YBR010W / HHT1

Histone H3, core histone protein required for chromatin assembly, part of heterochromatin-mediated telomeric and HM silencing; one of two identical histone H3 proteins (see HHT2); regulated by acetylation, methylation, and phosphorylation

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR010W / HHT1

Click on Significant Values for Screen Details ID:SGTC_129|Compound:0088-0017|FD-Score:6.48|P-value:1.52E-10 ID:SGTC_134|Compound:0269-0018|FD-Score:-3.74|P-value:1.19E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:4.31|P-value:1.45E-5 ID:SGTC_270|Compound:tamoxifen|FD-Score:3.81|P-value:1.08E-4 ID:SGTC_344|Compound:k064-0035|FD-Score:3.53|P-value:3.13E-4 ID:SGTC_615|Compound:k087-0205|FD-Score:3.33|P-value:6.30E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:3.99|P-value:5.38E-5 ID:SGTC_880|Compound:0833-0487|FD-Score:4.43|P-value:8.61E-6 ID:SGTC_904|Compound:1141-0088|FD-Score:4.69|P-value:2.63E-6 ID:SGTC_913|Compound:3487-1245|FD-Score:3.96|P-value:6.20E-5 ID:SGTC_950|Compound:1165-0508|FD-Score:3.69|P-value:1.74E-4 ID:SGTC_1145|Compound:3546-0597|FD-Score:3.69|P-value:1.73E-4 ID:SGTC_1177|Compound:0983-0204|FD-Score:3.75|P-value:1.38E-4 ID:SGTC_1264|Compound:0783-0040|FD-Score:4.00|P-value:5.19E-5 ID:SGTC_1287|Compound:0971-0001|FD-Score:3.45|P-value:4.09E-4 ID:SGTC_1447|Compound:4239-0816|FD-Score:3.72|P-value:1.52E-4 ID:SGTC_1617|Compound:st002906|FD-Score:3.88|P-value:8.45E-5 ID:SGTC_1626|Compound:st003712|FD-Score:3.68|P-value:1.80E-4 ID:SGTC_1659|Compound:st012954|FD-Score:6.92|P-value:8.76E-12 ID:SGTC_1672|Compound:st016598|FD-Score:3.55|P-value:2.90E-4 ID:SGTC_1851|Compound:st056236|FD-Score:4.65|P-value:3.19E-6 ID:SGTC_1934|Compound:st074720|FD-Score:5.01|P-value:5.74E-7 ID:SGTC_1942|Compound:st076330|FD-Score:3.33|P-value:6.33E-4 ID:SGTC_2030|Compound:5175110|FD-Score:3.94|P-value:6.66E-5 ID:SGTC_2040|Compound:5100729|FD-Score:5.03|P-value:5.16E-7 ID:SGTC_2112|Compound:5488546|FD-Score:3.58|P-value:2.58E-4 ID:SGTC_2152|Compound:5568786|FD-Score:3.62|P-value:2.28E-4 ID:SGTC_2251|Compound:lansoprazole|FD-Score:3.25|P-value:8.14E-4 ID:SGTC_2284|Compound:7945075|FD-Score:5.31|P-value:1.23E-7 ID:SGTC_2295|Compound:7971645|FD-Score:-3.46|P-value:3.42E-4 ID:SGTC_2415|Compound:st077333|FD-Score:3.23|P-value:8.83E-4 ID:SGTC_2841|Compound:9004761|FD-Score:3.58|P-value:2.56E-4 ID:SGTC_3041|Compound:9091929|FD-Score:5.58|P-value:2.88E-8 ID:SGTC_3100|Compound:9120536|FD-Score:-3.21|P-value:8.00E-4 ID:SGTC_3126|Compound:9127922|FD-Score:3.78|P-value:1.25E-4 ID:SGTC_3129|Compound:9127257|FD-Score:3.64|P-value:2.12E-4 ID:SGTC_3144|Compound:9087057|FD-Score:-3.20|P-value:8.40E-4 ID:SGTC_3175|Compound:9106517|FD-Score:4.19|P-value:2.40E-5 ID:SGTC_3238|Compound:9133470|FD-Score:-4.20|P-value:1.86E-5 ID:SGTC_129|Compound:0088-0017|FD-Score:6.48|P-value:1.52E-10 ID:SGTC_134|Compound:0269-0018|FD-Score:-3.74|P-value:1.19E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:4.31|P-value:1.45E-5 ID:SGTC_270|Compound:tamoxifen|FD-Score:3.81|P-value:1.08E-4 ID:SGTC_344|Compound:k064-0035|FD-Score:3.53|P-value:3.13E-4 ID:SGTC_615|Compound:k087-0205|FD-Score:3.33|P-value:6.30E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:3.99|P-value:5.38E-5 ID:SGTC_880|Compound:0833-0487|FD-Score:4.43|P-value:8.61E-6 ID:SGTC_904|Compound:1141-0088|FD-Score:4.69|P-value:2.63E-6 ID:SGTC_913|Compound:3487-1245|FD-Score:3.96|P-value:6.20E-5 ID:SGTC_950|Compound:1165-0508|FD-Score:3.69|P-value:1.74E-4 ID:SGTC_1145|Compound:3546-0597|FD-Score:3.69|P-value:1.73E-4 ID:SGTC_1177|Compound:0983-0204|FD-Score:3.75|P-value:1.38E-4 ID:SGTC_1264|Compound:0783-0040|FD-Score:4.00|P-value:5.19E-5 ID:SGTC_1287|Compound:0971-0001|FD-Score:3.45|P-value:4.09E-4 ID:SGTC_1447|Compound:4239-0816|FD-Score:3.72|P-value:1.52E-4 ID:SGTC_1617|Compound:st002906|FD-Score:3.88|P-value:8.45E-5 ID:SGTC_1626|Compound:st003712|FD-Score:3.68|P-value:1.80E-4 ID:SGTC_1659|Compound:st012954|FD-Score:6.92|P-value:8.76E-12 ID:SGTC_1672|Compound:st016598|FD-Score:3.55|P-value:2.90E-4 ID:SGTC_1851|Compound:st056236|FD-Score:4.65|P-value:3.19E-6 ID:SGTC_1934|Compound:st074720|FD-Score:5.01|P-value:5.74E-7 ID:SGTC_1942|Compound:st076330|FD-Score:3.33|P-value:6.33E-4 ID:SGTC_2030|Compound:5175110|FD-Score:3.94|P-value:6.66E-5 ID:SGTC_2040|Compound:5100729|FD-Score:5.03|P-value:5.16E-7 ID:SGTC_2112|Compound:5488546|FD-Score:3.58|P-value:2.58E-4 ID:SGTC_2152|Compound:5568786|FD-Score:3.62|P-value:2.28E-4 ID:SGTC_2251|Compound:lansoprazole|FD-Score:3.25|P-value:8.14E-4 ID:SGTC_2284|Compound:7945075|FD-Score:5.31|P-value:1.23E-7 ID:SGTC_2295|Compound:7971645|FD-Score:-3.46|P-value:3.42E-4 ID:SGTC_2415|Compound:st077333|FD-Score:3.23|P-value:8.83E-4 ID:SGTC_2841|Compound:9004761|FD-Score:3.58|P-value:2.56E-4 ID:SGTC_3041|Compound:9091929|FD-Score:5.58|P-value:2.88E-8 ID:SGTC_3100|Compound:9120536|FD-Score:-3.21|P-value:8.00E-4 ID:SGTC_3126|Compound:9127922|FD-Score:3.78|P-value:1.25E-4 ID:SGTC_3129|Compound:9127257|FD-Score:3.64|P-value:2.12E-4 ID:SGTC_3144|Compound:9087057|FD-Score:-3.20|P-value:8.40E-4 ID:SGTC_3175|Compound:9106517|FD-Score:4.19|P-value:2.40E-5 ID:SGTC_3238|Compound:9133470|FD-Score:-4.20|P-value:1.86E-5

Top fitness defect scores for YBR010W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1659 st012954 6.92 42.1 µM 8.76E-12 3 2.33E-12
2 SGTC_129 0088-0017 6.48 176.6 µM 1.52E-10 28 4.70E-11
3 SGTC_3041 9091929 5.58 49.5 µM 2.88E-8 redox potentiating 5 1.17E-8
4 SGTC_2284 7945075 5.31 39.2 µM 1.23E-7 mitochondrial processes 9 5.42E-8
5 SGTC_2040 5100729 5.03 123.0 µM 5.16E-7 19 2.45E-7
6 SGTC_1934 st074720 5.01 32.6 µM 5.74E-7 27 2.74E-7
7 SGTC_904 1141-0088 4.69 396.0 µM 2.63E-6 9 1.36E-6
8 SGTC_1851 st056236 4.65 18.9 µM 3.19E-6 6 1.67E-6
9 SGTC_880 0833-0487 4.43 87.2 µM 8.61E-6 mitochondrial processes 14 4.75E-6
10 SGTC_137 0438-0332 4.31 85.4 µM 1.45E-5 ubiquinone biosynthesis & proteasome 103 8.22E-6
11 SGTC_3175 9106517 4.19 49.5 µM 2.40E-5 iron homeostasis 15 1.40E-5
12 SGTC_1264 0783-0040 4.00 158.0 µM 5.19E-5 28 3.15E-5
13 SGTC_733 4069-0007 3.99 56.1 µM 5.38E-5 ERAD & cell cycle 84 3.27E-5
14 SGTC_913 3487-1245 3.96 167.0 µM 6.20E-5 30 3.80E-5
15 SGTC_2030 5175110 3.94 200.0 µM 6.66E-5 Golgi 26 4.10E-5
16 SGTC_1617 st002906 3.88 78.0 µM 8.45E-5 27 5.26E-5
17 SGTC_270 tamoxifen 3.81 5.5 µM 1.08E-4 NEO1 34 6.83E-5
18 SGTC_3126 9127922 3.78 49.5 µM 1.25E-4 fatty acid desaturase (OLE1) 39 7.94E-5
19 SGTC_1177 0983-0204 3.75 23.6 µM 1.38E-4 20 8.80E-5
20 SGTC_1447 4239-0816 3.72 81.9 µM 1.52E-4 36 9.80E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.105 1.08E-9 YPR006C ICL2 hom 2-methylisocitrate lyase of the mitochondrial matrix, functions in the methylcitrate cycle to catalyze the conversion of 2-methylisocitrate to succinate and pyruvate; ICL2 transcription is repressed by glucose and induced by ethanol
0.096 2.30E-8 YNL204C SPS18 hom Protein of unknown function, contains a putative zinc-binding domain; expressed during sporulation
0.093 7.46E-8 YPR007C REC8 hom Meiosis-specific component of sister chromatid cohesion complex; maintains cohesion between sister chromatids during meiosis I; maintains cohesion between centromeres of sister chromatids until meiosis II; homolog of S. pombe Rec8p
0.091 1.14E-7 YCR006C_d YCR006C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.090 1.94E-7 YPL212C PUS1 hom tRNA:pseudouridine synthase, introduces pseudouridines at positions 26-28, 34-36, 65, and 67 of tRNA; nuclear protein that appears to be involved in tRNA export; also acts on U2 snRNA
0.087 4.31E-7 YLR031W_p YLR031W_p hom Putative protein of unknown function
0.087 4.94E-7 YGR027C RPS25A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S25, no bacterial homolog; RPS25A has a paralog, RPS25B, that arose from the whole genome duplication
0.086 5.32E-7 YPL130W SPO19 hom Meiosis-specific prospore protein; required to produce bending force necessary for proper assembly of the prospore membrane during sporulation; identified as a weak high-copy suppressor of the spo1-1 ts mutation
0.086 6.90E-7 YDR381W YRA1 het RNA binding protein required for export of poly(A)+ mRNA from the nucleus; proposed to couple mRNA export with 3' end processing via its interactions with Mex67p and Pcf11p; functionally redundant with Yra2p, another REF family member
0.085 8.82E-7 YJR116W_p TDA4_p hom Putative protein of unknown function; null mutant is sensitive to expression of the top1-T722A allele
0.082 1.86E-6 YOR027W STI1 hom Hsp90 cochaperone, interacts with the Ssa group of the cytosolic Hsp70 chaperones and activates Ssa1p ATPase activity; interacts with Hsp90 chaperones and inhibits their ATPase activity; homolog of mammalian Hop
0.078 6.81E-6 YGR031W IMO32 hom Conserved mitochondrial protein of unknown function; processed by both mitochondrial processing peptidase and mitochondrial octapeptidyl aminopeptidase; gene contains the nested antisense gene NAG1
0.077 7.27E-6 YDL113C ATG20 hom Sorting nexin family member required for the cytoplasm-to-vacuole targeting (Cvt) pathway and for endosomal sorting; has a Phox homology domain that binds phosphatidylinositol-3-phosphate; interacts with Snx4p; potential Cdc28p substrate
0.076 1.01E-5 YOL046C_d YOL046C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data;almost completely overlaps the verified gene PSK2/YOL045W
0.075 1.29E-5 YOR165W SEY1 hom Dynamin-like GTPase that mediates homotypic ER fusion; has a role in ER morphology; interacts physically and genetically with Yop1p and Rtn1p; functional ortholog of the human atlastin ATL1, defects in which cause a form of the human disease hereditary spastic paraplegia; homolog of Arabidopsis RHD3