YBL107C / MIC23

Mitochondrial intermembrane space protein of unknown function; imported via the MIA import machinery; contains an unusual twin cysteine motif (CX13C CX14C)

Zygosity: Homozygous strain
fixedexpanded
Profile for YBL107C / MIC23

Click on Significant Values for Screen Details

Top fitness defect scores for YBL107C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_139 0099-0334 5.44 718.6 µM 1.85E-7 8 2.64E-8
2 SGTC_2604 4'-hydroxychalcone 4.94 11.3 µM 1.95E-6 18 3.96E-7
3 SGTC_2606 farnesol 4.73 9.8 µM 4.95E-6 11 1.15E-6
4 SGTC_2860 9025725 4.63 39.0 µM 7.42E-6 RPP1 & pyrimidine depletion 3 1.83E-6
5 SGTC_2612 dictamnine 4.40 15.5 µM 1.90E-5 RNA pol III & RNase P/MRP 32 5.37E-6
6 SGTC_1254 0550-0035 4.12 264.0 µM 5.65E-5 17 1.86E-5
7 SGTC_2587 piperic acid 4.09 92.2 µM 6.42E-5 19 2.16E-5
8 SGTC_1880 MG-132 4.08 525.0 µM 6.67E-5 15 2.25E-5
9 SGTC_1172 0370-0043 3.98 85.0 µM 9.69E-5 24 3.45E-5
10 SGTC_2873 9040596 3.92 71.4 µM 1.19E-4 49 4.37E-5
11 SGTC_2877 9040724 3.91 71.4 µM 1.26E-4 10 4.65E-5
12 SGTC_1156 4092-0367 3.78 4.9 µM 2.00E-4 27 7.91E-5
13 SGTC_2541 muurolladie-3-one 3.75 83.1 µM 2.19E-4 excess fatty acid 39 8.77E-5
14 SGTC_727 3032-0951 3.75 202.0 µM 2.20E-4 32 8.79E-5
15 SGTC_1285 0929-0069 3.58 65.5 µM 3.92E-4 30 1.70E-4
16 SGTC_141 0443-0274 3.57 32.3 µM 4.03E-4 mitochondrial response to ROS 62 1.75E-4
17 SGTC_1539 benzyladenosine 3.57 56.0 µM 4.07E-4 23 1.77E-4
18 SGTC_898 1000-0849 3.48 28.3 µM 5.54E-4 11 2.52E-4
19 SGTC_659 k018-0002 3.38 107.0 µM 7.58E-4 34 3.60E-4
20 SGTC_1486 3970-0793 3.34 4.5 µM 8.56E-4 17 4.14E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.107 4.60E-10 YNL034W_p YNL034W_p hom Putative protein of unknown function; YNL034W is not an essential gene
0.104 1.32E-9 YOR234C RPL33B hom Ribosomal 60S subunit protein L33B; rpl33b null mutant exhibits normal growth while rpl33a rpl33b double null mutant is inviable; homologous to mammalian ribosomal protein L35A, no bacterial homolog; RPL33B has a paralog, RPL33A, that arose from the whole genome duplication
0.086 5.62E-7 YBR196C-A_p YBR196C-A_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR
0.077 6.99E-6 YPR148C YPR148C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
0.077 7.42E-6 YBR054W YRO2 hom Protein of unknown function with similarity to archaeal rhodopsins; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; transcriptionally regulated by Haa1p; YRO2 has a paralog, MRH1, that arose from the whole genome duplication
0.076 1.07E-5 YNL220W ADE12 hom Adenylosuccinate synthase, catalyzes the first step in synthesis of adenosine monophosphate from inosine 5'monophosphate during purine nucleotide biosynthesis; exhibits binding to single-stranded autonomously replicating (ARS) core sequence
0.076 1.10E-5 YDR086C SSS1 het Subunit of the Sec61p translocation complex (Sec61p-Sss1p-Sbh1p) that forms a channel for passage of secretory proteins through the endoplasmic reticulum membrane, and of the Ssh1p complex (Ssh1p-Sbh2p-Sss1p); interacts with Ost4p and Wbp1p
0.075 1.30E-5 YHR086W-A_p YHR086W-A_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR
0.075 1.39E-5 YDR090C_p YDR090C_p hom Putative protein of unknown function
0.073 2.23E-5 YLL062C MHT1 hom S-methylmethionine-homocysteine methyltransferase, functions along with Sam4p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio
0.073 2.32E-5 YDR157W_d YDR157W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.073 2.65E-5 YGL085W_p LCL3_p hom Putative protein of unknown function; mutant has long chronological lifespan; has homology to Staphylococcus aureus nuclease; GFP-fusion protein localizes to mitochondria; is induced in response to the DNA-damaging agent MMS
0.072 2.76E-5 YNL297C MON2 hom Peripheral membrane protein with a role in endocytosis and vacuole integrity, interacts with Arl1p and localizes to the endosome; member of the Sec7p family of proteins
0.072 3.05E-5 YHR132W-A IGO2 hom Protein required for initiation of G0 program; prevents degradation of nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway; phosphorylated by Rim15p; GFP protein localizes to the cytoplasm and nucleus; similar to Igo1p
0.070 5.13E-5 YOL102C TPT1 het tRNA 2'-phosphotransferase, catalyzes the final step in yeast tRNA splicing: the transfer of the 2'-PO(4) from the splice junction to NAD(+) to form ADP-ribose 1''-2''cyclic phosphate and nicotinamide