YBL102W / SFT2

Non-essential tetra-spanning membrane protein found mostly in the late Golgi, can suppress some sed5 alleles; may be part of the transport machinery, but precise function is unknown; similar to mammalian syntaxin 5

Zygosity: Homozygous strain
fixedexpanded
Profile for YBL102W / SFT2

Click on Significant Values for Screen Details ID:SGTC_146|Compound:3448-8650|FD-Score:-3.42|P-value:5.04E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:3.95|P-value:9.28E-5 ID:SGTC_208|Compound:k072-0098|FD-Score:3.47|P-value:5.11E-4 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:3.38|P-value:6.96E-4 ID:SGTC_260|Compound:nsc-65238|FD-Score:-3.79|P-value:1.36E-4 ID:SGTC_263|Compound:alizarin|FD-Score:3.39|P-value:6.81E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-6.67|P-value:8.23E-11 ID:SGTC_619|Compound:1652-1634|FD-Score:-3.41|P-value:5.19E-4 ID:SGTC_785|Compound:1270-0111|FD-Score:4.29|P-value:2.42E-5 ID:SGTC_878|Compound:0828-0289|FD-Score:3.29|P-value:9.30E-4 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:4.58|P-value:7.08E-6 ID:SGTC_1078|Compound:idebenone|FD-Score:5.43|P-value:1.28E-7 ID:SGTC_1089|Compound:terbinafine|FD-Score:4.11|P-value:4.93E-5 ID:SGTC_1164|Compound:k060-0068|FD-Score:6.46|P-value:4.36E-10 ID:SGTC_1212|Compound:0520-0165|FD-Score:3.92|P-value:1.04E-4 ID:SGTC_1257|Compound:0669-0121|FD-Score:3.95|P-value:9.31E-5 ID:SGTC_1264|Compound:0783-0040|FD-Score:-3.95|P-value:7.54E-5 ID:SGTC_1266|Compound:0828-0227|FD-Score:-3.91|P-value:8.59E-5 ID:SGTC_1373|Compound:2887-0003|FD-Score:3.68|P-value:2.49E-4 ID:SGTC_1562|Compound:morin hydrate|FD-Score:4.63|P-value:5.78E-6 ID:SGTC_1574|Compound:spiramycin|FD-Score:3.47|P-value:5.06E-4 ID:SGTC_1772|Compound:st048439|FD-Score:5.80|P-value:1.83E-8 ID:SGTC_1846|Compound:st056244|FD-Score:3.43|P-value:5.85E-4 ID:SGTC_1892|Compound:st058411|FD-Score:3.27|P-value:9.96E-4 ID:SGTC_1965|Compound:Pectolinarigenin|FD-Score:3.43|P-value:5.97E-4 ID:SGTC_2122|Compound:5258151|FD-Score:6.03|P-value:5.20E-9 ID:SGTC_2238|Compound:6671620|FD-Score:4.44|P-value:1.29E-5 ID:SGTC_2261|Compound:9010538|FD-Score:5.31|P-value:2.39E-7 ID:SGTC_2279|Compound:7948423|FD-Score:-3.34|P-value:6.66E-4 ID:SGTC_2280|Compound:7785178|FD-Score:3.37|P-value:7.09E-4 ID:SGTC_2282|Compound:7944268|FD-Score:6.90|P-value:2.73E-11 ID:SGTC_2289|Compound:7946404|FD-Score:-3.73|P-value:1.72E-4 ID:SGTC_2313|Compound:7726885|FD-Score:3.51|P-value:4.54E-4 ID:SGTC_2329|Compound:6138490|FD-Score:-3.55|P-value:3.22E-4 ID:SGTC_2331|Compound:7980721|FD-Score:-5.97|P-value:5.48E-9 ID:SGTC_2334|Compound:9017922|FD-Score:-6.42|P-value:3.93E-10 ID:SGTC_2361|Compound:9034121|FD-Score:3.34|P-value:7.81E-4 ID:SGTC_2364|Compound:9055074|FD-Score:-3.99|P-value:6.27E-5 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:3.47|P-value:5.22E-4 ID:SGTC_2849|Compound:9019321|FD-Score:-4.24|P-value:2.38E-5 ID:SGTC_2856|Compound:9022925|FD-Score:-4.52|P-value:7.24E-6 ID:SGTC_2902|Compound:5787006|FD-Score:5.72|P-value:2.83E-8 ID:SGTC_2907|Compound:7721985|FD-Score:4.45|P-value:1.22E-5 ID:SGTC_2991|Compound:9074669|FD-Score:3.94|P-value:9.70E-5 ID:SGTC_3011|Compound:9081274|FD-Score:5.98|P-value:6.90E-9 ID:SGTC_3078|Compound:9116413|FD-Score:4.26|P-value:2.76E-5 ID:SGTC_3262|Compound:9137218|FD-Score:3.57|P-value:3.68E-4 ID:SGTC_3270|Compound:9137563|FD-Score:4.31|P-value:2.25E-5 ID:SGTC_3272|Compound:9137413|FD-Score:4.79|P-value:2.74E-6 ID:SGTC_3274|Compound:9138298|FD-Score:3.42|P-value:6.12E-4 ID:SGTC_3292|Compound:9120825|FD-Score:-3.55|P-value:3.19E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:-3.42|P-value:5.04E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:3.95|P-value:9.28E-5 ID:SGTC_208|Compound:k072-0098|FD-Score:3.47|P-value:5.11E-4 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:3.38|P-value:6.96E-4 ID:SGTC_260|Compound:nsc-65238|FD-Score:-3.79|P-value:1.36E-4 ID:SGTC_263|Compound:alizarin|FD-Score:3.39|P-value:6.81E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-6.67|P-value:8.23E-11 ID:SGTC_619|Compound:1652-1634|FD-Score:-3.41|P-value:5.19E-4 ID:SGTC_785|Compound:1270-0111|FD-Score:4.29|P-value:2.42E-5 ID:SGTC_878|Compound:0828-0289|FD-Score:3.29|P-value:9.30E-4 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:4.58|P-value:7.08E-6 ID:SGTC_1078|Compound:idebenone|FD-Score:5.43|P-value:1.28E-7 ID:SGTC_1089|Compound:terbinafine|FD-Score:4.11|P-value:4.93E-5 ID:SGTC_1164|Compound:k060-0068|FD-Score:6.46|P-value:4.36E-10 ID:SGTC_1212|Compound:0520-0165|FD-Score:3.92|P-value:1.04E-4 ID:SGTC_1257|Compound:0669-0121|FD-Score:3.95|P-value:9.31E-5 ID:SGTC_1264|Compound:0783-0040|FD-Score:-3.95|P-value:7.54E-5 ID:SGTC_1266|Compound:0828-0227|FD-Score:-3.91|P-value:8.59E-5 ID:SGTC_1373|Compound:2887-0003|FD-Score:3.68|P-value:2.49E-4 ID:SGTC_1562|Compound:morin hydrate|FD-Score:4.63|P-value:5.78E-6 ID:SGTC_1574|Compound:spiramycin|FD-Score:3.47|P-value:5.06E-4 ID:SGTC_1772|Compound:st048439|FD-Score:5.80|P-value:1.83E-8 ID:SGTC_1846|Compound:st056244|FD-Score:3.43|P-value:5.85E-4 ID:SGTC_1892|Compound:st058411|FD-Score:3.27|P-value:9.96E-4 ID:SGTC_1965|Compound:Pectolinarigenin|FD-Score:3.43|P-value:5.97E-4 ID:SGTC_2122|Compound:5258151|FD-Score:6.03|P-value:5.20E-9 ID:SGTC_2238|Compound:6671620|FD-Score:4.44|P-value:1.29E-5 ID:SGTC_2261|Compound:9010538|FD-Score:5.31|P-value:2.39E-7 ID:SGTC_2279|Compound:7948423|FD-Score:-3.34|P-value:6.66E-4 ID:SGTC_2280|Compound:7785178|FD-Score:3.37|P-value:7.09E-4 ID:SGTC_2282|Compound:7944268|FD-Score:6.90|P-value:2.73E-11 ID:SGTC_2289|Compound:7946404|FD-Score:-3.73|P-value:1.72E-4 ID:SGTC_2313|Compound:7726885|FD-Score:3.51|P-value:4.54E-4 ID:SGTC_2329|Compound:6138490|FD-Score:-3.55|P-value:3.22E-4 ID:SGTC_2331|Compound:7980721|FD-Score:-5.97|P-value:5.48E-9 ID:SGTC_2334|Compound:9017922|FD-Score:-6.42|P-value:3.93E-10 ID:SGTC_2361|Compound:9034121|FD-Score:3.34|P-value:7.81E-4 ID:SGTC_2364|Compound:9055074|FD-Score:-3.99|P-value:6.27E-5 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:3.47|P-value:5.22E-4 ID:SGTC_2849|Compound:9019321|FD-Score:-4.24|P-value:2.38E-5 ID:SGTC_2856|Compound:9022925|FD-Score:-4.52|P-value:7.24E-6 ID:SGTC_2902|Compound:5787006|FD-Score:5.72|P-value:2.83E-8 ID:SGTC_2907|Compound:7721985|FD-Score:4.45|P-value:1.22E-5 ID:SGTC_2991|Compound:9074669|FD-Score:3.94|P-value:9.70E-5 ID:SGTC_3011|Compound:9081274|FD-Score:5.98|P-value:6.90E-9 ID:SGTC_3078|Compound:9116413|FD-Score:4.26|P-value:2.76E-5 ID:SGTC_3262|Compound:9137218|FD-Score:3.57|P-value:3.68E-4 ID:SGTC_3270|Compound:9137563|FD-Score:4.31|P-value:2.25E-5 ID:SGTC_3272|Compound:9137413|FD-Score:4.79|P-value:2.74E-6 ID:SGTC_3274|Compound:9138298|FD-Score:3.42|P-value:6.12E-4 ID:SGTC_3292|Compound:9120825|FD-Score:-3.55|P-value:3.19E-4

Top fitness defect scores for YBL102W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2282 7944268 6.90 200.0 µM 2.73E-11 RPP1 & pyrimidine depletion 3 2.52E-12
2 SGTC_1164 k060-0068 6.46 93.7 µM 4.36E-10 1 5.34E-11
3 SGTC_2122 5258151 6.03 111.7 µM 5.20E-9 6 8.20E-10
4 SGTC_3011 9081274 5.98 71.4 µM 6.90E-9 1 1.12E-9
5 SGTC_1772 st048439 5.80 82.2 µM 1.83E-8 10 3.27E-9
6 SGTC_2902 5787006 5.72 60.5 µM 2.83E-8 Golgi 5 5.29E-9
7 SGTC_1078 idebenone 5.43 36.1 µM 1.28E-7 Golgi 16 2.80E-8
8 SGTC_2261 9010538 5.31 184.7 µM 2.39E-7 3 5.55E-8
9 SGTC_3272 9137413 4.79 49.5 µM 2.74E-6 6 8.17E-7
10 SGTC_1562 morin hydrate 4.63 59.1 µM 5.78E-6 6 1.86E-6
11 SGTC_1069 diphenylcyclopropenone 4.58 8.5 µM 7.08E-6 23 2.32E-6
12 SGTC_2907 7721985 4.45 69.9 µM 1.22E-5 12 4.22E-6
13 SGTC_2238 6671620 4.44 73.2 µM 1.29E-5 18 4.50E-6
14 SGTC_3270 9137563 4.31 49.5 µM 2.25E-5 RPP1 & pyrimidine depletion 5 8.30E-6
15 SGTC_785 1270-0111 4.29 65.3 µM 2.42E-5 20 9.01E-6
16 SGTC_3078 9116413 4.26 49.5 µM 2.76E-5 unfolded protein response 30 1.04E-5
17 SGTC_1089 terbinafine 4.11 2.2 µM 4.93E-5 11 1.97E-5
18 SGTC_166 k072-0058 3.95 166.4 µM 9.28E-5 DNA intercalators 39 3.95E-5
19 SGTC_1257 0669-0121 3.95 16.0 µM 9.31E-5 27 3.97E-5
20 SGTC_2991 9074669 3.94 71.4 µM 9.70E-5 azole & statin 64 4.15E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.093 6.86E-8 YHR177W_p YHR177W_p hom Putative protein of unknown function; overexpression causes a cell cycle delay or arrest
0.092 9.57E-8 YNL146C-A_p YNL146C-A_p hom Putative protein of unknown function
0.087 3.85E-7 YMR059W SEN15 het Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p
0.085 7.72E-7 YER068W MOT2 hom Ubiquitin-protein ligase subunit of the CCR4-NOT complex; with Ubc4p, ubiquitinates nascent polypeptide-associated complex subunits and histone demethyase Jhd2p; CCR4-NOT has roles in transcription regulation, mRNA degradation, and post-transcriptional modifications
0.084 1.01E-6 YGL136C MRM2 hom Mitochondrial 2' O-ribose methyltransferase, required for methylation of U(2791) in 21S rRNA; MRM2 deletion confers thermosensitive respiration and loss of mitochondrial DNA; has similarity to Spb1p and Trm7p, and to E. coli FtsJ/RrmJ
0.080 3.51E-6 YLR094C GIS3 hom Protein of unknown function
0.078 5.80E-6 YDR246W-A_p YDR246W-A_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR
0.076 1.03E-5 YIL024C_p YIL024C_p hom Putative protein of unknown function; non-essential gene; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p
0.074 1.79E-5 YER144C UBP5 hom Putative ubiquitin-specific protease, closest paralog of Doa4p but has no functional overlap; concentrates at the bud neck
0.073 2.08E-5 YDR359C EAF1 hom Component of the NuA4 histone acetyltransferase complex; acts as a platform for assembly of NuA4 subunits into the native complex; required for initiation of pre-meiotic DNA replication, likely due to its requirement for expression of IME1
0.073 2.47E-5 YIL121W QDR2 hom Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; exports copper; has broad substrate specificity and can transport many mono- and divalent cations; transports a variety of drugs and is required for resistance to quinidine, barban, cisplatin, and bleomycin; contributes to potassium homeostasis; expression is regulated by copper
0.070 4.41E-5 YJL015C_d YJL015C_d het Dubious open reading frame unlikely to encode a functional protein; expression if heat-inducible; located in promoter region of essential CCT3 gene encoding a subunit of the cytosolic chaperonin Cct ring complex, overlaps ORF YJL016W
0.070 4.59E-5 YOR008C-A_p YOR008C-A_p hom Putative protein of unknown function, includes a potential transmembrane domain; deletion results in slightly lengthened telomeres
0.070 4.94E-5 YDR527W RBA50 het Protein involved in transcription; interacts with RNA polymerase II subunits Rpb2p, Rpb3, and Rpb11p; has similarity to human RPAP1
0.070 5.10E-5 YLR279W_d YLR279W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data