YBR004C / GPI18

Functional ortholog of human PIG-V, which is a mannosyltransferase that transfers the second mannose in glycosylphosphatidylinositol biosynthesis; the authentic, non-tagged protein was localized to mitochondria

Zygosity: Heterozygous strain
fixedexpanded
Profile for YBR004C / GPI18

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:4.76|P-value:5.78E-7 ID:SGTC_19|Compound:0279-0214|FD-Score:4.08|P-value:1.58E-5 ID:SGTC_44|Compound:0929-0055|FD-Score:3.51|P-value:1.78E-4 ID:SGTC_50|Compound:0929-0078|FD-Score:3.45|P-value:2.27E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:4.94|P-value:2.11E-7 ID:SGTC_131|Compound:0141-0277|FD-Score:3.74|P-value:7.03E-5 ID:SGTC_151|Compound:3013-0144|FD-Score:-3.61|P-value:7.32E-5 ID:SGTC_173|Compound:1273-0061|FD-Score:3.47|P-value:2.10E-4 ID:SGTC_186|Compound:3455-3465|FD-Score:3.05|P-value:9.94E-4 ID:SGTC_195|Compound:4234-0266|FD-Score:5.15|P-value:6.69E-8 ID:SGTC_386|Compound:1509-0011|FD-Score:4.13|P-value:1.27E-5 ID:SGTC_435|Compound:c-PAF|FD-Score:-2.94|P-value:9.39E-4 ID:SGTC_534|Compound:k292-0788|FD-Score:3.17|P-value:6.38E-4 ID:SGTC_551|Compound:k048-0028|FD-Score:4.17|P-value:1.04E-5 ID:SGTC_576|Compound:1073-0113|FD-Score:3.21|P-value:5.49E-4 ID:SGTC_648|Compound:0375-0473|FD-Score:3.29|P-value:4.08E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:4.51|P-value:1.99E-6 ID:SGTC_700|Compound:3453-2283|FD-Score:3.10|P-value:8.08E-4 ID:SGTC_705|Compound:1124-0212|FD-Score:-3.07|P-value:5.93E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:4.20|P-value:8.91E-6 ID:SGTC_767|Compound:0929-0023|FD-Score:3.31|P-value:3.79E-4 ID:SGTC_818|Compound:4072-2707|FD-Score:-2.98|P-value:8.12E-4 ID:SGTC_923|Compound:1900-2434|FD-Score:3.61|P-value:1.17E-4 ID:SGTC_948|Compound:3448-0295|FD-Score:4.48|P-value:2.34E-6 ID:SGTC_953|Compound:1188-0045|FD-Score:-3.07|P-value:6.06E-4 ID:SGTC_958|Compound:1222-0007|FD-Score:-3.00|P-value:7.61E-4 ID:SGTC_964|Compound:1287-0107|FD-Score:4.10|P-value:1.44E-5 ID:SGTC_966|Compound:1300-0360|FD-Score:-4.16|P-value:6.33E-6 ID:SGTC_1028|Compound:k015-0029|FD-Score:3.16|P-value:6.65E-4 ID:SGTC_1141|Compound:3253-0389|FD-Score:4.04|P-value:1.92E-5 ID:SGTC_1150|Compound:3909-7983|FD-Score:3.62|P-value:1.14E-4 ID:SGTC_1176|Compound:0848-0131|FD-Score:3.17|P-value:6.37E-4 ID:SGTC_1190|Compound:1486-1332|FD-Score:3.44|P-value:2.32E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:4.49|P-value:2.27E-6 ID:SGTC_1248|Compound:0469-0687|FD-Score:4.68|P-value:8.71E-7 ID:SGTC_1249|Compound:0481-0015|FD-Score:4.69|P-value:8.17E-7 ID:SGTC_1251|Compound:0490-5699|FD-Score:4.36|P-value:4.16E-6 ID:SGTC_1289|Compound:0976-0073|FD-Score:3.20|P-value:5.75E-4 ID:SGTC_1385|Compound:3091-4834|FD-Score:3.40|P-value:2.70E-4 ID:SGTC_1452|Compound:4194-0072|FD-Score:4.74|P-value:6.38E-7 ID:SGTC_1466|Compound:k213-0079|FD-Score:3.94|P-value:2.90E-5 ID:SGTC_1472|Compound:k841-0093|FD-Score:3.20|P-value:5.80E-4 ID:SGTC_1484|Compound:3473-2379|FD-Score:3.30|P-value:3.98E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:3.16|P-value:6.51E-4 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:3.35|P-value:3.32E-4 ID:SGTC_1534|Compound:6-azauridine|FD-Score:4.61|P-value:1.25E-6 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:3.98|P-value:2.50E-5 ID:SGTC_1667|Compound:st014849|FD-Score:3.05|P-value:9.69E-4 ID:SGTC_1742|Compound:st038235|FD-Score:4.41|P-value:3.39E-6 ID:SGTC_1768|Compound:st044301|FD-Score:3.72|P-value:7.63E-5 ID:SGTC_1799|Compound:st045822|FD-Score:5.76|P-value:1.82E-9 ID:SGTC_1828|Compound:st055811|FD-Score:3.92|P-value:3.20E-5 ID:SGTC_1841|Compound:st054148|FD-Score:5.37|P-value:1.86E-8 ID:SGTC_1861|Compound:st057647|FD-Score:3.05|P-value:9.92E-4 ID:SGTC_1871|Compound:st057448|FD-Score:3.29|P-value:4.05E-4 ID:SGTC_1881|Compound:5652484|FD-Score:3.99|P-value:2.38E-5 ID:SGTC_1882|Compound:5615643|FD-Score:3.35|P-value:3.32E-4 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:4.05|P-value:1.80E-5 ID:SGTC_1917|Compound:st066507|FD-Score:-3.95|P-value:1.67E-5 ID:SGTC_1921|Compound:5740136|FD-Score:5.35|P-value:2.14E-8 ID:SGTC_1930|Compound:st074634|FD-Score:4.89|P-value:2.88E-7 ID:SGTC_1939|Compound:st074455|FD-Score:4.82|P-value:4.04E-7 ID:SGTC_1945|Compound:st075991|FD-Score:3.09|P-value:8.53E-4 ID:SGTC_1961|Compound:st076550|FD-Score:5.10|P-value:8.98E-8 ID:SGTC_1966|Compound:st070145|FD-Score:3.82|P-value:4.99E-5 ID:SGTC_2002|Compound:4023503|FD-Score:4.07|P-value:1.66E-5 ID:SGTC_2060|Compound:5238662|FD-Score:3.78|P-value:5.86E-5 ID:SGTC_2086|Compound:5274770|FD-Score:5.37|P-value:1.90E-8 ID:SGTC_2141|Compound:5621638|FD-Score:-3.39|P-value:1.76E-4 ID:SGTC_2142|Compound:5622915|FD-Score:3.22|P-value:5.29E-4 ID:SGTC_2152|Compound:5568786|FD-Score:3.91|P-value:3.30E-5 ID:SGTC_2164|Compound:5685496|FD-Score:4.13|P-value:1.26E-5 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:3.80|P-value:5.45E-5 ID:SGTC_2171|Compound:5739187|FD-Score:3.57|P-value:1.40E-4 ID:SGTC_2231|Compound:micatex|FD-Score:5.09|P-value:9.60E-8 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.45|P-value:2.26E-4 ID:SGTC_2375|Compound:9072683|FD-Score:4.49|P-value:2.24E-6 ID:SGTC_2390|Compound:9097792|FD-Score:3.89|P-value:3.70E-5 ID:SGTC_2513|Compound:baicalein|FD-Score:3.08|P-value:8.76E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-3.50|P-value:1.16E-4 ID:SGTC_2569|Compound:tetrandrine|FD-Score:3.83|P-value:4.78E-5 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:4.37|P-value:4.03E-6 ID:SGTC_2639|Compound:lactacystin|FD-Score:4.43|P-value:2.95E-6 ID:SGTC_2728|Compound:chlorpromazine|FD-Score:3.88|P-value:3.77E-5 ID:SGTC_2729|Compound:fluphenazine|FD-Score:5.30|P-value:2.83E-8 ID:SGTC_2761|Compound:levamisole|FD-Score:3.29|P-value:4.14E-4 ID:SGTC_2770|Compound:toltrazuril|FD-Score:3.23|P-value:5.10E-4 ID:SGTC_2964|Compound:9083345|FD-Score:3.44|P-value:2.29E-4 ID:SGTC_3063|Compound:1327-0034|FD-Score:-3.02|P-value:7.04E-4 ID:SGTC_3091|Compound:9116372|FD-Score:4.13|P-value:1.23E-5 ID:SGTC_3117|Compound:9124945|FD-Score:3.41|P-value:2.63E-4 ID:SGTC_3337|Compound:9144342|FD-Score:3.18|P-value:6.13E-4 ID:SGTC_10|Compound:0279-0212|FD-Score:4.76|P-value:5.78E-7 ID:SGTC_19|Compound:0279-0214|FD-Score:4.08|P-value:1.58E-5 ID:SGTC_44|Compound:0929-0055|FD-Score:3.51|P-value:1.78E-4 ID:SGTC_50|Compound:0929-0078|FD-Score:3.45|P-value:2.27E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:4.94|P-value:2.11E-7 ID:SGTC_131|Compound:0141-0277|FD-Score:3.74|P-value:7.03E-5 ID:SGTC_151|Compound:3013-0144|FD-Score:-3.61|P-value:7.32E-5 ID:SGTC_173|Compound:1273-0061|FD-Score:3.47|P-value:2.10E-4 ID:SGTC_186|Compound:3455-3465|FD-Score:3.05|P-value:9.94E-4 ID:SGTC_195|Compound:4234-0266|FD-Score:5.15|P-value:6.69E-8 ID:SGTC_386|Compound:1509-0011|FD-Score:4.13|P-value:1.27E-5 ID:SGTC_435|Compound:c-PAF|FD-Score:-2.94|P-value:9.39E-4 ID:SGTC_534|Compound:k292-0788|FD-Score:3.17|P-value:6.38E-4 ID:SGTC_551|Compound:k048-0028|FD-Score:4.17|P-value:1.04E-5 ID:SGTC_576|Compound:1073-0113|FD-Score:3.21|P-value:5.49E-4 ID:SGTC_648|Compound:0375-0473|FD-Score:3.29|P-value:4.08E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:4.51|P-value:1.99E-6 ID:SGTC_700|Compound:3453-2283|FD-Score:3.10|P-value:8.08E-4 ID:SGTC_705|Compound:1124-0212|FD-Score:-3.07|P-value:5.93E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:4.20|P-value:8.91E-6 ID:SGTC_767|Compound:0929-0023|FD-Score:3.31|P-value:3.79E-4 ID:SGTC_818|Compound:4072-2707|FD-Score:-2.98|P-value:8.12E-4 ID:SGTC_923|Compound:1900-2434|FD-Score:3.61|P-value:1.17E-4 ID:SGTC_948|Compound:3448-0295|FD-Score:4.48|P-value:2.34E-6 ID:SGTC_953|Compound:1188-0045|FD-Score:-3.07|P-value:6.06E-4 ID:SGTC_958|Compound:1222-0007|FD-Score:-3.00|P-value:7.61E-4 ID:SGTC_964|Compound:1287-0107|FD-Score:4.10|P-value:1.44E-5 ID:SGTC_966|Compound:1300-0360|FD-Score:-4.16|P-value:6.33E-6 ID:SGTC_1028|Compound:k015-0029|FD-Score:3.16|P-value:6.65E-4 ID:SGTC_1141|Compound:3253-0389|FD-Score:4.04|P-value:1.92E-5 ID:SGTC_1150|Compound:3909-7983|FD-Score:3.62|P-value:1.14E-4 ID:SGTC_1176|Compound:0848-0131|FD-Score:3.17|P-value:6.37E-4 ID:SGTC_1190|Compound:1486-1332|FD-Score:3.44|P-value:2.32E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:4.49|P-value:2.27E-6 ID:SGTC_1248|Compound:0469-0687|FD-Score:4.68|P-value:8.71E-7 ID:SGTC_1249|Compound:0481-0015|FD-Score:4.69|P-value:8.17E-7 ID:SGTC_1251|Compound:0490-5699|FD-Score:4.36|P-value:4.16E-6 ID:SGTC_1289|Compound:0976-0073|FD-Score:3.20|P-value:5.75E-4 ID:SGTC_1385|Compound:3091-4834|FD-Score:3.40|P-value:2.70E-4 ID:SGTC_1452|Compound:4194-0072|FD-Score:4.74|P-value:6.38E-7 ID:SGTC_1466|Compound:k213-0079|FD-Score:3.94|P-value:2.90E-5 ID:SGTC_1472|Compound:k841-0093|FD-Score:3.20|P-value:5.80E-4 ID:SGTC_1484|Compound:3473-2379|FD-Score:3.30|P-value:3.98E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:3.16|P-value:6.51E-4 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:3.35|P-value:3.32E-4 ID:SGTC_1534|Compound:6-azauridine|FD-Score:4.61|P-value:1.25E-6 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:3.98|P-value:2.50E-5 ID:SGTC_1667|Compound:st014849|FD-Score:3.05|P-value:9.69E-4 ID:SGTC_1742|Compound:st038235|FD-Score:4.41|P-value:3.39E-6 ID:SGTC_1768|Compound:st044301|FD-Score:3.72|P-value:7.63E-5 ID:SGTC_1799|Compound:st045822|FD-Score:5.76|P-value:1.82E-9 ID:SGTC_1828|Compound:st055811|FD-Score:3.92|P-value:3.20E-5 ID:SGTC_1841|Compound:st054148|FD-Score:5.37|P-value:1.86E-8 ID:SGTC_1861|Compound:st057647|FD-Score:3.05|P-value:9.92E-4 ID:SGTC_1871|Compound:st057448|FD-Score:3.29|P-value:4.05E-4 ID:SGTC_1881|Compound:5652484|FD-Score:3.99|P-value:2.38E-5 ID:SGTC_1882|Compound:5615643|FD-Score:3.35|P-value:3.32E-4 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:4.05|P-value:1.80E-5 ID:SGTC_1917|Compound:st066507|FD-Score:-3.95|P-value:1.67E-5 ID:SGTC_1921|Compound:5740136|FD-Score:5.35|P-value:2.14E-8 ID:SGTC_1930|Compound:st074634|FD-Score:4.89|P-value:2.88E-7 ID:SGTC_1939|Compound:st074455|FD-Score:4.82|P-value:4.04E-7 ID:SGTC_1945|Compound:st075991|FD-Score:3.09|P-value:8.53E-4 ID:SGTC_1961|Compound:st076550|FD-Score:5.10|P-value:8.98E-8 ID:SGTC_1966|Compound:st070145|FD-Score:3.82|P-value:4.99E-5 ID:SGTC_2002|Compound:4023503|FD-Score:4.07|P-value:1.66E-5 ID:SGTC_2060|Compound:5238662|FD-Score:3.78|P-value:5.86E-5 ID:SGTC_2086|Compound:5274770|FD-Score:5.37|P-value:1.90E-8 ID:SGTC_2141|Compound:5621638|FD-Score:-3.39|P-value:1.76E-4 ID:SGTC_2142|Compound:5622915|FD-Score:3.22|P-value:5.29E-4 ID:SGTC_2152|Compound:5568786|FD-Score:3.91|P-value:3.30E-5 ID:SGTC_2164|Compound:5685496|FD-Score:4.13|P-value:1.26E-5 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:3.80|P-value:5.45E-5 ID:SGTC_2171|Compound:5739187|FD-Score:3.57|P-value:1.40E-4 ID:SGTC_2231|Compound:micatex|FD-Score:5.09|P-value:9.60E-8 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.45|P-value:2.26E-4 ID:SGTC_2375|Compound:9072683|FD-Score:4.49|P-value:2.24E-6 ID:SGTC_2390|Compound:9097792|FD-Score:3.89|P-value:3.70E-5 ID:SGTC_2513|Compound:baicalein|FD-Score:3.08|P-value:8.76E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-3.50|P-value:1.16E-4 ID:SGTC_2569|Compound:tetrandrine|FD-Score:3.83|P-value:4.78E-5 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:4.37|P-value:4.03E-6 ID:SGTC_2639|Compound:lactacystin|FD-Score:4.43|P-value:2.95E-6 ID:SGTC_2728|Compound:chlorpromazine|FD-Score:3.88|P-value:3.77E-5 ID:SGTC_2729|Compound:fluphenazine|FD-Score:5.30|P-value:2.83E-8 ID:SGTC_2761|Compound:levamisole|FD-Score:3.29|P-value:4.14E-4 ID:SGTC_2770|Compound:toltrazuril|FD-Score:3.23|P-value:5.10E-4 ID:SGTC_2964|Compound:9083345|FD-Score:3.44|P-value:2.29E-4 ID:SGTC_3063|Compound:1327-0034|FD-Score:-3.02|P-value:7.04E-4 ID:SGTC_3091|Compound:9116372|FD-Score:4.13|P-value:1.23E-5 ID:SGTC_3117|Compound:9124945|FD-Score:3.41|P-value:2.63E-4 ID:SGTC_3337|Compound:9144342|FD-Score:3.18|P-value:6.13E-4

Top fitness defect scores for YBR004C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1799 st045822 5.76 46.1 µM 1.82E-9 1 4.30E-9 1.76
2 SGTC_1841 st054148 5.37 70.0 µM 1.86E-8 1 3.85E-8 0.71
3 SGTC_2086 5274770 5.37 176.6 µM 1.90E-8 4 3.93E-8 0.56
4 SGTC_1921 5740136 5.35 50.0 µM 2.14E-8 TRP & mitochondrial translation 8 4.39E-8 0.97
5 SGTC_2729 fluphenazine 5.30 10.7 µM 2.83E-8 3 5.73E-8 0.63
6 SGTC_195 4234-0266 5.15 16.6 µM 6.69E-8 7 1.29E-7 0.79
7 SGTC_1961 st076550 5.10 68.7 µM 8.98E-8 3 1.70E-7 0.47
8 SGTC_2231 micatex 5.09 6.8 µM 9.60E-8 2 1.82E-7 0.48
9 SGTC_68 0986-0284 4.94 82.8 µM 2.11E-7 5 3.83E-7 0.14
10 SGTC_1930 st074634 4.89 34.3 µM 2.88E-7 RNA pol III & RNase P/MRP 11 5.12E-7 0.17
11 SGTC_1939 st074455 4.82 53.6 µM 4.04E-7 3 7.06E-7 0.51
12 SGTC_10 0279-0212 4.76 42.6 µM 5.78E-7 TRP & mitochondrial translation 5 9.91E-7 0.46
13 SGTC_1452 4194-0072 4.74 190.0 µM 6.38E-7 2 1.09E-6 0.74
14 SGTC_1249 0481-0015 4.69 10.2 µM 8.17E-7 3 1.37E-6 0.07
15 SGTC_1248 0469-0687 4.68 58.6 µM 8.71E-7 6 1.46E-6 0.37
16 SGTC_1534 6-azauridine 4.61 81.6 µM 1.25E-6 RNA pol III & RNase P/MRP 4 2.06E-6 0.29
17 SGTC_691 1548-0686 4.51 185.0 µM 1.99E-6 6 3.19E-6 0.06
18 SGTC_2375 9072683 4.49 200.0 µM 2.24E-6 mitochondrial processes 4 3.58E-6 0.50
19 SGTC_1246 0422-0085 4.49 105.0 µM 2.27E-6 4 3.62E-6 0.05
20 SGTC_948 3448-0295 4.48 75.3 µM 2.34E-6 8 3.72E-6 0.49

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.256 3.91E-51 YBR002C RER2 het Cis-prenyltransferase involved in dolichol synthesis; participates in endoplasmic reticulum (ER) protein sorting
0.164 1.56E-21 YLR149C YLR149C hom Protein of unknown function; overexpression causes a cell cycle delay or arrest; null mutation results in a decrease in plasma membrane electron transport; YLR149C is not an essential gene; protein abundance increases in response to DNA replication stress
0.161 8.31E-21 YIL026C IRR1 het Subunit of the cohesin complex, which is required for sister chromatid cohesion during mitosis and meiosis and interacts with centromeres and chromosome arms, essential for viability
0.156 1.39E-19 YDL193W NUS1 het Putative prenyltransferase, required for cell viability; proposed to be involved in protein trafficking because tet-repressible mutant shows accumulation of hypoglycosylated forms of CPY
0.151 1.23E-18 YBR251W MRPS5 hom Mitochondrial ribosomal protein of the small subunit
0.149 3.93E-18 YIL060W_p YIL060W_p hom Putative protein of unknown function; mutant accumulates less glycogen than does wild type; null mutation results in a decrease in plasma membrane electron transport; YIL060W is not an essential gene
0.144 5.76E-17 YER087W AIM10 hom Protein with similarity to tRNA synthetases; non-tagged protein is detected in purified mitochondria; null mutant is viable and displays elevated frequency of mitochondrial genome loss
0.143 8.07E-17 YGL064C MRH4 hom Mitochondrial ATP-dependent RNA helicase of the DEAD-box family, plays an essential role in mitochondrial function
0.140 4.55E-16 YKL138C MRPL31 hom Mitochondrial ribosomal protein of the large subunit
0.137 1.67E-15 YDR332W IRC3 hom Putative RNA helicase of the DEAH/D-box family; null mutant displays increased levels of spontaneous Rad52p foci; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion
0.137 1.85E-15 YDR509W_d YDR509W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.135 4.65E-15 YLR439W MRPL4 hom Mitochondrial ribosomal protein of the large subunit, homolog of prokaryotic L29 ribosomal protein; located at the ribosomal tunnel exit
0.133 1.39E-14 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.133 1.25E-14 YDR210W_p YDR210W_p hom Predicted tail-anchored plasma membrane protein containing a conserved CYSTM module; related proteins in other organisms may be involved in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.133 1.26E-14 YCR003W MRPL32 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress