SIP5	hom	Protein of unknown function; interacts with both the Reg1p/Glc7p phosphatase and the Snf1p kinase; forms cytoplasmic foci upon DNA replication stress