YBR008C / FLR1

Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; involved in efflux of fluconazole, diazaborine, benomyl, methotrexate, and other drugs; expression induced in cells treated with the mycotoxin patulin; relocalizes from nucleus to plasma membrane upon DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR008C / FLR1

Click on Significant Values for Screen Details ID:SGTC_89|Compound:0302-0250|FD-Score:3.12|P-value:4.72E-4 ID:SGTC_113|Compound:0099-0221|FD-Score:6.19|P-value:3.08E-11 ID:SGTC_139|Compound:0099-0334|FD-Score:3.80|P-value:2.95E-5 ID:SGTC_149|Compound:3970-0822|FD-Score:4.00|P-value:1.16E-5 ID:SGTC_168|Compound:3970-0862|FD-Score:6.81|P-value:3.36E-13 ID:SGTC_205|Compound:1486-1330|FD-Score:4.43|P-value:1.44E-6 ID:SGTC_210|Compound:3551-0445|FD-Score:3.81|P-value:2.73E-5 ID:SGTC_233|Compound:rapamycin|FD-Score:5.15|P-value:2.71E-8 ID:SGTC_379|Compound:3970-0972|FD-Score:4.41|P-value:1.55E-6 ID:SGTC_400|Compound:oxethazaine|FD-Score:4.32|P-value:2.45E-6 ID:SGTC_462|Compound:ag-879|FD-Score:-3.93|P-value:2.02E-5 ID:SGTC_470|Compound:aa-861|FD-Score:-3.04|P-value:7.58E-4 ID:SGTC_477|Compound:mead ethanolamide|FD-Score:-2.99|P-value:9.14E-4 ID:SGTC_524|Compound:r073-0010|FD-Score:5.11|P-value:3.33E-8 ID:SGTC_588|Compound:3970-1144|FD-Score:3.18|P-value:3.81E-4 ID:SGTC_694|Compound:1315-0438|FD-Score:3.24|P-value:2.98E-4 ID:SGTC_732|Compound:3970-1727|FD-Score:2.94|P-value:9.19E-4 ID:SGTC_774|Compound:k060-0086|FD-Score:3.01|P-value:7.18E-4 ID:SGTC_836|Compound:0330-0104|FD-Score:3.17|P-value:3.93E-4 ID:SGTC_849|Compound:0386-0493|FD-Score:2.92|P-value:9.77E-4 ID:SGTC_927|Compound:2425-1185|FD-Score:3.27|P-value:2.69E-4 ID:SGTC_990|Compound:3985-0011|FD-Score:7.66|P-value:3.20E-16 ID:SGTC_1103|Compound:duloxetine|FD-Score:3.69|P-value:4.73E-5 ID:SGTC_1131|Compound:3454-3128|FD-Score:3.51|P-value:9.97E-5 ID:SGTC_1174|Compound:0739-0097|FD-Score:3.12|P-value:4.82E-4 ID:SGTC_1186|Compound:1319-0216|FD-Score:3.57|P-value:7.95E-5 ID:SGTC_1203|Compound:3992-3522|FD-Score:-5.60|P-value:2.25E-9 ID:SGTC_1257|Compound:0669-0121|FD-Score:3.37|P-value:1.79E-4 ID:SGTC_1291|Compound:0993-0025|FD-Score:4.40|P-value:1.63E-6 ID:SGTC_1510|Compound:1123-0200|FD-Score:3.12|P-value:4.79E-4 ID:SGTC_1551|Compound:6-bromo-3'-methylflavone|FD-Score:2.93|P-value:9.38E-4 ID:SGTC_1629|Compound:st005085|FD-Score:6.40|P-value:7.35E-12 ID:SGTC_1654|Compound:st012436|FD-Score:3.12|P-value:4.71E-4 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:3.35|P-value:1.94E-4 ID:SGTC_1719|Compound:st032227|FD-Score:2.96|P-value:8.67E-4 ID:SGTC_1725|Compound:st036284|FD-Score:5.49|P-value:3.30E-9 ID:SGTC_1799|Compound:st045822|FD-Score:3.42|P-value:1.45E-4 ID:SGTC_1834|Compound:st055981|FD-Score:3.85|P-value:2.35E-5 ID:SGTC_1876|Compound:myriocin|FD-Score:3.19|P-value:3.60E-4 ID:SGTC_1932|Compound:st074806|FD-Score:3.69|P-value:4.66E-5 ID:SGTC_2057|Compound:5236571|FD-Score:3.21|P-value:3.36E-4 ID:SGTC_2128|Compound:5255449|FD-Score:3.90|P-value:1.82E-5 ID:SGTC_2177|Compound:5811945|FD-Score:3.47|P-value:1.19E-4 ID:SGTC_2212|Compound:7123476|FD-Score:3.10|P-value:5.17E-4 ID:SGTC_2268|Compound:7933382|FD-Score:3.42|P-value:1.45E-4 ID:SGTC_2431|Compound:5490079|FD-Score:3.45|P-value:1.27E-4 ID:SGTC_2432|Compound:5630864|FD-Score:5.30|P-value:1.06E-8 ID:SGTC_2526|Compound:patulin|FD-Score:6.31|P-value:1.35E-11 ID:SGTC_2589|Compound:lobaric acid|FD-Score:6.30|P-value:1.44E-11 ID:SGTC_2602|Compound:kawain|FD-Score:3.78|P-value:3.11E-5 ID:SGTC_2661|Compound:dactinomycin|FD-Score:-3.40|P-value:1.89E-4 ID:SGTC_2669|Compound:eugenol|FD-Score:3.41|P-value:1.52E-4 ID:SGTC_2685|Compound:mycophenolic acid|FD-Score:3.21|P-value:3.39E-4 ID:SGTC_2690|Compound:usnic acid|FD-Score:3.57|P-value:7.95E-5 ID:SGTC_2740|Compound:felodipine|FD-Score:3.60|P-value:6.90E-5 ID:SGTC_2782|Compound:7736369|FD-Score:5.79|P-value:4.98E-10 ID:SGTC_2787|Compound:5284540|FD-Score:2.92|P-value:9.88E-4 ID:SGTC_2806|Compound:7952793|FD-Score:3.00|P-value:7.26E-4 ID:SGTC_2842|Compound:9000675|FD-Score:-2.98|P-value:9.46E-4 ID:SGTC_2846|Compound:9008642|FD-Score:-3.12|P-value:5.65E-4 ID:SGTC_2914|Compound:7968218|FD-Score:3.06|P-value:5.85E-4 ID:SGTC_2940|Compound:9060638|FD-Score:-4.01|P-value:1.35E-5 ID:SGTC_2963|Compound:9082507|FD-Score:3.27|P-value:2.65E-4 ID:SGTC_2964|Compound:9083345|FD-Score:3.97|P-value:1.33E-5 ID:SGTC_3080|Compound:9117754|FD-Score:3.87|P-value:2.07E-5 ID:SGTC_3146|Compound:9095609|FD-Score:3.91|P-value:1.76E-5 ID:SGTC_3211|Compound:9128781|FD-Score:4.49|P-value:1.05E-6 ID:SGTC_3320|Compound:9137005|FD-Score:3.96|P-value:1.41E-5 ID:SGTC_89|Compound:0302-0250|FD-Score:3.12|P-value:4.72E-4 ID:SGTC_113|Compound:0099-0221|FD-Score:6.19|P-value:3.08E-11 ID:SGTC_139|Compound:0099-0334|FD-Score:3.80|P-value:2.95E-5 ID:SGTC_149|Compound:3970-0822|FD-Score:4.00|P-value:1.16E-5 ID:SGTC_168|Compound:3970-0862|FD-Score:6.81|P-value:3.36E-13 ID:SGTC_205|Compound:1486-1330|FD-Score:4.43|P-value:1.44E-6 ID:SGTC_210|Compound:3551-0445|FD-Score:3.81|P-value:2.73E-5 ID:SGTC_233|Compound:rapamycin|FD-Score:5.15|P-value:2.71E-8 ID:SGTC_379|Compound:3970-0972|FD-Score:4.41|P-value:1.55E-6 ID:SGTC_400|Compound:oxethazaine|FD-Score:4.32|P-value:2.45E-6 ID:SGTC_462|Compound:ag-879|FD-Score:-3.93|P-value:2.02E-5 ID:SGTC_470|Compound:aa-861|FD-Score:-3.04|P-value:7.58E-4 ID:SGTC_477|Compound:mead ethanolamide|FD-Score:-2.99|P-value:9.14E-4 ID:SGTC_524|Compound:r073-0010|FD-Score:5.11|P-value:3.33E-8 ID:SGTC_588|Compound:3970-1144|FD-Score:3.18|P-value:3.81E-4 ID:SGTC_694|Compound:1315-0438|FD-Score:3.24|P-value:2.98E-4 ID:SGTC_732|Compound:3970-1727|FD-Score:2.94|P-value:9.19E-4 ID:SGTC_774|Compound:k060-0086|FD-Score:3.01|P-value:7.18E-4 ID:SGTC_836|Compound:0330-0104|FD-Score:3.17|P-value:3.93E-4 ID:SGTC_849|Compound:0386-0493|FD-Score:2.92|P-value:9.77E-4 ID:SGTC_927|Compound:2425-1185|FD-Score:3.27|P-value:2.69E-4 ID:SGTC_990|Compound:3985-0011|FD-Score:7.66|P-value:3.20E-16 ID:SGTC_1103|Compound:duloxetine|FD-Score:3.69|P-value:4.73E-5 ID:SGTC_1131|Compound:3454-3128|FD-Score:3.51|P-value:9.97E-5 ID:SGTC_1174|Compound:0739-0097|FD-Score:3.12|P-value:4.82E-4 ID:SGTC_1186|Compound:1319-0216|FD-Score:3.57|P-value:7.95E-5 ID:SGTC_1203|Compound:3992-3522|FD-Score:-5.60|P-value:2.25E-9 ID:SGTC_1257|Compound:0669-0121|FD-Score:3.37|P-value:1.79E-4 ID:SGTC_1291|Compound:0993-0025|FD-Score:4.40|P-value:1.63E-6 ID:SGTC_1510|Compound:1123-0200|FD-Score:3.12|P-value:4.79E-4 ID:SGTC_1551|Compound:6-bromo-3'-methylflavone|FD-Score:2.93|P-value:9.38E-4 ID:SGTC_1629|Compound:st005085|FD-Score:6.40|P-value:7.35E-12 ID:SGTC_1654|Compound:st012436|FD-Score:3.12|P-value:4.71E-4 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:3.35|P-value:1.94E-4 ID:SGTC_1719|Compound:st032227|FD-Score:2.96|P-value:8.67E-4 ID:SGTC_1725|Compound:st036284|FD-Score:5.49|P-value:3.30E-9 ID:SGTC_1799|Compound:st045822|FD-Score:3.42|P-value:1.45E-4 ID:SGTC_1834|Compound:st055981|FD-Score:3.85|P-value:2.35E-5 ID:SGTC_1876|Compound:myriocin|FD-Score:3.19|P-value:3.60E-4 ID:SGTC_1932|Compound:st074806|FD-Score:3.69|P-value:4.66E-5 ID:SGTC_2057|Compound:5236571|FD-Score:3.21|P-value:3.36E-4 ID:SGTC_2128|Compound:5255449|FD-Score:3.90|P-value:1.82E-5 ID:SGTC_2177|Compound:5811945|FD-Score:3.47|P-value:1.19E-4 ID:SGTC_2212|Compound:7123476|FD-Score:3.10|P-value:5.17E-4 ID:SGTC_2268|Compound:7933382|FD-Score:3.42|P-value:1.45E-4 ID:SGTC_2431|Compound:5490079|FD-Score:3.45|P-value:1.27E-4 ID:SGTC_2432|Compound:5630864|FD-Score:5.30|P-value:1.06E-8 ID:SGTC_2526|Compound:patulin|FD-Score:6.31|P-value:1.35E-11 ID:SGTC_2589|Compound:lobaric acid|FD-Score:6.30|P-value:1.44E-11 ID:SGTC_2602|Compound:kawain|FD-Score:3.78|P-value:3.11E-5 ID:SGTC_2661|Compound:dactinomycin|FD-Score:-3.40|P-value:1.89E-4 ID:SGTC_2669|Compound:eugenol|FD-Score:3.41|P-value:1.52E-4 ID:SGTC_2685|Compound:mycophenolic acid|FD-Score:3.21|P-value:3.39E-4 ID:SGTC_2690|Compound:usnic acid|FD-Score:3.57|P-value:7.95E-5 ID:SGTC_2740|Compound:felodipine|FD-Score:3.60|P-value:6.90E-5 ID:SGTC_2782|Compound:7736369|FD-Score:5.79|P-value:4.98E-10 ID:SGTC_2787|Compound:5284540|FD-Score:2.92|P-value:9.88E-4 ID:SGTC_2806|Compound:7952793|FD-Score:3.00|P-value:7.26E-4 ID:SGTC_2842|Compound:9000675|FD-Score:-2.98|P-value:9.46E-4 ID:SGTC_2846|Compound:9008642|FD-Score:-3.12|P-value:5.65E-4 ID:SGTC_2914|Compound:7968218|FD-Score:3.06|P-value:5.85E-4 ID:SGTC_2940|Compound:9060638|FD-Score:-4.01|P-value:1.35E-5 ID:SGTC_2963|Compound:9082507|FD-Score:3.27|P-value:2.65E-4 ID:SGTC_2964|Compound:9083345|FD-Score:3.97|P-value:1.33E-5 ID:SGTC_3080|Compound:9117754|FD-Score:3.87|P-value:2.07E-5 ID:SGTC_3146|Compound:9095609|FD-Score:3.91|P-value:1.76E-5 ID:SGTC_3211|Compound:9128781|FD-Score:4.49|P-value:1.05E-6 ID:SGTC_3320|Compound:9137005|FD-Score:3.96|P-value:1.41E-5

Top fitness defect scores for YBR008C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_990 3985-0011 7.66 41.3 µM 3.20E-16 amide catabolism 3 9.22E-15
2 SGTC_168 3970-0862 6.81 530.5 µM 3.36E-13 30 4.93E-12
3 SGTC_1629 st005085 6.40 44.9 µM 7.35E-12 RPP1 & pyrimidine depletion 7 7.99E-11
4 SGTC_2526 patulin 6.31 37.6 µM 1.35E-11 23 1.39E-10
5 SGTC_2589 lobaric acid 6.30 100.0 µM 1.44E-11 6 1.47E-10
6 SGTC_113 0099-0221 6.19 2.5 µM 3.08E-11 2 2.92E-10
7 SGTC_2782 7736369 5.79 71.4 µM 4.98E-10 8 3.59E-9
8 SGTC_1725 st036284 5.49 20.6 µM 3.30E-9 9 1.98E-8
9 SGTC_2432 5630864 5.30 12.2 µM 1.06E-8 6 5.67E-8
10 SGTC_233 rapamycin 5.15 362.0 pM 2.71E-8 4 1.33E-7
11 SGTC_524 r073-0010 5.11 27.8 µM 3.33E-8 26 1.60E-7
12 SGTC_3211 9128781 4.49 49.5 µM 1.05E-6 44 3.61E-6
13 SGTC_205 1486-1330 4.43 71.9 µM 1.44E-6 13 4.81E-6
14 SGTC_379 3970-0972 4.41 5.9 µM 1.55E-6 tubulin folding & SWR complex 28 5.13E-6
15 SGTC_1291 0993-0025 4.40 5.8 µM 1.63E-6 8 5.38E-6
16 SGTC_400 oxethazaine 4.32 37.5 µM 2.45E-6 calcium & mitochondrial duress 12 7.77E-6
17 SGTC_149 3970-0822 4.00 46.1 µM 1.16E-5 tubulin folding & SWR complex 96 3.16E-5
18 SGTC_2964 9083345 3.97 53.4 µM 1.33E-5 18 3.59E-5
19 SGTC_3320 9137005 3.96 35.1 µM 1.41E-5 endomembrane recycling 16 3.78E-5
20 SGTC_3146 9095609 3.91 49.5 µM 1.76E-5 14 4.62E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.112 8.92E-11 YER005W YND1 hom Apyrase with wide substrate specificity, helps prevent inhibition of glycosylation by hydrolyzing nucleoside tri- and diphosphates that inhibit glycotransferases; partially redundant with Gda1p; mediates adenovirus E4orf4-induced toxicity
0.104 1.31E-9 YER069W ARG5,6 hom Acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase; N-acetyl-L-glutamate kinase (NAGK) catalyzes the 2nd and N-acetyl-gamma-glutamyl-phosphate reductase (NAGSA), the 3rd step in arginine biosynthesis; synthesized as a precursor which is processed in the mitochondrion to yield mature NAGK and NAGSA; enzymes form a metabolon complex with Arg2p; NAGK C-terminal domain stabilizes the enzymes, slows catalysis and is involved in feed-back inhibition by arginine
0.101 4.48E-9 YJL101C GSH1 hom Gamma glutamylcysteine synthetase; catalyzes the first step in glutathione (GSH) biosynthesis; expression induced by oxidants, cadmium, and mercury; protein abundance increases in response to DNA replication stress
0.096 2.41E-8 YOL077C BRX1 het Nucleolar protein, constituent of 66S pre-ribosomal particles; depletion leads to defects in rRNA processing and a block in the assembly of large ribosomal subunits; possesses a sigma(70)-like RNA-binding motif
0.096 2.76E-8 YDR002W YRB1 het Ran GTPase binding protein; involved in nuclear protein import and RNA export, ubiquitin-mediated protein degradation during the cell cycle; shuttles between the nucleus and cytoplasm; is essential; homolog of human RanBP1
0.092 9.25E-8 YIL130W ASG1 hom Zinc cluster protein proposed to function as a transcriptional regulator involved in the stress response; null mutants have a respiratory deficiency, calcofluor white sensitivity and slightly increased cycloheximide resistance
0.090 1.75E-7 YGL012W ERG4 hom C-24(28) sterol reductase, catalyzes the final step in ergosterol biosynthesis; mutants are viable, but lack ergosterol
0.089 2.15E-7 YBL034C STU1 het Component of the mitotic spindle that binds to interpolar microtubules via its association with beta-tubulin (Tub2p); required for interpolar microtubules to provide an outward force on the spindle poles
0.089 2.37E-7 YDR005C MAF1 hom Highly conserved negative regulator of RNA polymerase III; binds to the N-terminal domain of the Rpc160p subunit of Pol III to prevent closed-complex formation; localization and activity are regulated by phosphorylation, mediated by TORC1, protein kinase A, and Sch9p; localizes to cytoplasm during vegetative growth and translocates to the nucleus and nucleolus under stress conditions
0.089 2.58E-7 YOR064C YNG1 hom Subunit of the NuA3 histone acetyltransferase complex that acetylates histone H3; contains PHD finger domain that interacts with methylated histone H3, has similarity to the human tumor suppressor ING1
0.087 4.25E-7 YER083C GET2 hom Subunit of the GET complex; involved in insertion of proteins into the ER membrane; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for meiotic nuclear division
0.086 6.28E-7 YGR212W SLI1 hom N-acetyltransferase, confers resistance to the sphingolipid biosynthesis inhibitor myriocin (ISP-1) by converting it into N-acetyl-myriocin, co-operates with Ypk1p in mediating resistance to myriocin
0.086 6.84E-7 YAL024C LTE1 hom Protein similar to GDP/GTP exchange factors but without detectable GEF activity; required for asymmetric localization of Bfa1p at daughter-directed spindle pole bodies and for mitotic exit at low temperatures
0.085 7.33E-7 YER007W PAC2 hom Microtubule effector required for tubulin heterodimer formation, binds alpha-tubulin, required for normal microtubule function, null mutant exhibits cold-sensitive microtubules and sensitivity to benomyl
0.085 7.59E-7 YBR216C YBP1 hom Protein involved in cellular response to oxidative stress; required for oxidation of specific cysteine residues of transcription factor Yap1p, resulting in nuclear localization of Yap1p in response to stress; YBP1 has a paralog, YBP2, that arose from the whole genome duplication