YBR011C / IPP1

Cytoplasmic inorganic pyrophosphatase (PPase), homodimer that catalyzes the rapid exchange of oxygens from Pi with water, highly expressed and essential for viability, active-site residues show identity to those from E. coli PPase

Zygosity: Heterozygous strain
fixedexpanded
Profile for YBR011C / IPP1

Click on Significant Values for Screen Details ID:SGTC_119|Compound:0121-0043|FD-Score:7.04|P-value:7.91E-11 ID:SGTC_181|Compound:1447-1644|FD-Score:3.41|P-value:9.37E-4 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:3.40|P-value:9.84E-4 ID:SGTC_497|Compound:capsazepine|FD-Score:6.38|P-value:3.40E-9 ID:SGTC_501|Compound:nsc-95397|FD-Score:4.34|P-value:3.95E-5 ID:SGTC_502|Compound:l-744,832|FD-Score:3.91|P-value:1.85E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:3.89|P-value:1.96E-4 ID:SGTC_521|Compound:r062-0005|FD-Score:3.51|P-value:6.83E-4 ID:SGTC_1078|Compound:idebenone|FD-Score:4.03|P-value:1.22E-4 ID:SGTC_1275|Compound:0867-0008|FD-Score:-3.79|P-value:3.23E-4 ID:SGTC_1291|Compound:0993-0025|FD-Score:-4.40|P-value:3.71E-5 ID:SGTC_1326|Compound:1431-2094|FD-Score:3.81|P-value:2.63E-4 ID:SGTC_1331|Compound:1472-0049|FD-Score:3.65|P-value:4.36E-4 ID:SGTC_1372|Compound:2752-0194|FD-Score:3.42|P-value:9.06E-4 ID:SGTC_1419|Compound:3993-2473|FD-Score:4.40|P-value:3.05E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.56|P-value:6.79E-4 ID:SGTC_1464|Compound:k208-0027|FD-Score:3.45|P-value:8.43E-4 ID:SGTC_1678|Compound:st019265|FD-Score:-3.44|P-value:9.87E-4 ID:SGTC_1913|Compound:st060213|FD-Score:-5.88|P-value:5.81E-8 ID:SGTC_2482|Compound:5981709|FD-Score:3.51|P-value:7.00E-4 ID:SGTC_2560|Compound:caryophyllene|FD-Score:4.16|P-value:7.53E-5 ID:SGTC_3046|Compound:9092212|FD-Score:3.51|P-value:6.93E-4 ID:SGTC_3157|Compound:9099274|FD-Score:-3.73|P-value:4.01E-4 ID:SGTC_3198|Compound:9112019|FD-Score:4.92|P-value:3.77E-6 ID:SGTC_119|Compound:0121-0043|FD-Score:7.04|P-value:7.91E-11 ID:SGTC_181|Compound:1447-1644|FD-Score:3.41|P-value:9.37E-4 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:3.40|P-value:9.84E-4 ID:SGTC_497|Compound:capsazepine|FD-Score:6.38|P-value:3.40E-9 ID:SGTC_501|Compound:nsc-95397|FD-Score:4.34|P-value:3.95E-5 ID:SGTC_502|Compound:l-744,832|FD-Score:3.91|P-value:1.85E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:3.89|P-value:1.96E-4 ID:SGTC_521|Compound:r062-0005|FD-Score:3.51|P-value:6.83E-4 ID:SGTC_1078|Compound:idebenone|FD-Score:4.03|P-value:1.22E-4 ID:SGTC_1275|Compound:0867-0008|FD-Score:-3.79|P-value:3.23E-4 ID:SGTC_1291|Compound:0993-0025|FD-Score:-4.40|P-value:3.71E-5 ID:SGTC_1326|Compound:1431-2094|FD-Score:3.81|P-value:2.63E-4 ID:SGTC_1331|Compound:1472-0049|FD-Score:3.65|P-value:4.36E-4 ID:SGTC_1372|Compound:2752-0194|FD-Score:3.42|P-value:9.06E-4 ID:SGTC_1419|Compound:3993-2473|FD-Score:4.40|P-value:3.05E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.56|P-value:6.79E-4 ID:SGTC_1464|Compound:k208-0027|FD-Score:3.45|P-value:8.43E-4 ID:SGTC_1678|Compound:st019265|FD-Score:-3.44|P-value:9.87E-4 ID:SGTC_1913|Compound:st060213|FD-Score:-5.88|P-value:5.81E-8 ID:SGTC_2482|Compound:5981709|FD-Score:3.51|P-value:7.00E-4 ID:SGTC_2560|Compound:caryophyllene|FD-Score:4.16|P-value:7.53E-5 ID:SGTC_3046|Compound:9092212|FD-Score:3.51|P-value:6.93E-4 ID:SGTC_3157|Compound:9099274|FD-Score:-3.73|P-value:4.01E-4 ID:SGTC_3198|Compound:9112019|FD-Score:4.92|P-value:3.77E-6

Top fitness defect scores for YBR011C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_119 0121-0043 7.04 24.8 µM 7.91E-11 mitochondrial stress 5 9.37E-13 0.96
2 SGTC_497 capsazepine 6.38 133.0 µM 3.40E-9 1 8.91E-11 1.43
3 SGTC_3198 9112019 4.92 49.5 µM 3.77E-6 mitochondrial processes 2 4.26E-7 0.10
4 SGTC_1419 3993-2473 4.40 62.6 µM 3.05E-5 2 5.29E-6 0.35
5 SGTC_501 nsc-95397 4.34 161.0 µM 3.95E-5 5 7.23E-6 0.17
6 SGTC_2560 caryophyllene 4.16 100.0 µM 7.53E-5 6 1.57E-5 0.02
7 SGTC_1078 idebenone 4.03 36.1 µM 1.22E-4 Golgi 4 2.81E-5 0.03
8 SGTC_502 l-744,832 3.91 89.3 µM 1.85E-4 calcium & mitochondrial duress 7 4.62E-5 0.50
9 SGTC_513 4245-1575 3.89 41.7 µM 1.96E-4 unfolded protein response 31 4.95E-5 0.10
10 SGTC_1326 1431-2094 3.81 10.8 µM 2.63E-4 tubulin folding & SWR complex 6 7.06E-5 0.25
11 SGTC_1331 1472-0049 3.65 76.2 µM 4.36E-4 7 1.29E-4 0.00
12 SGTC_521 r062-0005 3.51 13.8 µM 6.83E-4 6 2.22E-4 0.27
13 SGTC_3046 9092212 3.51 49.5 µM 6.93E-4 2 2.25E-4 0.20
14 SGTC_2482 5981709 3.51 142.7 µM 7.00E-4 PDR1 19 2.28E-4 0.07
15 SGTC_1464 k208-0027 3.45 110.0 µM 8.43E-4 7 2.85E-4 0.17
16 SGTC_1372 2752-0194 3.42 270.0 µM 9.06E-4 4 3.11E-4 0.17
17 SGTC_181 1447-1644 3.41 8.1 µM 9.37E-4 endomembrane recycling 14 3.24E-4 0.01
18 SGTC_390 dec-rvkr-cmk 3.40 16.7 µM 9.84E-4 calcium & mitochondrial duress 15 3.43E-4 0.00
19 SGTC_370 0180-0345 3.30 38.7 µM 0.00133 DNA intercalators 13 4.91E-4 0.11
20 SGTC_1645 Cervolide 3.23 78.0 µM 0.00160 8 6.13E-4 0.02

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.121 1.64E-12 YGR267C FOL2 het GTP-cyclohydrolase I, catalyzes the first step in the folic acid biosynthetic pathway
0.118 6.29E-12 YDL036C PUS9 hom Mitochondrial tRNA:pseudouridine synthase, catalyzes the formation of pseudouridine at position 32 in mitochondrial tRNAs; contains an N-terminal mitochondrial targeting sequence
0.102 3.84E-9 YOR109W INP53 hom Polyphosphatidylinositol phosphatase, dephosphorylates multiple phosphatidylinositols; involved in trans Golgi network-to-early endosome pathway; hyperosmotic stress causes translocation to actin patches; contains Sac1 and 5-ptase domains
0.101 4.35E-9 YDR530C APA2 hom Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase II; AP4A phosphorylase involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; APA2 has a paralog, APA1, that arose from the whole genome duplication
0.092 1.10E-7 YFL014W HSP12 hom Plasma membrane protein involved in maintaining membrane organization in stress conditions; induced by heat shock, oxidative stress, osmostress, stationary phase, glucose depletion, oleate and alcohol; protein abundance increased in response to DNA replication stress and dietary restriction; regulated by the HOG and Ras-Pka pathways; required for dietary restriction-induced lifespan extension
0.091 1.47E-7 YLR187W SKG3 hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; potential Cdc28p substrate; similar to Skg4p; relocalizes from bud neck to cytoplasm upon DNA replication stress; SKG3 has a paralog, CAF120, that arose from the whole genome duplication
0.088 3.12E-7 YFR028C CDC14 het Protein phosphatase required for mitotic exit; located in the nucleolus until liberated by the FEAR and Mitotic Exit Network in anaphase, enabling it to act on key substrates to effect a decrease in CDK/B-cyclin activity and mitotic exit; required for meiosis I spindle disassembly; released from nucleolus upon entry into anaphase I of meiosis, resequestered in metaphase II, then released again upon entry into anaphase II; maintained in nucleolus by Cdc55p in early meiosis
0.086 6.41E-7 YPL088W_p YPL088W_p hom Putative aryl alcohol dehydrogenase; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance
0.083 1.43E-6 YLL048C YBT1 hom Transporter of the ATP-binding cassette (ABC) family; involved in bile acid transport; negative regulator of vacuole fusion; regulates the release of lumenal Ca2+ stores; similar to mammalian bile transporters
0.082 1.73E-6 YLL040C VPS13 hom Protein of unknown function; heterooligomeric or homooligomeric complex; peripherally associated with membranes; involved in sporulation, vacuolar protein sorting, prospore membrane formation and protein-Golgi retention; homologous to human CHAC and COH1 which are involved in chorea acanthocytosis and Cohen syndrome, respectively
0.082 1.99E-6 YOR215C AIM41 hom Putative protein of unknown function; the authentic protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays reduced frequency of mitochondrial genome loss
0.080 3.26E-6 YGR011W_d YGR011W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.079 4.24E-6 YPL133C RDS2 hom Transcription factor involved in regulating gluconeogenesis and glyoxylate cycle genes; member of the zinc cluster family of proteins; confers resistance to ketoconazole
0.078 6.38E-6 YOR164C GET4 hom Protein with a role in insertion of tail-anchored proteins into the ER membrane; forms a complex with Mdy2p; highly conserved across species and homologous to human gene C7orf20
0.077 8.12E-6 YGL039W YGL039W hom Oxidoreductase shown to reduce carbonyl compounds to chiral alcohols