YBL097W / BRN1

Subunit of the condensin complex; required for chromosome condensation and for clustering of tRNA genes at the nucleolus; may influence multiple aspects of chromosome transmission

Zygosity: Heterozygous strain
fixedexpanded
Profile for YBL097W / BRN1

Click on Significant Values for Screen Details ID:SGTC_69|Compound:0096-0274|FD-Score:-3.97|P-value:4.88E-5 ID:SGTC_109|Compound:0132-0036|FD-Score:3.47|P-value:3.24E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:-4.01|P-value:4.12E-5 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:-3.30|P-value:5.85E-4 ID:SGTC_583|Compound:1488-1091|FD-Score:3.25|P-value:7.09E-4 ID:SGTC_663|Compound:1486-0733|FD-Score:4.56|P-value:3.75E-6 ID:SGTC_688|Compound:0527-0193|FD-Score:4.71|P-value:1.83E-6 ID:SGTC_823|Compound:0417-1665|FD-Score:3.48|P-value:3.19E-4 ID:SGTC_921|Compound:1561-0023|FD-Score:3.19|P-value:8.61E-4 ID:SGTC_999|Compound:4022-0066|FD-Score:4.59|P-value:3.33E-6 ID:SGTC_1003|Compound:4049-0218|FD-Score:5.58|P-value:2.16E-8 ID:SGTC_1005|Compound:4092-0690|FD-Score:4.74|P-value:1.65E-6 ID:SGTC_1042|Compound:0350-0096|FD-Score:5.74|P-value:8.83E-9 ID:SGTC_1085|Compound:doxorubicin|FD-Score:5.18|P-value:1.77E-7 ID:SGTC_1259|Compound:0671-0132|FD-Score:3.30|P-value:5.93E-4 ID:SGTC_1435|Compound:4092-0789|FD-Score:3.45|P-value:3.55E-4 ID:SGTC_1677|Compound:st019204|FD-Score:3.27|P-value:6.63E-4 ID:SGTC_1723|Compound:st034307|FD-Score:3.48|P-value:3.20E-4 ID:SGTC_1936|Compound:st074407|FD-Score:-5.10|P-value:2.70E-7 ID:SGTC_2133|Compound:5320837|FD-Score:3.53|P-value:2.61E-4 ID:SGTC_2238|Compound:6671620|FD-Score:-4.35|P-value:9.49E-6 ID:SGTC_2246|Compound:7293507|FD-Score:5.31|P-value:8.97E-8 ID:SGTC_2316|Compound:5844804|FD-Score:3.57|P-value:2.30E-4 ID:SGTC_2344|Compound:7990960|FD-Score:3.88|P-value:7.02E-5 ID:SGTC_2365|Compound:9042475|FD-Score:3.34|P-value:5.22E-4 ID:SGTC_2393|Compound:9031399|FD-Score:-3.28|P-value:6.29E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:5.20|P-value:1.64E-7 ID:SGTC_2490|Compound:carminic acid|FD-Score:5.04|P-value:3.65E-7 ID:SGTC_2495|Compound:cafestol|FD-Score:4.46|P-value:6.01E-6 ID:SGTC_2503|Compound:beta-caryophyllene alcohol|FD-Score:3.96|P-value:5.07E-5 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:-3.71|P-value:1.36E-4 ID:SGTC_2511|Compound:berberine|FD-Score:7.37|P-value:2.26E-13 ID:SGTC_2517|Compound:totarol|FD-Score:3.24|P-value:7.37E-4 ID:SGTC_2522|Compound:biochanin a|FD-Score:-4.29|P-value:1.26E-5 ID:SGTC_2528|Compound:xanthyletin|FD-Score:8.51|P-value:3.20E-17 ID:SGTC_2529|Compound:gangaleoidin|FD-Score:4.83|P-value:1.07E-6 ID:SGTC_2533|Compound:agelasine|FD-Score:6.45|P-value:1.18E-10 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:-6.36|P-value:2.12E-10 ID:SGTC_2537|Compound:larixol|FD-Score:3.66|P-value:1.65E-4 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-7.42|P-value:1.59E-13 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:-4.63|P-value:2.70E-6 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:3.82|P-value:8.92E-5 ID:SGTC_2730|Compound:imipramine|FD-Score:-3.31|P-value:5.83E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:4.02|P-value:3.90E-5 ID:SGTC_2774|Compound:tamoxifen|FD-Score:3.91|P-value:6.10E-5 ID:SGTC_2816|Compound:7982706|FD-Score:4.05|P-value:3.51E-5 ID:SGTC_2844|Compound:9010103|FD-Score:4.19|P-value:1.97E-5 ID:SGTC_2934|Compound:9036370|FD-Score:5.03|P-value:3.97E-7 ID:SGTC_2982|Compound:9019404|FD-Score:-3.16|P-value:9.43E-4 ID:SGTC_3087|Compound:9117406|FD-Score:-3.15|P-value:9.70E-4 ID:SGTC_3100|Compound:9120536|FD-Score:3.22|P-value:7.78E-4 ID:SGTC_3132|Compound:9126706|FD-Score:4.36|P-value:9.29E-6 ID:SGTC_3345|Compound:9148410|FD-Score:3.21|P-value:8.07E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:-3.97|P-value:4.88E-5 ID:SGTC_109|Compound:0132-0036|FD-Score:3.47|P-value:3.24E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:-4.01|P-value:4.12E-5 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:-3.30|P-value:5.85E-4 ID:SGTC_583|Compound:1488-1091|FD-Score:3.25|P-value:7.09E-4 ID:SGTC_663|Compound:1486-0733|FD-Score:4.56|P-value:3.75E-6 ID:SGTC_688|Compound:0527-0193|FD-Score:4.71|P-value:1.83E-6 ID:SGTC_823|Compound:0417-1665|FD-Score:3.48|P-value:3.19E-4 ID:SGTC_921|Compound:1561-0023|FD-Score:3.19|P-value:8.61E-4 ID:SGTC_999|Compound:4022-0066|FD-Score:4.59|P-value:3.33E-6 ID:SGTC_1003|Compound:4049-0218|FD-Score:5.58|P-value:2.16E-8 ID:SGTC_1005|Compound:4092-0690|FD-Score:4.74|P-value:1.65E-6 ID:SGTC_1042|Compound:0350-0096|FD-Score:5.74|P-value:8.83E-9 ID:SGTC_1085|Compound:doxorubicin|FD-Score:5.18|P-value:1.77E-7 ID:SGTC_1259|Compound:0671-0132|FD-Score:3.30|P-value:5.93E-4 ID:SGTC_1435|Compound:4092-0789|FD-Score:3.45|P-value:3.55E-4 ID:SGTC_1677|Compound:st019204|FD-Score:3.27|P-value:6.63E-4 ID:SGTC_1723|Compound:st034307|FD-Score:3.48|P-value:3.20E-4 ID:SGTC_1936|Compound:st074407|FD-Score:-5.10|P-value:2.70E-7 ID:SGTC_2133|Compound:5320837|FD-Score:3.53|P-value:2.61E-4 ID:SGTC_2238|Compound:6671620|FD-Score:-4.35|P-value:9.49E-6 ID:SGTC_2246|Compound:7293507|FD-Score:5.31|P-value:8.97E-8 ID:SGTC_2316|Compound:5844804|FD-Score:3.57|P-value:2.30E-4 ID:SGTC_2344|Compound:7990960|FD-Score:3.88|P-value:7.02E-5 ID:SGTC_2365|Compound:9042475|FD-Score:3.34|P-value:5.22E-4 ID:SGTC_2393|Compound:9031399|FD-Score:-3.28|P-value:6.29E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:5.20|P-value:1.64E-7 ID:SGTC_2490|Compound:carminic acid|FD-Score:5.04|P-value:3.65E-7 ID:SGTC_2495|Compound:cafestol|FD-Score:4.46|P-value:6.01E-6 ID:SGTC_2503|Compound:beta-caryophyllene alcohol|FD-Score:3.96|P-value:5.07E-5 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:-3.71|P-value:1.36E-4 ID:SGTC_2511|Compound:berberine|FD-Score:7.37|P-value:2.26E-13 ID:SGTC_2517|Compound:totarol|FD-Score:3.24|P-value:7.37E-4 ID:SGTC_2522|Compound:biochanin a|FD-Score:-4.29|P-value:1.26E-5 ID:SGTC_2528|Compound:xanthyletin|FD-Score:8.51|P-value:3.20E-17 ID:SGTC_2529|Compound:gangaleoidin|FD-Score:4.83|P-value:1.07E-6 ID:SGTC_2533|Compound:agelasine|FD-Score:6.45|P-value:1.18E-10 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:-6.36|P-value:2.12E-10 ID:SGTC_2537|Compound:larixol|FD-Score:3.66|P-value:1.65E-4 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-7.42|P-value:1.59E-13 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:-4.63|P-value:2.70E-6 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:3.82|P-value:8.92E-5 ID:SGTC_2730|Compound:imipramine|FD-Score:-3.31|P-value:5.83E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:4.02|P-value:3.90E-5 ID:SGTC_2774|Compound:tamoxifen|FD-Score:3.91|P-value:6.10E-5 ID:SGTC_2816|Compound:7982706|FD-Score:4.05|P-value:3.51E-5 ID:SGTC_2844|Compound:9010103|FD-Score:4.19|P-value:1.97E-5 ID:SGTC_2934|Compound:9036370|FD-Score:5.03|P-value:3.97E-7 ID:SGTC_2982|Compound:9019404|FD-Score:-3.16|P-value:9.43E-4 ID:SGTC_3087|Compound:9117406|FD-Score:-3.15|P-value:9.70E-4 ID:SGTC_3100|Compound:9120536|FD-Score:3.22|P-value:7.78E-4 ID:SGTC_3132|Compound:9126706|FD-Score:4.36|P-value:9.29E-6 ID:SGTC_3345|Compound:9148410|FD-Score:3.21|P-value:8.07E-4

Top fitness defect scores for YBL097W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2528 xanthyletin 8.51 44.8 µM 3.20E-17 1 8.81E-18 1.99
2 SGTC_2511 berberine 7.37 10.5 µM 2.26E-13 60S ribosome export 3 8.53E-14 1.06
3 SGTC_2533 agelasine 6.45 13.7 µM 1.18E-10 ERG2 5 5.57E-11 1.08
4 SGTC_1042 0350-0096 5.74 82.0 µM 8.83E-9 TSC3-RPN4 2 4.86E-9 0.85
5 SGTC_1003 4049-0218 5.58 100.0 µM 2.16E-8 2 1.23E-8 0.51
6 SGTC_2246 7293507 5.31 91.6 µM 8.97E-8 4 5.37E-8 0.02
7 SGTC_2406 ethylparaben 5.20 405.7 µM 1.64E-7 2 1.00E-7 0.49
8 SGTC_1085 doxorubicin 5.18 7.7 µM 1.77E-7 anthracycline transcription coupled DNA repair 3 1.08E-7 0.86
9 SGTC_2490 carminic acid 5.04 95.4 µM 3.65E-7 2 2.29E-7 0.07
10 SGTC_2934 9036370 5.03 36.9 µM 3.97E-7 1 2.50E-7 0.46
11 SGTC_2529 gangaleoidin 4.83 93.6 µM 1.07E-6 1 6.95E-7 0.96
12 SGTC_1005 4092-0690 4.74 4.4 µM 1.65E-6 plasma membrane duress 4 1.09E-6 0.28
13 SGTC_688 0527-0193 4.71 473.0 µM 1.83E-6 fatty acid desaturase (OLE1) 1 1.21E-6 0.56
14 SGTC_999 4022-0066 4.59 22.7 µM 3.33E-6 Golgi 7 2.26E-6 0.09
15 SGTC_663 1486-0733 4.56 13.9 µM 3.75E-6 cell wall signaling 5 2.56E-6 0.11
16 SGTC_2495 cafestol 4.46 54.5 µM 6.01E-6 Golgi 6 4.17E-6 0.02
17 SGTC_3132 9126706 4.36 49.5 µM 9.29E-6 7 6.53E-6 0.23
18 SGTC_2844 9010103 4.19 26.0 µM 1.97E-5 7 1.42E-5 0.05
19 SGTC_2816 7982706 4.05 58.4 µM 3.51E-5 azole & statin 10 2.59E-5 0.03
20 SGTC_2752 diclazuril 4.02 33.1 µM 3.90E-5 6 2.88E-5 0.02

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.116 1.91E-11 YJR067C YAE1 het Protein that forms a complex with Lto1p and Rli1p; essential for growth under standard (aerobic) conditions but not under anaerobic conditions; may have a role in protection of ribosomal assembly and function from damage due to reactive oxygen species
0.107 5.47E-10 YJL105W SET4 hom Protein of unknown function, contains a SET domain; SET4 has a paralog, SET3, that arose from the whole genome duplication
0.106 6.45E-10 YGL131C SNT2 hom DNA binding protein with similarity to the S. pombe Snt2 protein; RING finger ubiquitin ligase (E3) involved in ubiquitylation and degradation of excess histones; interacts with Ubc4p; null mutant sensitive to hydroxyurea (HU); computational analysis suggests that Snt2p is a transcription factor with a role in regulation of expression of genes encoding amine transporters; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.099 1.00E-8 YIR027C DAL1 hom Allantoinase, converts allantoin to allantoate in the first step of allantoin degradation; expression sensitive to nitrogen catabolite repression
0.098 1.34E-8 YPL133C RDS2 hom Transcription factor involved in regulating gluconeogenesis and glyoxylate cycle genes; member of the zinc cluster family of proteins; confers resistance to ketoconazole
0.098 1.48E-8 YBR090C_p YBR090C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
0.097 1.93E-8 YKR058W GLG1 hom Glycogenin glucosyltransferase; self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; similar to mammalian glycogenin; GLG1 has a paralog, GLG2, that arose from the whole genome duplication
0.096 2.19E-8 YOR228C YOR228C hom Protein of unknown function, localized to the mitochondrial outer membrane
0.089 2.82E-7 YPL107W_p YPL107W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YPL107W is not an essential gene
0.085 7.55E-7 YGL037C PNC1 hom Nicotinamidase that converts nicotinamide to nicotinic acid; part of the NAD(+) salvage pathway; required for life span extension by calorie restriction; PNC1 expression responds to all known stimuli that extend replicative life span; protein increases in abundance and relative distribution to cytoplasmic foci decreases upon DNA replication stress
0.085 7.92E-7 YPR031W NTO1 hom Subunit of the NuA3 histone acetyltransferase complex that acetylates histone H3; contains PHD finger domain that interacts with methylated histone H3
0.083 1.46E-6 YDR170C SEC7 het Guanine nucleotide exchange factor (GEF) for ADP ribosylation factors involved in proliferation of the Golgi, intra-Golgi transport and ER-to-Golgi transport; found in the cytoplasm and on Golgi-associated coated vesicles
0.081 2.46E-6 YFL049W SWP82 hom Member of the SWI/SNF chromatin remodeling complex; has an as yet unidentified role in the complex; has identifiable counterparts in closely related yeast species; abundantly expressed in many growth conditions; paralog of Npl6p; relocates to the cytosol under hypoxic conditions
0.079 4.27E-6 YER028C MIG3 hom Transcriptional regulator; partially nonfunctional in S288C strains but has a major role in catabolite repression and ethanol response in some other strains; involved in response to toxic agents; phosphorylation by Snf1p or the Mec1p pathway inactivates Mig3p, allowing induction of damage response genes; MIG3 has a paralog, MIG2, that arose from the whole genome duplication
0.079 5.06E-6 YJR019C TES1 hom Peroxisomal acyl-CoA thioesterase likely to be involved in fatty acid oxidation rather than fatty acid synthesis; conserved protein also found in human peroxisomes; TES1 mRNA levels increase during growth on fatty acids