YBL100W-C_p

Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching

Zygosity: Homozygous strain
fixedexpanded
Profile for YBL100W-C / YBL100W-C

Click on Significant Values for Screen Details ID:SGTC_68|Compound:0986-0284|FD-Score:3.07|P-value:9.12E-4 ID:SGTC_71|Compound:0417-1750|FD-Score:3.08|P-value:8.77E-4 ID:SGTC_100|Compound:0086-0128|FD-Score:3.36|P-value:3.24E-4 ID:SGTC_113|Compound:0099-0221|FD-Score:4.30|P-value:6.22E-6 ID:SGTC_115|Compound:0527-0192|FD-Score:4.73|P-value:7.75E-7 ID:SGTC_121|Compound:0557-0495|FD-Score:3.42|P-value:2.57E-4 ID:SGTC_126|Compound:0417-1624|FD-Score:4.36|P-value:4.77E-6 ID:SGTC_127|Compound:0180-0333|FD-Score:-3.69|P-value:8.55E-5 ID:SGTC_142|Compound:0335-0849|FD-Score:-3.22|P-value:5.30E-4 ID:SGTC_301|Compound:4119-0100|FD-Score:4.19|P-value:1.03E-5 ID:SGTC_306|Compound:1672-3436|FD-Score:3.12|P-value:7.59E-4 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:-3.74|P-value:6.99E-5 ID:SGTC_445|Compound:e6 berbamine|FD-Score:-3.04|P-value:9.77E-4 ID:SGTC_616|Compound:4092-0450|FD-Score:3.08|P-value:8.82E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:-3.49|P-value:1.91E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:-3.82|P-value:4.98E-5 ID:SGTC_913|Compound:3487-1245|FD-Score:-5.58|P-value:6.65E-9 ID:SGTC_914|Compound:3820-6779|FD-Score:-7.77|P-value:1.30E-15 ID:SGTC_944|Compound:3370-0224|FD-Score:4.62|P-value:1.31E-6 ID:SGTC_950|Compound:1165-0508|FD-Score:3.72|P-value:7.91E-5 ID:SGTC_1008|Compound:4106-0037|FD-Score:3.10|P-value:8.06E-4 ID:SGTC_1013|Compound:4112-3890|FD-Score:3.39|P-value:2.82E-4 ID:SGTC_1014|Compound:4130-3005|FD-Score:5.49|P-value:1.19E-8 ID:SGTC_1015|Compound:4130-4525|FD-Score:6.06|P-value:3.70E-10 ID:SGTC_1328|Compound:1441-0025|FD-Score:3.35|P-value:3.30E-4 ID:SGTC_1340|Compound:1486-1359|FD-Score:-4.04|P-value:1.94E-5 ID:SGTC_1651|Compound:st011928|FD-Score:3.59|P-value:1.31E-4 ID:SGTC_1711|Compound:st032263|FD-Score:3.27|P-value:4.43E-4 ID:SGTC_1713|Compound:st033146|FD-Score:3.09|P-value:8.33E-4 ID:SGTC_1716|Compound:st033144|FD-Score:3.48|P-value:2.05E-4 ID:SGTC_1745|Compound:st081495|FD-Score:3.50|P-value:1.88E-4 ID:SGTC_1770|Compound:st043884|FD-Score:-3.39|P-value:2.78E-4 ID:SGTC_1807|Compound:st050092|FD-Score:3.18|P-value:6.13E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:4.06|P-value:1.88E-5 ID:SGTC_1947|Compound:st076332|FD-Score:3.67|P-value:9.75E-5 ID:SGTC_2018|Compound:5133068|FD-Score:4.65|P-value:1.16E-6 ID:SGTC_2088|Compound:5278280|FD-Score:3.07|P-value:9.04E-4 ID:SGTC_2090|Compound:5301565|FD-Score:4.24|P-value:8.03E-6 ID:SGTC_2102|Compound:5377816|FD-Score:-4.17|P-value:1.09E-5 ID:SGTC_2180|Compound:6301957|FD-Score:3.29|P-value:4.20E-4 ID:SGTC_2185|Compound:6113692|FD-Score:3.95|P-value:2.97E-5 ID:SGTC_2504|Compound:purpurogallin|FD-Score:-3.19|P-value:5.79E-4 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:4.23|P-value:8.42E-6 ID:SGTC_2793|Compound:7325131|FD-Score:4.59|P-value:1.55E-6 ID:SGTC_2897|Compound:9048598|FD-Score:3.23|P-value:5.12E-4 ID:SGTC_2917|Compound:7979103|FD-Score:3.17|P-value:6.45E-4 ID:SGTC_2955|Compound:9076254|FD-Score:-3.22|P-value:5.25E-4 ID:SGTC_2956|Compound:9076196|FD-Score:3.26|P-value:4.56E-4 ID:SGTC_3143|Compound:9086658|FD-Score:3.24|P-value:4.89E-4 ID:SGTC_3216|Compound:9129716|FD-Score:-3.88|P-value:3.88E-5 ID:SGTC_3217|Compound:9129673|FD-Score:-3.46|P-value:2.15E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:3.07|P-value:9.12E-4 ID:SGTC_71|Compound:0417-1750|FD-Score:3.08|P-value:8.77E-4 ID:SGTC_100|Compound:0086-0128|FD-Score:3.36|P-value:3.24E-4 ID:SGTC_113|Compound:0099-0221|FD-Score:4.30|P-value:6.22E-6 ID:SGTC_115|Compound:0527-0192|FD-Score:4.73|P-value:7.75E-7 ID:SGTC_121|Compound:0557-0495|FD-Score:3.42|P-value:2.57E-4 ID:SGTC_126|Compound:0417-1624|FD-Score:4.36|P-value:4.77E-6 ID:SGTC_127|Compound:0180-0333|FD-Score:-3.69|P-value:8.55E-5 ID:SGTC_142|Compound:0335-0849|FD-Score:-3.22|P-value:5.30E-4 ID:SGTC_301|Compound:4119-0100|FD-Score:4.19|P-value:1.03E-5 ID:SGTC_306|Compound:1672-3436|FD-Score:3.12|P-value:7.59E-4 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:-3.74|P-value:6.99E-5 ID:SGTC_445|Compound:e6 berbamine|FD-Score:-3.04|P-value:9.77E-4 ID:SGTC_616|Compound:4092-0450|FD-Score:3.08|P-value:8.82E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:-3.49|P-value:1.91E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:-3.82|P-value:4.98E-5 ID:SGTC_913|Compound:3487-1245|FD-Score:-5.58|P-value:6.65E-9 ID:SGTC_914|Compound:3820-6779|FD-Score:-7.77|P-value:1.30E-15 ID:SGTC_944|Compound:3370-0224|FD-Score:4.62|P-value:1.31E-6 ID:SGTC_950|Compound:1165-0508|FD-Score:3.72|P-value:7.91E-5 ID:SGTC_1008|Compound:4106-0037|FD-Score:3.10|P-value:8.06E-4 ID:SGTC_1013|Compound:4112-3890|FD-Score:3.39|P-value:2.82E-4 ID:SGTC_1014|Compound:4130-3005|FD-Score:5.49|P-value:1.19E-8 ID:SGTC_1015|Compound:4130-4525|FD-Score:6.06|P-value:3.70E-10 ID:SGTC_1328|Compound:1441-0025|FD-Score:3.35|P-value:3.30E-4 ID:SGTC_1340|Compound:1486-1359|FD-Score:-4.04|P-value:1.94E-5 ID:SGTC_1651|Compound:st011928|FD-Score:3.59|P-value:1.31E-4 ID:SGTC_1711|Compound:st032263|FD-Score:3.27|P-value:4.43E-4 ID:SGTC_1713|Compound:st033146|FD-Score:3.09|P-value:8.33E-4 ID:SGTC_1716|Compound:st033144|FD-Score:3.48|P-value:2.05E-4 ID:SGTC_1745|Compound:st081495|FD-Score:3.50|P-value:1.88E-4 ID:SGTC_1770|Compound:st043884|FD-Score:-3.39|P-value:2.78E-4 ID:SGTC_1807|Compound:st050092|FD-Score:3.18|P-value:6.13E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:4.06|P-value:1.88E-5 ID:SGTC_1947|Compound:st076332|FD-Score:3.67|P-value:9.75E-5 ID:SGTC_2018|Compound:5133068|FD-Score:4.65|P-value:1.16E-6 ID:SGTC_2088|Compound:5278280|FD-Score:3.07|P-value:9.04E-4 ID:SGTC_2090|Compound:5301565|FD-Score:4.24|P-value:8.03E-6 ID:SGTC_2102|Compound:5377816|FD-Score:-4.17|P-value:1.09E-5 ID:SGTC_2180|Compound:6301957|FD-Score:3.29|P-value:4.20E-4 ID:SGTC_2185|Compound:6113692|FD-Score:3.95|P-value:2.97E-5 ID:SGTC_2504|Compound:purpurogallin|FD-Score:-3.19|P-value:5.79E-4 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:4.23|P-value:8.42E-6 ID:SGTC_2793|Compound:7325131|FD-Score:4.59|P-value:1.55E-6 ID:SGTC_2897|Compound:9048598|FD-Score:3.23|P-value:5.12E-4 ID:SGTC_2917|Compound:7979103|FD-Score:3.17|P-value:6.45E-4 ID:SGTC_2955|Compound:9076254|FD-Score:-3.22|P-value:5.25E-4 ID:SGTC_2956|Compound:9076196|FD-Score:3.26|P-value:4.56E-4 ID:SGTC_3143|Compound:9086658|FD-Score:3.24|P-value:4.89E-4 ID:SGTC_3216|Compound:9129716|FD-Score:-3.88|P-value:3.88E-5 ID:SGTC_3217|Compound:9129673|FD-Score:-3.46|P-value:2.15E-4

Top fitness defect scores for YBL100W-C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1015 4130-4525 6.06 82.0 µM 3.70E-10 60S ribosome export 3 6.95E-10
2 SGTC_1014 4130-3005 5.49 69.3 µM 1.19E-8 3 2.00E-8
3 SGTC_115 0527-0192 4.73 112.0 µM 7.75E-7 40 1.14E-6
4 SGTC_2018 5133068 4.65 143.0 µM 1.16E-6 9 1.68E-6
5 SGTC_944 3370-0224 4.62 231.0 µM 1.31E-6 13 1.90E-6
6 SGTC_2793 7325131 4.59 81.8 µM 1.55E-6 9 2.23E-6
7 SGTC_126 0417-1624 4.36 672.5 µM 4.77E-6 DNA intercalators 20 6.64E-6
8 SGTC_113 0099-0221 4.30 2.5 µM 6.22E-6 16 8.57E-6
9 SGTC_2090 5301565 4.24 104.5 µM 8.03E-6 TSC3-RPN4 37 1.10E-5
10 SGTC_2604 4'-hydroxychalcone 4.23 11.3 µM 8.42E-6 30 1.15E-5
11 SGTC_301 4119-0100 4.19 24.5 µM 1.03E-5 NEO1 75 1.40E-5
12 SGTC_1926 methyl fluorone black 4.06 53.6 µM 1.88E-5 DNA intercalators 57 2.50E-5
13 SGTC_2185 6113692 3.95 200.0 µM 2.97E-5 ergosterol biosynthesis 17 3.91E-5
14 SGTC_950 1165-0508 3.72 94.1 µM 7.91E-5 37 1.01E-4
15 SGTC_1947 st076332 3.67 61.6 µM 9.75E-5 19 1.23E-4
16 SGTC_1651 st011928 3.59 86.1 µM 1.31E-4 RSC complex & mRNA processing 19 1.64E-4
17 SGTC_1745 st081495 3.50 74.0 µM 1.88E-4 RNA processing & uracil transport 94 2.33E-4
18 SGTC_1716 st033144 3.48 30.6 µM 2.05E-4 35 2.54E-4
19 SGTC_121 0557-0495 3.42 61.3 µM 2.57E-4 calcium & mitochondrial duress 88 3.15E-4
20 SGTC_1013 4112-3890 3.39 241.0 µM 2.82E-4 TSC3-RPN4 57 3.45E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.172 1.09E-23 YEL064C AVT2 hom Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
0.144 6.02E-17 YGR070W ROM1 hom GDP/GTP exchange protein (GEP) for Rho1p; mutations are synthetically lethal with mutations in rom2, which also encodes a GEP
0.119 5.75E-12 YGR069W_d YGR069W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.117 1.36E-11 YGL002W ERP6 hom Member of the p24 family involved in ER to Golgi transport; similar to Emp24p and Erv25p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; ERP6 has a paralog, ERP1, that arose from the whole genome duplication
0.106 6.51E-10 YER099C PRS2 hom 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; PRS2 has a paralog, PRS4, that arose from the whole genome duplication
0.103 2.22E-9 YLR120C YPS1 hom Aspartic protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor
0.103 2.42E-9 YLL001W DNM1 hom Dynamin-related GTPase required for mitochondrial fission and morphology; assembles on the cytoplasmic face of mitochondrial tubules at sites at which division will occur; also participates in endocytosis and regulating peroxisome abundance
0.102 3.48E-9 YDR382W RPP2B hom Ribosomal protein P2 beta, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm
0.099 9.51E-9 YDL060W TSR1 het Protein required for processing of 20S pre-rRNA in the cytoplasm; associates with pre-40S ribosomal particles; inhibits the premature association of 60S subunits with assembling 40S subunits in the cytoplasm; similar to Bms1p; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.098 1.19E-8 YGL075C MPS2 het Essential membrane protein localized at the nuclear envelope and spindle pole body (SPB), required for insertion of the newly duplicated SPB into the nuclear envelope; potentially phosphorylated by Cdc28p
0.097 1.67E-8 YDR286C_p YDR286C_p hom Putative protein of unknown function; predicted to have thiol-disulfide oxidoreductase active site
0.096 3.04E-8 YJR065C ARP3 het Essential component of the Arp2/3 complex, which is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity
0.093 7.45E-8 YOR294W RRS1 het Essential protein that binds ribosomal protein L11; required for nuclear export of the 60S pre-ribosomal subunit during ribosome biogenesis; localizes to the nucleolus and in foci along nuclear periphery; cooperates with Ebp2p and Mps3p to mediate telomere clustering by binding Sir4p, but is not involved in telomere tethering; mouse homolog shows altered expression in Huntington's disease model mice
0.091 1.26E-7 YEL017C-A PMP2 hom Proteolipid associated with plasma membrane H(+)-ATPase (Pma1p); regulates plasma membrane H(+)-ATPase activity; protein abundance increases in response to DNA replication stress; PMP2 has a paralog, PMP1, that arose from the whole genome duplication
0.091 1.44E-7 YBR056W YBR056W hom Putative glycoside hydrolase of the mitochondrial intermembrane space