HIPHOP chemogenomics database
YBL097W / BRN1 
Subunit of the condensin complex; required for chromosome condensation and for clustering of tRNA genes at the nucleolus; may influence multiple aspects of chromosome transmission
Zygosity: Heterozygous strain
fixedexpanded
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Top fitness defect scores for YBL097W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.116 | 1.91E-11 | YJR067C | YAE1 | het | Protein that forms a complex with Lto1p and Rli1p; essential for growth under standard (aerobic) conditions but not under anaerobic conditions; may have a role in protection of ribosomal assembly and function from damage due to reactive oxygen species |
| 0.107 | 5.47E-10 | YJL105W | SET4 | hom | Protein of unknown function, contains a SET domain; SET4 has a paralog, SET3, that arose from the whole genome duplication |
| 0.106 | 6.45E-10 | YGL131C | SNT2 | hom | DNA binding protein with similarity to the S. pombe Snt2 protein; RING finger ubiquitin ligase (E3) involved in ubiquitylation and degradation of excess histones; interacts with Ubc4p; null mutant sensitive to hydroxyurea (HU); computational analysis suggests that Snt2p is a transcription factor with a role in regulation of expression of genes encoding amine transporters; relocalizes from nucleus to cytoplasm upon DNA replication stress |
| 0.099 | 1.00E-8 | YIR027C | DAL1 | hom | Allantoinase, converts allantoin to allantoate in the first step of allantoin degradation; expression sensitive to nitrogen catabolite repression |
| 0.098 | 1.34E-8 | YPL133C | RDS2 | hom | Transcription factor involved in regulating gluconeogenesis and glyoxylate cycle genes; member of the zinc cluster family of proteins; confers resistance to ketoconazole |
| 0.098 | 1.48E-8 | YBR090C_p | YBR090C_p | hom | Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus |
| 0.097 | 1.93E-8 | YKR058W | GLG1 | hom | Glycogenin glucosyltransferase; self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; similar to mammalian glycogenin; GLG1 has a paralog, GLG2, that arose from the whole genome duplication |
| 0.096 | 2.19E-8 | YOR228C | YOR228C | hom | Protein of unknown function, localized to the mitochondrial outer membrane |
| 0.089 | 2.82E-7 | YPL107W_p | YPL107W_p | hom | Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YPL107W is not an essential gene |
| 0.085 | 7.55E-7 | YGL037C | PNC1 | hom | Nicotinamidase that converts nicotinamide to nicotinic acid; part of the NAD(+) salvage pathway; required for life span extension by calorie restriction; PNC1 expression responds to all known stimuli that extend replicative life span; protein increases in abundance and relative distribution to cytoplasmic foci decreases upon DNA replication stress |
| 0.085 | 7.92E-7 | YPR031W | NTO1 | hom | Subunit of the NuA3 histone acetyltransferase complex that acetylates histone H3; contains PHD finger domain that interacts with methylated histone H3 |
| 0.083 | 1.46E-6 | YDR170C | SEC7 | het | Guanine nucleotide exchange factor (GEF) for ADP ribosylation factors involved in proliferation of the Golgi, intra-Golgi transport and ER-to-Golgi transport; found in the cytoplasm and on Golgi-associated coated vesicles |
| 0.081 | 2.46E-6 | YFL049W | SWP82 | hom | Member of the SWI/SNF chromatin remodeling complex; has an as yet unidentified role in the complex; has identifiable counterparts in closely related yeast species; abundantly expressed in many growth conditions; paralog of Npl6p; relocates to the cytosol under hypoxic conditions |
| 0.079 | 4.27E-6 | YER028C | MIG3 | hom | Transcriptional regulator; partially nonfunctional in S288C strains but has a major role in catabolite repression and ethanol response in some other strains; involved in response to toxic agents; phosphorylation by Snf1p or the Mec1p pathway inactivates Mig3p, allowing induction of damage response genes; MIG3 has a paralog, MIG2, that arose from the whole genome duplication |
| 0.079 | 5.06E-6 | YJR019C | TES1 | hom | Peroxisomal acyl-CoA thioesterase likely to be involved in fatty acid oxidation rather than fatty acid synthesis; conserved protein also found in human peroxisomes; TES1 mRNA levels increase during growth on fatty acids |