YBR007C / DSF2

Deletion suppressor of mpt5 mutation; relocalizes from bud neck to cytoplasm upon DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR007C / DSF2

Click on Significant Values for Screen Details

Top fitness defect scores for YBR007C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
1 SGTC_2841 9004761 8.65 39.0 µM 4.85E-17 amide catabolism 3 2.47E-18
2 SGTC_1021 4476-0760 8.23 85.3 µM 1.40E-15 1 9.38E-17
3 SGTC_1511 0906-3109 7.35 28.5 µM 8.93E-13 excess fatty acid 9 1.02E-13
4 SGTC_975 1335-0046 7.34 28.5 µM 9.67E-13 RPP1 & pyrimidine depletion 1 1.11E-13
5 SGTC_558 k064-0027 7.17 21.3 µM 2.91E-12 DNA damage response 4 3.65E-13
6 SGTC_1068 loratadine 7.12 26.9 µM 4.08E-12 3 5.24E-13
7 SGTC_2970 9090938 6.99 41.9 µM 9.70E-12 RNA processing & uracil transport 3 1.34E-12
8 SGTC_251 melphalan 6.46 456.5 µM 2.93E-10 DNA damage response 5 5.34E-11
9 SGTC_1465 k213-0056 6.34 144.0 µM 5.86E-10 DNA intercalators 3 1.13E-10
10 SGTC_1263 0774-1208 6.10 64.8 µM 2.42E-9 6 5.24E-10
11 SGTC_1071 trifluoperazine 6.04 6.3 µM 3.39E-9 5 7.55E-10
12 SGTC_1471 k673-0312 5.77 37.0 µM 1.55E-8 RNA processing & uracil transport 5 3.89E-9
13 SGTC_1685 st024049 5.67 53.1 µM 2.70E-8 TSC3-RPN4 5 7.13E-9
14 SGTC_2645 abamectin 5.49 100.0 µM 7.12E-8 heme requiring 14 2.03E-8
15 SGTC_3200 9114385 5.45 49.5 µM 8.89E-8 7 2.58E-8
16 SGTC_3063 1327-0034 5.40 4.0 µM 1.10E-7 26 3.26E-8
17 SGTC_2165 5727197 5.35 32.1 µM 1.48E-7 16 4.49E-8
18 SGTC_918 glabranin 5.34 770.7 nM 1.57E-7 6 4.76E-8
19 SGTC_1443 4112-3303 5.27 14.0 µM 2.17E-7 2 6.79E-8
20 SGTC_3217 9129673 5.21 49.5 µM 2.98E-7 8 9.56E-8

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.083 1.31E-6 YOL088C MPD2 hom Member of the protein disulfide isomerase (PDI) family, exhibits chaperone activity; overexpression suppresses the lethality of a pdi1 deletion but does not complement all Pdi1p functions; undergoes oxidation by Ero1p
0.077 7.29E-6 YMR118C_p SHH3_p hom Putative mitochondrial inner membrane protein of unknown function; although similar to Sdh3p, Shh3p is not a stoichiometric subunit of either succinate dehydrogenase or of the TIM22 translocase
0.071 4.11E-5 YLR080W EMP46 hom Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport
0.069 5.79E-5 YNR019W ARE2 hom Acyl-CoA:sterol acyltransferase; endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the presence of oxygen; ARE2 has a paralog, ARE1, that arose from the whole genome duplication
0.069 6.03E-5 YKR087C OMA1 hom Metalloendopeptidase of the mitochondrial inner membrane; involved in turnover of membrane-embedded proteins; mediates degradation of Cox1p in coa2 mutant cells; member of a family of predicted membrane-bound metallopeptidases in prokaryotes and higher eukaryotes
0.067 1.13E-4 YML026C RPS18B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S18 and bacterial S13; RPS18B has a paralog, RPS18A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.065 1.59E-4 YBL078C ATG8 hom Component of autophagosomes and Cvt vesicles; unique ubiquitin-like protein whose conjugation target is the lipid phosphatidylethanolamine (PE); Atg8p-PE is anchored to membranes, is involved in phagophore expansion, and may mediate membrane fusion during autophagosome formation; deconjugation of Atg8p-PE is required for efficient autophagosome biogenesis
0.064 1.99E-4 YKL107W_p YKL107W_p hom Putative short-chain dehydrogenase/reductase; proposed to be a palmitoylated membrane protein
0.063 2.43E-4 YNR051C BRE5 hom Ubiquitin protease cofactor, forms deubiquitination complex with Ubp3p that coregulates anterograde and retrograde transport between the endoplasmic reticulum and Golgi compartments; null is sensitive to brefeldin A
0.063 2.87E-4 YNL130C-A_p DGR1_p hom Protein of unknown function; dgr1 null mutant is resistant to 2-deoxy-D-glucose
0.059 6.39E-4 YLR029C RPL15A het Ribosomal 60S subunit protein L15A; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L15, no bacterial homolog; RPL15A has a paralog, RPL15B, that arose from the whole genome duplication
0.057 9.08E-4 YBR279W PAF1 hom Component of the Paf1p complex involved in transcription elongation; binds to and modulates the activity of RNA polymerases I and II; required for expression of a subset of genes, including cell cycle-regulated genes; involved in SER3 repression by helping to maintain SRG1 transcription-dependent nucleosome occupancy; homolog of human PD2/hPAF1
0.057 9.96E-4 YFL034C-A RPL22B hom Ribosomal 60S subunit protein L22B; homologous to mammalian ribosomal protein L22, no bacterial homolog; RPL22B has a paralog, RPL22A, that arose from the whole genome duplication
0.057 0.00102 YLR031W_p YLR031W_p hom Putative protein of unknown function
0.055 0.00130 YIR001C SGN1 hom Cytoplasmic RNA-binding protein, contains an RNA recognition motif (RRM); may have a role in mRNA translation, as suggested by genetic interactions with genes encoding proteins involved in translational initiation