YBR009C / HHF1

Histone H4, core histone protein required for chromatin assembly and chromosome function; one of two identical histone proteins (see also HHF2); contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR009C / HHF1

Click on Significant Values for Screen Details ID:SGTC_48|Compound:0382-0018|FD-Score:-4.61|P-value:2.55E-5 ID:SGTC_49|Compound:0717-0965|FD-Score:3.63|P-value:2.65E-4 ID:SGTC_57|Compound:miconazole|FD-Score:-4.57|P-value:2.97E-5 ID:SGTC_150|Compound:3970-0969|FD-Score:5.24|P-value:4.04E-7 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:3.90|P-value:1.06E-4 ID:SGTC_274|Compound:sirtinol|FD-Score:3.61|P-value:2.88E-4 ID:SGTC_297|Compound:0986-0032|FD-Score:5.02|P-value:1.13E-6 ID:SGTC_311|Compound:1315-0136|FD-Score:3.26|P-value:8.86E-4 ID:SGTC_316|Compound:k060-0003|FD-Score:4.20|P-value:3.44E-5 ID:SGTC_466|Compound:geldanamycin|FD-Score:3.46|P-value:4.72E-4 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:-4.41|P-value:5.58E-5 ID:SGTC_485|Compound:niflumic acid|FD-Score:3.98|P-value:7.75E-5 ID:SGTC_491|Compound:tetrandrine|FD-Score:3.68|P-value:2.25E-4 ID:SGTC_517|Compound:1365-0151|FD-Score:4.42|P-value:1.45E-5 ID:SGTC_523|Compound:1934-0222|FD-Score:3.38|P-value:6.04E-4 ID:SGTC_565|Compound:1418-0001|FD-Score:4.19|P-value:3.57E-5 ID:SGTC_604|Compound:1000-0114|FD-Score:4.10|P-value:5.07E-5 ID:SGTC_636|Compound:0kpi-0074|FD-Score:3.27|P-value:8.51E-4 ID:SGTC_696|Compound:1560-0013|FD-Score:3.64|P-value:2.56E-4 ID:SGTC_697|Compound:0508-1955|FD-Score:-3.98|P-value:2.58E-4 ID:SGTC_704|Compound:1310-0270|FD-Score:3.90|P-value:1.03E-4 ID:SGTC_705|Compound:1124-0212|FD-Score:-4.43|P-value:5.10E-5 ID:SGTC_737|Compound:1950-0117|FD-Score:-4.55|P-value:3.27E-5 ID:SGTC_895|Compound:0964-0006|FD-Score:-3.69|P-value:6.59E-4 ID:SGTC_896|Compound:0964-0007|FD-Score:-4.45|P-value:4.77E-5 ID:SGTC_939|Compound:1165-0479|FD-Score:4.12|P-value:4.72E-5 ID:SGTC_944|Compound:3370-0224|FD-Score:4.97|P-value:1.40E-6 ID:SGTC_949|Compound:1165-0505|FD-Score:3.70|P-value:2.11E-4 ID:SGTC_967|Compound:1306-0166|FD-Score:3.64|P-value:2.61E-4 ID:SGTC_976|Compound:1348-1067|FD-Score:-3.73|P-value:5.80E-4 ID:SGTC_981|Compound:1488-1094|FD-Score:3.81|P-value:1.43E-4 ID:SGTC_1151|Compound:3909-8316|FD-Score:3.29|P-value:8.09E-4 ID:SGTC_1152|Compound:3909-8331|FD-Score:3.51|P-value:4.06E-4 ID:SGTC_1178|Compound:0988-0033|FD-Score:3.46|P-value:4.70E-4 ID:SGTC_1354|Compound:1498-1681|FD-Score:3.59|P-value:3.10E-4 ID:SGTC_1367|Compound:1812-0510|FD-Score:4.34|P-value:1.98E-5 ID:SGTC_1416|Compound:3966-0321|FD-Score:3.62|P-value:2.77E-4 ID:SGTC_1428|Compound:4049-0204|FD-Score:4.00|P-value:7.20E-5 ID:SGTC_1438|Compound:4092-1045|FD-Score:4.38|P-value:1.71E-5 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:5.98|P-value:1.07E-8 ID:SGTC_1590|Compound:st077108|FD-Score:4.79|P-value:3.12E-6 ID:SGTC_1613|Compound:st002381|FD-Score:4.94|P-value:1.63E-6 ID:SGTC_1620|Compound:st003704|FD-Score:5.12|P-value:7.17E-7 ID:SGTC_1640|Compound:st009078|FD-Score:4.57|P-value:7.98E-6 ID:SGTC_1664|Compound:st014217|FD-Score:3.65|P-value:2.50E-4 ID:SGTC_1723|Compound:st034307|FD-Score:3.51|P-value:3.98E-4 ID:SGTC_1866|Compound:st057638|FD-Score:3.30|P-value:7.76E-4 ID:SGTC_1876|Compound:myriocin|FD-Score:-3.72|P-value:5.98E-4 ID:SGTC_1892|Compound:st058411|FD-Score:3.54|P-value:3.57E-4 ID:SGTC_1903|Compound:st060211|FD-Score:3.24|P-value:9.57E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:3.53|P-value:3.73E-4 ID:SGTC_1927|Compound:st060202|FD-Score:-3.59|P-value:8.95E-4 ID:SGTC_1936|Compound:st074407|FD-Score:3.95|P-value:8.73E-5 ID:SGTC_1957|Compound:st077035|FD-Score:3.85|P-value:1.26E-4 ID:SGTC_2019|Compound:4016004|FD-Score:4.49|P-value:1.07E-5 ID:SGTC_2071|Compound:5230951|FD-Score:3.25|P-value:9.22E-4 ID:SGTC_2081|Compound:5214970|FD-Score:3.45|P-value:4.95E-4 ID:SGTC_2083|Compound:5306046|FD-Score:4.47|P-value:1.17E-5 ID:SGTC_2113|Compound:5491891|FD-Score:3.60|P-value:2.95E-4 ID:SGTC_2170|Compound:morpholine|FD-Score:4.50|P-value:1.05E-5 ID:SGTC_2278|Compound:7948257|FD-Score:3.75|P-value:1.77E-4 ID:SGTC_2280|Compound:7785178|FD-Score:4.56|P-value:8.11E-6 ID:SGTC_2291|Compound:7917025|FD-Score:5.06|P-value:9.38E-7 ID:SGTC_2431|Compound:5490079|FD-Score:4.23|P-value:3.00E-5 ID:SGTC_2503|Compound:beta-caryophyllene alcohol|FD-Score:3.58|P-value:3.17E-4 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:3.41|P-value:5.49E-4 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:3.55|P-value:3.52E-4 ID:SGTC_2832|Compound:7992762|FD-Score:-3.90|P-value:3.36E-4 ID:SGTC_2848|Compound:9016370|FD-Score:-3.98|P-value:2.59E-4 ID:SGTC_2856|Compound:9022925|FD-Score:-4.87|P-value:8.92E-6 ID:SGTC_2938|Compound:9059746|FD-Score:4.23|P-value:3.08E-5 ID:SGTC_3018|Compound:9082602|FD-Score:-3.90|P-value:3.39E-4 ID:SGTC_3066|Compound:9117245|FD-Score:4.12|P-value:4.61E-5 ID:SGTC_3314|Compound:9135860|FD-Score:4.02|P-value:6.72E-5 ID:SGTC_48|Compound:0382-0018|FD-Score:-4.61|P-value:2.55E-5 ID:SGTC_49|Compound:0717-0965|FD-Score:3.63|P-value:2.65E-4 ID:SGTC_57|Compound:miconazole|FD-Score:-4.57|P-value:2.97E-5 ID:SGTC_150|Compound:3970-0969|FD-Score:5.24|P-value:4.04E-7 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:3.90|P-value:1.06E-4 ID:SGTC_274|Compound:sirtinol|FD-Score:3.61|P-value:2.88E-4 ID:SGTC_297|Compound:0986-0032|FD-Score:5.02|P-value:1.13E-6 ID:SGTC_311|Compound:1315-0136|FD-Score:3.26|P-value:8.86E-4 ID:SGTC_316|Compound:k060-0003|FD-Score:4.20|P-value:3.44E-5 ID:SGTC_466|Compound:geldanamycin|FD-Score:3.46|P-value:4.72E-4 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:-4.41|P-value:5.58E-5 ID:SGTC_485|Compound:niflumic acid|FD-Score:3.98|P-value:7.75E-5 ID:SGTC_491|Compound:tetrandrine|FD-Score:3.68|P-value:2.25E-4 ID:SGTC_517|Compound:1365-0151|FD-Score:4.42|P-value:1.45E-5 ID:SGTC_523|Compound:1934-0222|FD-Score:3.38|P-value:6.04E-4 ID:SGTC_565|Compound:1418-0001|FD-Score:4.19|P-value:3.57E-5 ID:SGTC_604|Compound:1000-0114|FD-Score:4.10|P-value:5.07E-5 ID:SGTC_636|Compound:0kpi-0074|FD-Score:3.27|P-value:8.51E-4 ID:SGTC_696|Compound:1560-0013|FD-Score:3.64|P-value:2.56E-4 ID:SGTC_697|Compound:0508-1955|FD-Score:-3.98|P-value:2.58E-4 ID:SGTC_704|Compound:1310-0270|FD-Score:3.90|P-value:1.03E-4 ID:SGTC_705|Compound:1124-0212|FD-Score:-4.43|P-value:5.10E-5 ID:SGTC_737|Compound:1950-0117|FD-Score:-4.55|P-value:3.27E-5 ID:SGTC_895|Compound:0964-0006|FD-Score:-3.69|P-value:6.59E-4 ID:SGTC_896|Compound:0964-0007|FD-Score:-4.45|P-value:4.77E-5 ID:SGTC_939|Compound:1165-0479|FD-Score:4.12|P-value:4.72E-5 ID:SGTC_944|Compound:3370-0224|FD-Score:4.97|P-value:1.40E-6 ID:SGTC_949|Compound:1165-0505|FD-Score:3.70|P-value:2.11E-4 ID:SGTC_967|Compound:1306-0166|FD-Score:3.64|P-value:2.61E-4 ID:SGTC_976|Compound:1348-1067|FD-Score:-3.73|P-value:5.80E-4 ID:SGTC_981|Compound:1488-1094|FD-Score:3.81|P-value:1.43E-4 ID:SGTC_1151|Compound:3909-8316|FD-Score:3.29|P-value:8.09E-4 ID:SGTC_1152|Compound:3909-8331|FD-Score:3.51|P-value:4.06E-4 ID:SGTC_1178|Compound:0988-0033|FD-Score:3.46|P-value:4.70E-4 ID:SGTC_1354|Compound:1498-1681|FD-Score:3.59|P-value:3.10E-4 ID:SGTC_1367|Compound:1812-0510|FD-Score:4.34|P-value:1.98E-5 ID:SGTC_1416|Compound:3966-0321|FD-Score:3.62|P-value:2.77E-4 ID:SGTC_1428|Compound:4049-0204|FD-Score:4.00|P-value:7.20E-5 ID:SGTC_1438|Compound:4092-1045|FD-Score:4.38|P-value:1.71E-5 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:5.98|P-value:1.07E-8 ID:SGTC_1590|Compound:st077108|FD-Score:4.79|P-value:3.12E-6 ID:SGTC_1613|Compound:st002381|FD-Score:4.94|P-value:1.63E-6 ID:SGTC_1620|Compound:st003704|FD-Score:5.12|P-value:7.17E-7 ID:SGTC_1640|Compound:st009078|FD-Score:4.57|P-value:7.98E-6 ID:SGTC_1664|Compound:st014217|FD-Score:3.65|P-value:2.50E-4 ID:SGTC_1723|Compound:st034307|FD-Score:3.51|P-value:3.98E-4 ID:SGTC_1866|Compound:st057638|FD-Score:3.30|P-value:7.76E-4 ID:SGTC_1876|Compound:myriocin|FD-Score:-3.72|P-value:5.98E-4 ID:SGTC_1892|Compound:st058411|FD-Score:3.54|P-value:3.57E-4 ID:SGTC_1903|Compound:st060211|FD-Score:3.24|P-value:9.57E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:3.53|P-value:3.73E-4 ID:SGTC_1927|Compound:st060202|FD-Score:-3.59|P-value:8.95E-4 ID:SGTC_1936|Compound:st074407|FD-Score:3.95|P-value:8.73E-5 ID:SGTC_1957|Compound:st077035|FD-Score:3.85|P-value:1.26E-4 ID:SGTC_2019|Compound:4016004|FD-Score:4.49|P-value:1.07E-5 ID:SGTC_2071|Compound:5230951|FD-Score:3.25|P-value:9.22E-4 ID:SGTC_2081|Compound:5214970|FD-Score:3.45|P-value:4.95E-4 ID:SGTC_2083|Compound:5306046|FD-Score:4.47|P-value:1.17E-5 ID:SGTC_2113|Compound:5491891|FD-Score:3.60|P-value:2.95E-4 ID:SGTC_2170|Compound:morpholine|FD-Score:4.50|P-value:1.05E-5 ID:SGTC_2278|Compound:7948257|FD-Score:3.75|P-value:1.77E-4 ID:SGTC_2280|Compound:7785178|FD-Score:4.56|P-value:8.11E-6 ID:SGTC_2291|Compound:7917025|FD-Score:5.06|P-value:9.38E-7 ID:SGTC_2431|Compound:5490079|FD-Score:4.23|P-value:3.00E-5 ID:SGTC_2503|Compound:beta-caryophyllene alcohol|FD-Score:3.58|P-value:3.17E-4 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:3.41|P-value:5.49E-4 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:3.55|P-value:3.52E-4 ID:SGTC_2832|Compound:7992762|FD-Score:-3.90|P-value:3.36E-4 ID:SGTC_2848|Compound:9016370|FD-Score:-3.98|P-value:2.59E-4 ID:SGTC_2856|Compound:9022925|FD-Score:-4.87|P-value:8.92E-6 ID:SGTC_2938|Compound:9059746|FD-Score:4.23|P-value:3.08E-5 ID:SGTC_3018|Compound:9082602|FD-Score:-3.90|P-value:3.39E-4 ID:SGTC_3066|Compound:9117245|FD-Score:4.12|P-value:4.61E-5 ID:SGTC_3314|Compound:9135860|FD-Score:4.02|P-value:6.72E-5

Top fitness defect scores for YBR009C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1580 hydrocortisone 21-hemisuccinate 5.98 43.2 µM 1.07E-8 2 1.15E-9
2 SGTC_150 3970-0969 5.24 77.2 µM 4.04E-7 33 7.85E-8
3 SGTC_1620 st003704 5.12 16.5 µM 7.17E-7 3 1.53E-7
4 SGTC_2291 7917025 5.06 104.3 µM 9.38E-7 iron homeostasis 28 2.09E-7
5 SGTC_297 0986-0032 5.02 24.0 µM 1.13E-6 60S ribosome export 1 2.59E-7
6 SGTC_944 3370-0224 4.97 231.0 µM 1.40E-6 10 3.33E-7
7 SGTC_1613 st002381 4.94 52.1 µM 1.63E-6 9 3.95E-7
8 SGTC_1590 st077108 4.79 57.8 µM 3.12E-6 3 8.41E-7
9 SGTC_1640 st009078 4.57 66.4 µM 7.98E-6 3 2.49E-6
10 SGTC_2280 7785178 4.56 200.0 µM 8.11E-6 5 2.53E-6
11 SGTC_2170 morpholine 4.50 200.0 µM 1.05E-5 7 3.42E-6
12 SGTC_2019 4016004 4.49 108.0 µM 1.07E-5 14 3.50E-6
13 SGTC_2083 5306046 4.47 65.9 µM 1.17E-5 14 3.88E-6
14 SGTC_517 1365-0151 4.42 113.0 µM 1.45E-5 25 4.95E-6
15 SGTC_1438 4092-1045 4.38 4.0 µM 1.71E-5 4 6.01E-6
16 SGTC_1367 1812-0510 4.34 76.9 µM 1.98E-5 14 7.12E-6
17 SGTC_2431 5490079 4.23 200.0 µM 3.00E-5 25 1.15E-5
18 SGTC_2938 9059746 4.23 27.3 µM 3.08E-5 fatty acid desaturase (OLE1) 36 1.18E-5
19 SGTC_316 k060-0003 4.20 58.6 µM 3.44E-5 15 1.34E-5
20 SGTC_565 1418-0001 4.19 44.5 µM 3.57E-5 14 1.40E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.098 1.15E-8 YMR058W FET3 hom Ferro-O2-oxidoreductase; required for high-affinity iron uptake and involved in mediating resistance to copper ion toxicity, belongs to class of integral membrane multicopper oxidases; protein abundance increases in response to DNA replication stress
0.077 9.06E-6 YJL172W CPS1 hom Vacuolar carboxypeptidase yscS; expression is induced under low-nitrogen conditions
0.073 2.47E-5 YKL004W AUR1 het Phosphatidylinositol:ceramide phosphoinositol transferase (IPC synthase), required for sphingolipid synthesis; can mutate to confer aureobasidin A resistance
0.072 3.34E-5 YER106W MAM1 hom Monopolin, kinetochore associated protein involved in chromosome attachment to meiotic spindle
0.070 4.76E-5 YIR020C_p YIR020C_p hom Protein of unknown function; mRNA identified as translated by ribosome profiling data
0.068 7.50E-5 YMR084W_p YMR084W_p hom Putative protein of unknown function; YMR084W and adjacent ORF YMR085W are merged in related strains, and together are paralogous to glutamine-fructose-6-phosphate amidotransferase GFA1
0.068 8.25E-5 YMR140W SIP5 hom Protein of unknown function; interacts with both the Reg1p/Glc7p phosphatase and the Snf1p kinase; forms cytoplasmic foci upon DNA replication stress
0.067 1.01E-4 YJR003C_p YJR003C_p hom Putative protein of unknown function; detected in highly purified mitochondria in high-throughput studies; predicted to be involved in ribosome biogenesis
0.066 1.26E-4 YOR248W_d YOR248W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.063 2.67E-4 YNL141W AAH1 hom Adenine deaminase (adenine aminohydrolase), converts adenine to hypoxanthine; involved in purine salvage; transcriptionally regulated by nutrient levels and growth phase; Aah1p degraded upon entry into quiescence via SCF and the proteasome
0.063 2.78E-4 YIL087C AIM19 hom Putative protein of unknown function; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays reduced respiratory growth
0.060 4.73E-4 YKL119C VPH2 hom Integral membrane protein required for vacuolar H+-ATPase (V-ATPase) function, although not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the endoplasmic reticulum (ER)
0.060 4.91E-4 YHL015W-A_p YHL015W-A_p hom Putative protein of unknown function
0.060 5.41E-4 YLR406C RPL31B hom Ribosomal 60S subunit protein L31B; associates with karyopherin Sxm1p; loss of both Rpl31p and Rpl39p confers lethality; homologous to mammalian ribosomal protein L31, no bacterial homolog; RPL31B has a paralog, RPL31A, that arose from the whole genome duplication
0.060 5.47E-4 YOR320C GNT1 hom N-acetylglucosaminyltransferase capable of modification of N-linked glycans in the Golgi apparatus