YBL098W / BNA4

Kynurenine 3-mono oxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p; putative therapeutic target for Huntington disease

Zygosity: Homozygous strain
fixedexpanded
Profile for YBL098W / BNA4

Click on Significant Values for Screen Details ID:SGTC_261|Compound:5-fluorouridine|FD-Score:-3.73|P-value:7.06E-5 ID:SGTC_421|Compound:streptovitacin|FD-Score:4.19|P-value:8.20E-6 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:5.04|P-value:1.11E-7 ID:SGTC_572|Compound:0960-0087|FD-Score:3.50|P-value:1.56E-4 ID:SGTC_578|Compound:3460-0051|FD-Score:3.03|P-value:8.80E-4 ID:SGTC_655|Compound:k060-0012|FD-Score:3.19|P-value:5.09E-4 ID:SGTC_702|Compound:1488-0190|FD-Score:3.16|P-value:5.68E-4 ID:SGTC_740|Compound:k014-0057|FD-Score:4.65|P-value:8.76E-7 ID:SGTC_866|Compound:0495-0101|FD-Score:5.07|P-value:9.27E-8 ID:SGTC_945|Compound:3381-0768|FD-Score:3.22|P-value:4.46E-4 ID:SGTC_1021|Compound:4476-0760|FD-Score:3.24|P-value:4.14E-4 ID:SGTC_1027|Compound:k015-0025|FD-Score:4.15|P-value:9.81E-6 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:3.53|P-value:1.37E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:3.55|P-value:1.27E-4 ID:SGTC_1207|Compound:2099-0101|FD-Score:3.38|P-value:2.48E-4 ID:SGTC_1231|Compound:0242-0792|FD-Score:4.35|P-value:3.81E-6 ID:SGTC_1268|Compound:0828-0275|FD-Score:3.72|P-value:6.35E-5 ID:SGTC_1468|Compound:k284-1086|FD-Score:3.15|P-value:5.78E-4 ID:SGTC_1482|Compound:3346-2049|FD-Score:3.05|P-value:8.17E-4 ID:SGTC_1500|Compound:4488-1866|FD-Score:3.35|P-value:2.78E-4 ID:SGTC_1571|Compound:st070080|FD-Score:3.29|P-value:3.42E-4 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:3.64|P-value:8.88E-5 ID:SGTC_1618|Compound:st003135|FD-Score:3.18|P-value:5.28E-4 ID:SGTC_1676|Compound:st018489|FD-Score:3.87|P-value:3.40E-5 ID:SGTC_1733|Compound:st037357|FD-Score:3.86|P-value:3.58E-5 ID:SGTC_1757|Compound:st041620|FD-Score:4.00|P-value:1.90E-5 ID:SGTC_1775|Compound:st081588|FD-Score:-3.25|P-value:4.70E-4 ID:SGTC_1786|Compound:berberine|FD-Score:3.14|P-value:6.06E-4 ID:SGTC_1798|Compound:st045719|FD-Score:5.35|P-value:1.87E-8 ID:SGTC_1921|Compound:5740136|FD-Score:-3.76|P-value:6.27E-5 ID:SGTC_1922|Compound:5578187|FD-Score:4.71|P-value:6.14E-7 ID:SGTC_1949|Compound:st076024|FD-Score:3.91|P-value:2.86E-5 ID:SGTC_1987|Compound:st072290|FD-Score:-3.06|P-value:9.13E-4 ID:SGTC_1995|Compound:st072814|FD-Score:4.57|P-value:1.31E-6 ID:SGTC_2068|Compound:5226020|FD-Score:5.02|P-value:1.18E-7 ID:SGTC_2255|Compound:7941087|FD-Score:4.50|P-value:1.82E-6 ID:SGTC_2320|Compound:7373003|FD-Score:3.53|P-value:1.37E-4 ID:SGTC_2352|Compound:9027995|FD-Score:3.27|P-value:3.77E-4 ID:SGTC_2378|Compound:9074213|FD-Score:3.43|P-value:2.02E-4 ID:SGTC_2452|Compound:5863136|FD-Score:5.46|P-value:9.64E-9 ID:SGTC_2460|Compound:5552655|FD-Score:3.10|P-value:6.91E-4 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:3.56|P-value:1.23E-4 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:3.89|P-value:3.03E-5 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:4.05|P-value:1.50E-5 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:3.54|P-value:1.35E-4 ID:SGTC_2723|Compound:salbutamol|FD-Score:3.66|P-value:8.11E-5 ID:SGTC_2766|Compound:oltipraz|FD-Score:3.98|P-value:2.11E-5 ID:SGTC_2790|Compound:5423970|FD-Score:3.86|P-value:3.45E-5 ID:SGTC_2827|Compound:7993847|FD-Score:3.32|P-value:3.10E-4 ID:SGTC_2835|Compound:9006588|FD-Score:8.27|P-value:1.01E-17 ID:SGTC_2837|Compound:9008476|FD-Score:3.48|P-value:1.69E-4 ID:SGTC_2873|Compound:9040596|FD-Score:3.07|P-value:7.65E-4 ID:SGTC_2961|Compound:9083290|FD-Score:3.40|P-value:2.29E-4 ID:SGTC_3049|Compound:9092223|FD-Score:4.14|P-value:1.01E-5 ID:SGTC_3106|Compound:9121286|FD-Score:3.70|P-value:7.01E-5 ID:SGTC_3129|Compound:9127257|FD-Score:10.50|P-value:3.51E-27 ID:SGTC_3130|Compound:9127414|FD-Score:6.30|P-value:4.64E-11 ID:SGTC_3177|Compound:9107506|FD-Score:-4.06|P-value:1.72E-5 ID:SGTC_3203|Compound:9113543|FD-Score:6.35|P-value:3.31E-11 ID:SGTC_3204|Compound:9114183|FD-Score:4.01|P-value:1.83E-5 ID:SGTC_3287|Compound:9117173|FD-Score:3.55|P-value:1.27E-4 ID:SGTC_3328|Compound:9140624|FD-Score:4.13|P-value:1.06E-5 ID:SGTC_3334|Compound:9142812|FD-Score:6.34|P-value:3.67E-11 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:-3.73|P-value:7.06E-5 ID:SGTC_421|Compound:streptovitacin|FD-Score:4.19|P-value:8.20E-6 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:5.04|P-value:1.11E-7 ID:SGTC_572|Compound:0960-0087|FD-Score:3.50|P-value:1.56E-4 ID:SGTC_578|Compound:3460-0051|FD-Score:3.03|P-value:8.80E-4 ID:SGTC_655|Compound:k060-0012|FD-Score:3.19|P-value:5.09E-4 ID:SGTC_702|Compound:1488-0190|FD-Score:3.16|P-value:5.68E-4 ID:SGTC_740|Compound:k014-0057|FD-Score:4.65|P-value:8.76E-7 ID:SGTC_866|Compound:0495-0101|FD-Score:5.07|P-value:9.27E-8 ID:SGTC_945|Compound:3381-0768|FD-Score:3.22|P-value:4.46E-4 ID:SGTC_1021|Compound:4476-0760|FD-Score:3.24|P-value:4.14E-4 ID:SGTC_1027|Compound:k015-0025|FD-Score:4.15|P-value:9.81E-6 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:3.53|P-value:1.37E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:3.55|P-value:1.27E-4 ID:SGTC_1207|Compound:2099-0101|FD-Score:3.38|P-value:2.48E-4 ID:SGTC_1231|Compound:0242-0792|FD-Score:4.35|P-value:3.81E-6 ID:SGTC_1268|Compound:0828-0275|FD-Score:3.72|P-value:6.35E-5 ID:SGTC_1468|Compound:k284-1086|FD-Score:3.15|P-value:5.78E-4 ID:SGTC_1482|Compound:3346-2049|FD-Score:3.05|P-value:8.17E-4 ID:SGTC_1500|Compound:4488-1866|FD-Score:3.35|P-value:2.78E-4 ID:SGTC_1571|Compound:st070080|FD-Score:3.29|P-value:3.42E-4 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:3.64|P-value:8.88E-5 ID:SGTC_1618|Compound:st003135|FD-Score:3.18|P-value:5.28E-4 ID:SGTC_1676|Compound:st018489|FD-Score:3.87|P-value:3.40E-5 ID:SGTC_1733|Compound:st037357|FD-Score:3.86|P-value:3.58E-5 ID:SGTC_1757|Compound:st041620|FD-Score:4.00|P-value:1.90E-5 ID:SGTC_1775|Compound:st081588|FD-Score:-3.25|P-value:4.70E-4 ID:SGTC_1786|Compound:berberine|FD-Score:3.14|P-value:6.06E-4 ID:SGTC_1798|Compound:st045719|FD-Score:5.35|P-value:1.87E-8 ID:SGTC_1921|Compound:5740136|FD-Score:-3.76|P-value:6.27E-5 ID:SGTC_1922|Compound:5578187|FD-Score:4.71|P-value:6.14E-7 ID:SGTC_1949|Compound:st076024|FD-Score:3.91|P-value:2.86E-5 ID:SGTC_1987|Compound:st072290|FD-Score:-3.06|P-value:9.13E-4 ID:SGTC_1995|Compound:st072814|FD-Score:4.57|P-value:1.31E-6 ID:SGTC_2068|Compound:5226020|FD-Score:5.02|P-value:1.18E-7 ID:SGTC_2255|Compound:7941087|FD-Score:4.50|P-value:1.82E-6 ID:SGTC_2320|Compound:7373003|FD-Score:3.53|P-value:1.37E-4 ID:SGTC_2352|Compound:9027995|FD-Score:3.27|P-value:3.77E-4 ID:SGTC_2378|Compound:9074213|FD-Score:3.43|P-value:2.02E-4 ID:SGTC_2452|Compound:5863136|FD-Score:5.46|P-value:9.64E-9 ID:SGTC_2460|Compound:5552655|FD-Score:3.10|P-value:6.91E-4 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:3.56|P-value:1.23E-4 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:3.89|P-value:3.03E-5 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:4.05|P-value:1.50E-5 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:3.54|P-value:1.35E-4 ID:SGTC_2723|Compound:salbutamol|FD-Score:3.66|P-value:8.11E-5 ID:SGTC_2766|Compound:oltipraz|FD-Score:3.98|P-value:2.11E-5 ID:SGTC_2790|Compound:5423970|FD-Score:3.86|P-value:3.45E-5 ID:SGTC_2827|Compound:7993847|FD-Score:3.32|P-value:3.10E-4 ID:SGTC_2835|Compound:9006588|FD-Score:8.27|P-value:1.01E-17 ID:SGTC_2837|Compound:9008476|FD-Score:3.48|P-value:1.69E-4 ID:SGTC_2873|Compound:9040596|FD-Score:3.07|P-value:7.65E-4 ID:SGTC_2961|Compound:9083290|FD-Score:3.40|P-value:2.29E-4 ID:SGTC_3049|Compound:9092223|FD-Score:4.14|P-value:1.01E-5 ID:SGTC_3106|Compound:9121286|FD-Score:3.70|P-value:7.01E-5 ID:SGTC_3129|Compound:9127257|FD-Score:10.50|P-value:3.51E-27 ID:SGTC_3130|Compound:9127414|FD-Score:6.30|P-value:4.64E-11 ID:SGTC_3177|Compound:9107506|FD-Score:-4.06|P-value:1.72E-5 ID:SGTC_3203|Compound:9113543|FD-Score:6.35|P-value:3.31E-11 ID:SGTC_3204|Compound:9114183|FD-Score:4.01|P-value:1.83E-5 ID:SGTC_3287|Compound:9117173|FD-Score:3.55|P-value:1.27E-4 ID:SGTC_3328|Compound:9140624|FD-Score:4.13|P-value:1.06E-5 ID:SGTC_3334|Compound:9142812|FD-Score:6.34|P-value:3.67E-11

Top fitness defect scores for YBL098W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3129 9127257 10.50 49.5 µM 3.51E-27 1 6.97E-26
2 SGTC_2835 9006588 8.27 71.4 µM 1.01E-17 2 6.82E-17
3 SGTC_3203 9113543 6.35 49.5 µM 3.31E-11 2 1.07E-10
4 SGTC_3334 9142812 6.34 21.9 µM 3.67E-11 3 1.18E-10
5 SGTC_3130 9127414 6.30 49.5 µM 4.64E-11 5 1.47E-10
6 SGTC_2452 5863136 5.46 48.4 µM 9.64E-9 7 2.34E-8
7 SGTC_1798 st045719 5.35 61.0 µM 1.87E-8 2 4.38E-8
8 SGTC_866 0495-0101 5.07 262.0 µM 9.27E-8 60S ribosome export 5 2.01E-7
9 SGTC_423 5-fluorouracil 5.04 457.0 µM 1.11E-7 exosome 7 2.38E-7
10 SGTC_2068 5226020 5.02 147.0 µM 1.18E-7 11 2.54E-7
11 SGTC_1922 5578187 4.71 25.0 µM 6.14E-7 TRP & mitochondrial translation 15 1.21E-6
12 SGTC_740 k014-0057 4.65 261.0 µM 8.76E-7 11 1.70E-6
13 SGTC_1995 st072814 4.57 61.1 µM 1.31E-6 6 2.48E-6
14 SGTC_2255 7941087 4.50 197.4 µM 1.82E-6 20 3.40E-6
15 SGTC_1231 0242-0792 4.35 125.0 µM 3.81E-6 14 6.86E-6
16 SGTC_421 streptovitacin 4.19 30.0 mM 8.20E-6 16 1.42E-5
17 SGTC_1027 k015-0025 4.15 8.7 µM 9.81E-6 23 1.69E-5
18 SGTC_3049 9092223 4.14 49.5 µM 1.01E-5 17 1.74E-5
19 SGTC_3328 9140624 4.13 29.0 µM 1.06E-5 16 1.81E-5
20 SGTC_2536 dehydroabietamide 4.05 32.0 µM 1.50E-5 32 2.53E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.103 2.29E-9 YJL182C_d YJL182C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized ORF YJL181W
0.099 9.50E-9 YDR185C UPS3 hom Mitochondrial protein of unknown function; similar to Ups1p and Ups2p which are involved in regulation of mitochondrial cardiolipin and phosphatidylethanolamine levels; null is viable but interacts synthetically with ups1 and ups2 mutations
0.095 3.52E-8 YPL087W YDC1 hom Alkaline dihydroceramidase, involved in sphingolipid metabolism; preferentially hydrolyzes dihydroceramide to a free fatty acid and dihydrosphingosine; has a minor reverse activity; YDC1 has a paralog, YPC1, that arose from the whole genome duplication
0.093 6.24E-8 YPL250C ICY2 hom Protein of unknown function; mobilized into polysomes upon a shift from a fermentable to nonfermentable carbon source; potential Cdc28p substrate
0.091 1.32E-7 YLR041W_d YLR041W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YLR040C
0.087 4.01E-7 YPL251W_d YPL251W_d het Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified, essential gene YAH1/YPL252C
0.087 4.26E-7 YAL008W FUN14 hom Mitochondrial protein of unknown function
0.084 1.10E-6 YMR172W HOT1 hom Transcription factor required for the transient induction of glycerol biosynthetic genes GPD1 and GPP2 in response to high osmolarity; targets Hog1p to osmostress responsive promoters; has similarity to Msn1p and Gcr1p
0.081 2.41E-6 YHR095W_d YHR095W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.077 7.25E-6 YOR057W SGT1 het Cochaperone protein; regulates activity of adenylyl cyclase Cyr1p; involved in kinetochore complex assembly; associates with the SCF (Skp1p/Cdc53p/F box protein) ubiquitin ligase complex; acts as a linker between Skp1p and HSP90 complexes; protein abundance increases in response to DNA replication stress
0.077 8.79E-6 YOR332W VMA4 hom Subunit E of the V1 domain of the vacuolar H+-ATPase (V-ATPase); V-ATPase is an electrogenic proton pump found throughout the endomembrane system; V1 domain has eight subunits; required for the V1 domain to assemble onto the vacuolar membrane; protein abundance increases in response to DNA replication stress
0.074 1.82E-5 YPL252C YAH1 het Ferredoxin of the mitochondrial matrix required for formation of cellular iron-sulfur proteins; involved in heme A biosynthesis; homologous to human adrenodoxin
0.074 2.02E-5 YPL021W ECM23 hom Non-essential protein of unconfirmed function; affects pre-rRNA processing, may act as a negative regulator of the transcription of genes involved in pseudohyphal growth; homologous to Srd1p
0.073 2.55E-5 YEL008W_d YEL008W_d hom Hypothetical protein predicted to be involved in metabolism
0.072 3.13E-5 YJL215C_d YJL215C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data