YBL106C / SRO77

Protein with roles in exocytosis and cation homeostasis; functions in docking and fusion of post-Golgi vesicles with plasma membrane; homolog of Drosophila lethal giant larvae tumor suppressor; interacts with SNARE protein Sec9p; SRO77 has a paralog, SRO7, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YBL106C / SRO77

Click on Significant Values for Screen Details ID:SGTC_92|Compound:0063-0024|FD-Score:3.81|P-value:2.36E-4 ID:SGTC_177|Compound:1327-0068|FD-Score:3.97|P-value:1.31E-4 ID:SGTC_306|Compound:1672-3436|FD-Score:4.94|P-value:2.36E-6 ID:SGTC_316|Compound:k060-0003|FD-Score:4.21|P-value:5.21E-5 ID:SGTC_359|Compound:0081-0058|FD-Score:4.05|P-value:9.84E-5 ID:SGTC_378|Compound:3970-0959|FD-Score:5.59|P-value:9.59E-8 ID:SGTC_391|Compound:gliotoxin|FD-Score:5.77|P-value:3.70E-8 ID:SGTC_450|Compound:aminopyrene|FD-Score:3.76|P-value:2.84E-4 ID:SGTC_455|Compound:paf C-16|FD-Score:3.75|P-value:2.91E-4 ID:SGTC_591|Compound:4299-0174|FD-Score:3.46|P-value:7.87E-4 ID:SGTC_672|Compound:1441-0018|FD-Score:4.84|P-value:3.68E-6 ID:SGTC_675|Compound:1309-0189|FD-Score:7.61|P-value:4.29E-13 ID:SGTC_714|Compound:4296-0578|FD-Score:3.73|P-value:3.20E-4 ID:SGTC_716|Compound:1683-5115|FD-Score:4.88|P-value:3.05E-6 ID:SGTC_732|Compound:3970-1727|FD-Score:-3.37|P-value:3.23E-4 ID:SGTC_891|Compound:0929-0073|FD-Score:4.83|P-value:3.76E-6 ID:SGTC_909|Compound:3448-9333|FD-Score:4.67|P-value:7.80E-6 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:5.59|P-value:9.87E-8 ID:SGTC_1164|Compound:k060-0068|FD-Score:4.00|P-value:1.18E-4 ID:SGTC_1184|Compound:1269-1718|FD-Score:4.44|P-value:2.05E-5 ID:SGTC_1249|Compound:0481-0015|FD-Score:3.90|P-value:1.72E-4 ID:SGTC_1265|Compound:0819-1001|FD-Score:4.07|P-value:9.23E-5 ID:SGTC_1303|Compound:1160-0052|FD-Score:3.83|P-value:2.19E-4 ID:SGTC_1307|Compound:1187-1599|FD-Score:5.43|P-value:2.18E-7 ID:SGTC_1360|Compound:1598-0022|FD-Score:4.85|P-value:3.43E-6 ID:SGTC_1385|Compound:3091-4834|FD-Score:4.48|P-value:1.76E-5 ID:SGTC_1474|Compound:0330-0125|FD-Score:4.02|P-value:1.10E-4 ID:SGTC_1488|Compound:4013-0813|FD-Score:3.43|P-value:8.77E-4 ID:SGTC_1508|Compound:1080-0625|FD-Score:5.25|P-value:5.26E-7 ID:SGTC_1542|Compound:7-hydroxy-3'-methoxyflavone|FD-Score:3.99|P-value:1.21E-4 ID:SGTC_1556|Compound:plumbagin|FD-Score:4.22|P-value:4.98E-5 ID:SGTC_1632|Compound:st005650|FD-Score:7.21|P-value:6.85E-12 ID:SGTC_1636|Compound:st007707|FD-Score:5.04|P-value:1.48E-6 ID:SGTC_1677|Compound:st019204|FD-Score:3.44|P-value:8.45E-4 ID:SGTC_1711|Compound:st032263|FD-Score:3.84|P-value:2.15E-4 ID:SGTC_1714|Compound:st033236|FD-Score:3.53|P-value:6.25E-4 ID:SGTC_1720|Compound:st037298|FD-Score:-5.19|P-value:1.21E-7 ID:SGTC_1756|Compound:st041558|FD-Score:4.12|P-value:7.45E-5 ID:SGTC_1757|Compound:st041620|FD-Score:4.08|P-value:8.76E-5 ID:SGTC_1764|Compound:st044502|FD-Score:4.88|P-value:3.06E-6 ID:SGTC_1765|Compound:st044815|FD-Score:5.00|P-value:1.74E-6 ID:SGTC_1766|Compound:st045414|FD-Score:3.56|P-value:5.63E-4 ID:SGTC_1798|Compound:st045719|FD-Score:3.78|P-value:2.61E-4 ID:SGTC_1834|Compound:st055981|FD-Score:5.09|P-value:1.13E-6 ID:SGTC_1865|Compound:st057639|FD-Score:3.76|P-value:2.86E-4 ID:SGTC_1868|Compound:st057644|FD-Score:6.83|P-value:7.78E-11 ID:SGTC_1872|Compound:amphotericin b|FD-Score:4.16|P-value:6.38E-5 ID:SGTC_1895|Compound:st058434|FD-Score:4.84|P-value:3.63E-6 ID:SGTC_1900|Compound:st060200|FD-Score:4.88|P-value:3.07E-6 ID:SGTC_1942|Compound:st076330|FD-Score:4.84|P-value:3.58E-6 ID:SGTC_1945|Compound:st075991|FD-Score:-4.14|P-value:1.61E-5 ID:SGTC_1949|Compound:st076024|FD-Score:9.99|P-value:1.93E-21 ID:SGTC_1950|Compound:st077106|FD-Score:-5.24|P-value:9.30E-8 ID:SGTC_2019|Compound:4016004|FD-Score:5.10|P-value:1.12E-6 ID:SGTC_2053|Compound:5265679|FD-Score:4.32|P-value:3.32E-5 ID:SGTC_2056|Compound:5235370|FD-Score:6.18|P-value:3.86E-9 ID:SGTC_2069|Compound:5228469|FD-Score:3.52|P-value:6.45E-4 ID:SGTC_2167|Compound:5876490|FD-Score:5.23|P-value:5.77E-7 ID:SGTC_2198|Compound:6589944|FD-Score:4.24|P-value:4.67E-5 ID:SGTC_2373|Compound:9071805|FD-Score:5.91|P-value:1.77E-8 ID:SGTC_2375|Compound:9072683|FD-Score:3.98|P-value:1.26E-4 ID:SGTC_2376|Compound:9072922|FD-Score:3.58|P-value:5.41E-4 ID:SGTC_2377|Compound:9073351|FD-Score:4.11|P-value:7.90E-5 ID:SGTC_2379|Compound:9035213|FD-Score:4.86|P-value:3.36E-6 ID:SGTC_2411|Compound:st077133|FD-Score:3.94|P-value:1.48E-4 ID:SGTC_2453|Compound:5731132|FD-Score:3.45|P-value:8.34E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:4.23|P-value:4.78E-5 ID:SGTC_2561|Compound:acetosyringone|FD-Score:4.59|P-value:1.11E-5 ID:SGTC_2570|Compound:licareol|FD-Score:3.54|P-value:6.19E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:4.18|P-value:5.84E-5 ID:SGTC_2624|Compound:nerol|FD-Score:3.46|P-value:7.95E-4 ID:SGTC_2699|Compound:st077704|FD-Score:5.38|P-value:2.74E-7 ID:SGTC_2710|Compound:st078562|FD-Score:5.09|P-value:1.14E-6 ID:SGTC_2780|Compound:5215298|FD-Score:4.82|P-value:3.96E-6 ID:SGTC_2782|Compound:7736369|FD-Score:-3.54|P-value:1.71E-4 ID:SGTC_2787|Compound:5284540|FD-Score:-3.97|P-value:3.21E-5 ID:SGTC_2831|Compound:7999036|FD-Score:5.38|P-value:2.76E-7 ID:SGTC_2834|Compound:9001755|FD-Score:-3.36|P-value:3.26E-4 ID:SGTC_2844|Compound:9010103|FD-Score:-3.58|P-value:1.48E-4 ID:SGTC_2846|Compound:9008642|FD-Score:4.38|P-value:2.65E-5 ID:SGTC_2849|Compound:9019321|FD-Score:3.65|P-value:4.18E-4 ID:SGTC_2850|Compound:9015429|FD-Score:-3.38|P-value:3.08E-4 ID:SGTC_2867|Compound:9039098|FD-Score:3.71|P-value:3.37E-4 ID:SGTC_2944|Compound:9067346|FD-Score:5.49|P-value:1.60E-7 ID:SGTC_2945|Compound:9067681|FD-Score:3.85|P-value:2.04E-4 ID:SGTC_2950|Compound:9072895|FD-Score:4.27|P-value:4.15E-5 ID:SGTC_2963|Compound:9082507|FD-Score:3.96|P-value:1.36E-4 ID:SGTC_3054|Compound:9094397|FD-Score:3.83|P-value:2.20E-4 ID:SGTC_3145|Compound:9085516|FD-Score:4.03|P-value:1.04E-4 ID:SGTC_3158|Compound:9100007|FD-Score:4.40|P-value:2.45E-5 ID:SGTC_3210|Compound:9128157|FD-Score:-4.53|P-value:2.95E-6 ID:SGTC_3294|Compound:9122953|FD-Score:3.56|P-value:5.62E-4 ID:SGTC_3331|Compound:9141060|FD-Score:-3.45|P-value:2.40E-4 ID:SGTC_92|Compound:0063-0024|FD-Score:3.81|P-value:2.36E-4 ID:SGTC_177|Compound:1327-0068|FD-Score:3.97|P-value:1.31E-4 ID:SGTC_306|Compound:1672-3436|FD-Score:4.94|P-value:2.36E-6 ID:SGTC_316|Compound:k060-0003|FD-Score:4.21|P-value:5.21E-5 ID:SGTC_359|Compound:0081-0058|FD-Score:4.05|P-value:9.84E-5 ID:SGTC_378|Compound:3970-0959|FD-Score:5.59|P-value:9.59E-8 ID:SGTC_391|Compound:gliotoxin|FD-Score:5.77|P-value:3.70E-8 ID:SGTC_450|Compound:aminopyrene|FD-Score:3.76|P-value:2.84E-4 ID:SGTC_455|Compound:paf C-16|FD-Score:3.75|P-value:2.91E-4 ID:SGTC_591|Compound:4299-0174|FD-Score:3.46|P-value:7.87E-4 ID:SGTC_672|Compound:1441-0018|FD-Score:4.84|P-value:3.68E-6 ID:SGTC_675|Compound:1309-0189|FD-Score:7.61|P-value:4.29E-13 ID:SGTC_714|Compound:4296-0578|FD-Score:3.73|P-value:3.20E-4 ID:SGTC_716|Compound:1683-5115|FD-Score:4.88|P-value:3.05E-6 ID:SGTC_732|Compound:3970-1727|FD-Score:-3.37|P-value:3.23E-4 ID:SGTC_891|Compound:0929-0073|FD-Score:4.83|P-value:3.76E-6 ID:SGTC_909|Compound:3448-9333|FD-Score:4.67|P-value:7.80E-6 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:5.59|P-value:9.87E-8 ID:SGTC_1164|Compound:k060-0068|FD-Score:4.00|P-value:1.18E-4 ID:SGTC_1184|Compound:1269-1718|FD-Score:4.44|P-value:2.05E-5 ID:SGTC_1249|Compound:0481-0015|FD-Score:3.90|P-value:1.72E-4 ID:SGTC_1265|Compound:0819-1001|FD-Score:4.07|P-value:9.23E-5 ID:SGTC_1303|Compound:1160-0052|FD-Score:3.83|P-value:2.19E-4 ID:SGTC_1307|Compound:1187-1599|FD-Score:5.43|P-value:2.18E-7 ID:SGTC_1360|Compound:1598-0022|FD-Score:4.85|P-value:3.43E-6 ID:SGTC_1385|Compound:3091-4834|FD-Score:4.48|P-value:1.76E-5 ID:SGTC_1474|Compound:0330-0125|FD-Score:4.02|P-value:1.10E-4 ID:SGTC_1488|Compound:4013-0813|FD-Score:3.43|P-value:8.77E-4 ID:SGTC_1508|Compound:1080-0625|FD-Score:5.25|P-value:5.26E-7 ID:SGTC_1542|Compound:7-hydroxy-3'-methoxyflavone|FD-Score:3.99|P-value:1.21E-4 ID:SGTC_1556|Compound:plumbagin|FD-Score:4.22|P-value:4.98E-5 ID:SGTC_1632|Compound:st005650|FD-Score:7.21|P-value:6.85E-12 ID:SGTC_1636|Compound:st007707|FD-Score:5.04|P-value:1.48E-6 ID:SGTC_1677|Compound:st019204|FD-Score:3.44|P-value:8.45E-4 ID:SGTC_1711|Compound:st032263|FD-Score:3.84|P-value:2.15E-4 ID:SGTC_1714|Compound:st033236|FD-Score:3.53|P-value:6.25E-4 ID:SGTC_1720|Compound:st037298|FD-Score:-5.19|P-value:1.21E-7 ID:SGTC_1756|Compound:st041558|FD-Score:4.12|P-value:7.45E-5 ID:SGTC_1757|Compound:st041620|FD-Score:4.08|P-value:8.76E-5 ID:SGTC_1764|Compound:st044502|FD-Score:4.88|P-value:3.06E-6 ID:SGTC_1765|Compound:st044815|FD-Score:5.00|P-value:1.74E-6 ID:SGTC_1766|Compound:st045414|FD-Score:3.56|P-value:5.63E-4 ID:SGTC_1798|Compound:st045719|FD-Score:3.78|P-value:2.61E-4 ID:SGTC_1834|Compound:st055981|FD-Score:5.09|P-value:1.13E-6 ID:SGTC_1865|Compound:st057639|FD-Score:3.76|P-value:2.86E-4 ID:SGTC_1868|Compound:st057644|FD-Score:6.83|P-value:7.78E-11 ID:SGTC_1872|Compound:amphotericin b|FD-Score:4.16|P-value:6.38E-5 ID:SGTC_1895|Compound:st058434|FD-Score:4.84|P-value:3.63E-6 ID:SGTC_1900|Compound:st060200|FD-Score:4.88|P-value:3.07E-6 ID:SGTC_1942|Compound:st076330|FD-Score:4.84|P-value:3.58E-6 ID:SGTC_1945|Compound:st075991|FD-Score:-4.14|P-value:1.61E-5 ID:SGTC_1949|Compound:st076024|FD-Score:9.99|P-value:1.93E-21 ID:SGTC_1950|Compound:st077106|FD-Score:-5.24|P-value:9.30E-8 ID:SGTC_2019|Compound:4016004|FD-Score:5.10|P-value:1.12E-6 ID:SGTC_2053|Compound:5265679|FD-Score:4.32|P-value:3.32E-5 ID:SGTC_2056|Compound:5235370|FD-Score:6.18|P-value:3.86E-9 ID:SGTC_2069|Compound:5228469|FD-Score:3.52|P-value:6.45E-4 ID:SGTC_2167|Compound:5876490|FD-Score:5.23|P-value:5.77E-7 ID:SGTC_2198|Compound:6589944|FD-Score:4.24|P-value:4.67E-5 ID:SGTC_2373|Compound:9071805|FD-Score:5.91|P-value:1.77E-8 ID:SGTC_2375|Compound:9072683|FD-Score:3.98|P-value:1.26E-4 ID:SGTC_2376|Compound:9072922|FD-Score:3.58|P-value:5.41E-4 ID:SGTC_2377|Compound:9073351|FD-Score:4.11|P-value:7.90E-5 ID:SGTC_2379|Compound:9035213|FD-Score:4.86|P-value:3.36E-6 ID:SGTC_2411|Compound:st077133|FD-Score:3.94|P-value:1.48E-4 ID:SGTC_2453|Compound:5731132|FD-Score:3.45|P-value:8.34E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:4.23|P-value:4.78E-5 ID:SGTC_2561|Compound:acetosyringone|FD-Score:4.59|P-value:1.11E-5 ID:SGTC_2570|Compound:licareol|FD-Score:3.54|P-value:6.19E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:4.18|P-value:5.84E-5 ID:SGTC_2624|Compound:nerol|FD-Score:3.46|P-value:7.95E-4 ID:SGTC_2699|Compound:st077704|FD-Score:5.38|P-value:2.74E-7 ID:SGTC_2710|Compound:st078562|FD-Score:5.09|P-value:1.14E-6 ID:SGTC_2780|Compound:5215298|FD-Score:4.82|P-value:3.96E-6 ID:SGTC_2782|Compound:7736369|FD-Score:-3.54|P-value:1.71E-4 ID:SGTC_2787|Compound:5284540|FD-Score:-3.97|P-value:3.21E-5 ID:SGTC_2831|Compound:7999036|FD-Score:5.38|P-value:2.76E-7 ID:SGTC_2834|Compound:9001755|FD-Score:-3.36|P-value:3.26E-4 ID:SGTC_2844|Compound:9010103|FD-Score:-3.58|P-value:1.48E-4 ID:SGTC_2846|Compound:9008642|FD-Score:4.38|P-value:2.65E-5 ID:SGTC_2849|Compound:9019321|FD-Score:3.65|P-value:4.18E-4 ID:SGTC_2850|Compound:9015429|FD-Score:-3.38|P-value:3.08E-4 ID:SGTC_2867|Compound:9039098|FD-Score:3.71|P-value:3.37E-4 ID:SGTC_2944|Compound:9067346|FD-Score:5.49|P-value:1.60E-7 ID:SGTC_2945|Compound:9067681|FD-Score:3.85|P-value:2.04E-4 ID:SGTC_2950|Compound:9072895|FD-Score:4.27|P-value:4.15E-5 ID:SGTC_2963|Compound:9082507|FD-Score:3.96|P-value:1.36E-4 ID:SGTC_3054|Compound:9094397|FD-Score:3.83|P-value:2.20E-4 ID:SGTC_3145|Compound:9085516|FD-Score:4.03|P-value:1.04E-4 ID:SGTC_3158|Compound:9100007|FD-Score:4.40|P-value:2.45E-5 ID:SGTC_3210|Compound:9128157|FD-Score:-4.53|P-value:2.95E-6 ID:SGTC_3294|Compound:9122953|FD-Score:3.56|P-value:5.62E-4 ID:SGTC_3331|Compound:9141060|FD-Score:-3.45|P-value:2.40E-4

Top fitness defect scores for YBL106C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1949 st076024 9.99 69.1 µM 1.93E-21 1 8.81E-24
2 SGTC_675 1309-0189 7.61 238.0 µM 4.29E-13 1 1.36E-14
3 SGTC_1632 st005650 7.21 90.0 µM 6.85E-12 1 2.90E-13
4 SGTC_1868 st057644 6.83 42.7 µM 7.78E-11 6 4.24E-12
5 SGTC_2056 5235370 6.18 200.0 µM 3.86E-9 11 3.20E-10
6 SGTC_2373 9071805 5.91 200.0 µM 1.77E-8 2 1.74E-9
7 SGTC_391 gliotoxin 5.77 8.3 µM 3.70E-8 25 3.93E-9
8 SGTC_378 3970-0959 5.59 8.3 µM 9.59E-8 3 1.13E-8
9 SGTC_915 methyl methanesulfonate (MMS) 5.59 110.0 mM 9.87E-8 DNA damage response 14 1.17E-8
10 SGTC_2944 9067346 5.49 25.6 µM 1.60E-7 5 2.00E-8
11 SGTC_1307 1187-1599 5.43 12.2 µM 2.18E-7 PDR1 5 2.82E-8
12 SGTC_2699 st077704 5.38 54.6 µM 2.74E-7 endomembrane recycling 25 3.63E-8
13 SGTC_2831 7999036 5.38 19.5 µM 2.76E-7 12 3.67E-8
14 SGTC_1508 1080-0625 5.25 72.9 µM 5.26E-7 4 7.51E-8
15 SGTC_2167 5876490 5.23 200.0 µM 5.77E-7 10 8.32E-8
16 SGTC_2019 4016004 5.10 108.0 µM 1.12E-6 5 1.74E-7
17 SGTC_1834 st055981 5.09 52.8 µM 1.13E-6 RPP1 & pyrimidine depletion 12 1.76E-7
18 SGTC_2710 st078562 5.09 53.7 µM 1.14E-6 3 1.78E-7
19 SGTC_1636 st007707 5.04 68.9 µM 1.48E-6 24 2.38E-7
20 SGTC_1765 st044815 5.00 90.4 µM 1.74E-6 11 2.84E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.089 2.58E-7 YMR182W-A_p YMR182W-A_p hom Putative protein of unknown function
0.087 4.04E-7 YGR232W NAS6 hom Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); ortholog of human oncoprotein gankyrin, which interacts with the Rb tumor suppressor and CDK4/6
0.087 4.10E-7 YNL281W HCH1 hom Heat shock protein regulator; binds to Hsp90p and may stimulate ATPase activity; originally identified as a high-copy number suppressor of a HSP90 loss-of-function mutation; GFP-fusion protein localizes to the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress
0.082 1.90E-6 YMR250W GAD1 hom Glutamate decarboxylase, converts glutamate into gamma-aminobutyric acid (GABA) during glutamate catabolism; involved in response to oxidative stress
0.082 2.28E-6 YJL182C_d YJL182C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized ORF YJL181W
0.081 2.33E-6 YKL202W_d YKL202W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.080 3.56E-6 YBL071W-A KTI11 hom Zn-ribbon protein that co-purifies with Dph1 and Dph2 in a complex required for synthesis of diphthamide on translation factor eEF2 and with Elongator subunits Iki3p, Elp2p, and Elp3p involved in modification of wobble nucleosides in tRNAs
0.080 3.67E-6 YNR070W_p PDR18_p hom Putative transporter of the ATP-binding cassette (ABC) family, implicated in pleiotropic drug resistance; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.078 6.47E-6 YLR455W YLR455W hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO); protein abundance increases in response to DNA replication stress
0.074 1.89E-5 YOR314W_d YOR314W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.071 4.00E-5 YNL221C POP1 het Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; binds to the RPR1 RNA subunit in RNase P
0.070 4.66E-5 YCR010C ADY2 hom Acetate transporter required for normal sporulation; phosphorylated in mitochondria; ADY2 has a paralog, ATO2, that arose from the whole genome duplication
0.070 4.98E-5 YHR137W ARO9 hom Aromatic aminotransferase II, catalyzes the first step of tryptophan, phenylalanine, and tyrosine catabolism
0.069 5.66E-5 YKL189W HYM1 het Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with Kic1p and Sog2p, localizes to sites of polarized growth during budding and during the mating response
0.068 7.48E-5 YMR251W-A HOR7 hom Protein of unknown function; overexpression suppresses Ca2+ sensitivity of mutants lacking inositol phosphorylceramide mannosyltransferases Csg1p and Csh1p; transcription is induced under hyperosmotic stress and repressed by alpha factor; HOR7 has a paralog, DDR2, that arose from the whole genome duplication