YBR001C / NTH2

Putative neutral trehalase, required for thermotolerance; may mediate resistance to other cellular stresses; NTH2 has a paralog, NTH1, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR001C / NTH2

Click on Significant Values for Screen Details ID:SGTC_4|Compound:0960-0234|FD-Score:4.52|P-value:4.22E-6 ID:SGTC_31|Compound:0508-1974|FD-Score:4.52|P-value:4.07E-6 ID:SGTC_94|Compound:0334-0113|FD-Score:3.33|P-value:6.09E-4 ID:SGTC_128|Compound:0906-2981|FD-Score:4.04|P-value:3.65E-5 ID:SGTC_140|Compound:0062-0056|FD-Score:3.90|P-value:6.63E-5 ID:SGTC_194|Compound:1486-1323|FD-Score:3.51|P-value:3.11E-4 ID:SGTC_211|Compound:3455-0679|FD-Score:3.40|P-value:4.59E-4 ID:SGTC_218|Compound:alverine citrate|FD-Score:4.02|P-value:3.96E-5 ID:SGTC_257|Compound:daunorubicin|FD-Score:3.42|P-value:4.36E-4 ID:SGTC_285|Compound:1486-1325|FD-Score:3.19|P-value:9.76E-4 ID:SGTC_290|Compound:2043-6722|FD-Score:3.76|P-value:1.16E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:-3.56|P-value:6.33E-5 ID:SGTC_389|Compound:tpck|FD-Score:3.64|P-value:1.88E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:4.64|P-value:2.34E-6 ID:SGTC_452|Compound:diindolylmethane|FD-Score:3.62|P-value:2.01E-4 ID:SGTC_466|Compound:geldanamycin|FD-Score:3.41|P-value:4.54E-4 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:3.38|P-value:5.08E-4 ID:SGTC_601|Compound:0986-0029|FD-Score:3.57|P-value:2.50E-4 ID:SGTC_603|Compound:3794-0023|FD-Score:3.57|P-value:2.43E-4 ID:SGTC_631|Compound:k072-0230|FD-Score:3.29|P-value:6.87E-4 ID:SGTC_646|Compound:4092-0839|FD-Score:4.24|P-value:1.51E-5 ID:SGTC_654|Compound:1124-0271|FD-Score:4.29|P-value:1.20E-5 ID:SGTC_713|Compound:1488-1073|FD-Score:3.20|P-value:9.39E-4 ID:SGTC_755|Compound:1995-0008|FD-Score:4.18|P-value:1.97E-5 ID:SGTC_765|Compound:1319-0117|FD-Score:3.91|P-value:6.40E-5 ID:SGTC_814|Compound:3342-0569|FD-Score:4.15|P-value:2.28E-5 ID:SGTC_821|Compound:1114-0266|FD-Score:3.38|P-value:4.96E-4 ID:SGTC_833|Compound:3852-0053|FD-Score:3.63|P-value:1.99E-4 ID:SGTC_889|Compound:0919-1524|FD-Score:3.91|P-value:6.26E-5 ID:SGTC_990|Compound:3985-0011|FD-Score:3.51|P-value:3.08E-4 ID:SGTC_1015|Compound:4130-4525|FD-Score:3.55|P-value:2.62E-4 ID:SGTC_1070|Compound:indatraline|FD-Score:5.20|P-value:1.25E-7 ID:SGTC_1098|Compound:clofazimine|FD-Score:4.77|P-value:1.18E-6 ID:SGTC_1103|Compound:duloxetine|FD-Score:4.38|P-value:8.07E-6 ID:SGTC_1239|Compound:0337-0584|FD-Score:3.31|P-value:6.41E-4 ID:SGTC_1254|Compound:0550-0035|FD-Score:3.67|P-value:1.66E-4 ID:SGTC_1341|Compound:1486-1360|FD-Score:3.27|P-value:7.56E-4 ID:SGTC_1358|Compound:1509-0022|FD-Score:3.23|P-value:8.73E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:4.08|P-value:3.09E-5 ID:SGTC_1375|Compound:2910-0797|FD-Score:4.62|P-value:2.58E-6 ID:SGTC_1496|Compound:4469-0713|FD-Score:3.87|P-value:7.42E-5 ID:SGTC_1521|Compound:st012942|FD-Score:3.34|P-value:5.86E-4 ID:SGTC_1535|Compound:tetrahydropapaveroline hydrobromide|FD-Score:3.98|P-value:4.68E-5 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:4.93|P-value:5.30E-7 ID:SGTC_1617|Compound:st002906|FD-Score:4.30|P-value:1.15E-5 ID:SGTC_1625|Compound:st003711|FD-Score:5.49|P-value:2.47E-8 ID:SGTC_1627|Compound:st003713|FD-Score:3.22|P-value:9.02E-4 ID:SGTC_1695|Compound:st026914|FD-Score:4.45|P-value:5.74E-6 ID:SGTC_1697|Compound:st025554|FD-Score:3.37|P-value:5.22E-4 ID:SGTC_1711|Compound:st032263|FD-Score:3.24|P-value:8.36E-4 ID:SGTC_1824|Compound:st053723|FD-Score:3.33|P-value:6.02E-4 ID:SGTC_1825|Compound:st052143|FD-Score:5.52|P-value:2.12E-8 ID:SGTC_1865|Compound:st057639|FD-Score:3.48|P-value:3.52E-4 ID:SGTC_1922|Compound:5578187|FD-Score:3.46|P-value:3.79E-4 ID:SGTC_1927|Compound:st060202|FD-Score:5.15|P-value:1.61E-7 ID:SGTC_1941|Compound:st076221|FD-Score:3.69|P-value:1.53E-4 ID:SGTC_1944|Compound:st076371|FD-Score:3.65|P-value:1.83E-4 ID:SGTC_1965|Compound:Pectolinarigenin|FD-Score:5.32|P-value:6.49E-8 ID:SGTC_1969|Compound:st069479|FD-Score:3.78|P-value:1.10E-4 ID:SGTC_1977|Compound:st070720|FD-Score:5.11|P-value:2.01E-7 ID:SGTC_1985|Compound:st071382|FD-Score:3.31|P-value:6.41E-4 ID:SGTC_1999|Compound:st074831|FD-Score:4.77|P-value:1.21E-6 ID:SGTC_2061|Compound:5245884|FD-Score:4.07|P-value:3.17E-5 ID:SGTC_2065|Compound:5221596|FD-Score:3.72|P-value:1.40E-4 ID:SGTC_2092|Compound:5303694|FD-Score:3.40|P-value:4.67E-4 ID:SGTC_2110|Compound:5483698|FD-Score:3.88|P-value:7.06E-5 ID:SGTC_2111|Compound:5486399|FD-Score:3.49|P-value:3.38E-4 ID:SGTC_2210|Compound:7115885|FD-Score:3.25|P-value:7.94E-4 ID:SGTC_2213|Compound:7173844|FD-Score:3.76|P-value:1.19E-4 ID:SGTC_2265|Compound:7929201|FD-Score:3.22|P-value:9.03E-4 ID:SGTC_2279|Compound:7948423|FD-Score:3.30|P-value:6.78E-4 ID:SGTC_2359|Compound:9039622|FD-Score:3.39|P-value:4.92E-4 ID:SGTC_2379|Compound:9035213|FD-Score:3.43|P-value:4.13E-4 ID:SGTC_2380|Compound:9035439|FD-Score:3.95|P-value:5.28E-5 ID:SGTC_2448|Compound:5185112|FD-Score:3.76|P-value:1.18E-4 ID:SGTC_2482|Compound:5981709|FD-Score:3.53|P-value:2.85E-4 ID:SGTC_2507|Compound:purpurin|FD-Score:3.37|P-value:5.19E-4 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:3.77|P-value:1.11E-4 ID:SGTC_2585|Compound:alliin|FD-Score:3.99|P-value:4.59E-5 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:4.03|P-value:3.86E-5 ID:SGTC_2623|Compound:humulene|FD-Score:3.53|P-value:2.88E-4 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:5.02|P-value:3.40E-7 ID:SGTC_2814|Compound:7977482|FD-Score:-2.85|P-value:9.69E-4 ID:SGTC_2823|Compound:7987624|FD-Score:4.53|P-value:3.88E-6 ID:SGTC_2826|Compound:7992541|FD-Score:3.20|P-value:9.50E-4 ID:SGTC_2828|Compound:7998861|FD-Score:3.33|P-value:6.07E-4 ID:SGTC_2836|Compound:9010338|FD-Score:4.91|P-value:5.82E-7 ID:SGTC_2967|Compound:9089538|FD-Score:4.47|P-value:5.13E-6 ID:SGTC_2981|Compound:9013952|FD-Score:6.00|P-value:1.14E-9 ID:SGTC_3054|Compound:9094397|FD-Score:-4.42|P-value:1.25E-6 ID:SGTC_3089|Compound:9117425|FD-Score:3.36|P-value:5.50E-4 ID:SGTC_3232|Compound:9132874|FD-Score:3.76|P-value:1.19E-4 ID:SGTC_4|Compound:0960-0234|FD-Score:4.52|P-value:4.22E-6 ID:SGTC_31|Compound:0508-1974|FD-Score:4.52|P-value:4.07E-6 ID:SGTC_94|Compound:0334-0113|FD-Score:3.33|P-value:6.09E-4 ID:SGTC_128|Compound:0906-2981|FD-Score:4.04|P-value:3.65E-5 ID:SGTC_140|Compound:0062-0056|FD-Score:3.90|P-value:6.63E-5 ID:SGTC_194|Compound:1486-1323|FD-Score:3.51|P-value:3.11E-4 ID:SGTC_211|Compound:3455-0679|FD-Score:3.40|P-value:4.59E-4 ID:SGTC_218|Compound:alverine citrate|FD-Score:4.02|P-value:3.96E-5 ID:SGTC_257|Compound:daunorubicin|FD-Score:3.42|P-value:4.36E-4 ID:SGTC_285|Compound:1486-1325|FD-Score:3.19|P-value:9.76E-4 ID:SGTC_290|Compound:2043-6722|FD-Score:3.76|P-value:1.16E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:-3.56|P-value:6.33E-5 ID:SGTC_389|Compound:tpck|FD-Score:3.64|P-value:1.88E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:4.64|P-value:2.34E-6 ID:SGTC_452|Compound:diindolylmethane|FD-Score:3.62|P-value:2.01E-4 ID:SGTC_466|Compound:geldanamycin|FD-Score:3.41|P-value:4.54E-4 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:3.38|P-value:5.08E-4 ID:SGTC_601|Compound:0986-0029|FD-Score:3.57|P-value:2.50E-4 ID:SGTC_603|Compound:3794-0023|FD-Score:3.57|P-value:2.43E-4 ID:SGTC_631|Compound:k072-0230|FD-Score:3.29|P-value:6.87E-4 ID:SGTC_646|Compound:4092-0839|FD-Score:4.24|P-value:1.51E-5 ID:SGTC_654|Compound:1124-0271|FD-Score:4.29|P-value:1.20E-5 ID:SGTC_713|Compound:1488-1073|FD-Score:3.20|P-value:9.39E-4 ID:SGTC_755|Compound:1995-0008|FD-Score:4.18|P-value:1.97E-5 ID:SGTC_765|Compound:1319-0117|FD-Score:3.91|P-value:6.40E-5 ID:SGTC_814|Compound:3342-0569|FD-Score:4.15|P-value:2.28E-5 ID:SGTC_821|Compound:1114-0266|FD-Score:3.38|P-value:4.96E-4 ID:SGTC_833|Compound:3852-0053|FD-Score:3.63|P-value:1.99E-4 ID:SGTC_889|Compound:0919-1524|FD-Score:3.91|P-value:6.26E-5 ID:SGTC_990|Compound:3985-0011|FD-Score:3.51|P-value:3.08E-4 ID:SGTC_1015|Compound:4130-4525|FD-Score:3.55|P-value:2.62E-4 ID:SGTC_1070|Compound:indatraline|FD-Score:5.20|P-value:1.25E-7 ID:SGTC_1098|Compound:clofazimine|FD-Score:4.77|P-value:1.18E-6 ID:SGTC_1103|Compound:duloxetine|FD-Score:4.38|P-value:8.07E-6 ID:SGTC_1239|Compound:0337-0584|FD-Score:3.31|P-value:6.41E-4 ID:SGTC_1254|Compound:0550-0035|FD-Score:3.67|P-value:1.66E-4 ID:SGTC_1341|Compound:1486-1360|FD-Score:3.27|P-value:7.56E-4 ID:SGTC_1358|Compound:1509-0022|FD-Score:3.23|P-value:8.73E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:4.08|P-value:3.09E-5 ID:SGTC_1375|Compound:2910-0797|FD-Score:4.62|P-value:2.58E-6 ID:SGTC_1496|Compound:4469-0713|FD-Score:3.87|P-value:7.42E-5 ID:SGTC_1521|Compound:st012942|FD-Score:3.34|P-value:5.86E-4 ID:SGTC_1535|Compound:tetrahydropapaveroline hydrobromide|FD-Score:3.98|P-value:4.68E-5 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:4.93|P-value:5.30E-7 ID:SGTC_1617|Compound:st002906|FD-Score:4.30|P-value:1.15E-5 ID:SGTC_1625|Compound:st003711|FD-Score:5.49|P-value:2.47E-8 ID:SGTC_1627|Compound:st003713|FD-Score:3.22|P-value:9.02E-4 ID:SGTC_1695|Compound:st026914|FD-Score:4.45|P-value:5.74E-6 ID:SGTC_1697|Compound:st025554|FD-Score:3.37|P-value:5.22E-4 ID:SGTC_1711|Compound:st032263|FD-Score:3.24|P-value:8.36E-4 ID:SGTC_1824|Compound:st053723|FD-Score:3.33|P-value:6.02E-4 ID:SGTC_1825|Compound:st052143|FD-Score:5.52|P-value:2.12E-8 ID:SGTC_1865|Compound:st057639|FD-Score:3.48|P-value:3.52E-4 ID:SGTC_1922|Compound:5578187|FD-Score:3.46|P-value:3.79E-4 ID:SGTC_1927|Compound:st060202|FD-Score:5.15|P-value:1.61E-7 ID:SGTC_1941|Compound:st076221|FD-Score:3.69|P-value:1.53E-4 ID:SGTC_1944|Compound:st076371|FD-Score:3.65|P-value:1.83E-4 ID:SGTC_1965|Compound:Pectolinarigenin|FD-Score:5.32|P-value:6.49E-8 ID:SGTC_1969|Compound:st069479|FD-Score:3.78|P-value:1.10E-4 ID:SGTC_1977|Compound:st070720|FD-Score:5.11|P-value:2.01E-7 ID:SGTC_1985|Compound:st071382|FD-Score:3.31|P-value:6.41E-4 ID:SGTC_1999|Compound:st074831|FD-Score:4.77|P-value:1.21E-6 ID:SGTC_2061|Compound:5245884|FD-Score:4.07|P-value:3.17E-5 ID:SGTC_2065|Compound:5221596|FD-Score:3.72|P-value:1.40E-4 ID:SGTC_2092|Compound:5303694|FD-Score:3.40|P-value:4.67E-4 ID:SGTC_2110|Compound:5483698|FD-Score:3.88|P-value:7.06E-5 ID:SGTC_2111|Compound:5486399|FD-Score:3.49|P-value:3.38E-4 ID:SGTC_2210|Compound:7115885|FD-Score:3.25|P-value:7.94E-4 ID:SGTC_2213|Compound:7173844|FD-Score:3.76|P-value:1.19E-4 ID:SGTC_2265|Compound:7929201|FD-Score:3.22|P-value:9.03E-4 ID:SGTC_2279|Compound:7948423|FD-Score:3.30|P-value:6.78E-4 ID:SGTC_2359|Compound:9039622|FD-Score:3.39|P-value:4.92E-4 ID:SGTC_2379|Compound:9035213|FD-Score:3.43|P-value:4.13E-4 ID:SGTC_2380|Compound:9035439|FD-Score:3.95|P-value:5.28E-5 ID:SGTC_2448|Compound:5185112|FD-Score:3.76|P-value:1.18E-4 ID:SGTC_2482|Compound:5981709|FD-Score:3.53|P-value:2.85E-4 ID:SGTC_2507|Compound:purpurin|FD-Score:3.37|P-value:5.19E-4 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:3.77|P-value:1.11E-4 ID:SGTC_2585|Compound:alliin|FD-Score:3.99|P-value:4.59E-5 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:4.03|P-value:3.86E-5 ID:SGTC_2623|Compound:humulene|FD-Score:3.53|P-value:2.88E-4 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:5.02|P-value:3.40E-7 ID:SGTC_2814|Compound:7977482|FD-Score:-2.85|P-value:9.69E-4 ID:SGTC_2823|Compound:7987624|FD-Score:4.53|P-value:3.88E-6 ID:SGTC_2826|Compound:7992541|FD-Score:3.20|P-value:9.50E-4 ID:SGTC_2828|Compound:7998861|FD-Score:3.33|P-value:6.07E-4 ID:SGTC_2836|Compound:9010338|FD-Score:4.91|P-value:5.82E-7 ID:SGTC_2967|Compound:9089538|FD-Score:4.47|P-value:5.13E-6 ID:SGTC_2981|Compound:9013952|FD-Score:6.00|P-value:1.14E-9 ID:SGTC_3054|Compound:9094397|FD-Score:-4.42|P-value:1.25E-6 ID:SGTC_3089|Compound:9117425|FD-Score:3.36|P-value:5.50E-4 ID:SGTC_3232|Compound:9132874|FD-Score:3.76|P-value:1.19E-4

Top fitness defect scores for YBR001C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2981 9013952 6.00 39.0 µM 1.14E-9 13 9.91E-10
2 SGTC_1825 st052143 5.52 62.6 µM 2.12E-8 4 1.73E-8
3 SGTC_1625 st003711 5.49 30.1 µM 2.47E-8 calcium & mitochondrial duress 13 2.01E-8
4 SGTC_1965 Pectolinarigenin 5.32 58.4 µM 6.49E-8 RPP1 & pyrimidine depletion 5 5.19E-8
5 SGTC_1070 indatraline 5.20 8.8 µM 1.25E-7 60S ribosome export 9 9.92E-8
6 SGTC_1927 st060202 5.15 13.8 µM 1.61E-7 10 1.27E-7
7 SGTC_1977 st070720 5.11 65.3 µM 2.01E-7 1 1.58E-7
8 SGTC_2626 ethyl orsellinate 5.02 100.0 µM 3.40E-7 14 2.64E-7
9 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 4.93 66.5 µM 5.30E-7 8 4.09E-7
10 SGTC_2836 9010338 4.91 19.5 µM 5.82E-7 RPP1 & pyrimidine depletion 12 4.48E-7
11 SGTC_1098 clofazimine 4.77 15.1 µM 1.18E-6 heme biosynthesis & mitochondrial translocase 8 9.01E-7
12 SGTC_1999 st074831 4.77 12.5 µM 1.21E-6 plasma membrane duress 17 9.24E-7
13 SGTC_451 chloral hydrate 4.64 100.0 µM 2.34E-6 30 1.77E-6
14 SGTC_1375 2910-0797 4.62 186.0 µM 2.58E-6 15 1.94E-6
15 SGTC_2823 7987624 4.53 58.4 µM 3.88E-6 15 2.91E-6
16 SGTC_31 0508-1974 4.52 57.2 µM 4.07E-6 17 3.05E-6
17 SGTC_4 0960-0234 4.52 25.7 µM 4.22E-6 Golgi 6 3.16E-6
18 SGTC_2967 9089538 4.47 49.9 µM 5.13E-6 21 3.83E-6
19 SGTC_1695 st026914 4.45 34.5 µM 5.74E-6 8 4.28E-6
20 SGTC_1103 duloxetine 4.38 36.1 µM 8.07E-6 20 6.00E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.090 1.78E-7 YLR132C USB1 het Putative phosphodiesterase specific for U6 snRNA 3' end modification; trims the 3' poly(u) tract to leave a terminal 3' phosphate; human homolog, hUSB1 (aka C16orf57) produces a 2',3' cyclic phosphate; mutations in hUSB1 are associated with a rare skin condition (OMIM 604173); essential protein that localizes to the nucleus and mitochondria; overexpression suppresses the respiratory defects of oxa1 and mtf2 mutants
0.076 9.46E-6 YNL155W YNL155W hom Protein of unknown function; contains a DHHC domain and an AN1-type zinc finger; predicted to have thiol-disulfide oxidoreductase active site; transcriptionally regulated by Rpn4p along with proteasome subunit genes; putative ortholog of human AIRAP, which stimulates proteasome activity in response to arsenic; protein abundance increases in response to DNA replication stress
0.075 1.20E-5 YBL032W HEK2 hom RNA binding protein involved in the asymmetric localization of ASH1 mRNA; represses translation of ASH1 mRNA, an effect reversed by Yck1p-dependent phosphoryation; regulates telomere position effect and length; similarity to hnRNP-K
0.070 5.20E-5 YGR204W ADE3 hom Cytoplasmic trifunctional enzyme C1-tetrahydrofolate synthase, involved in single carbon metabolism and required for biosynthesis of purines, thymidylate, methionine, and histidine; null mutation causes auxotrophy for adenine and histidine
0.067 9.59E-5 YPL163C SVS1 hom Cell wall and vacuolar protein; required for wild-type resistance to vanadate; SVS1 has a paralog, SRL1, that arose from the whole genome duplication
0.067 1.01E-4 YBR212W NGR1 hom RNA binding protein that negatively regulates growth rate; interacts with the 3' UTR of the mitochondrial porin (POR1) mRNA and enhances its degradation; overexpression impairs mitochondrial function; interacts with Dhh1p to mediate POR1 mRNA decay; expressed in stationary phase
0.065 1.55E-4 YPL110C GDE1 hom Glycerophosphocholine (GroPCho) phosphodiesterase; hydrolyzes GroPCho to choline and glycerolphosphate, for use as a phosphate source and as a precursor for phosphocholine synthesis; may interact with ribosomes
0.065 1.59E-4 YLR003C CMS1 hom Putative subunit of the 90S preribosome processome complex; overexpression rescues supressor mutant of mcm10; null mutant is viable; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.065 1.70E-4 YOR142W LSC1 hom Alpha subunit of succinyl-CoA ligase, which is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate; phosphorylated
0.065 1.78E-4 YER081W SER3 hom 3-phosphoglycerate dehydrogenase; catalyzes the first step in serine and glycine biosynthesis; SER3 has a paralog, SER33, that arose from the whole genome duplication
0.064 2.29E-4 YOL164W-A_p YOL164W-A_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR
0.063 2.39E-4 YER078C ICP55 hom Mitochondrial aminopeptidase; cleaves the N termini of at least 38 imported proteins after cleavage by the mitochondrial processing peptidase (MPP), thereby increasing their stability; member of the aminopeptidase P family
0.063 2.43E-4 YEL034W HYP2 het Translation elongation factor eIF-5A; may function in translation initiation; structural homolog of bacterial EF-P; undergoes an essential hypusination modification; HYP2 has a paralog, ANB1, that arose from the whole genome duplication
0.063 2.54E-4 YOR222W ODC2 hom Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for use in lysine and glutamate biosynthesis and in lysine catabolism
0.062 3.53E-4 YNL116W DMA2 hom Ubiquitin-protein ligase (E3); controls septin dynamics and the spindle position checkpoint (SPOC) along with functionally redundant ligase Dma1p by regulating the recruitment of Elm1p to the bud neck; regulates levels of the translation initiation factor eIF2 subunit Gcd11p, as well as abundance, localization, and ubiquitination of Cdk inhibitory kinase Swe1p; ortholog of human RNF8 protein, with sequence similarity to human Chfr; contains FHA and RING finger domains