Deletion suppressor of mpt5 mutation; relocalizes from bud neck to cytoplasm upon DNA replication stress
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YBR007C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Correlation | pval | ORF | Gene | Zygosity | Description |
---|---|---|---|---|---|
0.083 | 1.31E-6 | YOL088C | MPD2 | hom | Member of the protein disulfide isomerase (PDI) family, exhibits chaperone activity; overexpression suppresses the lethality of a pdi1 deletion but does not complement all Pdi1p functions; undergoes oxidation by Ero1p |
0.077 | 7.29E-6 | YMR118C_p | SHH3_p | hom | Putative mitochondrial inner membrane protein of unknown function; although similar to Sdh3p, Shh3p is not a stoichiometric subunit of either succinate dehydrogenase or of the TIM22 translocase |
0.071 | 4.11E-5 | YLR080W | EMP46 | hom | Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport |
0.069 | 5.79E-5 | YNR019W | ARE2 | hom | Acyl-CoA:sterol acyltransferase; endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the presence of oxygen; ARE2 has a paralog, ARE1, that arose from the whole genome duplication |
0.069 | 6.03E-5 | YKR087C | OMA1 | hom | Metalloendopeptidase of the mitochondrial inner membrane; involved in turnover of membrane-embedded proteins; mediates degradation of Cox1p in coa2 mutant cells; member of a family of predicted membrane-bound metallopeptidases in prokaryotes and higher eukaryotes |
0.067 | 1.13E-4 | YML026C | RPS18B | hom | Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S18 and bacterial S13; RPS18B has a paralog, RPS18A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress |
0.065 | 1.59E-4 | YBL078C | ATG8 | hom | Component of autophagosomes and Cvt vesicles; unique ubiquitin-like protein whose conjugation target is the lipid phosphatidylethanolamine (PE); Atg8p-PE is anchored to membranes, is involved in phagophore expansion, and may mediate membrane fusion during autophagosome formation; deconjugation of Atg8p-PE is required for efficient autophagosome biogenesis |
0.064 | 1.99E-4 | YKL107W_p | YKL107W_p | hom | Putative short-chain dehydrogenase/reductase; proposed to be a palmitoylated membrane protein |
0.063 | 2.43E-4 | YNR051C | BRE5 | hom | Ubiquitin protease cofactor, forms deubiquitination complex with Ubp3p that coregulates anterograde and retrograde transport between the endoplasmic reticulum and Golgi compartments; null is sensitive to brefeldin A |
0.063 | 2.87E-4 | YNL130C-A_p | DGR1_p | hom | Protein of unknown function; dgr1 null mutant is resistant to 2-deoxy-D-glucose |
0.059 | 6.39E-4 | YLR029C | RPL15A | het | Ribosomal 60S subunit protein L15A; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L15, no bacterial homolog; RPL15A has a paralog, RPL15B, that arose from the whole genome duplication |
0.057 | 9.08E-4 | YBR279W | PAF1 | hom | Component of the Paf1p complex involved in transcription elongation; binds to and modulates the activity of RNA polymerases I and II; required for expression of a subset of genes, including cell cycle-regulated genes; involved in SER3 repression by helping to maintain SRG1 transcription-dependent nucleosome occupancy; homolog of human PD2/hPAF1 |
0.057 | 9.96E-4 | YFL034C-A | RPL22B | hom | Ribosomal 60S subunit protein L22B; homologous to mammalian ribosomal protein L22, no bacterial homolog; RPL22B has a paralog, RPL22A, that arose from the whole genome duplication |
0.057 | 0.00102 | YLR031W_p | YLR031W_p | hom | Putative protein of unknown function |
0.055 | 0.00130 | YIR001C | SGN1 | hom | Cytoplasmic RNA-binding protein, contains an RNA recognition motif (RRM); may have a role in mRNA translation, as suggested by genetic interactions with genes encoding proteins involved in translational initiation |