YBR005W / RCR1

Protein of the ER membrane involved in cell wall chitin deposition; may function in the endosomal-vacuolar trafficking pathway, helping determine whether plasma membrane proteins are degraded or routed to the plasma membrane; RCR1 has a paralog, RCR2, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR005W / RCR1

Click on Significant Values for Screen Details ID:SGTC_143|Compound:4032-1194|FD-Score:-3.11|P-value:8.94E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:-4.25|P-value:9.12E-6 ID:SGTC_350|Compound:k064-0020|FD-Score:4.11|P-value:1.23E-5 ID:SGTC_538|Compound:2922-0838|FD-Score:-3.70|P-value:9.79E-5 ID:SGTC_567|Compound:1080-0542|FD-Score:-3.56|P-value:1.72E-4 ID:SGTC_643|Compound:k048-0106|FD-Score:-5.00|P-value:2.22E-7 ID:SGTC_645|Compound:0845-0943|FD-Score:3.13|P-value:6.39E-4 ID:SGTC_655|Compound:k060-0012|FD-Score:3.79|P-value:5.00E-5 ID:SGTC_819|Compound:1013-0258|FD-Score:4.86|P-value:3.19E-7 ID:SGTC_823|Compound:0417-1665|FD-Score:-3.08|P-value:9.95E-4 ID:SGTC_824|Compound:1304-0008|FD-Score:3.85|P-value:3.90E-5 ID:SGTC_826|Compound:1683-5028|FD-Score:-6.13|P-value:2.95E-10 ID:SGTC_863|Compound:0466-0191|FD-Score:-3.41|P-value:3.07E-4 ID:SGTC_992|Compound:3909-8734|FD-Score:3.86|P-value:3.76E-5 ID:SGTC_995|Compound:3931-2021|FD-Score:-3.95|P-value:3.49E-5 ID:SGTC_997|Compound:3996-0078|FD-Score:4.35|P-value:4.07E-6 ID:SGTC_1134|Compound:3477-0009|FD-Score:4.46|P-value:2.45E-6 ID:SGTC_1226|Compound:3909-7979|FD-Score:-3.76|P-value:7.56E-5 ID:SGTC_1390|Compound:3413-2614|FD-Score:4.25|P-value:6.53E-6 ID:SGTC_1484|Compound:3473-2379|FD-Score:-3.43|P-value:2.81E-4 ID:SGTC_1539|Compound:benzyladenosine|FD-Score:3.74|P-value:6.08E-5 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:4.42|P-value:2.91E-6 ID:SGTC_1825|Compound:st052143|FD-Score:-3.19|P-value:6.77E-4 ID:SGTC_1847|Compound:st056231|FD-Score:4.53|P-value:1.71E-6 ID:SGTC_1850|Compound:st056238|FD-Score:-3.82|P-value:6.05E-5 ID:SGTC_1922|Compound:5578187|FD-Score:-3.66|P-value:1.16E-4 ID:SGTC_1938|Compound:st074717|FD-Score:-4.25|P-value:9.02E-6 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:-3.57|P-value:1.66E-4 ID:SGTC_2473|Compound:5854593|FD-Score:3.53|P-value:1.46E-4 ID:SGTC_2999|Compound:9069765|FD-Score:4.12|P-value:1.21E-5 ID:SGTC_3016|Compound:9080866|FD-Score:-3.09|P-value:9.59E-4 ID:SGTC_3093|Compound:9117344|FD-Score:3.39|P-value:2.52E-4 ID:SGTC_143|Compound:4032-1194|FD-Score:-3.11|P-value:8.94E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:-4.25|P-value:9.12E-6 ID:SGTC_350|Compound:k064-0020|FD-Score:4.11|P-value:1.23E-5 ID:SGTC_538|Compound:2922-0838|FD-Score:-3.70|P-value:9.79E-5 ID:SGTC_567|Compound:1080-0542|FD-Score:-3.56|P-value:1.72E-4 ID:SGTC_643|Compound:k048-0106|FD-Score:-5.00|P-value:2.22E-7 ID:SGTC_645|Compound:0845-0943|FD-Score:3.13|P-value:6.39E-4 ID:SGTC_655|Compound:k060-0012|FD-Score:3.79|P-value:5.00E-5 ID:SGTC_819|Compound:1013-0258|FD-Score:4.86|P-value:3.19E-7 ID:SGTC_823|Compound:0417-1665|FD-Score:-3.08|P-value:9.95E-4 ID:SGTC_824|Compound:1304-0008|FD-Score:3.85|P-value:3.90E-5 ID:SGTC_826|Compound:1683-5028|FD-Score:-6.13|P-value:2.95E-10 ID:SGTC_863|Compound:0466-0191|FD-Score:-3.41|P-value:3.07E-4 ID:SGTC_992|Compound:3909-8734|FD-Score:3.86|P-value:3.76E-5 ID:SGTC_995|Compound:3931-2021|FD-Score:-3.95|P-value:3.49E-5 ID:SGTC_997|Compound:3996-0078|FD-Score:4.35|P-value:4.07E-6 ID:SGTC_1134|Compound:3477-0009|FD-Score:4.46|P-value:2.45E-6 ID:SGTC_1226|Compound:3909-7979|FD-Score:-3.76|P-value:7.56E-5 ID:SGTC_1390|Compound:3413-2614|FD-Score:4.25|P-value:6.53E-6 ID:SGTC_1484|Compound:3473-2379|FD-Score:-3.43|P-value:2.81E-4 ID:SGTC_1539|Compound:benzyladenosine|FD-Score:3.74|P-value:6.08E-5 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:4.42|P-value:2.91E-6 ID:SGTC_1825|Compound:st052143|FD-Score:-3.19|P-value:6.77E-4 ID:SGTC_1847|Compound:st056231|FD-Score:4.53|P-value:1.71E-6 ID:SGTC_1850|Compound:st056238|FD-Score:-3.82|P-value:6.05E-5 ID:SGTC_1922|Compound:5578187|FD-Score:-3.66|P-value:1.16E-4 ID:SGTC_1938|Compound:st074717|FD-Score:-4.25|P-value:9.02E-6 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:-3.57|P-value:1.66E-4 ID:SGTC_2473|Compound:5854593|FD-Score:3.53|P-value:1.46E-4 ID:SGTC_2999|Compound:9069765|FD-Score:4.12|P-value:1.21E-5 ID:SGTC_3016|Compound:9080866|FD-Score:-3.09|P-value:9.59E-4 ID:SGTC_3093|Compound:9117344|FD-Score:3.39|P-value:2.52E-4

Top fitness defect scores for YBR005W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_819 1013-0258 4.86 27.7 µM 3.19E-7 21 5.81E-7
2 SGTC_1847 st056231 4.53 15.0 µM 1.71E-6 22 2.92E-6
3 SGTC_1134 3477-0009 4.46 42.5 µM 2.45E-6 32 4.13E-6
4 SGTC_1565 sinapyl alcohol 4.42 95.1 µM 2.91E-6 20 4.87E-6
5 SGTC_997 3996-0078 4.35 137.0 µM 4.07E-6 12 6.73E-6
6 SGTC_1390 3413-2614 4.25 145.0 µM 6.53E-6 fatty acid desaturase (OLE1) 18 1.06E-5
7 SGTC_2999 9069765 4.12 71.4 µM 1.21E-5 amide catabolism 21 1.91E-5
8 SGTC_350 k064-0020 4.11 19.8 µM 1.23E-5 heme requiring 26 1.95E-5
9 SGTC_992 3909-8734 3.86 162.0 µM 3.76E-5 23 5.70E-5
10 SGTC_824 1304-0008 3.85 100.0 µM 3.90E-5 DNA damage response 41 5.91E-5
11 SGTC_655 k060-0012 3.79 42.0 µM 5.00E-5 13 7.51E-5
12 SGTC_1539 benzyladenosine 3.74 56.0 µM 6.08E-5 21 9.06E-5
13 SGTC_2473 5854593 3.53 8.9 µM 1.46E-4 21 2.10E-4
14 SGTC_3093 9117344 3.39 49.5 µM 2.52E-4 60S ribosome export 35 3.55E-4
15 SGTC_645 0845-0943 3.13 5.4 µM 6.39E-4 60S ribosome export 35 8.68E-4
16 SGTC_3287 9117173 3.00 37.1 µM 0.00101 60S ribosome export 20 0.00135
17 SGTC_3203 9113543 2.96 49.5 µM 0.00118 89 0.00156
18 SGTC_402 epigallocatechin gallate 2.93 10.0 µM 0.00128 86 0.00169
19 SGTC_1571 st070080 2.91 73.4 µM 0.00136 62 0.00179
20 SGTC_2083 5306046 2.91 65.9 µM 0.00139 85 0.00183

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.093 6.86E-8 YMR031C EIS1 hom Component of the eisosome required for proper eisosome assembly; similarity to Ykl050cp and Uso1p; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; protein increases in abundance and relocalizes from plasma membrane to cytoplasm upon DNA replication stress
0.084 1.18E-6 YJL175W_d YJL175W_d hom Dubious open reading frame unlikely to encode a functional protein; deletion confers resistance to cisplatin, hypersensitivity to 5-fluorouracil, and growth defect at high pH with high calcium; overlaps gene for SWI3 transcription factor
0.083 1.41E-6 YER186C_p YER186C_p hom Putative protein of unknown function
0.080 3.33E-6 YHR175W-A_p YHR175W-A_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR
0.080 3.74E-6 YER013W PRP22 het DEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase, associates with lariat intermediates before the second catalytic step of splicing; mediates ATP-dependent mRNA release from the spliceosome and unwinds RNA duplexes
0.074 1.58E-5 YGL058W RAD6 hom Ubiquitin-conjugating enzyme (E2), involved in postreplication repair (as a heterodimer with Rad18p), DSBR and checkpoint control (as a heterodimer with Bre1p), ubiquitin-mediated N-end rule protein degradation (as a heterodimer with Ubr1p
0.073 2.19E-5 YAL037W_p YAL037W_p hom Putative protein of unknown function; YAL037W has a paralog, YOR342C, that arose from the whole genome duplication
0.073 2.38E-5 YPL098C MGR2 hom Subunit of the TIM23 translocase complex; acts to couple Tim21p with the core Tim23 translocase; absolutely required for mitochondrial import of presequence-containing proteins at elevated temperature; required for viability of cells lacking the mitochondrial genome (petite-negative phenotype)
0.073 2.57E-5 YPL121C MEI5 hom Meiosis specific protein involved in DMC1-dependent meiotic recombination, forms heterodimer with Sae3p; proposed to be an assembly factor for Dmc1p
0.071 3.74E-5 YER118C SHO1 hom Transmembrane osmosensor involved in activation of the Cdc42p- and MAP kinase-dependent filamentous growth pathway and the high-osmolarity glycerol response pathway; phosphorylated by Hog1p; interacts with Pbs2p, Msb2p, Hkr1p, and Ste11p
0.069 5.97E-5 YLR125W_p YLR125W_p hom Putative protein of unknown function; mutant has decreased Ty3 transposition; YLR125W is not an essential gene
0.069 6.76E-5 YIR007W_p YIR007W_p hom Putative glycosidase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YIR007W is a non-essential gene
0.068 7.73E-5 YIL132C CSM2 hom Component of the Shu complex, which promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p function; structural analysis reveals a similar DNA-binding region in both Psy3p and Csm2p and that both regions work together to form a single DNA binding site; required for accurate chromosome segregation during meiosis
0.067 1.11E-4 YNL014W HEF3 hom Translational elongation factor EF-3; member of the ABC superfamily; stimulates EF-1 alpha-dependent binding of aminoacyl-tRNA by the ribosome; normally expressed in zinc deficient cells; HEF3 has a paralog, YEF3, that arose from the whole genome duplication
0.065 1.81E-4 YDL218W_p YDL218W_p hom Putative protein of unknown function; YDL218W transcription is regulated by Azf1p and induced by starvation and aerobic conditions; expression also induced in cells treated with the mycotoxin patulin